TACR2 (tachykinin receptor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: TACR2 (tachykinin receptor 2) Homo sapiens
Analyze
Symbol: TACR2
Name: tachykinin receptor 2
RGD ID: 736836
HGNC Page HGNC:11527
Description: Predicted to enable substance K receptor activity. Involved in positive regulation of flagellated sperm motility. Located in plasma membrane; sperm head; and sperm midpiece. Implicated in asthma.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neurokinin 2 receptor; neurokinin A receptor; neurokinin B receptor; NK-2 receptor; NK-2R; NK2R; NKNAR; seven transmembrane helix receptor; SKR; substance K receptor; substance-K receptor; TAC2R
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381069,403,903 - 69,416,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1069,403,903 - 69,416,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371071,163,659 - 71,176,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,833,964 - 70,846,680 (-)NCBINCBI36Build 36hg18NCBI36
Build 341070,834,587 - 70,846,085NCBI
Celera1064,440,372 - 64,453,089 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1065,163,875 - 65,176,488 (-)NCBIHuRef
CHM1_11071,445,702 - 71,458,328 (-)NCBICHM1_1
T2T-CHM13v2.01070,271,946 - 70,284,965 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IDA,IEA,TAS)
sperm flagellum  (IDA)
sperm head  (IDA)
sperm midpiece  (IBA,IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats. Abdel-Gawad M, etal., J Urol. 2001 May;165(5):1739-44.
2. Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat. Birder LA, etal., J Pharmacol Exp Ther. 2003 Jan;304(1):272-6.
3. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
4. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. Kim TB, etal., J Clin Pharm Ther. 2009 Aug;34(4):457-64.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The effect of the tachykinin NK(2) receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics. Schelfhout V, etal., Ther Adv Respir Dis. 2009 Oct;3(5):219-26.
9. Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment. Ye YM, etal., J Clin Pharm Ther. 2009 Dec;34(6):693-701.
Additional References at PubMed
PMID:1370160   PMID:1659296   PMID:1659297   PMID:1661704   PMID:1710456   PMID:1845990   PMID:1848773   PMID:2173708   PMID:7721803   PMID:7961636   PMID:8307161   PMID:10189055  
PMID:10862829   PMID:11786503   PMID:11906947   PMID:12427486   PMID:12477932   PMID:12716968   PMID:12742655   PMID:12801882   PMID:14702039   PMID:15294896   PMID:15452121   PMID:15690122  
PMID:16344560   PMID:16385451   PMID:16754659   PMID:16893949   PMID:17402972   PMID:17437961   PMID:17448763   PMID:17503489   PMID:17532769   PMID:17703412   PMID:18051367   PMID:18203813  
PMID:18219665   PMID:18601911   PMID:18835556   PMID:19086053   PMID:19258923   PMID:19375820   PMID:20503287   PMID:21873635   PMID:22199357   PMID:22474018   PMID:22733436   PMID:23142211  
PMID:23597562   PMID:26371842   PMID:27146034   PMID:27456549   PMID:28030866   PMID:32600668   PMID:35561088   PMID:37944618  


Genomics

Comparative Map Data
TACR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381069,403,903 - 69,416,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1069,403,903 - 69,416,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371071,163,659 - 71,176,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,833,964 - 70,846,680 (-)NCBINCBI36Build 36hg18NCBI36
Build 341070,834,587 - 70,846,085NCBI
Celera1064,440,372 - 64,453,089 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1065,163,875 - 65,176,488 (-)NCBIHuRef
CHM1_11071,445,702 - 71,458,328 (-)NCBICHM1_1
T2T-CHM13v2.01070,271,946 - 70,284,965 (-)NCBIT2T-CHM13v2.0
Tacr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,088,217 - 62,101,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,088,217 - 62,101,769 (+)EnsemblGRCm39 Ensembl
GRCm381062,252,438 - 62,265,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,252,438 - 62,265,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371061,715,186 - 61,728,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361061,648,113 - 61,661,347 (+)NCBIMGSCv36mm8
Celera1063,355,717 - 63,369,239 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.37NCBI
Tacr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,751,645 - 30,766,181 (+)NCBIGRCr8
mRatBN7.22030,208,907 - 30,223,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,208,907 - 30,223,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2031,219,840 - 31,234,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02030,610,743 - 30,625,283 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02031,347,369 - 31,361,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,892,515 - 31,905,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,892,515 - 31,905,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02033,683,625 - 33,697,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,631,222 - 31,645,611 (+)NCBICelera
Cytogenetic Map20q11NCBI
Tacr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,719,246 - 21,731,963 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543721,719,246 - 21,731,963 (+)NCBIChiLan1.0ChiLan1.0
TACR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2881,552,259 - 81,564,930 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11081,555,052 - 81,570,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,872,795 - 65,885,154 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11068,403,637 - 68,415,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1068,403,979 - 68,415,224 (-)Ensemblpanpan1.1panPan2
TACR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,518,797 - 20,531,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,517,563 - 20,531,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,648,836 - 20,661,157 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,789,440 - 20,803,600 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,789,441 - 20,803,805 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,690,847 - 20,703,141 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,894,732 - 20,907,028 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,238,092 - 21,250,413 (-)NCBIUU_Cfam_GSD_1.0
Tacr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721360,560,454 - 60,573,628 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365219,053,179 - 9,065,797 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365219,053,179 - 9,065,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TACR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,462,046 - 72,475,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11472,463,405 - 72,476,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,472,145 - 78,484,779 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TACR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,902,565 - 61,915,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl961,903,477 - 61,914,558 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604822,643,039 - 22,655,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247543,656,319 - 3,670,432 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247543,658,128 - 3,670,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TACR2
21 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2		 pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2		 pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2		 pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3		 pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2		 pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_001057.3(TACR2):c.392+8G>A single nucleotide variant not provided [RCV000967759] Chr10:69415924 [GRCh38]
Chr10:71175680 [GRCh37]
Chr10:10q22.1		 benign
NM_001057.3(TACR2):c.751A>G (p.Thr251Ala) single nucleotide variant not provided [RCV000959875] Chr10:69407271 [GRCh38]
Chr10:71167027 [GRCh37]
Chr10:10q22.1		 benign
NM_001057.3(TACR2):c.968G>A (p.Arg323His) single nucleotide variant not provided [RCV000886794] Chr10:69405055 [GRCh38]
Chr10:71164811 [GRCh37]
Chr10:10q22.1		 benign
NM_001057.3(TACR2):c.1023G>A (p.Thr341=) single nucleotide variant not provided [RCV000924845] Chr10:69405000 [GRCh38]
Chr10:71164756 [GRCh37]
Chr10:10q22.1		 likely benign
NM_001057.3(TACR2):c.943C>T (p.Arg315Cys) single nucleotide variant not specified [RCV004296544] Chr10:69405080 [GRCh38]
Chr10:71164836 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.1128C>T (p.Pro376=) single nucleotide variant not provided [RCV000890063] Chr10:69404895 [GRCh38]
Chr10:71164651 [GRCh37]
Chr10:10q22.1		 benign
NM_001057.3(TACR2):c.14A>G (p.Asp5Gly) single nucleotide variant not provided [RCV000956833] Chr10:69416310 [GRCh38]
Chr10:71176066 [GRCh37]
Chr10:10q22.1		 benign
GRCh37/hg19 10q21.3-22.3(chr10:68735254-78885714) copy number loss not specified [RCV002052875] Chr10:68735254..78885714 [GRCh37]
Chr10:10q21.3-22.3		 pathogenic
NC_000010.10:g.(?_67680088)_(71332799_?)del deletion not provided [RCV001956019] Chr10:67680088..71332799 [GRCh37]
Chr10:10q21.3-22.1		 pathogenic|uncertain significance
NM_001057.3(TACR2):c.250G>T (p.Ala84Ser) single nucleotide variant not specified [RCV004223682] Chr10:69416074 [GRCh38]
Chr10:71175830 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.278A>G (p.Tyr93Cys) single nucleotide variant not specified [RCV004164573] Chr10:69416046 [GRCh38]
Chr10:71175802 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.761T>C (p.Leu254Pro) single nucleotide variant not specified [RCV004123798] Chr10:69407261 [GRCh38]
Chr10:71167017 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.1022C>G (p.Thr341Arg) single nucleotide variant not specified [RCV004184040] Chr10:69405001 [GRCh38]
Chr10:71164757 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.556C>T (p.Pro186Ser) single nucleotide variant not specified [RCV004159789] Chr10:69414976 [GRCh38]
Chr10:71174732 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.967C>T (p.Arg323Cys) single nucleotide variant not specified [RCV004215771] Chr10:69405056 [GRCh38]
Chr10:71164812 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.173T>A (p.Ile58Asn) single nucleotide variant not specified [RCV004168263] Chr10:69416151 [GRCh38]
Chr10:71175907 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.194G>A (p.Arg65His) single nucleotide variant not specified [RCV004078229] Chr10:69416130 [GRCh38]
Chr10:71175886 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.1181C>A (p.Thr394Asn) single nucleotide variant not specified [RCV004177667] Chr10:69404842 [GRCh38]
Chr10:71164598 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.632C>T (p.Ala211Val) single nucleotide variant not specified [RCV004274824] Chr10:69409031 [GRCh38]
Chr10:71168787 [GRCh37]
Chr10:10q22.1		 likely benign
NM_001057.3(TACR2):c.424C>T (p.Arg142Trp) single nucleotide variant not specified [RCV004252706] Chr10:69415108 [GRCh38]
Chr10:71174864 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
NM_001057.3(TACR2):c.157A>G (p.Ile53Val) single nucleotide variant not specified [RCV004344928] Chr10:69416167 [GRCh38]
Chr10:71175923 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.1142G>C (p.Gly381Ala) single nucleotide variant not specified [RCV004346042] Chr10:69404881 [GRCh38]
Chr10:71164637 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.239T>G (p.Leu80Arg) single nucleotide variant not specified [RCV004355810] Chr10:69416085 [GRCh38]
Chr10:71175841 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
NM_001057.3(TACR2):c.565A>G (p.Ser189Gly) single nucleotide variant not specified [RCV004466256] Chr10:69414967 [GRCh38]
Chr10:71174723 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.59C>T (p.Thr20Ile) single nucleotide variant not specified [RCV004466257] Chr10:69416265 [GRCh38]
Chr10:71176021 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.974G>A (p.Cys325Tyr) single nucleotide variant not specified [RCV004466259] Chr10:69405049 [GRCh38]
Chr10:71164805 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.769C>G (p.Leu257Val) single nucleotide variant not specified [RCV004466258] Chr10:69407253 [GRCh38]
Chr10:71167009 [GRCh37]
Chr10:10q22.1		 likely benign
NM_001057.3(TACR2):c.988C>T (p.Pro330Ser) single nucleotide variant not specified [RCV004466260] Chr10:69405035 [GRCh38]
Chr10:71164791 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.221A>G (p.Asn74Ser) single nucleotide variant not specified [RCV004466255] Chr10:69416103 [GRCh38]
Chr10:71175859 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.351G>A (p.Met117Ile) single nucleotide variant not specified [RCV004671067] Chr10:69415973 [GRCh38]
Chr10:71175729 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_001057.3(TACR2):c.481G>T (p.Ala161Ser) single nucleotide variant not specified [RCV004671068] Chr10:69415051 [GRCh38]
Chr10:71174807 [GRCh37]
Chr10:10q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:551
Count of miRNA genes:361
Interacting mature miRNAs:385
Transcripts:ENST00000373306, ENST00000373307
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407300251GWAS949227_Hmortality QTL GWAS949227 (human)0.000004mortalityratio of deaths to total study population during a period of time (CMO:0001023)106941585369415854Human

Markers in Region
RH11099  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371071,164,564 - 71,164,779UniSTSGRCh37
Build 361070,834,570 - 70,834,785RGDNCBI36
Celera1064,440,978 - 64,441,193RGD
Cytogenetic Map10q22.1UniSTS
HuRef1065,164,481 - 65,164,696UniSTS
G59370  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371071,176,028 - 71,176,300UniSTSGRCh37
Build 361070,846,034 - 70,846,306RGDNCBI36
Celera1064,452,443 - 64,452,715RGD
Cytogenetic Map10q22.1UniSTS
HuRef1065,175,842 - 65,176,114UniSTS
TNG Radiation Hybrid Map1032024.0UniSTS
GDB:193874  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371071,176,283 - 71,176,491UniSTSGRCh37
Build 361070,846,289 - 70,846,497RGDNCBI36
Celera1064,452,698 - 64,452,906RGD
Cytogenetic Map10q22.1UniSTS
HuRef1065,176,097 - 65,176,305UniSTS
RH46959  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371071,164,031 - 71,164,190UniSTSGRCh37
Build 361070,834,037 - 70,834,196RGDNCBI36
Celera1064,440,445 - 64,440,604RGD
Cytogenetic Map10q22.1UniSTS
HuRef1065,163,948 - 65,164,107UniSTS
GeneMap99-GB4 RH Map10369.45UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF361880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY322545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA929480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ200479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000373306   ⟹   ENSP00000362403
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1069,403,903 - 69,416,918 (-)Ensembl
Ensembl Acc Id: ENST00000373307   ⟹   ENSP00000362404
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1069,403,903 - 69,409,282 (-)Ensembl
Ensembl Acc Id: ENST00000619173   ⟹   ENSP00000482436
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1069,404,202 - 69,416,323 (-)Ensembl
RefSeq Acc Id: NM_001057   ⟹   NP_001048
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381069,403,903 - 69,416,918 (-)NCBI
GRCh371071,163,958 - 71,176,674 (-)ENTREZGENE
GRCh371071,163,958 - 71,176,674 (-)NCBI
Build 361070,833,964 - 70,846,680 (-)NCBI Archive
HuRef1065,163,875 - 65,176,488 (-)ENTREZGENE
CHM1_11071,445,702 - 71,458,328 (-)NCBI
T2T-CHM13v2.01070,271,946 - 70,284,965 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001048   ⟸   NM_001057
- UniProtKB: Q9UDE6 (UniProtKB/Swiss-Prot),   Q8NGQ8 (UniProtKB/Swiss-Prot),   Q4QRI5 (UniProtKB/Swiss-Prot),   A8K7I1 (UniProtKB/Swiss-Prot),   Q9UDE7 (UniProtKB/Swiss-Prot),   P21452 (UniProtKB/Swiss-Prot),   B4DUH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000362404   ⟸   ENST00000373307
Ensembl Acc Id: ENSP00000362403   ⟸   ENST00000373306
Ensembl Acc Id: ENSP00000482436   ⟸   ENST00000619173
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21452-F1-model_v2 AlphaFold P21452 1-398 view protein structure

Promoters
RGD ID:7217741
Promoter ID:EPDNEW_H14614
Type:initiation region
Name:TACR2_1
Description:tachykinin receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381069,416,918 - 69,416,978EPDNEW
RGD ID:6788291
Promoter ID:HG_KWN:9874
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000373307
Position:
Human AssemblyChrPosition (strand)Source
Build 361070,838,476 - 70,838,976 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11527 AgrOrtholog
COSMIC TACR2 COSMIC
Ensembl Genes ENSG00000075073 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000373306 ENTREZGENE
  ENST00000373306.5 UniProtKB/Swiss-Prot
  ENST00000373307.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000075073 GTEx
HGNC ID HGNC:11527 ENTREZGENE
Human Proteome Map TACR2 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurokn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NK2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6865 UniProtKB/Swiss-Prot
NCBI Gene 6865 ENTREZGENE
OMIM 162321 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46925:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36303 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININ2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NEW7_HUMAN UniProtKB/TrEMBL
  A8K7I1 ENTREZGENE
  B4DUH5 ENTREZGENE, UniProtKB/TrEMBL
  NK2R_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRI5 ENTREZGENE
  Q8NGQ8 ENTREZGENE
  Q9UDE6 ENTREZGENE
  Q9UDE7 ENTREZGENE
UniProt Secondary A8K7I1 UniProtKB/Swiss-Prot
  Q4QRI5 UniProtKB/Swiss-Prot
  Q8NGQ8 UniProtKB/Swiss-Prot
  Q9UDE6 UniProtKB/Swiss-Prot
  Q9UDE7 UniProtKB/Swiss-Prot