Pafah1b1 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 1) - Rat Genome Database
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Gene: Pafah1b1 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 1) Mus musculus
Analyze
Symbol: Pafah1b1
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
RGD ID: 1622377
MGI Page MGI
Description: Exhibits identical protein binding activity; microtubule binding activity; and phosphoprotein binding activity. Involved in several processes, including cytoskeleton organization; nervous system development; and transport along microtubule. Localizes to several cellular components, including microtubule cytoskeleton; perinuclear region of cytoplasm; and stereocilium. Colocalizes with cell leading edge. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L; LI; LIS-1; Lis1; lissencephaly-1 protein; Mds; Mdsh; MGC25297; MMS10-U; Ms10u; Pa; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Pafaha; Pafaha/Lis1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 45kD subunit; platelet-activating factor acetylhydrolase IB alpha subunit; platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit; truncated form platelet-activating factor acetylhydrolase 45kD subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Pafah1b1-ps1   Pafah1b1-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,564,775 - 74,615,210 (-)NCBIGRCm39mm39
GRCm381174,673,949 - 74,724,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,673,949 - 74,724,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,487,452 - 74,537,886 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,490,150 - 74,540,865 (-)NCBImm8
Celera1182,183,768 - 82,236,827 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Apafant  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (EXP)
castor oil  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
glucose  (EXP)
isosorbide mononitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium dichromate  (EXP)
succimer  (EXP)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosome assembly  (IMP)
actin cytoskeleton organization  (IMP)
adult locomotory behavior  (IMP,ISO)
ameboidal-type cell migration  (IMP)
auditory receptor cell development  (IMP)
brain development  (ISO)
brain morphogenesis  (IBA,ISO)
cell differentiation  (IEA)
cell division  (IEA)
cell migration  (IMP)
cerebral cortex development  (IGI,IMP,ISO)
cerebral cortex neuron differentiation  (ISO)
chemical synaptic transmission  (IMP)
cochlea development  (IMP)
corpus callosum morphogenesis  (ISO)
cortical microtubule organization  (IMP)
establishment of centrosome localization  (ISO)
establishment of mitotic spindle orientation  (IBA,ISO)
establishment of planar polarity of embryonic epithelium  (IMP)
germ cell development  (IBA)
hippocampus development  (IGI,IMP)
layer formation in cerebral cortex  (IGI)
learning or memory  (IMP)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
maintenance of centrosome location  (IMP)
microtubule cytoskeleton organization  (IGI,IMP)
microtubule cytoskeleton organization involved in establishment of planar polarity  (IMP)
microtubule organizing center organization  (IBA,ISO)
microtubule-based process  (ISO)
multicellular organism development  (IEA)
negative regulation of JNK cascade  (IGI)
negative regulation of neuron projection development  (ISO)
nervous system development  (IEA)
neuroblast proliferation  (IMP)
neuromuscular process controlling balance  (IMP,ISO)
neuron migration  (IGI,IMP,ISO)
nuclear envelope disassembly  (IMP)
nuclear migration  (IBA,ISO)
osteoclast development  (IMP)
positive regulation of axon extension  (ISO)
positive regulation of cellular component organization  (IMP)
positive regulation of cytokine-mediated signaling pathway  (IMP)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of embryonic development  (IMP)
positive regulation of mitotic cell cycle  (ISO)
protein secretion  (IMP)
reelin-mediated signaling pathway  (IMP)
regulation of GTPase activity  (IMP)
regulation of microtubule cytoskeleton organization  (IMP)
regulation of microtubule motor activity  (IBA)
retrograde axonal transport  (IBA,IDA)
stem cell division  (ISO)
transmission of nerve impulse  (IMP)
vesicle transport along microtubule  (IBA,IGI)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acrosome morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal germ cell morphology  (IAGP)
abnormal hippocampus layer morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal roof plate morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal spermiation  (IAGP)
abnormal spermiogenesis  (IAGP)
abnormal spinal cord dorsal horn morphology  (IAGP)
abnormal spinal cord interneuron morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spinal cord ventral horn morphology  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal testis morphology  (IAGP)
absent hippocampus stratum oriens  (IAGP)
arrest of spermiogenesis  (IAGP)
azoospermia  (IAGP)
choroid plexus hyperplasia  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased male germ cell number  (IAGP)
decreased neuron number  (IAGP)
decreased testis weight  (IAGP)
delayed brain development  (IAGP)
ectopic Purkinje cell  (IAGP)
embryonic lethality at implantation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged brain ventricles  (IAGP)
impaired coordination  (IAGP)
increased neuron apoptosis  (IAGP)
limb grasping  (IAGP)
male infertility  (IAGP)
multinucleated giant male germ cells  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
small testis  (IAGP)
References

Additional References at PubMed
PMID:2740347   PMID:7751941   PMID:7767001   PMID:7821822   PMID:8619131   PMID:8954729   PMID:9199935   PMID:9479492   PMID:9601647   PMID:9623676   PMID:9697693   PMID:10026115  
PMID:10349636   PMID:10371146   PMID:10393212   PMID:10403203   PMID:10491172   PMID:10729324   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11159375   PMID:11163258   PMID:11163259  
PMID:11163260   PMID:11172053   PMID:11210178   PMID:11217851   PMID:11231056   PMID:11344260   PMID:11756344   PMID:11803439   PMID:11940666   PMID:12130536   PMID:12200366   PMID:12466851  
PMID:12477932   PMID:12520002   PMID:12551946   PMID:12629176   PMID:12775763   PMID:12796778   PMID:12904583   PMID:12905154   PMID:12911752   PMID:12950100   PMID:13129914   PMID:14507966  
PMID:14578885   PMID:14610273   PMID:14681479   PMID:14691133   PMID:15208636   PMID:15274919   PMID:15331402   PMID:15572112   PMID:15762842   PMID:15939891   PMID:15998744   PMID:16107726  
PMID:16141072   PMID:16141073   PMID:16172262   PMID:16203747   PMID:16369480   PMID:16445939   PMID:16481446   PMID:16602821   PMID:17130546   PMID:17148952   PMID:17314247   PMID:17433713  
PMID:17555748   PMID:17881479   PMID:17903175   PMID:17967808   PMID:17997972   PMID:18075262   PMID:18075263   PMID:18267077   PMID:18331715   PMID:18434304   PMID:18446829   PMID:18469343  
PMID:18514414   PMID:18524253   PMID:18799693   PMID:18809722   PMID:18983980   PMID:19515951   PMID:19734909   PMID:19861636   PMID:19874786   PMID:19938147   PMID:20007476   PMID:20181597  
PMID:20360068   PMID:20364144   PMID:20531249   PMID:20620871   PMID:20624590   PMID:21070969   PMID:21092859   PMID:21183738   PMID:21267068   PMID:21350014   PMID:21423666   PMID:21515572  
PMID:21734362   PMID:21844209   PMID:21873635   PMID:21911489   PMID:21935943   PMID:22028625   PMID:22073305   PMID:22114287   PMID:22522921   PMID:22973010   PMID:23483698   PMID:23483716  
PMID:23533177   PMID:23673330   PMID:23783758   PMID:23830831   PMID:23926272   PMID:24030547   PMID:24487275   PMID:24812355   PMID:24853954   PMID:24952961   PMID:25245017   PMID:25698733  
PMID:26079645   PMID:26098214   PMID:26496610   PMID:26834590   PMID:27029586   PMID:27889896   PMID:28039900   PMID:28446568   PMID:28630356   PMID:28836069   PMID:29150182   PMID:29404402  
PMID:29470990   PMID:29475944   PMID:29562183   PMID:30923192   PMID:31027966   PMID:31073041   PMID:32325033  


Genomics

Comparative Map Data
Pafah1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,564,775 - 74,615,210 (-)NCBIGRCm39mm39
GRCm381174,673,949 - 74,724,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,673,949 - 74,724,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,487,452 - 74,537,886 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,490,150 - 74,540,865 (-)NCBImm8
Celera1182,183,768 - 82,236,827 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
PAFAH1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl172,593,210 - 2,685,615 (+)EnsemblGRCh38hg38GRCh38
GRCh38172,593,210 - 2,685,617 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37172,496,923 - 2,588,909 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37172,496,948 - 2,588,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36172,443,686 - 2,535,638 (+)NCBINCBI36hg18NCBI36
Build 34172,443,685 - 2,535,638NCBI
Celera172,513,612 - 2,605,584 (+)NCBI
Cytogenetic Map17p13.3NCBI
HuRef172,389,423 - 2,481,264 (+)NCBIHuRef
CHM1_1172,505,702 - 2,597,647 (+)NCBICHM1_1
CHM1_1172,525,188 - 2,529,780 (+)NCBICHM1_1
Pafah1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21059,533,042 - 59,591,808 (-)NCBI
Rnor_6.0 Ensembl1061,456,145 - 61,577,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01061,456,144 - 61,577,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01061,186,183 - 61,299,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41061,955,348 - 62,037,871 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11061,968,971 - 62,051,494 (-)NCBI
Celera1058,565,530 - 58,623,461 (-)NCBICelera
Cytogenetic Map10q24NCBI
Pafah1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955481608,897 - 686,452 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955481608,897 - 686,454 (-)NCBIChiLan1.0ChiLan1.0
PAFAH1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1172,589,129 - 2,680,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,590,007 - 2,680,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0172,584,349 - 2,676,928 (+)NCBIMhudiblu_PPA_v0panPan3
PAFAH1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl946,648,052 - 46,771,400 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1946,648,057 - 46,731,259 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pafah1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365388,612,142 - 8,693,698 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAFAH1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,567,337 - 48,735,838 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,567,329 - 48,735,836 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21250,398,376 - 50,505,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAFAH1B1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,270,126 - 2,293,705 (+)NCBI
ChlSab1.1 Ensembl162,270,085 - 2,296,825 (+)Ensembl
Pafah1b1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247865,223,890 - 5,306,033 (+)NCBI

Position Markers
D11Mit352  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381174,707,235 - 74,707,475UniSTSGRCm38
MGSCv371174,520,737 - 74,520,977UniSTSGRCm37
Celera1182,219,766 - 82,219,998UniSTS
Cytogenetic Map11B3UniSTS
cM Map1144.0UniSTS
Whitehead Genetic1140.4UniSTS
Whitehead_YAC11 UniSTS
Pafah1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS
cM Map1144.0UniSTS
Ms10u  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381174,707,145 - 74,707,576UniSTSGRCm38
MGSCv371174,520,647 - 74,521,078UniSTSGRCm37
Celera1182,219,676 - 82,220,099UniSTS
Cytogenetic Map11B3UniSTS
cM Map1143.0UniSTS
PMC310661P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381174,685,893 - 74,686,029UniSTSGRCm38
MGSCv371174,499,395 - 74,499,531UniSTSGRCm37
Celera1182,195,695 - 82,195,831UniSTS
Cytogenetic Map11B3UniSTS
cM Map1144.0UniSTS
D11Bhm7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381174,680,881 - 74,680,968UniSTSGRCm38
MGSCv371174,494,383 - 74,494,470UniSTSGRCm37
Celera1182,190,698 - 82,190,785UniSTS
Cytogenetic Map11B3UniSTS
cM Map1143.76UniSTS
D11Bhm9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381174,678,497 - 74,678,618UniSTSGRCm38
MGSCv371174,491,999 - 74,492,120UniSTSGRCm37
Celera1182,188,315 - 82,188,436UniSTS
Cytogenetic Map11B3UniSTS
cM Map1143.82UniSTS
Pafah1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117384671582178599Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2333
Count of miRNA genes:652
Interacting mature miRNAs:783
Transcripts:ENSMUST00000021091, ENSMUST00000102520, ENSMUST00000126341, ENSMUST00000155493, ENSMUST00000156794
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_037610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ248244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL607024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY189217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY189218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE456911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ895724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021091   ⟹   ENSMUSP00000021091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1174,673,949 - 74,724,670 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102520   ⟹   ENSMUSP00000099578
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1174,673,950 - 74,723,858 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1174,673,949 - 74,724,335 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155493   ⟹   ENSMUSP00000118231
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1174,689,085 - 74,723,171 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156794
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1174,673,950 - 74,724,318 (-)Ensembl
RefSeq Acc Id: NM_013625   ⟹   NP_038653
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391174,564,775 - 74,615,210 (-)NCBI
GRCm381174,673,949 - 74,724,384 (-)ENTREZGENE
MGSCv371174,487,452 - 74,537,886 (-)RGD
Celera1182,183,767 - 82,236,827 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_037610
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391174,564,775 - 74,614,684 (-)NCBI
GRCm381174,673,949 - 74,723,858 (-)NCBI
Celera1182,183,767 - 82,236,827 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038653   ⟸   NM_013625
- UniProtKB: P63005 (UniProtKB/Swiss-Prot),   Q5SW18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021091   ⟸   ENSMUST00000021091
RefSeq Acc Id: ENSMUSP00000099578   ⟸   ENSMUST00000102520
RefSeq Acc Id: ENSMUSP00000118231   ⟸   ENSMUST00000155493
Protein Domains
LisH   WD_REPEATS_REGION

Promoters
RGD ID:6821496
Promoter ID:MM_KWN:8454
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000102520,   OTTMUST00000013926,   OTTMUST00000013927,   OTTMUST00000048935,   UC007KCD.1,   UC007KCF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361174,537,201 - 74,538,387 (-)MPROMDB
RGD ID:8675500
Promoter ID:EPDNEW_M15781
Type:single initiation site
Name:Pafah1b1_3
Description:Mus musculus platelet-activating factor acetylhydrolase, isoform1b, subunit 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15782  EPDNEW_M15783  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381174,699,694 - 74,699,754EPDNEW
RGD ID:8675502
Promoter ID:EPDNEW_M15782
Type:multiple initiation site
Name:Pafah1b1_2
Description:Mus musculus platelet-activating factor acetylhydrolase, isoform1b, subunit 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15781  EPDNEW_M15783  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381174,723,838 - 74,723,898EPDNEW
RGD ID:8675504
Promoter ID:EPDNEW_M15783
Type:initiation region
Name:Pafah1b1_1
Description:Mus musculus platelet-activating factor acetylhydrolase, isoform1b, subunit 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15781  EPDNEW_M15782  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381174,724,350 - 74,724,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109520 AgrOrtholog
Ensembl Genes ENSMUSG00000020745 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021091 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000099578 UniProtKB/Swiss-Prot
  ENSMUSP00000118231 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021091 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000102520 UniProtKB/Swiss-Prot
  ENSMUST00000155493 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynein_regulator_LIS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIS1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109520 ENTREZGENE
NCBI Gene 18472 ENTREZGENE
Pfam LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pafah1b1 PhenoGen
PIRSF Dynein_regulator_Lis1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LISH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF109925 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LIS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TIK0_MOUSE UniProtKB/TrEMBL
  Q3TJG1_MOUSE UniProtKB/TrEMBL
  Q3TUH5_MOUSE UniProtKB/TrEMBL
  Q3UGR6_MOUSE UniProtKB/TrEMBL
  Q3UH92_MOUSE UniProtKB/TrEMBL
  Q3UHM0_MOUSE UniProtKB/TrEMBL
  Q5SW16_MOUSE UniProtKB/TrEMBL
  Q5SW18 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35592 UniProtKB/Swiss-Prot
  P43035 UniProtKB/Swiss-Prot
  P81692 UniProtKB/Swiss-Prot
  Q9R2A6 UniProtKB/Swiss-Prot