Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)) - Rat Genome Database

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Gene: Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)) Mus musculus
Analyze
Symbol: Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
RGD ID: 11035
MGI Page MGI
Description: Involved in extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Localizes to extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b); INTERACTS WITH (-)-anisomycin; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: O; OC; OCIF; Opg; osteoclastogenesis inhibitory factor; osteoprotegerin; TR; TR1; tumor necrosis factor receptor superfamily member 11B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391554,114,014 - 54,141,880 (-)NCBIGRCm39mm39
GRCm39 Ensembl1554,114,015 - 54,141,880 (-)Ensembl
GRCm381554,250,619 - 54,278,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1554,250,619 - 54,278,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371554,082,174 - 54,110,039 (-)NCBIGRCm37mm9NCBIm37
MGSCv361554,080,702 - 54,108,567 (-)NCBImm8
Celera1555,801,719 - 55,829,545 (-)NCBICelera
Cytogenetic Map15D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amsacrine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
aripiprazole  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbocyclic thromboxane A2  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carmustine  (ISO)
celecoxib  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
chondroitin sulfate  (ISO)
chromium(3+) trichloride  (EXP)
clothianidin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (EXP)
dihydro-beta-erythroidine  (ISO)
dioscin  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
icariin  (EXP)
icariside II  (ISO)
indometacin  (ISO)
iron dextran  (ISO)
isoflurane  (ISO)
isonicotinamide  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP)
menadione  (ISO)
menaquinone-7  (EXP)
menatetrenone  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (ISO)
ospemifene  (ISO)
ozagrel  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
paricalcitol  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
poly(ethylene)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
prostaglandin D2  (EXP)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rubiadin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium atom  (EXP,ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP,ISO)
uranium atom  (EXP,ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta morphology  (IAGP)
abnormal auditory brainstem response  (IEA)
abnormal bone remodeling  (IAGP)
abnormal bone structure  (IAGP)
abnormal brachiocephalic trunk morphology  (IAGP)
abnormal brain morphology  (IEA)
abnormal compact bone morphology  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal distortion product otoacoustic emission  (IAGP)
abnormal eye morphology  (IEA)
abnormal gait  (IEA)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal incus body morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal pro-B cell differentiation  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal skin morphology  (IEA)
abnormal stapes annular ligament morphology  (IAGP)
abnormal stapes footplate morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent bone trabeculae  (IAGP)
absent distortion product otoacoustic emissions  (IAGP)
anophthalmia  (IEA)
atherosclerotic lesions  (IAGP)
calcified artery  (IAGP)
corneal opacity  (IEA)
deafness  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased brain size  (IEA)
decreased circulating triglyceride level  (IEA)
decreased trabecular bone mass  (IAGP)
enlarged kidney  (IEA)
fragile skeleton  (IAGP)
increased B cell number  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating phosphate level  (IEA)
increased diameter of long bones  (IAGP)
increased immature B cell number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoclast cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
osteoporosis  (IAGP)
otosclerosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
short femur  (IAGP)
short femur neck  (IAGP)
small spleen  (IEA)
thin parietal bone  (IAGP)
References

References - curated
1. Akat K, etal., Am J Cardiol. 2010 Mar 15;105(6):862-4. doi: 10.1016/j.amjcard.2009.10.065.
2. Altun A, etal., J Endocrinol Invest. 2004 Oct;27(9):839-43.
3. Bilgin E, etal., Asian Pac J Cancer Prev. 2012;13(9):4331-4.
4. Blazquez-Medela AM, etal., Eur J Clin Invest. 2012 May;42(5):548-56. doi: 10.1111/j.1365-2362.2011.02619.x. Epub 2011 Nov 4.
5. Chuang FH, etal., J Oral Pathol Med. 2012 Feb;41(2):186-93. doi: 10.1111/j.1600-0714.2011.01065.x. Epub 2011 Jul 28.
6. Cosme-Silva L, etal., Int Endod J. 2020 Aug;53(8):1084-1092. doi: 10.1111/iej.13311. Epub 2020 May 21.
7. Crisafulli A, etal., Clin Sci (Lond). 2005 Oct;109(4):389-95.
8. Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
9. de Amorim FP, etal., J Mol Histol. 2008 Aug;39(4):401-8. Epub 2008 Jul 1.
10. El-Shehaby A, etal., J Clin Immunol. 2011 Oct;31(5):848-56. doi: 10.1007/s10875-011-9555-1. Epub 2011 Jun 21.
11. Gu SS, etal., Nephrology (Carlton). 2012 Nov;17(8):767-73. doi: 10.1111/j.1440-1797.2012.01656.x.
12. Guldiken B, etal., Thromb Res. 2007 Jan 24;.
13. Jensen JK, etal., J Intern Med. 2010 Apr;267(4):410-7. doi: 10.1111/j.1365-2796.2009.02163.x. Epub 2009 Aug 26.
14. Jorsal A, etal., Diabetologia. 2008 Nov;51(11):2100-7. doi: 10.1007/s00125-008-1123-8. Epub 2008 Aug 22.
15. Kiechl S, etal., Circulation. 2004 May 11;109(18):2175-80. Epub 2004 Apr 26.
16. Kurnatowska I, etal., Nephron Clin Pract. 2011;117(4):c297-304. doi: 10.1159/000321169. Epub 2010 Sep 22.
17. Li X, etal., PLoS One. 2013 Sep 16;8(9):e74274. doi: 10.1371/journal.pone.0074274. eCollection 2013.
18. Li YL and Wang H, Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):653-6.
19. Liu W, etal., Exp Mol Pathol. 2008 Jun;84(3):213-7. Epub 2008 Mar 7.
20. Liu YH, etal., Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):307-10.
21. MGD and Homologene mouse data transfer
22. MGD data from the GO Consortium
23. Ndip A, etal., Diabetes. 2011 Aug;60(8):2187-96. doi: 10.2337/db10-1220. Epub 2011 Jun 9.
24. Nezami N, etal., Clin Biochem. 2010 Nov;43(16-17):1294-9. doi: 10.1016/j.clinbiochem.2010.08.012. Epub 2010 Aug 19.
25. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. OMIM Disease Annotation Pipeline
27. RGD automated import pipeline
28. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. RGD automated import pipeline for gene-chemical interactions
30. Rhee EJ, etal., Clin Sci (Lond). 2005 Mar;108(3):237-43.
31. Simonet WS, etal., Cell 1997 Apr 18;89(2):309-19.
32. Singh DK, etal., Diabetes Res Clin Pract. 2012 Jul;97(1):158-65. doi: 10.1016/j.diabres.2012.01.038. Epub 2012 Mar 3.
33. Siomou E, etal., Pediatr Nephrol. 2011 Jul;26(7):1105-14. doi: 10.1007/s00467-011-1870-5. Epub 2011 Apr 9.
34. Ueland T, etal., Circulation. 2005 May 17;111(19):2461-8. Epub 2005 May 9.
35. Ugur-Altun B, etal., Diabetes Res Clin Pract. 2005 Jun;68(3):217-22. Epub 2005 Jan 18.
36. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
37. Zheng CM, etal., Tohoku J Exp Med. 2012;226(1):19-27.
38. Ziegler S, etal., Atherosclerosis. 2005 Sep;182(1):175-80. Epub 2005 Apr 26.
Additional References at PubMed
PMID:9573043   PMID:9647741   PMID:9714833   PMID:9837769   PMID:10349636   PMID:10952716   PMID:10965921   PMID:11042159   PMID:11076861   PMID:11160187   PMID:11217851   PMID:11239407  
PMID:11918293   PMID:11920384   PMID:12211438   PMID:12446599   PMID:12477932   PMID:12506018   PMID:12526098   PMID:12568404   PMID:12697767   PMID:12923331   PMID:14500574   PMID:14525906  
PMID:14764723   PMID:14969393   PMID:14977979   PMID:14981127   PMID:15226265   PMID:15340228   PMID:15474477   PMID:15564564   PMID:15845617   PMID:15855336   PMID:15866165   PMID:16141072  
PMID:16141073   PMID:16251181   PMID:16326388   PMID:16424941   PMID:16467704   PMID:16537572   PMID:16564235   PMID:16602821   PMID:16614077   PMID:16680826   PMID:16750437   PMID:16840715  
PMID:16927271   PMID:16951341   PMID:16995817   PMID:17148684   PMID:17182555   PMID:17516544   PMID:17560185   PMID:17615383   PMID:18172035   PMID:18242177   PMID:18297083   PMID:18337202  
PMID:18458345   PMID:18668542   PMID:18668550   PMID:18757743   PMID:18788552   PMID:18799150   PMID:18927151   PMID:19170762   PMID:19197242   PMID:19228596   PMID:19419310   PMID:19633200  
PMID:19641036   PMID:19819969   PMID:20142103   PMID:20200944   PMID:20200998   PMID:20369527   PMID:20440000   PMID:20936961   PMID:20963556   PMID:21079361   PMID:21148188   PMID:21267068  
PMID:21332025   PMID:21346198   PMID:21351141   PMID:21426505   PMID:21439958   PMID:21466864   PMID:21478097   PMID:21656335   PMID:21750093   PMID:22196183   PMID:22457635   PMID:22522930  
PMID:22551876   PMID:22564414   PMID:23039992   PMID:23071670   PMID:23268391   PMID:23291450   PMID:23331792   PMID:23567158   PMID:23580147   PMID:23607938   PMID:23722907   PMID:23728177  
PMID:23762316   PMID:23990207   PMID:24006456   PMID:24327965   PMID:24642764   PMID:24847069   PMID:24948010   PMID:24998520   PMID:25301844   PMID:25401279   PMID:25464126   PMID:25736226  
PMID:25846796   PMID:26093292   PMID:26094891   PMID:26134413   PMID:26254339   PMID:26329493   PMID:26751951   PMID:26783750   PMID:26825553   PMID:26825871   PMID:26923114   PMID:26947973  
PMID:27052174   PMID:27064449   PMID:27085457   PMID:27188231   PMID:27460899   PMID:27541035   PMID:27621061   PMID:27697839   PMID:27764222   PMID:27804995   PMID:27898403   PMID:28070143  
PMID:28319142   PMID:28336912   PMID:28373003   PMID:28543818   PMID:28840938   PMID:28937990   PMID:29202462   PMID:29382610   PMID:29415886   PMID:29644561   PMID:29662200   PMID:30254073  
PMID:30422320   PMID:30623241   PMID:30626205   PMID:30626485   PMID:31081236   PMID:31318102   PMID:31356686   PMID:31696568   PMID:31729368   PMID:31932605   PMID:31943048   PMID:31958462  
PMID:32053272   PMID:32186512   PMID:32307402   PMID:32315212   PMID:32614927   PMID:32636266   PMID:32694652   PMID:32905775   PMID:32913205   PMID:33141273   PMID:33633362  


Genomics

Comparative Map Data
Tnfrsf11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391554,114,014 - 54,141,880 (-)NCBIGRCm39mm39
GRCm39 Ensembl1554,114,015 - 54,141,880 (-)Ensembl
GRCm381554,250,619 - 54,278,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1554,250,619 - 54,278,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371554,082,174 - 54,110,039 (-)NCBIGRCm37mm9NCBIm37
MGSCv361554,080,702 - 54,108,567 (-)NCBImm8
Celera1555,801,719 - 55,829,545 (-)NCBICelera
Cytogenetic Map15D1NCBI
TNFRSF11B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8118,923,557 - 118,951,885 (-)EnsemblGRCh38hg38GRCh38
GRCh388118,923,557 - 118,951,885 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378119,935,796 - 119,964,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368120,004,977 - 120,033,564 (-)NCBINCBI36hg18NCBI36
Build 348120,004,977 - 120,033,492NCBI
Celera8116,124,073 - 116,152,621 (-)NCBI
Cytogenetic Map8q24.12NCBI
HuRef8115,263,331 - 115,291,874 (-)NCBIHuRef
CHM1_18119,976,820 - 120,005,398 (-)NCBICHM1_1
Tnfrsf11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2785,566,520 - 85,594,526 (-)NCBI
Rnor_6.0 Ensembl793,798,545 - 93,826,665 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0793,798,580 - 93,826,586 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0794,436,612 - 94,464,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4790,606,424 - 90,634,431 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1790,640,654 - 90,668,661 (-)NCBI
Celera782,388,596 - 82,416,602 (-)NCBICelera
Cytogenetic Map7q32NCBI
Tnfrsf11b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541724,804,664 - 24,831,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541724,804,708 - 24,831,338 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF11B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18118,134,305 - 118,162,422 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8118,134,305 - 118,162,422 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08115,614,778 - 115,643,387 (-)NCBIMhudiblu_PPA_v0panPan3
TNFRSF11B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11318,155,765 - 18,183,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1318,156,367 - 18,183,444 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1318,157,696 - 18,185,164 (-)NCBI
ROS_Cfam_1.01318,475,888 - 18,503,357 (-)NCBI
UMICH_Zoey_3.11318,206,469 - 18,233,953 (-)NCBI
UNSW_CanFamBas_1.01318,302,728 - 18,330,220 (-)NCBI
UU_Cfam_GSD_1.01318,533,442 - 18,560,917 (-)NCBI
Tnfrsf11b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530320,145,169 - 20,172,626 (+)NCBI
SpeTri2.0NW_00493647027,571,263 - 27,598,725 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF11B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1419,850,212 - 19,879,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,129,878 - 21,158,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFRSF11B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18113,520,711 - 113,549,370 (-)NCBI
ChlSab1.1 Ensembl8113,520,596 - 113,548,936 (-)Ensembl
Vero_WHO_p1.0NW_02366603926,748,455 - 26,777,113 (+)NCBI
Tnfrsf11b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476317,139,109 - 17,166,398 (-)NCBI

Position Markers
AB013898  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381554,251,254 - 54,251,361UniSTSGRCm38
MGSCv371554,082,809 - 54,082,916UniSTSGRCm37
Celera1555,802,354 - 55,802,461UniSTS
Cytogenetic Map15D1UniSTS
Whitehead/MRC_RH15485.83UniSTS
Tnfrsf11b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381554,251,042 - 54,251,147UniSTSGRCm38
Celera1555,802,142 - 55,802,247UniSTS
Cytogenetic Map15D1UniSTS
cM Map15 UniSTS
Tnfrsf11b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15D1UniSTS
cM Map15 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927293656323454Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
14928313Manh78_mmandible shape 78 (mouse)152148439755484397Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152273036956730369Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2302961857029764Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152459917658599409Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152543241059432532Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2562158259621582Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152644838460448484Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152644838460448484Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162644838460448484Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152644838460448484Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660000066500000Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152841925062419343Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152841925062419343Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020000058100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153414129868141408Mouse
1301324Cdif_mcolor difference (mouse)Not determined153611251070112623Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153923699973237197Mouse
1300949Lore5_mloss of righting induced by ethanol 5 (mouse)Not determined154015604558158901Mouse
4142459Lfnq3_mlung function QTL 3 (mouse)Not determined4031362672500731Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154468146478681588Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154498729278987432Mouse
26884420Cvht6_mcranial vault height 6, 10 week (mouse)154570000069300000Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154651779780517996Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154651779780517996Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154743448581434630Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154753774781537842Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154859351382593647Mouse
1357661Eae2b_msusceptibility to experimental allergic encephalomyelitis 2b (mouse)Not determined155114129865072459Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155114129876910293Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155128885985288984Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155154651285546662Mouse
35673313Ari8_mantibody response to influenza 8, day 15-45, TotalG (mouse)155160000055000000Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:304
Interacting mature miRNAs:359
Transcripts:ENSMUST00000079772
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079772   ⟹   ENSMUSP00000078705
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1554,250,619 - 54,278,484 (-)Ensembl
RefSeq Acc Id: NM_008764   ⟹   NP_032790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391554,114,015 - 54,141,880 (-)NCBI
GRCm381554,250,619 - 54,278,484 (-)ENTREZGENE
MGSCv371554,082,174 - 54,110,039 (-)RGD
Celera1555,801,719 - 55,829,545 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036159230   ⟹   XP_036015123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391554,114,014 - 54,141,776 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_032790   ⟸   NM_008764
- Peptide Label: precursor
- UniProtKB: O08712 (UniProtKB/Swiss-Prot),   Q3UK97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078705   ⟸   ENSMUST00000079772
RefSeq Acc Id: XP_036015123   ⟸   XM_036159230
- Peptide Label: isoform X1
Protein Domains
Death   TNFR-Cys

Promoters
RGD ID:6826551
Promoter ID:MM_KWN:18437
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:NM_008764
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361554,109,611 - 54,110,111 (-)MPROMDB
RGD ID:8683730
Promoter ID:EPDNEW_M19896
Type:single initiation site
Name:Tnfrsf11b_1
Description:Mus musculus tumor necrosis factor receptor superfamily, member11b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19897  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381554,278,304 - 54,278,364EPDNEW
RGD ID:8683734
Promoter ID:EPDNEW_M19897
Type:initiation region
Name:Tnfrsf11b_2
Description:Mus musculus tumor necrosis factor receptor superfamily, member11b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19896  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381554,278,426 - 54,278,486EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109587 AgrOrtholog
Ensembl Genes ENSMUSG00000063727 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078705 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079772 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_11B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109587 ENTREZGENE
NCBI Gene 18383 ENTREZGENE
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnfrsf11b PhenoGen
PIRSF TNFR_11B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TNFACTORR11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFACTORR11B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O08712 ENTREZGENE
  Q3UK97 ENTREZGENE, UniProtKB/TrEMBL
  Q6PI12_MOUSE UniProtKB/TrEMBL
  TR11B_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O70202 UniProtKB/Swiss-Prot