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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11035
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf11baffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TNFRSF11B mRNAPMID:21570461
Tnfrsf11bincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TNFRSF11B mRNAPMID:15972635
Tnfrsf11bmultiple interactionsEXP 6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TNFRSF11B mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TNFRSF11B mRNA]PMID:16054899 PMID:25975270
Tnfrsf11baffects expressionISOTnfrsf11b (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of TNFRSF11B mRNAPMID:34747641
Tnfrsf11baffects expressionISOTNFRSF11B (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of TNFRSF11B mRNAPMID:31887333
Tnfrsf11bdecreases expressionISOTNFRSF11B (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TNFRSF11B mRNAPMID:19684285
Tnfrsf11bincreases expressionISOTNFRSF11B (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TNFRSF11B mRNAPMID:19619570 PMID:22262711 PMID:28351761
Tnfrsf11bmultiple interactionsISOTNFRSF11B (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TNFRSF11B mRNA; [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of TNFRSF11B mRNAPMID:19619570 PMID:19684285
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