RGD Reference Report - Markers of bone metastases in breast and lung cancers. - Rat Genome Database

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Markers of bone metastases in breast and lung cancers.

Authors: Bilgin, E  Yasasever, V  Soydinc, HO  Yasasever, CT  Ozturk, N  Duranyildiz, D 
Citation: Bilgin E, etal., Asian Pac J Cancer Prev. 2012;13(9):4331-4.
RGD ID: 7205479
Pubmed: PMID:23167338   (View Abstract at PubMed)

Aim and Background: The aim of the present study was to evaluate correlations between serum osteocalcin, osteoprotegerin and NTX (Cross-linked N-telopeptides of Type I Collagen) and urinary NTX in breast and lung cancer patients with bone metastases. These four markers are considered to have important roles in bone formation, resorption and metastases. Methods: Four markers were determined in the sera of 60 breast cancer and 21 lung cancer patients and healthy controls (n=30). Serum levels were studied using ELISA and EIA. Results: The median levels of serum osteoprotegerin (p<0.001) and osteocalcin (p=0.003) were higher in patients. Significant correlations were observed between the serum NTX-osteocalcin (r=0.431; p<0.001), serum NTX- osteoprotegerin (r=0.42; p=0.003) and serum NTX - urine NTX (r=0.255; p=0.022). Conclusion: We conclude that osteocalcin, osteoprotegerin and NTX are independent diagnostic tools. Due to the ease of urine collection, urine NTX may be applied routinely to allow early detection of bone metastases and indicate progression of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm Metastasis  IEP 7205479associated with Breast Neoplasms and protein:increased expression:serumRGD 
Neoplasm Metastasis  ISOTNFRSF11B (Homo sapiens)7205479; 7205479associated with Breast Neoplasms and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf11b  (TNF receptor superfamily member 11B)

Genes (Mus musculus)
Tnfrsf11b  (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin))

Genes (Homo sapiens)
TNFRSF11B  (TNF receptor superfamily member 11b)


Additional Information