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Gene: TNFRSF11B (TNF receptor superfamily member 11b) Homo sapiens
Symbol: TNFRSF11B
Name: TNF receptor superfamily member 11b
Description: Predicted to have cytokine activity and signaling receptor activity. Predicted to be involved in skeletal system development and tumor necrosis factor-mediated signaling pathway. Localizes to the extracellular space. Implicated in Paget's disease of bone and osteoarthritis. Biomarker of several diseases, including artery disease (multiple); cerebral infarction; end stage renal failure; lupus nephritis; and secondary hyperparathyroidism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC29565; OCIF; OPG; osteoclastogenesis inhibitory factor; osteoprotegerin; Paget disease of bone 5; PDB5; TR1; tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Mus musculus (house mouse) : Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin))  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnfrsf11b (TNF receptor superfamily member 11B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfrsf11b (TNF receptor superfamily member 11b)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF11B (TNF receptor superfamily member 11b)
Canis lupus familiaris (dog) : TNFRSF11B (TNF receptor superfamily member 11b)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfrsf11b (TNF receptor superfamily member 11b)
Sus scrofa (pig) : TNFRSF11B (TNF receptor superfamily member 11b)
Chlorocebus sabaeus (green monkey) : TNFRSF11B (TNF receptor superfamily member 11b)
Heterocephalus glaber (naked mole-rat) : Tnfrsf11b (TNF receptor superfamily member 11b)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8118,923,557 - 118,951,885 (-)Ensembl
GRCh388118,923,557 - 118,951,885 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378119,935,796 - 119,964,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368120,004,977 - 120,033,564 (-)NCBINCBI36hg18NCBI36
Build 348120,004,977 - 120,033,492NCBI
Celera8116,124,073 - 116,152,621 (-)NCBI
Cytogenetic Map8q24.12NCBI
HuRef8115,263,331 - 115,291,874 (-)NCBIHuRef
CHM1_18119,976,820 - 120,005,398 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFRSF11B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730969
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.