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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730969
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF11B
Name: TNF receptor superfamily member 11b
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF11Bdecreases expressionEXP 6480464CTDAscorbic Acid results in decreased expression of TNFRSF11B mRNAPMID:17664058
TNFRSF11Bmultiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of TNFRSF11B mRNA; EZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of TNFRSF11B mRNA]PMID:26424790
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