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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730969
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF11B
Name: TNF receptor superfamily member 11b
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF11Bincreases expressionISORGD:110356480464CTDdioscin results in increased expression of TNFRSF11B mRNA

PMID:24742230
TNFRSF11Bmultiple interactionsISORGD:110356480464CTDfulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA] LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]

PMID:24742230
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