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Gene: Phgdh (3-phosphoglycerate dehydrogenase) Mus musculus
Symbol: Phgdh
Name: 3-phosphoglycerate dehydrogenase
RGD ID: 62279
Description: Predicted to have phosphoglycerate dehydrogenase activity. Involved in several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Localizes to myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-PGD; 3-PGDH; 3-phosphoglycerate dehyrogenase; 3PGD; 3PGDH; 4930479N23; A1; A10; D-3-phosphoglycerate dehydrogenase; MGC113796; MGC117966; PG; PGAD; PGD; PGDH; S; SERA
Homo sapiens (human) : PHGDH (phosphoglycerate dehydrogenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Phgdh (phosphoglycerate dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phgdh (phosphoglycerate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : PHGDH (phosphoglycerate dehydrogenase)
Canis lupus familiaris (dog) : LOC608055 (D-3-phosphoglycerate dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phgdh (phosphoglycerate dehydrogenase)
Sus scrofa (pig) : PHGDH (phosphoglycerate dehydrogenase)
Chlorocebus sabaeus (African green monkey) : PHGDH (phosphoglycerate dehydrogenase)
Heterocephalus glaber (naked mole-rat) : Phgdh (phosphoglycerate dehydrogenase)
more info ...
Related Pseudogenes: Gm13337   Gm13730   Gm18623   Gm5207   Gm5246   Gm5266   Gm5320   Gm5385   Gm5740   Gm5847   Gm6024   Gm6756   Gm7669   Gm7901   Gm8096   Gm8341   Gm8588   Gm8793   Gm9210   Gm9252   Gm9347   Phgdh-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39398,220,487 - 98,247,285 (-)NCBI
GRCm38398,313,171 - 98,339,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,313,170 - 98,339,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv37398,117,094 - 98,143,892 (-)NCBIGRCm37mm9NCBIm37
MGSCv36398,398,576 - 98,425,374 (-)NCBImm8
Celera399,712,302 - 99,738,644 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Phgdh
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62279
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.