Igfbp1 (insulin-like growth factor binding protein 1) - Rat Genome Database

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Gene: Igfbp1 (insulin-like growth factor binding protein 1) Mus musculus
Analyze
Symbol: Igfbp1
Name: insulin-like growth factor binding protein 1
RGD ID: 69039
MGI Page MGI
Description: Enables insulin-like growth factor binding activity. Acts upstream of or within response to insulin. Located in extracellular space. Is expressed in several structures, including early embryo; jaw; liver; mandible primordium; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IBP-1; IGF-binding protein 1; IGFBP; insulin-like growth factor binding protein 1 precursor (IGFBP-1) (IBP-1) (IGF-binding protein 1); insulin-like growth factor-binding protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,147,787 - 7,152,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,147,782 - 7,152,546 (+)EnsemblGRCm39 Ensembl
GRCm38117,197,787 - 7,202,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,097,790 - 7,102,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,097,785 - 7,102,539 (+)NCBIMGSCv36mm8
Celera117,672,987 - 7,677,746 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Igfbp1Mousebreast cancer  ISORGD:690382301715protein:decreased expression:serum:in patients with breast cancer versus benign breast disease (p=0.001) (human)RGD 
Igfbp1Mousebreast cancer no_associationISORGD:690382301716higher serum expression in cases vs controls but association not significant in multivariate analysis (human)RGD 
Igfbp1MouseBurns  ISORGD:287212910869mRNA:increased expression:kidney, liverRGD 
Igfbp1Mousediabetic angiopathy  ISORGD:690381625238DNA:SNPsRGD 
Igfbp1MouseDiabetic Nephropathies  ISORGD:690381625238DNA:SNPsRGD 
Igfbp1MouseEndotoxemia  ISORGD:2872625688 RGD 
Igfbp1MouseExperimental Diabetes Mellitus  ISORGD:2872152176653mRNA:altered expression:kidneyRGD 
Object Symbol
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Original Reference(s)
Igfbp1Mousepleomorphic xanthoastrocytoma  ISORGD:690388554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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Original Reference(s)
Igfbp1Mouseacute kidney failure  ISORGD:6903811554173CTD Direct Evidence: therapeuticCTDPMID:7540432
Igfbp1MouseColonic Neoplasms  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:15059925
Igfbp1MouseDrug-Related Side Effects and Adverse Reactions  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:15805072
Igfbp1Mouseendometriosis  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
Igfbp1MouseExperimental Liver Cirrhosis  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980|PMID:25380136
Igfbp1Mouseliver cirrhosis  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:26396155
Igfbp1Mousepre-malignant neoplasm  ISORGD:6903811554173CTD Direct Evidence: therapeuticCTDPMID:12619036
Igfbp1Mouseprimary biliary cholangitis  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:18422935
Igfbp1MouseSpontaneous Abortions  ISORGD:6903811554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
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Original Reference(s)
Igfbp1Mouse(+)-schisandrin B multiple interactionsISORGD:28726480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IGFBP1 mRNA]CTDPMID:31150632
Igfbp1Mouse1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISORGD:287264804642,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IGFBP1 mRNA]CTDPMID:19414516
Igfbp1Mouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of IGFBP1 mRNACTDPMID:26682919
Igfbp1Mouse1-methylphenanthrene multiple interactionsISORGD:690386480464[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNACTDPMID:17690111
Igfbp1Mouse1-naphthyl isothiocyanate increases expressionISORGD:287264804641-Naphthylisothiocyanate results in increased expression of IGFBP1 mRNACTDPMID:17522070|PMID:18289764|PMID:25380136
Igfbp1Mouse1-naphthyl isothiocyanate multiple interactionsISORGD:690386480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of IGFBP1 mRNACTDPMID:27344345
Igfbp1Mouse1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of IGFBP1 mRNACTDPMID:15913567
Igfbp1Mouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of IGFBP1 mRNACTDPMID:14976129
Igfbp1Mouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGFBP1 mRNACTDPMID:17942748
Igfbp1Mouse17alpha-ethynylestradiol increases expressionISORGD:28726480464Ethinyl Estradiol results in increased expression of IGFBP1 mRNACTDPMID:15795090
Igfbp1Mouse17beta-estradiol multiple interactionsISORGD:690386480464[Cyclic AMP co-treated with Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA; more ...CTDPMID:11756571|PMID:12093828|PMID:17404688|PMID:17484513|PMID:20085912|PMID:20823114|PMID:31154070|PMID:31646340|PMID:32446389
Igfbp1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of IGFBP1 mRNACTDPMID:39298647
Igfbp1Mouse17beta-estradiol affects expressionISORGD:28726480464Estradiol affects the expression of IGFBP1 mRNACTDPMID:32145629
Igfbp1Mouse17beta-estradiol decreases expressionISORGD:690386480464Estradiol results in decreased expression of IGFBP1 mRNACTDPMID:31646340
Igfbp1Mouse17beta-estradiol increases expressionISORGD:690386480464Estradiol results in increased expression of IGFBP1 mRNA; Estradiol results in increased expression of IGFBP1 more ...CTDPMID:12154049|PMID:17484513|PMID:31614463
Igfbp1Mouse17beta-hydroxy-5alpha-androstan-3-one increases expressionISORGD:690386480464Dihydrotestosterone results in increased expression of IGFBP1 mRNACTDPMID:29581250
Igfbp1Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:287264804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IGFBP1 mRNACTDPMID:27291303
Igfbp1Mouse2,2',4,4'-Tetrabromodiphenyl ether affects expressionEXP 64804642,2',4,4'-tetrabromodiphenyl ether affects the expression of IGFBP1 mRNACTDPMID:30294300
Igfbp1Mouse2,2'-bipyridine increases expressionISORGD:6903864804642,2'-Dipyridyl results in increased expression of IGFBP1 mRNACTDPMID:19924283
Igfbp1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 64804643'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA]; [Tetrachlorodibenzodioxin co-treated with more ...CTDPMID:17942748|PMID:18827440|PMID:19782052|PMID:25975270|PMID:28213091

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Biological Process

  
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Original Reference(s)
Igfbp1Mouseinsulin receptor signaling pathway  ISORGD:28729068941 RGDPMID:11784721|REF_RGD_ID:729306
Igfbp1Mouseinsulin receptor signaling pathway involved_inIEAUniProtKB:P21743|ensembl:ENSRNOP000000692472290270 EnsemblGO_REF:0000107
Igfbp1Mousepositive regulation of cell growth involved_inIEAUniProtKB:P21743|ensembl:ENSRNOP000000692472290270 EnsemblGO_REF:0000107
Igfbp1Mousepositive regulation of cell growth  ISORGD:28729068941 RGDPMID:1705004|REF_RGD_ID:1578549
Igfbp1Mouseregulation of insulin-like growth factor receptor signaling pathway involved_inIBAPANTHER:PTN000167605|MGI:96438|ZFIN:ZDB-GENE-000125-12|MGI:96439|UniProtKB:P24593|MGI:964402290270 GO_CentralGO_REF:0000033
Igfbp1Mouseresponse to insulin acts_upstream_of_or_withinIDA 2290270 PMID:29867121MGIPMID:29867121
Igfbp1Mousetissue regeneration  ISORGD:28729068941 RGDPMID:1705004|REF_RGD_ID:1578549
Igfbp1Mousetissue regeneration involved_inIEAUniProtKB:P21743|ensembl:ENSRNOP000000692472290270 EnsemblGO_REF:0000107

Cellular Component

  
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Original Reference(s)
Igfbp1Mouseextracellular space  ISORGD:28729068941 RGDPMID:16166214|REF_RGD_ID:1625239
Igfbp1Mouseextracellular space located_inISORGD:28722290270 GO_CentralGO_REF:0000096
Igfbp1Mouseextracellular space located_inIDA 2290270 PMID:7510770, PMID:7679139MGIPMID:7510770|PMID:7679139
Igfbp1Mouseextracellular space is_active_inIBAPANTHER:PTN000167605|MGI:96438|UniProtKB:P17936|MGI:96439|MGI:96436|UniProtKB:P24593|RGD:2872|UniProtKB:P24592|UniProtKB:P20959|RGD:2877|RGD:2873|RGD:2874|UniProtKB:P18065|MGI:96437|UniProtKB:P133842290270 GO_CentralGO_REF:0000033
Igfbp1MouseGolgi apparatus located_inISOUniProtKB:P088332290270 GO_CentralGO_REF:0000119
Igfbp1MouseGolgi apparatus located_inIEAUniProtKB:P08833|ensembl:ENSP000002755252290270 EnsemblGO_REF:0000107

Molecular Function
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Original Reference(s)
Igfbp1Mouseinsulin-like growth factor binding enablesIPIPR:P050172290270 PMID:7679139MGIPMID:7679139
Igfbp1Mouseinsulin-like growth factor I binding enablesIBAPANTHER:PTN000167605|ZFIN:ZDB-GENE-021231-1|UniProtKB:P08833|ZFIN:ZDB-GENE-081210-3|UniProtKB:P17936|RGD:2877|RGD:2873|ZFIN:ZDB-GENE-000125-12|ZFIN:ZDB-GENE-090107-3|UniProtKB:P18065|UniProtKB:P24593|ZFIN:ZDB-GENE-040412-12290270 GO_CentralGO_REF:0000033
Igfbp1Mouseinsulin-like growth factor I binding enablesISOUniProtKB:P088332290270 GO_CentralGO_REF:0000119
Igfbp1Mouseinsulin-like growth factor I binding enablesIEAUniProtKB:P08833|ensembl:ENSP000002755252290270 EnsemblGO_REF:0000107
Igfbp1Mouseinsulin-like growth factor II binding enablesIEAUniProtKB:P08833|ensembl:ENSP000002755252290270 EnsemblGO_REF:0000107
Igfbp1Mouseinsulin-like growth factor II binding enablesIBAPANTHER:PTN000167605|RGD:2877|ZFIN:ZDB-GENE-000125-12|RGD:2873|RGD:2874|ZFIN:ZDB-GENE-081210-3|UniProtKB:P08833|ZFIN:ZDB-GENE-021231-1|UniProtKB:P24592|ZFIN:ZDB-GENE-040412-12290270 GO_CentralGO_REF:0000033
Igfbp1Mouseinsulin-like growth factor II binding enablesISOUniProtKB:P088332290270 GO_CentralGO_REF:0000119
Igfbp1Mouseprotein binding enablesISOUniProtKB:Q8IXL69068941 PMID:26091039IntActPMID:26091039
Igfbp1Mouseprotein binding enablesISOUniProtKB:G5E9A7|UniProtKB:O14901|UniProtKB:P46379-2|UniProtKB:Q7Z6999068941 PMID:32814053IntActPMID:32814053
Igfbp1Mouseprotein binding enablesISOUniProtKB:P050199068941 PMID:16924115, PMID:22578544IntActPMID:16924115|PMID:22578544
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RGD Manual Annotations


  
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Original Reference(s)
Igfbp1Mouseinsulin-like growth factor signaling pathway  ISORGD:690381626333 RGD 

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Igfbp1Mouseforkhead class A signaling pathway  ISORGD:690386484113 PIDPID:200087
Igfbp1Mousehypoxia inducible factor pathway   ISORGD:690386484113 PIDPID:200202
Object Symbol
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Original Reference(s)
Igfbp1Mousedelayed liver regeneration  IAGP 5509061 MGIPMID:12556485
Igfbp1Mousefocal hepatic necrosis  IAGP 5509061 MGIPMID:12511596
Igfbp1Mousehepatic necrosis  IAGP 5509061 MGIPMID:12511596
Igfbp1Mousehepatic necrosis  IAGP 5509061 MGIPMID:12556485
Igfbp1Mousehepatic steatosis  IAGP 5509061 MGIPMID:12511596
Igfbp1Mouseimpaired liver regeneration  IAGP 5509061 MGIPMID:12556485
Igfbp1Mouseincreased hepatocyte apoptosis  IAGP 5509061 MGIPMID:12511596
Igfbp1Mouseliver inflammation  IAGP 5509061 MGIPMID:12511596

1 to 15 of 15 rows
#
Reference Title
Reference Citation
1. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
2. Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Kaulsay KK, etal., Eur J Endocrinol. 1999 Feb;140(2):164-8.
3. Mosaic analysis of insulin receptor function. Kitamura T, etal., J Clin Invest 2004 Jan;113(2):209-19.
4. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
5. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
6. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Polymorphisms in IGF-binding protein 1 are associated with impaired renal function in type 2 diabetes. Stephens RH, etal., Diabetes. 2005 Dec;54(12):3547-53.
1 to 15 of 15 rows
PMID:1284245   PMID:1419914   PMID:2062642   PMID:2355916   PMID:7505465   PMID:7509771   PMID:7510770   PMID:7511095   PMID:7525452   PMID:7529732   PMID:7640658   PMID:7679139  
PMID:7684980   PMID:7750499   PMID:8923818   PMID:8928760   PMID:8932988   PMID:9002662   PMID:9014844   PMID:9093203   PMID:9175833   PMID:9184077   PMID:9324049   PMID:9662407  
PMID:9685224   PMID:9785199   PMID:10226804   PMID:10502456   PMID:10579362   PMID:10645956   PMID:10744620   PMID:10888943   PMID:10976924   PMID:11033447   PMID:12163409   PMID:12477932  
PMID:12489207   PMID:12511596   PMID:12556485   PMID:12619036   PMID:12933651   PMID:14668353   PMID:14681479   PMID:15616563   PMID:15721138   PMID:15761081   PMID:15862298   PMID:16002520  
PMID:16141072   PMID:16293667   PMID:16338473   PMID:16416089   PMID:16452166   PMID:16602821   PMID:17062566   PMID:17077188   PMID:17169417   PMID:17255210   PMID:17693389   PMID:17697936  
PMID:18056423   PMID:18340042   PMID:18450962   PMID:18466921   PMID:18554416   PMID:18722179   PMID:18827440   PMID:19683511   PMID:20412791   PMID:21135503   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:21903863   PMID:22653858   PMID:22843786   PMID:23525041   PMID:23563309   PMID:23813480   PMID:24152801   PMID:24952961   PMID:25869614   PMID:26134413   PMID:26446156  
PMID:26456333   PMID:27732088   PMID:27861515   PMID:28617951   PMID:29438518   PMID:29867121   PMID:30301918   PMID:32993096   PMID:33505018   PMID:34292881   PMID:35741102   PMID:36326689  
PMID:36825684   PMID:37296072  



Igfbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,147,787 - 7,152,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,147,782 - 7,152,546 (+)EnsemblGRCm39 Ensembl
GRCm38117,197,787 - 7,202,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,097,790 - 7,102,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,097,785 - 7,102,539 (+)NCBIMGSCv36mm8
Celera117,672,987 - 7,677,746 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
IGFBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,888,360 - 45,893,660 (+)EnsemblGRCh38hg38GRCh38
GRCh37745,928,087 - 45,933,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36Build 36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
T2T-CHM13v2.0746,047,763 - 46,055,379 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
Igfbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81486,261,277 - 86,266,344 (+)NCBIGRCr8
mRatBN7.21482,047,415 - 82,052,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,448,608 - 86,453,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,688,457 - 87,693,380 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,137,002 - 84,142,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
Igfbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,810,056 - 6,815,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,810,461 - 6,814,944 (-)NCBIChiLan1.0ChiLan1.0
IGFBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,770,502 - 50,778,799 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1799,095,242 - 99,103,537 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,538,566 - 46,545,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,657,834 - 46,663,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl746,658,097 - 46,662,584 (+)Ensemblpanpan1.1panPan2
IGFBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,037,169 - 1,040,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,813,131 - 1,816,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,023,782 - 1,027,506 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,014,419 - 1,018,140 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016950,042 - 953,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016220,948 - 224,674 (+)NCBIUU_Cfam_GSD_1.0
Igfbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,282,472 - 101,287,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,494,203 - 20,499,001 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647820,494,190 - 20,499,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,018,487 - 50,022,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,018,487 - 50,022,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,862,385 - 54,866,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,932,727 - 12,939,078 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,932,732 - 12,937,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660629,598,999 - 9,604,182 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,893,867 - 6,897,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247406,893,334 - 6,897,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Igfbp1
134 total Variants

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:131
Interacting mature miRNAs:141
Transcripts:ENSMUST00000020704
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse

1 to 10 of 22 rows
PMC141131P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38117,197,723 - 7,198,333UniSTSGRCm38
MGSCv37117,097,726 - 7,098,336UniSTSGRCm37
Celera117,672,923 - 7,673,533UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.3UniSTS
X81579  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map111.3UniSTS
Whitehead/MRC_RH1150.81UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38117,199,803 - 7,199,912UniSTSGRCm38
MGSCv37117,099,806 - 7,099,915UniSTSGRCm37
Celera117,675,003 - 7,675,112UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.3UniSTS
cM Map111.3UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38117,198,201 - 7,199,861UniSTSGRCm38
MGSCv37117,098,204 - 7,099,864UniSTSGRCm37
Celera117,673,401 - 7,675,061UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.3UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38117,200,872 - 7,201,946UniSTSGRCm38
MGSCv37117,100,875 - 7,101,949UniSTSGRCm37
Celera117,676,072 - 7,677,146UniSTS
Cytogenetic Map11A1UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
Igfbp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38117,198,297 - 7,199,794UniSTSGRCm38
MGSCv37117,098,300 - 7,099,797UniSTSGRCm37
Celera117,673,497 - 7,674,994UniSTS
Cytogenetic Map11A1UniSTS







Ensembl Acc Id: ENSMUST00000020704   ⟹   ENSMUSP00000020704
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl117,147,782 - 7,152,546 (+)Ensembl
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)Ensembl
RefSeq Acc Id: NM_008341   ⟹   NP_032367
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39117,147,787 - 7,152,546 (+)NCBI
GRCm38117,197,787 - 7,202,546 (+)ENTREZGENE
MGSCv37117,097,790 - 7,102,549 (+)RGD
Celera117,672,987 - 7,677,746 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein RefSeqs NP_032367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA47832 (Get FASTA)   NCBI Sequence Viewer  
  CAA57269 (Get FASTA)   NCBI Sequence Viewer  
  EDL40607 (Get FASTA)   NCBI Sequence Viewer  
  EDL40608 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020704
  ENSMUSP00000020704.8
GenBank Protein P47876 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032367   ⟸   NM_008341
- Peptide Label: precursor
- UniProtKB: Q5SVY8 (UniProtKB/Swiss-Prot),   Q61732 (UniProtKB/Swiss-Prot),   P47876 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000020704   ⟸   ENSMUST00000020704
IGFBP N-terminal   Thyroglobulin type-1

Name Modeler Protein Id AA Range Protein Structure
AF-P47876-F1-model_v2 AlphaFold P47876 1-272 view protein structure

RGD ID:6821101
Promoter ID:MM_KWN:6400
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ENSMUST00000020704
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36117,097,666 - 7,098,166 (+)MPROMDB
RGD ID:8673932
Promoter ID:EPDNEW_M14997
Type:multiple initiation site
Name:Igfbp1_1
Description:Mus musculus insulin-like growth factor binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38117,197,787 - 7,197,847EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000020429 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020704 ENTREZGENE
  ENSMUST00000020704.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP1 UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report mmu:16006 UniProtKB/Swiss-Prot
MGD MGI:96436 ENTREZGENE
NCBI Gene 16006 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp1 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY1 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
UniProt IBP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SVY8 ENTREZGENE
  Q61732 ENTREZGENE
UniProt Secondary Q5SVY8 UniProtKB/Swiss-Prot
  Q61732 UniProtKB/Swiss-Prot
1 to 35 of 35 rows