IGFBP1 (insulin like growth factor binding protein 1) - Rat Genome Database

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Gene: IGFBP1 (insulin like growth factor binding protein 1) Homo sapiens
Analyze
Symbol: IGFBP1
Name: insulin like growth factor binding protein 1
RGD ID: 69038
HGNC Page HGNC
Description: Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Localizes to Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AFBP; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; hIGFBP-1; IBP-1; IBP1; IGF-binding protein 1; IGF-BP25; IGFBP-1; insulin-like growth factor binding protein 1; insulin-like growth factor-binding protein 1; placental protein 12; PP12
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   SAPOB3_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl745,888,360 - 45,893,660 (+)EnsemblGRCh38hg38GRCh38
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37745,928,087 - 45,933,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1-methylphenanthrene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-nitrofluorene  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
8-Br-cAMP  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP)
chenodeoxycholic acid  (ISO)
chlorpromazine  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP)
cortisol  (EXP)
curcumin  (EXP)
cyanamide  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
kynurenine  (EXP)
L-methionine  (ISO)
L-tryptophan  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
medroxyprogesterone acetate  (EXP)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel dichloride  (EXP)
nicotinamide  (ISO)
nitrofen  (ISO)
ochratoxin A  (EXP,ISO)
orphenadrine  (ISO)
oxazepam  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propanal  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rifampicin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
starch  (ISO)
stavudine  (ISO)
succimer  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vandetanib  (EXP)
vemurafenib  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1373120   PMID:1691735   PMID:1701175   PMID:1718783   PMID:2454104   PMID:2457513   PMID:2458522   PMID:2461294   PMID:2466665   PMID:2474129   PMID:2478445   PMID:2849945  
PMID:2971653   PMID:3419931   PMID:7504269   PMID:7678248   PMID:7683522   PMID:7683525   PMID:7694877   PMID:8754754   PMID:9408744   PMID:10329650   PMID:10350456   PMID:10352394  
PMID:10364674   PMID:10407151   PMID:10691413   PMID:10810289   PMID:10965886   PMID:10987657   PMID:11050672   PMID:11297622   PMID:11397868   PMID:11752456   PMID:11762714   PMID:11793026  
PMID:11834727   PMID:11956162   PMID:11969341   PMID:11972304   PMID:12006706   PMID:12082253   PMID:12119297   PMID:12135130   PMID:12150454   PMID:12153746   PMID:12163461   PMID:12351482  
PMID:12466191   PMID:12477932   PMID:12489207   PMID:12493691   PMID:12519841   PMID:12556485   PMID:12571183   PMID:12679458   PMID:12690205   PMID:12746292   PMID:12746836   PMID:12843178  
PMID:12843192   PMID:12853948   PMID:12861174   PMID:12870155   PMID:12882925   PMID:12933666   PMID:14568572   PMID:14624764   PMID:14715837   PMID:14718574   PMID:14726451   PMID:14764802  
PMID:15070833   PMID:15070959   PMID:15166120   PMID:15489334   PMID:15598684   PMID:15613433   PMID:15736102   PMID:15797461   PMID:15890677   PMID:15959422   PMID:15972819   PMID:15987820  
PMID:15987847   PMID:16002526   PMID:16041536   PMID:16118248   PMID:16222695   PMID:16293667   PMID:16337840   PMID:16338475   PMID:16404426   PMID:16687408   PMID:16776662   PMID:16809446  
PMID:16868142   PMID:16924115   PMID:16973813   PMID:17035411   PMID:17062566   PMID:17113753   PMID:17164371   PMID:17264182   PMID:17300730   PMID:17341623   PMID:17465992   PMID:17485842  
PMID:17566087   PMID:17634530   PMID:17640761   PMID:17655506   PMID:17803702   PMID:17890489   PMID:17914103   PMID:17972051   PMID:17972510   PMID:18166823   PMID:18259111   PMID:18305566  
PMID:18496669   PMID:18513511   PMID:18596909   PMID:18636124   PMID:18665784   PMID:18676680   PMID:18701096   PMID:18772238   PMID:18793810   PMID:18828733   PMID:18924579   PMID:19064572  
PMID:19124510   PMID:19158202   PMID:19170196   PMID:19193607   PMID:19308628   PMID:19434535   PMID:19453261   PMID:19463807   PMID:19539506   PMID:19551864   PMID:19625176   PMID:19692168  
PMID:19730683   PMID:19732896   PMID:19765076   PMID:19843326   PMID:19858071   PMID:19913121   PMID:19917654   PMID:19948975   PMID:20039319   PMID:20102313   PMID:20143870   PMID:20144192  
PMID:20149700   PMID:20155489   PMID:20413521   PMID:20416304   PMID:20453000   PMID:20484221   PMID:20587581   PMID:20628086   PMID:20634197   PMID:20637724   PMID:20711952   PMID:20731527  
PMID:20734064   PMID:20810604   PMID:20884247   PMID:20885978   PMID:21078522   PMID:21104586   PMID:21140206   PMID:21156761   PMID:21198359   PMID:21212012   PMID:21247237   PMID:21378090  
PMID:21457161   PMID:21521316   PMID:21550830   PMID:21741060   PMID:21852217   PMID:21873635   PMID:21892205   PMID:21930730   PMID:21933314   PMID:21940708   PMID:22072736   PMID:22104117  
PMID:22113073   PMID:22187946   PMID:22239027   PMID:22325929   PMID:22357965   PMID:22442270   PMID:22554827   PMID:22578544   PMID:22745191   PMID:22843786   PMID:22894543   PMID:23095194  
PMID:23183724   PMID:23190203   PMID:23354097   PMID:23377640   PMID:23408645   PMID:23548151   PMID:23585335   PMID:23603247   PMID:23815140   PMID:23942851   PMID:24056811   PMID:24132762  
PMID:24248464   PMID:24431302   PMID:24436153   PMID:24513543   PMID:24612210   PMID:24667918   PMID:24856042   PMID:24919336   PMID:25123037   PMID:25337205   PMID:25348852   PMID:25461385  
PMID:25543125   PMID:25597167   PMID:25620704   PMID:25746666   PMID:25757011   PMID:25869614   PMID:25890304   PMID:25957086   PMID:26025665   PMID:26091039   PMID:26118397   PMID:26232425  
PMID:26245897   PMID:26456333   PMID:26479890   PMID:26714229   PMID:26802879   PMID:27152521   PMID:27174569   PMID:27190088   PMID:27211553   PMID:27215343   PMID:27215930   PMID:27260393  
PMID:27452330   PMID:27515096   PMID:27516442   PMID:27775453   PMID:27834463   PMID:27919172   PMID:28051155   PMID:28096479   PMID:28103909   PMID:28143425   PMID:28316362   PMID:28435049  
PMID:28514442   PMID:28609475   PMID:28613021   PMID:28732569   PMID:28864349   PMID:28883617   PMID:28927302   PMID:29037858   PMID:29108879   PMID:29131315   PMID:29186427   PMID:29325466  
PMID:29453285   PMID:29693217   PMID:29718759   PMID:29992830   PMID:30124960   PMID:30274984   PMID:30309264   PMID:30400783   PMID:30898176   PMID:31177120   PMID:31201536   PMID:31242463  
PMID:31545483   PMID:31753913   PMID:31901863   PMID:32065979   PMID:32492897   PMID:32814053  


Genomics

Comparative Map Data
IGFBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl745,888,360 - 45,893,660 (+)EnsemblGRCh38hg38GRCh38
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37745,928,087 - 45,933,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
Igfbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,147,787 - 7,152,546 (+)NCBIGRCm39mm39
GRCm39 Ensembl117,147,782 - 7,152,546 (+)Ensembl
GRCm38117,197,787 - 7,202,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,097,790 - 7,102,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36117,097,785 - 7,102,539 (+)NCBImm8
Celera117,672,987 - 7,677,746 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21482,047,415 - 82,052,482 (+)NCBI
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
Igfbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,810,056 - 6,815,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,810,461 - 6,814,944 (-)NCBIChiLan1.0ChiLan1.0
IGFBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1746,657,834 - 46,663,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl746,658,097 - 46,662,584 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0746,538,566 - 46,545,536 (+)NCBIMhudiblu_PPA_v0panPan3
IGFBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,037,169 - 1,040,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,813,131 - 1,816,855 (-)NCBI
ROS_Cfam_1.0161,023,782 - 1,027,506 (-)NCBI
UMICH_Zoey_3.1161,014,419 - 1,018,140 (-)NCBI
UNSW_CanFamBas_1.016950,042 - 953,757 (-)NCBI
UU_Cfam_GSD_1.016220,948 - 224,674 (+)NCBI
Igfbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,282,472 - 101,287,845 (+)NCBI
SpeTri2.0NW_00493647820,494,190 - 20,499,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,018,487 - 50,022,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,018,487 - 50,022,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,862,385 - 54,866,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,932,727 - 12,939,078 (-)NCBI
ChlSab1.1 Ensembl2112,932,732 - 12,937,891 (-)Ensembl
Igfbp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247406,893,334 - 6,897,591 (-)NCBI

Position Markers
G54036  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,588 - 45,932,717UniSTSGRCh37
Build 36745,899,113 - 45,899,242RGDNCBI36
Celera746,031,509 - 46,031,638RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,494 - 45,817,623UniSTS
CRA_TCAGchr7v2745,971,921 - 45,972,050UniSTS
GDB:374628  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,928,751 - 45,929,118UniSTSGRCh37
Build 36745,895,276 - 45,895,643RGDNCBI36
Celera746,027,672 - 46,028,039RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,813,711 - 45,814,078UniSTS
CRA_TCAGchr7v2745,968,084 - 45,968,451UniSTS
SHGC-12673  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,695 - 45,933,027UniSTSGRCh37
Build 36745,899,220 - 45,899,552RGDNCBI36
Celera746,031,616 - 46,031,948RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,601 - 45,817,933UniSTS
CRA_TCAGchr7v2745,972,028 - 45,972,360UniSTS
TNG Radiation Hybrid Map722880.0UniSTS
Stanford-G3 RH Map72036.0UniSTS
GeneMap99-GB4 RH Map7215.42UniSTS
Whitehead-RH Map7165.0UniSTS
Whitehead-YAC Contig Map7 UniSTS
NCBI RH Map7666.8UniSTS
GeneMap99-G3 RH Map72036.0UniSTS
G67139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,927,961 - 45,928,408UniSTSGRCh37
Build 36745,894,486 - 45,894,933RGDNCBI36
Celera746,026,882 - 46,027,329RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,812,921 - 45,813,368UniSTS
CRA_TCAGchr7v2745,967,294 - 45,967,741UniSTS
G67140  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,928,305 - 45,928,681UniSTSGRCh37
Build 36745,894,830 - 45,895,206RGDNCBI36
Celera746,027,226 - 46,027,602RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,813,265 - 45,813,641UniSTS
CRA_TCAGchr7v2745,967,638 - 45,968,014UniSTS
G67141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,929,951 - 45,930,374UniSTSGRCh37
Build 36745,896,476 - 45,896,899RGDNCBI36
Celera746,028,872 - 46,029,295RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,814,911 - 45,815,334UniSTS
CRA_TCAGchr7v2745,969,284 - 45,969,707UniSTS
G67142  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,931,288 - 45,931,772UniSTSGRCh37
Build 36745,897,813 - 45,898,297RGDNCBI36
Celera746,030,209 - 46,030,693RGD
Cytogenetic Map7p13-p12UniSTS
CRA_TCAGchr7v2745,970,621 - 45,971,105UniSTS
G67143  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,519 - 45,933,084UniSTSGRCh37
Build 36745,899,044 - 45,899,609RGDNCBI36
Celera746,031,440 - 46,032,005RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,425 - 45,817,990UniSTS
CRA_TCAGchr7v2745,971,852 - 45,972,417UniSTS
G67173  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,927,497 - 45,928,031UniSTSGRCh37
Build 36745,894,022 - 45,894,556RGDNCBI36
Celera746,026,418 - 46,026,952RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,812,457 - 45,812,991UniSTS
CRA_TCAGchr7v2745,966,830 - 45,967,364UniSTS
G67174  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,975 - 45,933,418UniSTSGRCh37
Build 36745,899,500 - 45,899,943RGDNCBI36
Celera746,031,896 - 46,032,339RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,881 - 45,818,323UniSTS
CRA_TCAGchr7v2745,972,308 - 45,972,751UniSTS
IGFBP1_pre_5'A  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,927,139 - 45,927,660UniSTSGRCh37
Build 36745,893,664 - 45,894,185RGDNCBI36
Celera746,026,060 - 46,026,581RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,812,099 - 45,812,620UniSTS
CRA_TCAGchr7v2745,966,472 - 45,966,993UniSTS
G15906  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,693 - 45,932,935UniSTSGRCh37
Build 36745,899,218 - 45,899,460RGDNCBI36
Celera746,031,614 - 46,031,856RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,599 - 45,817,841UniSTS
CRA_TCAGchr7v2745,972,026 - 45,972,268UniSTS
SGC33000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,930,716 - 45,930,840UniSTSGRCh37
Build 36745,897,241 - 45,897,365RGDNCBI36
Celera746,029,637 - 46,029,761RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,815,676 - 45,815,800UniSTS
CRA_TCAGchr7v2745,970,049 - 45,970,173UniSTS
GeneMap99-GB4 RH Map7210.25UniSTS
Whitehead-RH Map7168.3UniSTS
NCBI RH Map7670.8UniSTS
IGFBP1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,931,645 - 45,931,984UniSTSGRCh37
Build 36745,898,170 - 45,898,509RGDNCBI36
Celera746,030,566 - 46,030,905RGD
Cytogenetic Map7p13-p12UniSTS
CRA_TCAGchr7v2745,970,978 - 45,971,317UniSTS
RH17691  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,932,976 - 45,933,191UniSTSGRCh37
Build 36745,899,501 - 45,899,716RGDNCBI36
Celera746,031,897 - 46,032,112RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,817,882 - 45,818,097UniSTS
CRA_TCAGchr7v2745,972,309 - 45,972,524UniSTS
GeneMap99-GB4 RH Map7217.16UniSTS
NCBI RH Map7670.1UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR29Chsa-miR-29c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21436257

Predicted Target Of
Summary Value
Count of predictions:517
Count of miRNA genes:153
Interacting mature miRNAs:160
Transcripts:ENST00000275525, ENST00000457280, ENST00000468955
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 123 123 123 3 1
Medium 13 7 311 306 2 306 5 6 10 26 125 31 55 1 1
Low 85 201 114 24 63 25 104 53 584 202 337 168 5 337 76 1
Below cutoff 1224 1562 729 96 687 6 1958 1058 2438 126 708 795 93 535 1197 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV695706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY434089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX336957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA429917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS138146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ795026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC007038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000275525   ⟹   ENSP00000275525
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl745,888,488 - 45,893,660 (+)Ensembl
RefSeq Acc Id: ENST00000457280   ⟹   ENSP00000413511
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl745,888,360 - 45,893,625 (+)Ensembl
RefSeq Acc Id: ENST00000468955   ⟹   ENSP00000417069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl745,888,497 - 45,893,653 (+)Ensembl
RefSeq Acc Id: NM_000596   ⟹   NP_000587
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,888,488 - 45,893,660 (+)NCBI
GRCh37745,927,959 - 45,933,267 (+)ENTREZGENE
Build 36745,894,484 - 45,899,792 (+)NCBI Archive
HuRef745,812,919 - 45,818,173 (+)ENTREZGENE
CHM1_1745,932,162 - 45,937,470 (+)NCBI
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000587   ⟸   NM_000596
- Peptide Label: precursor
- UniProtKB: P08833 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000417069   ⟸   ENST00000468955
RefSeq Acc Id: ENSP00000413511   ⟸   ENST00000457280
RefSeq Acc Id: ENSP00000275525   ⟸   ENST00000275525
Promoters
RGD ID:7210545
Promoter ID:EPDNEW_H11018
Type:multiple initiation site
Name:IGFBP1_1
Description:insulin like growth factor binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,888,488 - 45,888,548EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p13-12.3(chr7:44193369-46558381)x1 copy number loss See cases [RCV000052316] Chr7:44193369..46558381 [GRCh38]
Chr7:44232968..46597979 [GRCh37]
Chr7:44199493..46564504 [NCBI36]
Chr7:7p13-12.3
pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p13-12.1(chr7:44571949-53699760)x1 copy number loss See cases [RCV000134973] Chr7:44571949..53699760 [GRCh38]
Chr7:44611548..53767453 [GRCh37]
Chr7:44578073..53734947 [NCBI36]
Chr7:7p13-12.1
pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2
pathogenic
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 copy number loss See cases [RCV000136904] Chr7:40020598..50543500 [GRCh38]
Chr7:40060197..50611198 [GRCh37]
Chr7:40026722..50578692 [NCBI36]
Chr7:7p14.1-12.1
pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 copy number loss See cases [RCV000446941] Chr7:40350383..47034422 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p12.3(chr7:45895448-46380286)x3 copy number gain not provided [RCV001005947] Chr7:45895448..46380286 [GRCh37]
Chr7:7p12.3
uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:41124364-47945566) copy number loss Non-syndromic syndactyly [RCV001352654] Chr7:41124364..47945566 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p13-12.2(chr7:43341583-50171623) copy number loss Intracranial hemorrhage [RCV001352658] Chr7:43341583..50171623 [GRCh37]
Chr7:7p13-12.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5469 AgrOrtholog
COSMIC IGFBP1 COSMIC
Ensembl Genes ENSG00000146678 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000275525 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000413511 UniProtKB/TrEMBL
  ENSP00000417069 UniProtKB/TrEMBL
Ensembl Transcript ENST00000275525 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000457280 UniProtKB/TrEMBL
  ENST00000468955 UniProtKB/TrEMBL
Gene3D-CATH 4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000146678 GTEx
HGNC ID HGNC:5469 ENTREZGENE
Human Proteome Map IGFBP1 Human Proteome Map
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3484 UniProtKB/Swiss-Prot
NCBI Gene 3484 ENTREZGENE
OMIM 146730 OMIM
Pfam IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29703 PharmGKB
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBPFAMILY1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C1K3N3_HUMAN UniProtKB/TrEMBL
  C9J6H2_HUMAN UniProtKB/TrEMBL
  C9JXF9_HUMAN UniProtKB/TrEMBL
  IBP1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PEY6_HUMAN UniProtKB/TrEMBL
UniProt Secondary A4D2F4 UniProtKB/Swiss-Prot
  D3DVL9 UniProtKB/Swiss-Prot
  Q8IYP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 IGFBP1  insulin like growth factor binding protein 1    insulin-like growth factor binding protein 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 IGFBP1  insulin-like growth factor binding protein 1  IGFBP1  insulin-like growth factor binding protein 1  Symbol and/or name change 5135510 APPROVED