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Gene: IGFBP1 (insulin like growth factor binding protein 1) Homo sapiens
Symbol: IGFBP1
Name: insulin like growth factor binding protein 1
Description: Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Localizes to the Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AFBP; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; hIGFBP-1; IBP-1; IBP1; IGF-binding protein 1; IGF-BP25; IGFBP-1; insulin-like growth factor binding protein 1; insulin-like growth factor-binding protein 1; placental protein 12; PP12
Mus musculus (house mouse) : Igfbp1 (insulin-like growth factor binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Igfbp1 (insulin-like growth factor binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igfbp1 (insulin like growth factor binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IGFBP1 (insulin like growth factor binding protein 1)
Canis lupus familiaris (dog) : IGFBP1 (insulin like growth factor binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igfbp1 (insulin like growth factor binding protein 1)
Sus scrofa (pig) : IGFBP1 (insulin like growth factor binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   SAPOB3_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl745,888,360 - 45,893,660 (+)Ensembl
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37745,927,959 - 45,933,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IGFBP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69038
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.