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Gene: Sh3pxd2b (SH3 and PX domains 2B) Mus musculus
Symbol: Sh3pxd2b
Name: SH3 and PX domains 2B
Description: Exhibits SH2 domain binding activity and phosphatidylinositol phosphate binding activity. Involved in several processes, including animal organ development; osteoblast fate commitment; and podosome assembly. Localizes to cytoplasm and podosome. Used to study glaucoma and otitis media. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Is expressed in several structures, including branchial arch; central nervous system; heart; jaw; and skeleton. Orthologous to human SH3PXD2B (SH3 and PX domains 2B); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: factor for adipocyte differentiation 49; fad49; G431001E03Rik; RP23-375M9.7; SH3 and PX domain-containing protein 2B; TSK4; tyrosine kinase substrate with four SH3 domains
Homo sapiens (human) : SH3PXD2B (SH3 and PX domains 2B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh3pxd2b (SH3 and PX domains 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3pxd2b (SH3 and PX domains 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3PXD2B (SH3 and PX domains 2B)
Canis lupus familiaris (dog) : SH3PXD2B (SH3 and PX domains 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3pxd2b (SH3 and PX domains 2B)
Sus scrofa (pig) : SH3PXD2B (SH3 and PX domains 2B)
Chlorocebus sabaeus (African green monkey) : SH3PXD2B (SH3 and PX domains 2B)
Heterocephalus glaber (naked mole-rat) : Sh3pxd2b (SH3 and PX domains 2B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1132,347,820 - 32,428,173 (+)EnsemblGRCm38mm10GRCm38
GRCm381132,347,773 - 32,428,189 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371132,247,811 - 32,328,183 (+)NCBIGRCm37mm9NCBIm37
MGSCv361132,247,811 - 32,328,183 (+)NCBImm8
Celera1134,765,291 - 34,845,918 (+)NCBICelera
Cytogenetic Map11A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sh3pxd2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320533
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.