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Gene: Grm1 (glutamate receptor, metabotropic 1) Mus musculus
Symbol: Grm1
Name: glutamate receptor, metabotropic 1
Description: Exhibits G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including cellular response to electrical stimulus; positive regulation of MAP kinase activity; and regulation of sensory perception of pain. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1); PARTICIPATES IN glutamate signaling pathway; Huntington's disease pathway; long term depression; INTERACTS WITH (S)-amphetamine; 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930455H15Rik; ENSMUSG00000075319; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; Gm10828; Gprc1a; metabotropic glutamate receptor 1; MGC90744; mGluR1; nmf373; predicted gene 10828; rcw; wobl
Homo sapiens (human) : GRM1 (glutamate metabotropic receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grm1 (glutamate metabotropic receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm1 (glutamate metabotropic receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM1 (glutamate metabotropic receptor 1)
Canis lupus familiaris (dog) : GRM1 (glutamate metabotropic receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm1 (glutamate metabotropic receptor 1)
Sus scrofa (pig) : GRM1 (glutamate metabotropic receptor 1)
Chlorocebus sabaeus (African green monkey) : GRM1 (glutamate metabotropic receptor 1)
Heterocephalus glaber (naked mole-rat) : Grm1 (glutamate metabotropic receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1010,686,059 - 11,082,356 (-)EnsemblGRCm38mm10GRCm38
GRCm381010,686,059 - 11,082,382 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371010,408,551 - 10,802,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv361010,378,943 - 10,772,546 (-)NCBImm8
Celera1010,578,372 - 10,975,041 (-)NCBICelera
Cytogenetic Map10A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Grm1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731957
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.