Ihh (Indian hedgehog) - Rat Genome Database

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Gene: Ihh (Indian hedgehog) Mus musculus
Symbol: Ihh
Name: Indian hedgehog
RGD ID: 1552237
Description: Exhibits patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and regulation of T cell differentiation. Localizes to extracellular matrix. Is expressed in several structures, including alimentary system; egg cylinder; limb; skeleton; and urinary system. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; 17beta-estradiol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HHG-2; indian hedgehog protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,984,474 - 74,990,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl174,984,474 - 74,990,831 (-)Ensembl
GRCm38174,945,315 - 74,951,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,991,892 - 74,998,225 (-)NCBIGRCm37mm9NCBIm37
MGSCv36174,878,525 - 74,884,858 (-)NCBImm8
Celera175,500,289 - 75,506,631 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CHIR 99021  (ISO)
chloroethene  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
Deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
dichloroacetic acid  (EXP)
diuron  (ISO)
endosulfan  (ISO)
fipronil  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
glycidol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methotrexate  (EXP)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone resorption  (IDA)
branching involved in blood vessel morphogenesis  (IMP)
camera-type eye development  (IMP)
camera-type eye photoreceptor cell fate commitment  (IMP)
cartilage development  (IMP,ISO)
cell differentiation  (IDA)
cell fate specification  (IBA,IMP)
cell maturation  (IMP)
cell-cell signaling  (IEA)
chondrocyte differentiation involved in endochondral bone morphogenesis  (IMP)
chondrocyte proliferation  (IMP)
embryonic camera-type eye morphogenesis  (IMP)
embryonic digestive tract morphogenesis  (IMP)
embryonic digit morphogenesis  (IGI,IMP,ISO)
embryonic pattern specification  (IMP)
embryonic skeletal joint development  (IMP)
epithelial cell morphogenesis  (IMP)
epithelial cell-cell adhesion  (IMP)
head morphogenesis  (IMP)
heart looping  (IMP)
in utero embryonic development  (IMP)
intein-mediated protein splicing  (IEA)
liver regeneration  (ISO)
maternal process involved in female pregnancy  (ISO)
morphogenesis of a branching structure  (IMP)
multicellular organism development  (IEA)
multicellular organism growth  (IMP)
negative regulation of alpha-beta T cell differentiation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (IMP)
negative regulation of eye pigmentation  (IMP)
negative regulation of immature T cell proliferation in thymus  (IMP)
negative regulation of T cell differentiation in thymus  (IMP)
neuron development  (IMP)
ossification  (IMP)
osteoblast differentiation  (IDA,IGI,IMP)
pancreas development  (IGI,IMP)
pattern specification process  (IMP)
positive regulation of alpha-beta T cell differentiation  (IMP)
positive regulation of cell population proliferation  (IGI,IMP)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of smoothened signaling pathway  (IMP)
positive regulation of T cell differentiation in thymus  (IMP)
positive regulation of transcription by RNA polymerase II  (IGI)
protein autoprocessing  (IEA)
proteoglycan metabolic process  (IGI)
proteolysis  (IEA)
regulation of gene expression  (IBA)
regulation of growth  (IGI)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
retinal pigment epithelium development  (IMP)
skeletal system development  (IMP,ISO)
smooth muscle tissue development  (IMP)
smoothened signaling pathway  (IBA,IDA,IGI,ISO)
somite development  (IMP)
vasculature development  (IMP)
vitelline membrane formation  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal appendicular skeleton morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal digestive organ placement  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal digit morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal perichondrium morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal smooth muscle morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal synchondrosis  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent compact bone  (IAGP)
absent enteric neurons  (IAGP)
absent vitelline blood vessels  (IAGP)
aganglionic megacolon  (IAGP)
annular pancreas  (IAGP)
brachyphalangia  (IAGP)
chondrodystrophy  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased length of long bones  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed endochondral bone ossification  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
disproportionate dwarf  (IAGP)
domed cranium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
failure of initiation of embryo turning  (IAGP)
fused carpal bones  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
megacolon  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal lethality  (IAGP)
respiratory failure  (IAGP)
short femur  (IAGP)
short fibula  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short ribs  (IAGP)
short scapula  (IAGP)
short snout  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)

References - curated
1. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
2. Buller NV, etal., Gastroenterology. 2015 Jan;148(1):170-180.e6. doi: 10.1053/j.gastro.2014.10.006. Epub 2014 Oct 13.
3. Byrnes AM, etal., Eur J Hum Genet. 2009 Sep;17(9):1112-20. doi: 10.1038/ejhg.2009.18. Epub 2009 Mar 11.
4. Deckelbaum RA, etal., J Cell Sci 2002 Jul 15;115(Pt 14):3015-25.
5. Dong S, etal., Ann Clin Lab Sci. 2015 Winter;45(1):94-9.
6. Gao B, etal., Nat Genet. 2001 Aug;28(4):386-8.
7. Halepoto DM, etal., J Coll Physicians Surg Pak. 2015 Dec;25(12):882-5. doi: 12.2015/JCPSP.882885.
8. Hellemans J, etal., Am J Hum Genet. 2003 Apr;72(4):1040-6. Epub 2003 Mar 11.
9. Kirkpatrick TJ, etal., J Med Genet. 2003 Jan;40(1):42-4.
10. Klopocki E, etal., Am J Hum Genet. 2011 Jan 7;88(1):70-5. doi: 10.1016/j.ajhg.2010.11.006. Epub 2010 Dec 17.
11. Liu M, etal., J Hum Genet. 2006;51(8):727-31. Epub 2006 Jul 27.
12. Lodder EM, etal., Am J Med Genet A. 2008 Aug 15;146A(16):2152-4. doi: 10.1002/ajmg.a.32441.
13. McCready ME, etal., Hum Genet. 2002 Oct;111(4-5):368-75. Epub 2002 Sep 7.
14. MGD data from the GO Consortium
16. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
17. Mohamed S, etal., Pediatr Res. 2009 Feb;65(2):193-7. doi: 10.1203/PDR.0b013e31818d1dbd.
18. OMIM Disease Annotation Pipeline
19. Pereira TA, etal., Liver Int. 2013 Jan;33(1):149-61. doi: 10.1111/liv.12016. Epub 2012 Nov 1.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated import pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Stattin EL, etal., Eur J Med Genet. 2009 Sep-Oct;52(5):297-302. doi: 10.1016/j.ejmg.2009.05.008. Epub 2009 May 21.
26. Tatsumi H, etal., Int J Oral Maxillofac Surg. 2014 Feb;43(2):185-93. doi: 10.1016/j.ijom.2013.07.742. Epub 2013 Aug 28.
27. Zhang C, etal., Int J Mol Sci. 2014 Apr 28;15(5):7250-65. doi: 10.3390/ijms15057250.
28. Zhou S, etal., PLoS Genet. 2015 Jun 19;11(6):e1005214. doi: 10.1371/journal.pgen.1005214. eCollection 2015 Jun.
Additional References at PubMed
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PMID:24859162   PMID:24887312   PMID:24930703   PMID:25009997   PMID:25028519   PMID:25105964   PMID:25107907   PMID:25262822   PMID:25340332   PMID:25362352   PMID:25401279   PMID:25432534  
PMID:25446537   PMID:25564625   PMID:25581370   PMID:25587042   PMID:25600960   PMID:25631042   PMID:25639508   PMID:25736226   PMID:25761772   PMID:25808752   PMID:25842978   PMID:25917826  
PMID:25959774   PMID:25977369   PMID:26062940   PMID:26094741   PMID:26116392   PMID:26151572   PMID:26184908   PMID:26241389   PMID:26293299   PMID:26439398   PMID:26553654   PMID:26598695  
PMID:26620087   PMID:26794256   PMID:26859889   PMID:26890219   PMID:26918743   PMID:26932670   PMID:26963384   PMID:27019229   PMID:27160681   PMID:27299863   PMID:27320915   PMID:27370713  
PMID:27466187   PMID:27621061   PMID:27666725   PMID:27741240   PMID:27930311   PMID:28002442   PMID:28027321   PMID:28049832   PMID:28118357   PMID:28202523   PMID:28323137   PMID:28432216  
PMID:28696225   PMID:28749439   PMID:28846100   PMID:28943241   PMID:29031500   PMID:29107559   PMID:29222391   PMID:29244023   PMID:29282851   PMID:29287114   PMID:29437042   PMID:29447948  
PMID:29545125   PMID:29659575   PMID:29729398   PMID:29735531   PMID:29771958   PMID:29788357   PMID:29985470   PMID:30032718   PMID:30470823   PMID:30504126   PMID:30801848   PMID:30853186  
PMID:30854720   PMID:31201465   PMID:31202927   PMID:31382618   PMID:31442442   PMID:31449527   PMID:31550480   PMID:31845891   PMID:31847127   PMID:32108165   PMID:32144802   PMID:32223017  
PMID:32290615   PMID:32332736   PMID:32747435   PMID:32945847  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,984,474 - 74,990,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl174,984,474 - 74,990,831 (-)Ensembl
GRCm38174,945,315 - 74,951,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,991,892 - 74,998,225 (-)NCBIGRCm37mm9NCBIm37
MGSCv36174,878,525 - 74,884,858 (-)NCBImm8
Celera175,500,289 - 75,506,631 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.55NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2219,054,424 - 219,060,921 (-)EnsemblGRCh38hg38GRCh38
GRCh382219,054,424 - 219,060,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,919,146 - 219,925,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,627,390 - 219,633,433 (-)NCBINCBI36hg18NCBI36
Celera2213,688,833 - 213,694,930 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2211,773,140 - 211,779,240 (-)NCBIHuRef
CHM1_12219,926,506 - 219,932,606 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2976,504,315 - 76,510,532 (-)NCBI
Rnor_6.0 Ensembl982,208,223 - 82,214,440 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0982,208,223 - 82,214,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0981,977,484 - 81,983,701 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,287,115 - 74,293,332 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,435,304 - 74,439,783 (-)NCBI
Celera974,074,990 - 74,081,207 (-)NCBICelera
Cytogenetic Map9q33NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545314,376,718 - 14,381,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,376,665 - 14,382,536 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12B224,905,488 - 224,917,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13725,616,942 - 25,622,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBI
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBI
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBI
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBI
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303175,131,886 - 175,137,781 (-)NCBI
SpeTri2.0NW_0049365691,474,693 - 1,480,562 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,122,714 - 134,129,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110104,960,296 - 104,966,596 (-)NCBI
ChlSab1.1 Ensembl10104,960,120 - 104,966,585 (-)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248235,959,329 - 5,965,584 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,945,841 - 74,945,974UniSTSGRCm38
MGSCv37174,992,415 - 74,992,548UniSTSGRCm37
Celera175,500,812 - 75,500,945UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,946,676 - 74,948,324UniSTSGRCm38
MGSCv37174,993,250 - 74,994,898UniSTSGRCm37
Celera175,501,647 - 75,503,304UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.8UniSTS
cM Map140.8UniSTS
cM Map140.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,952,818 - 74,952,921UniSTSGRCm38
MGSCv37174,999,392 - 74,999,495UniSTSGRCm37
Celera175,507,798 - 75,507,921UniSTS
Cytogenetic Map1C3UniSTS
cM Map141.0UniSTS
Whitehead Genetic141.5UniSTS
Whitehead_YAC1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,945,353 - 74,945,439UniSTSGRCm38
MGSCv37174,991,927 - 74,992,013UniSTSGRCm37
Celera175,500,324 - 75,500,410UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,946,178 - 74,946,289UniSTSGRCm38
MGSCv37174,992,752 - 74,992,863UniSTSGRCm37
Celera175,501,149 - 75,501,260UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,951,252 - 74,951,476UniSTSGRCm38
MGSCv37174,997,826 - 74,998,050UniSTSGRCm37
Celera175,506,232 - 75,506,456UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6803218686307305Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7158552078206507Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17410000081800000Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:376
Count of miRNA genes:270
Interacting mature miRNAs:308
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000164097   ⟹   ENSMUSP00000128056
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189364
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl174,947,724 - 74,951,442 (-)Ensembl
RefSeq Acc Id: NM_001313683   ⟹   NP_001300612
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39174,986,882 - 74,990,831 (-)NCBI
GRCm38174,947,723 - 74,951,672 (-)NCBI
RefSeq Acc Id: NM_010544   ⟹   NP_034674
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39174,984,474 - 74,990,831 (-)NCBI
GRCm38174,945,315 - 74,951,672 (-)NCBI
MGSCv37174,991,892 - 74,998,225 (-)RGD
Celera175,500,289 - 75,506,631 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_034674   ⟸   NM_010544
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P97812 (UniProtKB/Swiss-Prot),   Q80XI9 (UniProtKB/TrEMBL),   F6RLD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300612   ⟸   NM_001313683
- Peptide Label: isoform 2 precursor
- UniProtKB: Q80XI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128056   ⟸   ENSMUST00000164097
Protein Domains
HintC   HintN

RGD ID:6874110
Promoter ID:EPDNEW_M506
Type:single initiation site
Description:Mus musculus Indian hedgehog , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38174,951,669 - 74,951,729EPDNEW
RGD ID:6817925
Promoter ID:MM_KWN:1208
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000006713,   UC007BNM.1
Mouse AssemblyChrPosition (strand)Source
MGSCv36174,997,436 - 74,997,936 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96533 AgrOrtholog
Ensembl Genes ENSMUSG00000006538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000128056 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000164097 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hedgehog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hedgehog_Hint UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hedgehog_sig/DD-Pept_Zn-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hedgehog_signalling_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hint_dom_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hint_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hint_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IHH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Intein_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16147 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11889:SF39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HH_signal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hint UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ihh PhenoGen
PIRSF Peptidase_C46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HintC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HintN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51294 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q61724 UniProtKB/Swiss-Prot