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Gene: Map2k5 (mitogen-activated protein kinase kinase 5) Mus musculus
Symbol: Map2k5
Name: mitogen-activated protein kinase kinase 5
RGD ID: 62183
Description: Predicted to have ATP binding activity; MAP kinase kinase activity; and protein serine/threonine kinase activity. Involved in MAPK cascade and heart development. Localizes to spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN altered Erk5 MAPK signaling pathway; Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI324775; AI428457; dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; Mapkk5; MEK 5; MEK5; mitogen activated protein kinase kinase 5; Prkmk5
Homo sapiens (human) : MAP2K5 (mitogen-activated protein kinase kinase 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Map2k5 (mitogen activated protein kinase kinase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k5 (mitogen-activated protein kinase kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Canis lupus familiaris (dog) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k5 (mitogen-activated protein kinase kinase 5)
Sus scrofa (pig) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Chlorocebus sabaeus (African green monkey) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Heterocephalus glaber (naked mole-rat) : Map2k5 (mitogen-activated protein kinase kinase 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl963,163,768 - 63,377,902 (-)EnsemblGRCm38mm10GRCm38
GRCm38963,163,768 - 63,381,682 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37963,011,577 - 63,225,659 (-)NCBIGRCm37mm9NCBIm37
MGSCv36962,961,776 - 63,175,858 (-)NCBImm8
Celera960,383,063 - 60,597,534 (-)NCBICelera
Cytogenetic Map9B-CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map2k5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62183
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.