Wfs1 (wolframin ER transmembrane glycoprotein) - Rat Genome Database

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Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Mus musculus
Analyze
Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
RGD ID: 731650
MGI Page MGI
Description: Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI481085; wol; Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); Wolfram syndrome 1 protein homolog; wolframin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,123,448 - 37,146,326 (-)NCBIGRCm39mm39
GRCm39 Ensembl537,123,448 - 37,146,549 (-)Ensembl
GRCm38536,966,104 - 36,988,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,357,343 - 37,380,221 (-)NCBIGRCm37mm9NCBIm37
MGSCv36537,254,356 - 37,277,158 (-)NCBImm8
Celera534,417,849 - 34,440,871 (-)NCBICelera
Cytogenetic Map5B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal associative learning  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal defecation  (IAGP)
abnormal eating behavior  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal pancreas secretion  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal vocalization  (IAGP)
analgesia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased exploration in new environment  (IAGP)
decreased food intake  (IAGP)
decreased insulin secretion  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased vertical activity  (IAGP)
disorganized pancreatic islets  (IAGP)
enhanced active avoidance behavior  (IAGP)
enhanced passive avoidance behavior  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
hypoactivity  (IAGP)
impaired behavioral response to addictive substance  (IAGP)
impaired glucose tolerance  (IAGP)
impaired swimming  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased coping response  (IAGP)
increased glucagon secretion  (IAGP)
increased oxygen consumption  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
slow postnatal weight gain  (IAGP)
weight loss  (IAGP)
References

References - curated
1. Awata T, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):612-6.
2. Bespalova IN, etal., Hum Mol Genet. 2001 Oct 15;10(22):2501-8.
3. Chistiakov DA, etal., Rev Diabet Stud. 2010 Winter;7(4):285-92. doi: 10.1900/RDS.2010.7.285. Epub 2011 Feb 10.
4. Di Lorenzo C, etal., Neurosci Lett. 2007 Sep 13;424(3):179-84. Epub 2007 Aug 6.
5. Domenech E, etal., Eur J Hum Genet. 2002 Jul;10(7):421-6.
6. Florez JC, etal., Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.
7. Franks PW, etal., Diabetologia. 2008 Mar;51(3):458-63. Epub 2007 Nov 27.
8. Inoue H, etal., Nat Genet. 1998 Oct;20(2):143-8.
9. Ishihara H, etal., Hum Mol Genet. 2004 Jun 1;13(11):1159-70. Epub 2004 Mar 31.
10. Kesner Y, etal., Mol Psychiatry. 2009 Jan;14(1):86-94. Epub 2007 Oct 30.
11. Kytovuori L, etal., J Hum Genet. 2013 Aug;58(8):495-500. doi: 10.1038/jhg.2013.29. Epub 2013 Apr 18.
12. Larsen ZM, etal., Diabet Med. 2004 Mar;21(3):218-22.
13. MGD and Homologene mouse data transfer
14. MGD data from the GO Consortium
15. MGD IEA
16. Minton JA, etal., Diabetes. 2002 Apr;51(4):1287-90.
17. OMIM Disease Annotation Pipeline
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
20. Rendtorff ND, etal., Am J Med Genet A. 2011 Jun;155A(6):1298-313. doi: 10.1002/ajmg.a.33970. Epub 2011 Apr 28.
21. RGD automated import pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Zemlyak I, etal., J Neurochem. 2009 Dec;111(5):1252-63. doi: 10.1111/j.1471-4159.2009.06415.x. Epub 2009 Oct 3.
Additional References at PubMed
PMID:9817917   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11597144   PMID:12466851   PMID:12477932   PMID:12649740   PMID:15142957   PMID:15522226   PMID:15782199  
PMID:15994758   PMID:16087305   PMID:16141072   PMID:16141073   PMID:16215705   PMID:16571599   PMID:16602821   PMID:17884289   PMID:17947299   PMID:18316032   PMID:18343518   PMID:18551525  
PMID:18613120   PMID:18799693   PMID:19041897   PMID:19125190   PMID:19190890   PMID:19293327   PMID:19428703   PMID:19477223   PMID:19664290   PMID:19911006   PMID:20090907   PMID:20160352  
PMID:20972658   PMID:21031341   PMID:21199859   PMID:21267068   PMID:21454619   PMID:21461749   PMID:21491433   PMID:21873635   PMID:22028430   PMID:22800759   PMID:23321269   PMID:23396150  
PMID:23567972   PMID:23914152   PMID:24694561   PMID:24710642   PMID:24799886   PMID:24823368   PMID:24952961   PMID:25274773   PMID:25385034   PMID:25422446   PMID:25725334   PMID:26106220  
PMID:26379490   PMID:26733243   PMID:27053292   PMID:27080063   PMID:27264872   PMID:27434582   PMID:28267787   PMID:28963041   PMID:29406269   PMID:30054673   PMID:30914711   PMID:31806049  
PMID:31935437   PMID:32060407   PMID:32325033   PMID:32581705  


Genomics

Comparative Map Data
Wfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,123,448 - 37,146,326 (-)NCBIGRCm39mm39
GRCm39 Ensembl537,123,448 - 37,146,549 (-)Ensembl
GRCm38536,966,104 - 36,988,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,357,343 - 37,380,221 (-)NCBIGRCm37mm9NCBIm37
MGSCv36537,254,356 - 37,277,158 (-)NCBImm8
Celera534,417,849 - 34,440,871 (-)NCBICelera
Cytogenetic Map5B3NCBI
WFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl46,269,849 - 6,303,265 (+)EnsemblGRCh38hg38GRCh38
GRCh3846,260,368 - 6,303,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3746,271,577 - 6,304,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3646,322,478 - 6,355,893 (+)NCBINCBI36hg18NCBI36
Build 3446,389,648 - 6,423,064NCBI
Celera46,172,234 - 6,205,670 (+)NCBI
Cytogenetic Map4p16.1NCBI
HuRef46,205,316 - 6,238,436 (+)NCBIHuRef
CHM1_146,269,525 - 6,302,942 (+)NCBICHM1_1
Wfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21473,810,478 - 73,834,993 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1473,810,404 - 73,835,602 (+)Ensembl
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Celera1472,756,725 - 72,781,236 (+)NCBICelera
Cytogenetic Map14q21NCBI
Wfs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,902,454 - 3,924,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555143,902,508 - 3,924,281 (-)NCBIChiLan1.0ChiLan1.0
WFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.146,345,960 - 6,379,094 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl46,345,864 - 6,379,287 (+)Ensemblpanpan1.1panPan2
WFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,451,722 - 38,466,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,451,710 - 38,475,827 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,428,703 - 38,449,916 (-)NCBI
ROS_Cfam_1.01338,942,257 - 38,963,449 (-)NCBI
UMICH_Zoey_3.11338,633,035 - 38,659,609 (-)NCBI
UNSW_CanFamBas_1.01338,742,939 - 38,764,184 (-)NCBI
UU_Cfam_GSD_1.01339,217,791 - 39,239,032 (-)NCBI
Wfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528564,638,197 - 64,663,281 (+)NCBI
SpeTri2.0NW_00493647718,339,915 - 18,364,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl84,362,678 - 4,385,272 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.184,362,678 - 4,405,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.282,954,118 - 2,962,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12742,404,028 - 42,437,988 (+)NCBI
ChlSab1.1 Ensembl2742,404,084 - 42,438,005 (+)Ensembl
Vero_WHO_p1.0NW_02366604789,197,417 - 89,231,280 (+)NCBI
Wfs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475522,818,653 - 22,841,717 (+)NCBI

Position Markers
39.MMHAP34FLE6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,984,318 - 36,984,511UniSTSGRCm38
MGSCv37537,375,557 - 37,375,750UniSTSGRCm37
Celera534,436,207 - 34,436,400UniSTS
Cytogenetic Map5B3UniSTS
Whitehead_YAC5 UniSTS
D18999  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,106 - 36,966,181UniSTSGRCm38
MGSCv37537,357,345 - 37,357,420UniSTSGRCm37
Celera534,417,851 - 34,417,926UniSTS
Cytogenetic Map5B3UniSTS
Whitehead_YAC5 UniSTS
AI481085  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,293 - 36,966,412UniSTSGRCm38
MGSCv37537,357,532 - 37,357,651UniSTSGRCm37
Celera534,418,038 - 34,418,157UniSTS
Cytogenetic Map5B3UniSTS
Whitehead/MRC_RH5488.07UniSTS
Wfs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,691 - 36,966,851UniSTSGRCm38
MGSCv37537,357,930 - 37,358,090UniSTSGRCm37
Celera534,418,436 - 34,418,596UniSTS
Cytogenetic Map5B3UniSTS
cM Map5 UniSTS
SHGC-59709  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,967,374 - 36,967,604UniSTSGRCm38
MGSCv37537,358,613 - 37,358,843UniSTSGRCm37
Celera534,419,119 - 34,419,349UniSTS
Cytogenetic Map5B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51340580847405808Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51547674049476846Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52052964954529790Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52150995255510060Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52189582554342976Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52189582564649236Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52705800661058109Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53086693364867138Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53086693364867138Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53141311665413116Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined31975890100630065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined31975890100630065Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53333132567331534Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53553712069537252Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53553712069537252Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53553712069537252Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53553712069537252Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53569722669697372Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53569722669697372Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3627608170276081Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53633714470337256Mouse
36049766Ars22_mantibody response to SARS-CoV 22, day 29, IgG3 (mouse)53680000045300000Mouse
36049767Ars23_mantibody response to SARS-CoV 23, day 29, Total IgG (mouse)53680000045300000Mouse
36049768Ars24_mantibody response to SARS-CoV 24, 4 days post-rechallenge, IgG3 (mouse)53680000045300000Mouse
36049769Ars13_mantibody response to SARS-CoV 13, day 7, IgG2a+IgG2c (mouse)53680000045300000Mouse
36049770Ars14_mantibody response to SARS-CoV 14, day 7, IgG3 (mouse)53680000045300000Mouse
36049771Ars15_mantibody response to SARS-CoV 15, day 7, IgM (mouse)53680000045300000Mouse
36049772Ars20_mantibody response to SARS-CoV 20, day 15, Total IgG (mouse)53680000045300000Mouse
36049773Ars21_mantibody response to SARS-CoV 21, day 29, IgG2a+IgG2c (mouse)53680000045300000Mouse
36049774Ars16_mantibody response to SARS-CoV 16, day 7, Total IgG (mouse)53680000045300000Mouse
36049775Ars17_mantibody response to SARS-CoV 17, day 15, IgG2a+IgG2c (mouse)53680000045300000Mouse
36049776Ars18_mantibody response to SARS-CoV 18, day 15, IgG3 (mouse)53680000045300000Mouse
36049777Ars19_mantibody response to SARS-CoV 19, day 15, IgM (mouse)53680000045300000Mouse
35673310Ari4_mantibody response to influenza 4, day 15-45, IgG2b (mouse)53680000045300000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:772
Count of miRNA genes:352
Interacting mature miRNAs:378
Transcripts:ENSMUST00000043964, ENSMUST00000166339, ENSMUST00000167937
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ011971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY063019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY296480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX562372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000043964   ⟹   ENSMUSP00000048053
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,123,448 - 37,146,549 (-)Ensembl
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166339   ⟹   ENSMUSP00000132404
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,123,451 - 37,146,277 (-)Ensembl
GRCm38.p6 Ensembl536,966,107 - 36,988,933 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167937   ⟹   ENSMUSP00000125779
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,125,845 - 37,134,300 (-)Ensembl
GRCm38.p6 Ensembl536,968,501 - 36,976,956 (-)Ensembl
RefSeq Acc Id: NM_011716   ⟹   NP_035846
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39537,123,448 - 37,146,326 (-)NCBI
GRCm38536,966,104 - 36,988,982 (-)ENTREZGENE
MGSCv37537,357,343 - 37,380,221 (-)RGD
Celera534,417,849 - 34,440,871 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035846   ⟸   NM_011716
- UniProtKB: P56695 (UniProtKB/Swiss-Prot),   Q3TDI2 (UniProtKB/TrEMBL),   Q3UN10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000132404   ⟸   ENSMUST00000166339
RefSeq Acc Id: ENSMUSP00000125779   ⟸   ENSMUST00000167937
RefSeq Acc Id: ENSMUSP00000048053   ⟸   ENSMUST00000043964

Promoters
RGD ID:6886556
Promoter ID:EPDNEW_M6729
Type:initiation region
Name:Wfs1_1
Description:Mus musculus wolframin ER transmembrane glycoprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38536,988,932 - 36,988,992EPDNEW
RGD ID:6838637
Promoter ID:MM_KWN:42069
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_011716
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36537,380,056 - 37,380,556 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1328355 AgrOrtholog
Ensembl Genes ENSMUSG00000039474 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000048053 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000125779 UniProtKB/TrEMBL
  ENSMUSP00000132404 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043964 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000166339 UniProtKB/TrEMBL
  ENSMUST00000167937 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wolframin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wolframin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1328355 ENTREZGENE
NCBI Gene 22393 ENTREZGENE
PANTHER PTHR13098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wfs1 PhenoGen
PRINTS WOLFFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WOLFRAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7D926_MOUSE UniProtKB/TrEMBL
  P56695 ENTREZGENE
  Q3TDI2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UMA8_MOUSE UniProtKB/TrEMBL
  Q3UN10 ENTREZGENE, UniProtKB/TrEMBL
  Q80UI9_MOUSE UniProtKB/TrEMBL
  WFS1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9Z276 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Wfs1  wolframin ER transmembrane glycoprotein    Wolfram syndrome 1 homolog (human)  Symbol and/or name change 5135510 APPROVED