Wfs1 (wolframin ER transmembrane glycoprotein)

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Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Mus musculus

Analyze

Symbol:

Wfs1

Name:

wolframin ER transmembrane glycoprotein

RGD ID:

731650

MGI Page

MGI

Description:

Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AI481085; wol; Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); Wolfram syndrome 1 protein homolog; wolframin

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	37,123,448 - 37,146,326 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	37,123,448 - 37,146,549 (-)	Ensembl
GRCm38	5	36,966,104 - 36,988,982 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	36,966,104 - 36,989,205 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	37,357,343 - 37,380,221 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	37,254,356 - 37,277,158 (-)	NCBI			mm8
Celera	5	34,417,849 - 34,440,871 (-)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal dominant nonsyndromic deafness 6 (ISO)

autosomal dominant Wolfram syndrome (ISO)

cataract (ISO)

cataract 41 (ISO)

Dandy-Walker syndrome (ISO)

diabetes mellitus (ISO)

genetic disease (ISO)

Headache (ISO)

Hearing Loss (ISO)

nonsyndromic deafness (ISO)

Nonsyndromic Sensorineural Hearing Loss (ISO)

optic atrophy (ISO)

optic atrophy 1 (ISO)

post-traumatic stress disorder (ISO)

sensorineural hearing loss (ISO)

type 1 diabetes mellitus (IMP,ISO)

type 2 diabetes mellitus (ISO)

visual epilepsy (ISO)

Wolfram syndrome (ISO)

Wolfram syndrome 1 (IEA,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

6-propyl-2-thiouracil (ISO)

aconitine (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

ammonium chloride (ISO)

aristolochic acid (ISO)

benzo[a]pyrene (EXP,ISO)

beta-naphthoflavone (ISO)

bisphenol A (ISO)

carbon nanotube (EXP)

chromium(6+) (EXP)

cisplatin (ISO)

clobetasol (EXP)

copper(II) sulfate (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (EXP,ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

endosulfan (ISO)

ethanol (EXP)

fluoxetine (ISO)

folic acid (EXP)

ivermectin (ISO)

kainic acid (EXP)

ketamine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

N,N-diethyl-m-toluamide (ISO)

nitrofen (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

permethrin (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (EXP)

silicon dioxide (EXP)

tetrachloromethane (EXP)

thapsigargin (ISO)

tolcapone (ISO)

tunicamycin (EXP,ISO)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion homeostasis (IBA,ISO)

endoplasmic reticulum calcium ion homeostasis (ISO)

endoplasmic reticulum unfolded protein response (IBA,IMP)

glucose homeostasis (ISO)

kidney development (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of ATF6-mediated unfolded protein response (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (IMP)

negative regulation of neuron apoptotic process (ISO)

negative regulation of programmed cell death (ISO)

negative regulation of response to endoplasmic reticulum stress (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of type B pancreatic cell apoptotic process (IMP,ISO)

nervous system process (ISO)

olfactory behavior (ISO)

pancreas development (ISO)

positive regulation of calcium ion transport (ISO)

positive regulation of growth (IMP)

positive regulation of protein metabolic process (ISO)

positive regulation of protein ubiquitination (IMP,ISO)

protein stabilization (IMP,ISO)

regulation of cell cycle (NAS)

renal water homeostasis (ISO)

response to endoplasmic reticulum stress (IDA,ISO)

sensory perception of sound (ISO)

ubiquitin-dependent ERAD pathway (IMP,ISO)

visual perception (ISO,NAS)

Cellular Component

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IDA,ISO)

integral component of endoplasmic reticulum membrane (IBA,ISO)

integral component of membrane (IEA)

integral component of synaptic vesicle membrane (ISO)

membrane (IEA)

secretory granule (ISO)

Molecular Function

ATPase binding (IDA,ISO)

calcium-dependent protein binding (ISO)

calmodulin binding (ISO)

DNA-binding transcription factor binding (ISO)

proteasome binding (ISO)

protein binding (ISO)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal associative learning (IAGP)

abnormal behavioral response to addictive substance (IAGP)

abnormal blood homeostasis (IAGP)

abnormal cued conditioning behavior (IAGP)

abnormal defecation (IAGP)

abnormal eating behavior (IAGP)

abnormal glucose homeostasis (IAGP)

abnormal pancreas secretion (IAGP)

abnormal pancreatic beta cell physiology (IAGP)

abnormal pancreatic islet morphology (IAGP)

abnormal social investigation (IAGP)

abnormal spatial learning (IAGP)

abnormal thyroid follicle morphology (IAGP)

abnormal thyroid gland morphology (IAGP)

abnormal vocalization (IAGP)

analgesia (IAGP)

decreased body size (IAGP)

decreased body weight (IAGP)

decreased circulating glucose level (IAGP)

decreased circulating insulin level (IAGP)

decreased circulating leptin level (IAGP)

decreased exploration in new environment (IAGP)

decreased food intake (IAGP)

decreased insulin secretion (IAGP)

decreased pancreatic beta cell mass (IAGP)

decreased pancreatic beta cell number (IAGP)

decreased vertical activity (IAGP)

disorganized pancreatic islets (IAGP)

enhanced active avoidance behavior (IAGP)

enhanced passive avoidance behavior (IAGP)

hyperactivity (IAGP)

hyperglycemia (IAGP)

hypoactivity (IAGP)

impaired behavioral response to addictive substance (IAGP)

impaired glucose tolerance (IAGP)

impaired swimming (IAGP)

increased anxiety-related response (IAGP)

increased circulating corticosterone level (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin-like growth factor I level (IAGP)

increased coping response (IAGP)

increased glucagon secretion (IAGP)

increased oxygen consumption (IAGP)

increased thigmotaxis (IAGP)

increased vertical activity (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

slow postnatal weight gain (IAGP)

weight loss (IAGP)

References

References - curated


1.	Awata T, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):612-6.
2.	Bespalova IN, etal., Hum Mol Genet. 2001 Oct 15;10(22):2501-8.
3.	Chistiakov DA, etal., Rev Diabet Stud. 2010 Winter;7(4):285-92. doi: 10.1900/RDS.2010.7.285. Epub 2011 Feb 10.
4.	Di Lorenzo C, etal., Neurosci Lett. 2007 Sep 13;424(3):179-84. Epub 2007 Aug 6.
5.	Domenech E, etal., Eur J Hum Genet. 2002 Jul;10(7):421-6.
6.	Florez JC, etal., Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.
7.	Franks PW, etal., Diabetologia. 2008 Mar;51(3):458-63. Epub 2007 Nov 27.
8.	Inoue H, etal., Nat Genet. 1998 Oct;20(2):143-8.
9.	Ishihara H, etal., Hum Mol Genet. 2004 Jun 1;13(11):1159-70. Epub 2004 Mar 31.
10.	Kesner Y, etal., Mol Psychiatry. 2009 Jan;14(1):86-94. Epub 2007 Oct 30.
11.	Kytovuori L, etal., J Hum Genet. 2013 Aug;58(8):495-500. doi: 10.1038/jhg.2013.29. Epub 2013 Apr 18.
12.	Larsen ZM, etal., Diabet Med. 2004 Mar;21(3):218-22.
13.	MGD and Homologene mouse data transfer
14.	MGD data from the GO Consortium
15.	MGD IEA
16.	Minton JA, etal., Diabetes. 2002 Apr;51(4):1287-90.
17.	OMIM Disease Annotation Pipeline
18.	Pipeline to import KEGG annotations from KEGG into RGD
19.	Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
20.	Rendtorff ND, etal., Am J Med Genet A. 2011 Jun;155A(6):1298-313. doi: 10.1002/ajmg.a.33970. Epub 2011 Apr 28.
21.	RGD automated import pipeline
22.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23.	RGD automated import pipeline for gene-chemical interactions
24.	Zemlyak I, etal., J Neurochem. 2009 Dec;111(5):1252-63. doi: 10.1111/j.1471-4159.2009.06415.x. Epub 2009 Oct 3.

Additional References at PubMed

PMID:9817917	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11597144	PMID:12466851	PMID:12477932	PMID:12649740	PMID:15142957	PMID:15522226	PMID:15782199
PMID:15994758	PMID:16087305	PMID:16141072	PMID:16141073	PMID:16215705	PMID:16571599	PMID:16602821	PMID:17884289	PMID:17947299	PMID:18316032	PMID:18343518	PMID:18551525
PMID:18613120	PMID:18799693	PMID:19041897	PMID:19125190	PMID:19190890	PMID:19293327	PMID:19428703	PMID:19477223	PMID:19664290	PMID:19911006	PMID:20090907	PMID:20160352
PMID:20972658	PMID:21031341	PMID:21199859	PMID:21267068	PMID:21454619	PMID:21461749	PMID:21491433	PMID:21873635	PMID:22028430	PMID:22800759	PMID:23321269	PMID:23396150
PMID:23567972	PMID:23914152	PMID:24694561	PMID:24710642	PMID:24799886	PMID:24823368	PMID:24952961	PMID:25274773	PMID:25385034	PMID:25422446	PMID:25725334	PMID:26106220
PMID:26379490	PMID:26733243	PMID:27053292	PMID:27080063	PMID:27264872	PMID:27434582	PMID:28267787	PMID:28963041	PMID:29406269	PMID:30054673	PMID:30914711	PMID:31806049
PMID:31935437	PMID:32060407	PMID:32325033	PMID:32581705

Genomics

Comparative Map Data

Wfs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	37,123,448 - 37,146,326 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	37,123,448 - 37,146,549 (-)	Ensembl
GRCm38	5	36,966,104 - 36,988,982 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	36,966,104 - 36,989,205 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	37,357,343 - 37,380,221 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	37,254,356 - 37,277,158 (-)	NCBI			mm8
Celera	5	34,417,849 - 34,440,871 (-)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI

WFS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	6,269,849 - 6,303,265 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	6,260,368 - 6,303,265 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	6,271,577 - 6,304,992 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	6,322,478 - 6,355,893 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	6,389,648 - 6,423,064	NCBI
Celera	4	6,172,234 - 6,205,670 (+)	NCBI
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	6,205,316 - 6,238,436 (+)	NCBI		HuRef
CHM1_1	4	6,269,525 - 6,302,942 (+)	NCBI		CHM1_1

Wfs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	73,810,478 - 73,834,993 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	14	73,810,404 - 73,835,602 (+)	Ensembl
Rnor_6.0	14	78,640,707 - 78,665,224 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	78,640,620 - 78,665,966 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	78,606,172 - 78,630,689 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,379,680 - 79,404,003 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	79,389,637 - 79,406,394 (+)	NCBI
Celera	14	72,756,725 - 72,781,236 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Wfs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	3,902,454 - 3,924,610 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	3,902,508 - 3,924,281 (-)	NCBI	ChiLan1.0	ChiLan1.0

WFS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	6,345,960 - 6,379,094 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	6,345,864 - 6,379,287 (+)	Ensembl	panpan1.1		panPan2

WFS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	38,451,722 - 38,466,481 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	38,451,710 - 38,475,827 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	38,428,703 - 38,449,916 (-)	NCBI
ROS_Cfam_1.0	13	38,942,257 - 38,963,449 (-)	NCBI
UMICH_Zoey_3.1	13	38,633,035 - 38,659,609 (-)	NCBI
UNSW_CanFamBas_1.0	13	38,742,939 - 38,764,184 (-)	NCBI
UU_Cfam_GSD_1.0	13	39,217,791 - 39,239,032 (-)	NCBI

Wfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	64,638,197 - 64,663,281 (+)	NCBI
SpeTri2.0	NW_004936477	18,339,915 - 18,364,973 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WFS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	4,362,678 - 4,385,272 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	4,362,678 - 4,405,185 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	2,954,118 - 2,962,286 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WFS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	42,404,028 - 42,437,988 (+)	NCBI
ChlSab1.1 Ensembl	27	42,404,084 - 42,438,005 (+)	Ensembl
Vero_WHO_p1.0	NW_023666047	89,197,417 - 89,231,280 (+)	NCBI

Wfs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624755	22,818,653 - 22,841,717 (+)	NCBI

Position Markers

39.MMHAP34FLE6.seq

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	36,984,318 - 36,984,511	UniSTS	GRCm38
MGSCv37	5	37,375,557 - 37,375,750	UniSTS	GRCm37
Celera	5	34,436,207 - 34,436,400	UniSTS
Cytogenetic Map	5	B3	UniSTS
Whitehead_YAC	5		UniSTS

D18999

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	36,966,106 - 36,966,181	UniSTS	GRCm38
MGSCv37	5	37,357,345 - 37,357,420	UniSTS	GRCm37
Celera	5	34,417,851 - 34,417,926	UniSTS
Cytogenetic Map	5	B3	UniSTS
Whitehead_YAC	5		UniSTS

AI481085

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	36,966,293 - 36,966,412	UniSTS	GRCm38
MGSCv37	5	37,357,532 - 37,357,651	UniSTS	GRCm37
Celera	5	34,418,038 - 34,418,157	UniSTS
Cytogenetic Map	5	B3	UniSTS
Whitehead/MRC_RH	5	488.07	UniSTS

Wfs1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	36,966,691 - 36,966,851	UniSTS	GRCm38
MGSCv37	5	37,357,930 - 37,358,090	UniSTS	GRCm37
Celera	5	34,418,436 - 34,418,596	UniSTS
Cytogenetic Map	5	B3	UniSTS
cM Map	5		UniSTS

SHGC-59709

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	36,967,374 - 36,967,604	UniSTS	GRCm38
MGSCv37	5	37,358,613 - 37,358,843	UniSTS	GRCm37
Celera	5	34,419,119 - 34,419,349	UniSTS
Cytogenetic Map	5	B3	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3299825	37299825	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5179522	39179654	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	7919119	41919241	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8840693	87693978	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8865949	40372526	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13405808	47405808	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15476740	49476846	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20529649	54529790	Mouse
1301776	Skts3_m	skin tumor susceptibility 3 (mouse)			Not determined		5	21509952	55510060	Mouse
11537368	Hmtb10_m	hemostasis and thrombosis 10 (mouse)					5	21895825	54342976	Mouse
11537367	Hmtb11_m	hemostasis and thrombosis 11 (mouse)					5	21895825	64649236	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26236236	138457140	Mouse
1300701	Cd8ts1_m	CD8 T cell subset 1 (mouse)			Not determined		5	27058006	61058109	Mouse
1301555	Alcp10_m	alcohol preference locus 10 (mouse)			Not determined		5	30866933	64867138	Mouse
1301403	Alcp9_m	alcohol preference locus 9 (mouse)			Not determined		5	30866933	64867138	Mouse
11353827	Hplq1_m	hot plate latency 1 (mouse)					5	31413116	65413116	Mouse
4140990	Lgq6_m	late growth QTL 6 (mouse)			Not determined			31975890	100630065	Mouse
4141219	W10q16_m	weight 10 weeks QTL 16 (mouse)			Not determined			31975890	100630065	Mouse
10043995	Hbnr9_m	Heligmosomoides bakeri nematode resistance 9 (mouse)			Not determined		5	33331325	67331534	Mouse
1301845	Lxw4_m	lupus BXSB x NZW 4 (mouse)			Not determined		5	35537120	69537252	Mouse
11049558	Lmr24b_m	leishmaniasis resistance 24b (mouse)					5	35537120	69537252	Mouse
11049559	Lmr24c_m	leishmaniasis resistance 24c (mouse)					5	35537120	69537252	Mouse
11049561	Lmr24e_m	leishmaniasis resistance 24e (mouse)					5	35537120	69537252	Mouse
1301223	Hdlq7_m	HDL QTL 7 (mouse)			Not determined		5	35697226	69697372	Mouse
13464252	Ahl10_m	age related hearing loss, early onset 10 (mouse)					5	35697226	69697372	Mouse
4141647	Hrvhf1_m	heart rate variability, high frequency 1 (mouse)			Not determined			36276081	70276081	Mouse
1301170	Lith13_m	lithogenic gene 13 (mouse)			Not determined		5	36337144	70337256	Mouse
36049766	Ars22_m	antibody response to SARS-CoV 22, day 29, IgG3 (mouse)					5	36800000	45300000	Mouse
36049767	Ars23_m	antibody response to SARS-CoV 23, day 29, Total IgG (mouse)					5	36800000	45300000	Mouse
36049768	Ars24_m	antibody response to SARS-CoV 24, 4 days post-rechallenge, IgG3 (mouse)					5	36800000	45300000	Mouse
36049769	Ars13_m	antibody response to SARS-CoV 13, day 7, IgG2a+IgG2c (mouse)					5	36800000	45300000	Mouse
36049770	Ars14_m	antibody response to SARS-CoV 14, day 7, IgG3 (mouse)					5	36800000	45300000	Mouse
36049771	Ars15_m	antibody response to SARS-CoV 15, day 7, IgM (mouse)					5	36800000	45300000	Mouse
36049772	Ars20_m	antibody response to SARS-CoV 20, day 15, Total IgG (mouse)					5	36800000	45300000	Mouse
36049773	Ars21_m	antibody response to SARS-CoV 21, day 29, IgG2a+IgG2c (mouse)					5	36800000	45300000	Mouse
36049774	Ars16_m	antibody response to SARS-CoV 16, day 7, Total IgG (mouse)					5	36800000	45300000	Mouse
36049775	Ars17_m	antibody response to SARS-CoV 17, day 15, IgG2a+IgG2c (mouse)					5	36800000	45300000	Mouse
36049776	Ars18_m	antibody response to SARS-CoV 18, day 15, IgG3 (mouse)					5	36800000	45300000	Mouse
36049777	Ars19_m	antibody response to SARS-CoV 19, day 15, IgM (mouse)					5	36800000	45300000	Mouse
35673310	Ari4_m	antibody response to influenza 4, day 15-45, IgG2b (mouse)					5	36800000	45300000	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	772
Count of miRNA genes:	352
Interacting mature miRNAs:	378
Transcripts:	ENSMUST00000043964, ENSMUST00000166339, ENSMUST00000167937
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_011716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF084482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ011971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK144561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK170180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK179248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK185636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK189923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK190421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK191825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK196875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK203181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK206433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC046988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY063019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY296480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CX562372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000043964 ⟹ ENSMUSP00000048053

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	37,123,448 - 37,146,549 (-)	Ensembl
GRCm38.p6 Ensembl	5	36,966,104 - 36,989,205 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000166339 ⟹ ENSMUSP00000132404

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	37,123,451 - 37,146,277 (-)	Ensembl
GRCm38.p6 Ensembl	5	36,966,107 - 36,988,933 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000167937 ⟹ ENSMUSP00000125779

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	37,125,845 - 37,134,300 (-)	Ensembl
GRCm38.p6 Ensembl	5	36,968,501 - 36,976,956 (-)	Ensembl

RefSeq Acc Id:

NM_011716 ⟹ NP_035846

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	37,123,448 - 37,146,326 (-)	NCBI
GRCm38	5	36,966,104 - 36,988,982 (-)	ENTREZGENE
MGSCv37	5	37,357,343 - 37,380,221 (-)	RGD
Celera	5	34,417,849 - 34,440,871 (-)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

TTTCCCGGGGCCGCGCTGAATGTAGGGCCGCGCGCTCCGCCTGCTCAGCTGGCCGCTGCAATCT
CCGCGGTTTCGGAGCAACTTCGCGGCGGGCTGGGAGGCCCAGCACTGCGGCCGGCAAGATGAAC
TCAGGCACCCCACCTCCGAGCCCCTCTGGCCCACCTCCTCCACCCGCACCACAGCCCCAGGCCC
GGGCCCGGCTCAATGCCACCGCCTCACTGGAGCAGGACAAGATTGAACCGCCTCGTGCTCCCAG
ACCTCAGGCTGACCCCAGTGCTGGACGAAGTGCTGGGGAAGCAGCCGCTCCGGAGCCTCGGGCC
CCTCAAACCGGCAGCCGGGAAGAAACGGACAGAGCTGGTCCCATGAAGGCAGATGTGGAGATCC
CCTTTGAAGAAGTCCTGGAGAAAGCCAAGGCTGGAGACCCCAAAGCACAGACTGAGGTGGGCAA
ACACTACCTACGCCTTGCCAACGATGCAGATGAAGAACTCAACAGCTGCTCAGCCGTAGCCTGG
CTAATCCTGGCAGCCAAGCAGGGCAGGCGGGAGGCCGTGAAGCTGCTGAGGCGGTGCCTAGCTG
ACCGGAAAGGCATCACTTCTGAGAACGAGGCTGAGGTGAAGCAGCTATCCTCTGAGACCGACCT
GGAAAGGGCTGTGCGCAAGGCTGCCCTGGTCATGTACTGGAAACTCAACCCCAAGAAGAAGAAG
CAGGTGGCTGTGTCCGAGCTGCTGGAGAATGTTGGACAGGTCAACGAGCAGGATGGAGGGGCGC
AGCCAGGCCCAGTCCCCAAGTCCCTGCAGAAGCAGAGGCGCATGCTGGAGCGCCTCGTCAGCAG
TGAATCCAAGAACTACATTGCTCTGGACGATTTTGTGGAGCTCACCAAGAAGTACGCCAAGGGC
ATCATTCCCACCAACCTGTTCCTGCAGGATGAGGATGAAGATGAGGACGAGCTGGCAGGGAAGA
GCCCCGAGGACCTGCCACTACGCCAGAAGGTGGTGAAGTACCCTTTACACGCCATCATGGAGAT
CAAAGAGTACCTGATTGACGTAGCCTCCAAGGCCGGCATGCACTGGCTCTCCACCATTGTACCC
ACCCATCACATCAACGCCCTCATCTTCTTCTTCATCATCAGCAACCTAACCATCGACTTCTTCG
CCTTCTTCATCCCCCTGGTGGTCTTCTATCTGTCCTTTGTGTCCATGGTCATCTGCACGCTCAA
GGTGTTCCAGGACAGCAAGGCCTGGGAGAACTTCCGTACTCTCACCGACCTGCTGCTGCGCTTC
GAGCCCAACCTAGACGTGGAGCAGGCCGAAGTGAACTTCGGCTGGAACCACCTGGAGCCCTACA
TCCACTTCCTACTGTCAGTCGTCTTTGTCATCTTCTCCTTCCCGCTGGCCAGCAAGGACTGCAT
CCCCTGCTCGGAGCTGGCCGTCATCTCCACCTTCTTCACGGTGACCAGCTACATGAGCCTGAGC
AGCTCTGCTGAGCCCTATACCAGGCGTGCCCTGGTCACCGAGGTGGCTGCCGGCTTGCTGTCCC
TTCTGCCCACCGTGCCTGTGGACTGGCGCTTCCTGAAAGTACTCGGCCAGACTTTCTTCACTGT
GCCCGTTGGCCACTTCATCATCCTCAACGTCAGCCTCCCCTGCCTGCTCTATGTCTATCTCTTT
TACCTCTTCTTCCGCATGGCCCAGCTGAGGAACTTCAAGGGCACTTATTGCTACCTGGTGCCCT
ACCTGGTGTGCTTCATGTGGTGTGAACTGTCCGTGGTCATCCTGCTCCAGTCTACCGGCCTGGG
CTTGGTCCGGGCCTCCATCGGCTACTTCCTCTTCCTCTTTGCCCTCCCCATCCTGGTGGCTGGC
CTCGCCTTGATGGGCACGGTGCAGTTTGCCCGATGGTTCCTGTCGCTGGACCTCACCAAGATCA
TGGTCACCACGGTGATCTGCGGCGTACCCCTGCTTTTCCGTTGGTGGACCAAGGCCAACTTCTC
AGTGATGGGGATGGTCAAGTCCCTGACGAAGAGCTCCATGGTGAAGCTCATTCTGGTGTGGCTA
ACGGCCATCCTGCTCTTCTGCTGGTTCTACGTGTACCGCTCAGAAGGCATGAAGGTCTACAACT
CCACACTCACCTGGCAGCAATATGGCTTCCTATGTGGGCCCCGGGCCTGGAAGGAAACTAACAT
GGCCCGGACCCAGATCCTGTGCAGCCACCTGGAGGGCCACAGGGTCACGTGGACAGGCCGCTTC
AAGTATGTCCGAGTGACCGAGATCGACAACAGTGCTGAGTCGGCCATCAACATGCTCCCGTTCT
TCCTGGGCGATTGGATGCGCTGCCTGTATGGCGAGGCCTACCCATCTTGTAGCTCTGGTAACAC
GTCCACGGCAGAGGAGGAGCTCTGCCGTCTCAAGCAGCTGGCCAAGCACCCCTGCCACATCAAG
AAGTTTGACCGCTACAAATTTGAGATCACAGTGGGCATGCCCTTTGGCACCAACGGCAACCGCG
GCCATGAAGAGGACGACATCACCAAGGACATTGTTCTCCGTGCCAGCAGCGAGTTCAAGGACGT
GCTGCTGAACCTGCGCCAGGGGAGCCTCATAGAGTTCAGCACCATCCTCGAGGGCCGCCTGGGT
AGCAAGTGGCCCGTCTTCGAGCTCAAGGCCATCAGCTGCCTCAACTGCATGACGCAGCTGTCAC
CTGCCCGGAGGCACGTGAAGATCGAACAGGACTGGCGTAGCACAGTGCACGGTGCCCTCAAGTT
TGCCTTCGACTTCTTCTTCTTCCCATTCCTGTCTGCCGCCTGAGGAGCGTCCGCCGCTGGAGGA
GGCTTTGGTGCATGTTGCTGTGAAGTCCTTCCGTGTGGCCACCCAGCCAGCTGGAGCAGCACTG
TGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTATTCTGCTCTCGTGTGGT
TAGATCCCAGGCTCTCTGCTCACCTGTAGATCGCAGATCCTGCTGGAGGGTGGTTCTCTTTAGC
ACTGTCCACTTTGAATGCCGAGTGTCATAAGAAATTGCATGCTATCTTCACTCACAATCCTGCC
CTTCCCTCACAGAGCTGGAACTCCAAGCCTGGCCCCAAAGACCCTCCATCACGAAGAGCACTTT
ACAGATAAGAATCTTCCTCCCCAGTTCTTCATGCCTCCTTCCTGCCCTTTCCTTACTTTGTGTT
GGATTTGTTTTCCAAATATGTGTGTATGTAGACTTCATGGTAGTGTTTCTTATTTATTTGGTTG
CTGCTAAGCCTTGACAGTGGTTCACCTTCCTGGGCTGTCCCCAGTGGTCACGTCCTGCCTGGCT
TCCTACTTGGGTATAGCATGTCCAAACTGGGCTCTGAACACTACAGCCTGCCTTGGAGCTGGCC
TATCTCTGGGGGTGTTAGAGAGTTTGTGGGGATCTCTTCTGAGTACCCCAGGACTTGGGAAATA
ATGCAAGAGTATCCCTTTCAGTACATAGGTAAGCTTGGCTATGTTCAATATGGCAGAGCCAAAA
GCCAAGTTCTAAGGCAGCCGAAATAAAAAGCTTTGAAACCTATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_035846	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC64944	(Get FASTA)	NCBI Sequence Viewer
	AAH46988	(Get FASTA)	NCBI Sequence Viewer
	BAE25938	(Get FASTA)	NCBI Sequence Viewer
	BAE26190	(Get FASTA)	NCBI Sequence Viewer
	BAE41619	(Get FASTA)	NCBI Sequence Viewer
	CAA09892	(Get FASTA)	NCBI Sequence Viewer
	EDL37519	(Get FASTA)	NCBI Sequence Viewer
	P56695	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_035846 ⟸ NM_011716

- UniProtKB:

P56695 (UniProtKB/Swiss-Prot), Q3TDI2 (UniProtKB/TrEMBL), Q3UN10 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAPRPQADPSAGRSAGEAAAPEP
RAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAV
AWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKK
KKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYA
KGIIPTNLFLQDEDEDEDELAGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTI
VPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLL
RFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMS
LSSSAEPYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVY
LFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILV
AGLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKSSMVKLILV
WLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTG
RFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCH
IKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGR
LGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA

hide sequence

RefSeq Acc Id:

ENSMUSP00000132404 ⟸ ENSMUST00000166339

RefSeq Acc Id:

ENSMUSP00000125779 ⟸ ENSMUST00000167937

RefSeq Acc Id:

ENSMUSP00000048053 ⟸ ENSMUST00000043964

Promoters

RGD ID:

6886556

Promoter ID:

EPDNEW_M6729

Type:

initiation region

Name:

Wfs1_1

Description:

Mus musculus wolframin ER transmembrane glycoprotein , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	36,988,932 - 36,988,992	EPDNEW

RGD ID:

6838637

Promoter ID:

MM_KWN:42069

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6

Transcripts:

NM_011716

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	37,380,056 - 37,380,556 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1328355	AgrOrtholog
Ensembl Genes	ENSMUSG00000039474	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000048053	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000125779	UniProtKB/TrEMBL
	ENSMUSP00000132404	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000043964	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000166339	UniProtKB/TrEMBL
	ENSMUST00000167937	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Wolframin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Wolframin_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:22393	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1328355	ENTREZGENE
NCBI Gene	22393	ENTREZGENE
PANTHER	PTHR13098	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Wfs1	PhenoGen
PRINTS	WOLFFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WOLFRAMIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F7D926_MOUSE	UniProtKB/TrEMBL
	P56695	ENTREZGENE
	Q3TDI2	ENTREZGENE, UniProtKB/TrEMBL
	Q3UMA8_MOUSE	UniProtKB/TrEMBL
	Q3UN10	ENTREZGENE, UniProtKB/TrEMBL
	Q80UI9_MOUSE	UniProtKB/TrEMBL
	WFS1_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q9Z276	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-21	Wfs1	wolframin ER transmembrane glycoprotein		Wolfram syndrome 1 homolog (human)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)