Wfs1 (wolframin ER transmembrane glycoprotein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Mus musculus
Analyze
Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
RGD ID: 731650
MGI Page MGI
Description: Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of protein metabolic process. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1 and nonsyndromic deafness. Human ortholog(s) of this gene implicated in several diseases, including Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI481085; wol; Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); Wolfram syndrome 1 protein homolog; wolframin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,123,448 - 37,146,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,123,448 - 37,146,549 (-)EnsemblGRCm39 Ensembl
GRCm38536,966,104 - 36,988,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,357,343 - 37,380,221 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36537,254,356 - 37,277,158 (-)NCBIMGSCv36mm8
Celera534,417,849 - 34,440,871 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
aconitine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
fluoxetine  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
lead(0)  (ISO)
maneb  (EXP)
methidathion  (EXP)
N,N-diethyl-m-toluamide  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
resveratrol  (EXP)
silicon dioxide  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion homeostasis  (IBA,IEA,ISO,ISS)
endoplasmic reticulum calcium ion homeostasis  (IEA,ISO,ISS)
endoplasmic reticulum unfolded protein response  (IBA,IMP,TAS)
ER overload response  (IEA,ISO)
ERAD pathway  (IEA,IMP,ISO)
glucose homeostasis  (IEA,ISO,ISS)
intracellular signal transduction  (IEA)
intrinsic apoptotic signaling pathway  (IDA,IMP)
kidney development  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of ATF6-mediated unfolded protein response  (IEA,ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of intracellular signal transduction  (IEA)
negative regulation of intrinsic apoptotic signaling pathway  (IDA)
negative regulation of macromolecule biosynthetic process  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO,ISS)
negative regulation of programmed cell death  (IEA,ISO,ISS)
negative regulation of response to endoplasmic reticulum stress  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of translation  (IMP,TAS)
negative regulation of type B pancreatic cell apoptotic process  (IEA,IMP,ISO)
nervous system process  (IEA,ISO,ISS)
olfactory behavior  (IEA,ISO)
pancreas development  (IEA,ISO)
positive regulation of calcium ion transport  (IEA,ISO,ISS)
positive regulation of ERAD pathway  (IMP,TAS)
positive regulation of growth  (IMP)
positive regulation of protein metabolic process  (IEA,ISO,ISS)
positive regulation of protein ubiquitination  (IEA,IMP,ISO)
protein stabilization  (IEA,IMP,ISO,ISS)
regulation of cell cycle  (NAS)
regulation of gene expression  (IEA)
renal water homeostasis  (IEA,ISO,ISS)
response to endoplasmic reticulum stress  (IDA,IEA,ISO)
sensory perception of sound  (IEA,ISO,ISS)
visual perception  (IEA,ISO,ISS,NAS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal associative learning  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal defecation  (IAGP)
abnormal eating behavior  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal inner hair cell stereociliary bundle morphology  (IAGP)
abnormal pancreas secretion  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal postural reflex  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal sperm flagellum morphology  (IAGP)
abnormal sperm head morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal vocalization  (IAGP)
absent distortion product otoacoustic emissions  (IAGP)
absent outer hair cell stereocilia  (IAGP)
analgesia  (IAGP)
circling  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased copulatory plug deposition  (IAGP)
decreased endocochlear potential  (IAGP)
decreased exploration in new environment  (IAGP)
decreased food intake  (IAGP)
decreased insulin secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased male germ cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased Sertoli cell number  (IAGP)
decreased spermatogonia number  (IAGP)
decreased vertical activity  (IAGP)
disorganized pancreatic islets  (IAGP)
enhanced active avoidance behavior  (IAGP)
enhanced passive avoidance behavior  (IAGP)
fused inner hair cell stereocilia  (IAGP)
fused vestibular hair cell stereocilia  (IAGP)
head bobbing  (IAGP)
hyperglycemia  (IAGP)
impaired behavioral response to addictive substance  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired hearing  (IAGP)
impaired righting response  (IAGP)
impaired swimming  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased coping response  (IAGP)
increased glucagon secretion  (IAGP)
increased locomotor activity  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased oxygen consumption  (IAGP)
increased sperm motility  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
slow postnatal weight gain  (IAGP)
stria vascularis degeneration  (IAGP)
vestibular hair cell degeneration  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis. Awata T, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):612-6.
2. Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss. Bespalova IN, etal., Hum Mol Genet. 2001 Oct 15;10(22):2501-8.
3. A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients. Chistiakov DA, etal., Rev Diabet Stud. 2010 Winter;7(4):285-92. doi: 10.1900/RDS.2010.7.285. Epub 2011 Feb 10.
4. The wolframin His611Arg polymorphism influences medication overuse headache. Di Lorenzo C, etal., Neurosci Lett. 2007 Sep 13;424(3):179-84. Epub 2007 Aug 6.
5. WFS1 mutations in Spanish patients with diabetes mellitus and deafness. Domenech E, etal., Eur J Hum Genet. 2002 Jul;10(7):421-6.
6. Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Florez JC, etal., Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.
7. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Franks PW, etal., Diabetologia. 2008 Mar;51(3):458-63. Epub 2007 Nov 27.
8. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Inoue H, etal., Nat Genet. 1998 Oct;20(2):143-8.
9. Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Ishihara H, etal., Hum Mol Genet. 2004 Jun 1;13(11):1159-70. Epub 2004 Mar 31.
10. WFS1 gene as a putative biomarker for development of post-traumatic syndrome in an animal model. Kesner Y, etal., Mol Psychiatry. 2009 Jan;14(1):86-94. Epub 2007 Oct 30.
11. WFS1 variants in Finnish patients with diabetes mellitus, sensorineural hearing impairment or optic atrophy, and in suicide victims. Kytovuori L, etal., J Hum Genet. 2013 Aug;58(8):495-500. doi: 10.1038/jhg.2013.29. Epub 2013 Apr 18.
12. Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene. Larsen ZM, etal., Diabet Med. 2004 Mar;21(3):218-22.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Minton JA, etal., Diabetes. 2002 Apr;51(4):1287-90.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, etal., Sci Rep. 2017 Aug 18;7(1):8812. doi: 10.1038/s41598-017-09010-w.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
21. Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. Rendtorff ND, etal., Am J Med Genet A. 2011 Jun;155A(6):1298-313. doi: 10.1002/ajmg.a.33970. Epub 2011 Apr 28.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Toots M, etal., Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z.
26. The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. Zemlyak I, etal., J Neurochem. 2009 Dec;111(5):1252-63. doi: 10.1111/j.1471-4159.2009.06415.x. Epub 2009 Oct 3.
Additional References at PubMed
PMID:9817917   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11597144   PMID:12466851   PMID:12477932   PMID:12649740   PMID:15142957   PMID:15522226   PMID:15782199  
PMID:15994758   PMID:16087305   PMID:16141072   PMID:16141073   PMID:16215705   PMID:16571599   PMID:16602821   PMID:17884289   PMID:17947299   PMID:18316032   PMID:18343518   PMID:18551525  
PMID:18613120   PMID:18799693   PMID:19041897   PMID:19125190   PMID:19190890   PMID:19293327   PMID:19428703   PMID:19477223   PMID:19664290   PMID:19911006   PMID:20090907   PMID:20160352  
PMID:20972658   PMID:21031341   PMID:21199859   PMID:21267068   PMID:21454619   PMID:21461749   PMID:21491433   PMID:21873635   PMID:22028430   PMID:22794259   PMID:22800759   PMID:23321269  
PMID:23396150   PMID:23567972   PMID:23914152   PMID:24694561   PMID:24710642   PMID:24799886   PMID:24823368   PMID:24952961   PMID:25274773   PMID:25385034   PMID:25422446   PMID:25725334  
PMID:26106220   PMID:26379490   PMID:26733243   PMID:27053292   PMID:27080063   PMID:27264872   PMID:27434582   PMID:28267787   PMID:28963041   PMID:29199018   PMID:29406269   PMID:30054673  
PMID:30914711   PMID:31806049   PMID:31935437   PMID:32060407   PMID:32325033   PMID:32581705   PMID:34312071   PMID:34848728   PMID:35399956   PMID:36417873   PMID:36496200   PMID:36645345  
PMID:36808153   PMID:36825503   PMID:36995380   PMID:37027908   PMID:37142655   PMID:37386014   PMID:37838801   PMID:37995181   PMID:38642554   PMID:39198924   PMID:39662795   PMID:39970233  


Genomics

Comparative Map Data
Wfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,123,448 - 37,146,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,123,448 - 37,146,549 (-)EnsemblGRCm39 Ensembl
GRCm38536,966,104 - 36,988,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,357,343 - 37,380,221 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36537,254,356 - 37,277,158 (-)NCBIMGSCv36mm8
Celera534,417,849 - 34,440,871 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.46NCBI
WFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3846,269,850 - 6,303,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl46,269,849 - 6,303,265 (+)EnsemblGRCh38hg38GRCh38
GRCh3746,271,577 - 6,304,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3646,322,478 - 6,355,893 (+)NCBINCBI36Build 36hg18NCBI36
Build 3446,389,648 - 6,423,064NCBI
Celera46,172,234 - 6,205,670 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef46,205,316 - 6,238,436 (+)NCBIHuRef
CHM1_146,269,525 - 6,302,942 (+)NCBICHM1_1
T2T-CHM13v2.046,243,866 - 6,277,297 (+)NCBIT2T-CHM13v2.0
Wfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,035,205 - 78,059,718 (+)NCBIGRCr8
GRCr8 Ensembl1478,034,864 - 78,060,459 (+)EnsemblGRCr8 Ensembl
mRatBN7.21473,810,478 - 73,834,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,810,404 - 73,835,602 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1478,251,934 - 78,276,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,492,790 - 79,517,297 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,937,753 - 75,962,260 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1472,756,725 - 72,781,236 (+)NCBICelera
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Cytogenetic Map14q21NCBI
Wfs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,902,454 - 3,924,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555143,902,508 - 3,924,281 (-)NCBIChiLan1.0ChiLan1.0
WFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v236,541,382 - 6,574,914 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan146,470,175 - 6,503,684 (+)NCBINHGRI_mPanPan1
PanPan1.146,345,960 - 6,379,094 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl46,345,864 - 6,379,287 (+)Ensemblpanpan1.1panPan2
WFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,451,722 - 38,466,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,451,710 - 38,475,827 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,428,703 - 38,449,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,942,257 - 38,963,449 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,942,257 - 38,968,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,633,035 - 38,659,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,742,939 - 38,764,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,217,791 - 39,239,032 (-)NCBIUU_Cfam_GSD_1.0
Wfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528564,638,197 - 64,663,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,339,827 - 18,364,998 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,339,915 - 18,364,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl84,362,680 - 4,385,273 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.184,362,678 - 4,405,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.282,954,118 - 2,962,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12742,404,028 - 42,437,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2742,404,084 - 42,438,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604789,197,417 - 89,231,280 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wfs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475522,824,143 - 22,841,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475522,818,653 - 22,841,717 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Wfs1
1329 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:772
Count of miRNA genes:352
Interacting mature miRNAs:378
Transcripts:ENSMUST00000043964, ENSMUST00000166339, ENSMUST00000167937
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
36049766Ars22_mantibody response to SARS-CoV 22, day 29, IgG3 (mouse)53695734445457342Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
36049767Ars23_mantibody response to SARS-CoV 23, day 29, Total IgG (mouse)53695734445457342Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
36049774Ars16_mantibody response to SARS-CoV 16, day 7, Total IgG (mouse)53695734445457342Mouse
36049775Ars17_mantibody response to SARS-CoV 17, day 15, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049772Ars20_mantibody response to SARS-CoV 20, day 15, Total IgG (mouse)53695734445457342Mouse
36049773Ars21_mantibody response to SARS-CoV 21, day 29, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049770Ars14_mantibody response to SARS-CoV 14, day 7, IgG3 (mouse)53695734445457342Mouse
36049771Ars15_mantibody response to SARS-CoV 15, day 7, IgM (mouse)53695734445457342Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
36049768Ars24_mantibody response to SARS-CoV 24, 4 days post-rechallenge, IgG3 (mouse)53695734445457342Mouse
36049769Ars13_mantibody response to SARS-CoV 13, day 7, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049776Ars18_mantibody response to SARS-CoV 18, day 15, IgG3 (mouse)53695734445457342Mouse
36049777Ars19_mantibody response to SARS-CoV 19, day 15, IgM (mouse)53695734445457342Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
35673310Ari4_mantibody response to influenza 4, day 15-45, IgG2b (mouse)53695734445457342Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse

Markers in Region
39.MMHAP34FLE6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,984,318 - 36,984,511UniSTSGRCm38
MGSCv37537,375,557 - 37,375,750UniSTSGRCm37
Celera534,436,207 - 34,436,400UniSTS
Cytogenetic Map5B3UniSTS
Whitehead_YAC5 UniSTS
D18999  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,106 - 36,966,181UniSTSGRCm38
MGSCv37537,357,345 - 37,357,420UniSTSGRCm37
Celera534,417,851 - 34,417,926UniSTS
Cytogenetic Map5B3UniSTS
Whitehead_YAC5 UniSTS
AI481085  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,293 - 36,966,412UniSTSGRCm38
MGSCv37537,357,532 - 37,357,651UniSTSGRCm37
Celera534,418,038 - 34,418,157UniSTS
Cytogenetic Map5B3UniSTS
Whitehead/MRC_RH5488.07UniSTS
Wfs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,966,691 - 36,966,851UniSTSGRCm38
MGSCv37537,357,930 - 37,358,090UniSTSGRCm37
Celera534,418,436 - 34,418,596UniSTS
Cytogenetic Map5B3UniSTS
cM Map5 UniSTS
SHGC-59709  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38536,967,374 - 36,967,604UniSTSGRCm38
MGSCv37537,358,613 - 37,358,843UniSTSGRCm37
Celera534,419,119 - 34,419,349UniSTS
Cytogenetic Map5B3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ011971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY063019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY296480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX562372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000043964   ⟹   ENSMUSP00000048053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,123,448 - 37,146,549 (-)Ensembl
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166339   ⟹   ENSMUSP00000132404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,123,451 - 37,146,277 (-)Ensembl
GRCm38.p6 Ensembl536,966,107 - 36,988,933 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167937   ⟹   ENSMUSP00000125779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,125,845 - 37,134,300 (-)Ensembl
GRCm38.p6 Ensembl536,968,501 - 36,976,956 (-)Ensembl
RefSeq Acc Id: NM_011716   ⟹   NP_035846
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39537,123,448 - 37,146,326 (-)NCBI
GRCm38536,966,104 - 36,988,982 (-)ENTREZGENE
MGSCv37537,357,343 - 37,380,221 (-)RGD
Celera534,417,849 - 34,440,871 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035846   ⟸   NM_011716
- UniProtKB: Q9Z276 (UniProtKB/Swiss-Prot),   P56695 (UniProtKB/Swiss-Prot),   Q3TDI2 (UniProtKB/TrEMBL),   Q80UI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000132404   ⟸   ENSMUST00000166339
Ensembl Acc Id: ENSMUSP00000125779   ⟸   ENSMUST00000167937
Ensembl Acc Id: ENSMUSP00000048053   ⟸   ENSMUST00000043964
Protein Domains
Wolframin cysteine-rich   Wolframin EF-hand   Wolframin OB-fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56695-F1-model_v2 AlphaFold P56695 1-890 view protein structure

Promoters
RGD ID:6886556
Promoter ID:EPDNEW_M6729
Type:initiation region
Name:Wfs1_1
Description:Mus musculus wolframin ER transmembrane glycoprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38536,988,932 - 36,988,992EPDNEW
RGD ID:6838637
Promoter ID:MM_KWN:42069
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_011716
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36537,380,056 - 37,380,556 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1328355 AgrOrtholog
Ensembl Genes ENSMUSG00000039474 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043964 ENTREZGENE
  ENSMUST00000043964.13 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  Wolframin UniProtKB/Swiss-Prot
  Wolframin_Cys-rich UniProtKB/Swiss-Prot
  Wolframin_EF-hand UniProtKB/Swiss-Prot
  Wolframin_fam UniProtKB/Swiss-Prot
  Wolframin_OB_fold UniProtKB/Swiss-Prot
  Wolframin_Sel1-like_rpt UniProtKB/Swiss-Prot
KEGG Report mmu:22393 UniProtKB/Swiss-Prot
MGD MGI:1328355 ENTREZGENE
NCBI Gene 22393 ENTREZGENE
PANTHER PTHR13098 UniProtKB/Swiss-Prot
  WOLFRAMIN UniProtKB/Swiss-Prot
Pfam WC-rich UniProtKB/Swiss-Prot
  WCOB UniProtKB/Swiss-Prot
  WEF-hand UniProtKB/Swiss-Prot
  WSLR UniProtKB/Swiss-Prot
PhenoGen Wfs1 PhenoGen
PRINTS WOLFFAMILY UniProtKB/Swiss-Prot
  WOLFRAMIN UniProtKB/Swiss-Prot
UniProt F7D926_MOUSE UniProtKB/TrEMBL
  P56695 ENTREZGENE
  Q3TDI2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UMA8_MOUSE UniProtKB/TrEMBL
  Q3UN10_MOUSE UniProtKB/TrEMBL
  Q80UI9 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z276 ENTREZGENE
  WFS1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9Z276 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Wfs1  wolframin ER transmembrane glycoprotein    Wolfram syndrome 1 homolog (human)  Symbol and/or name change 5135510 APPROVED