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Gene: WFS1 (wolframin ER transmembrane glycoprotein) Homo sapiens
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Symbol: WFS1
Name: wolframin ER transmembrane glycoprotein
Description: Exhibits ATPase binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; negative regulation of apoptotic process; and regulation of transcription, DNA-templated. Localizes to integral component of endoplasmic reticulum membrane. Implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CTRCT41; FLJ51211; WFRS; WFS; WFSL; Wolfram syndrome 1 (wolframin); wolframin
Orthologs:
Mus musculus (house mouse) : Wfs1 (wolframin ER transmembrane glycoprotein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wfs1 (wolframin ER transmembrane glycoprotein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wfs1 (wolframin ER transmembrane glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : WFS1 (wolframin ER transmembrane glycoprotein)
Canis lupus familiaris (dog) : WFS1 (wolframin ER transmembrane glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfs1 (wolframin ER transmembrane glycoprotein)
Sus scrofa (pig) : WFS1 (wolframin ER transmembrane glycoprotein)
Chlorocebus sabaeus (African green monkey) : WFS1 (wolframin ER transmembrane glycoprotein)
Heterocephalus glaber (naked mole-rat) : Wfs1 (wolframin ER transmembrane glycoprotein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl46,269,849 - 6,303,265 (+)EnsemblGRCh38hg38GRCh38
GRCh3846,260,368 - 6,303,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3746,271,577 - 6,304,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3646,322,478 - 6,355,893 (+)NCBINCBI36hg18NCBI36
Build 3446,389,648 - 6,423,064NCBI
Celera46,172,234 - 6,205,670 (+)NCBI
Cytogenetic Map4p16.1NCBI
HuRef46,205,316 - 6,238,436 (+)NCBIHuRef
CHM1_146,269,525 - 6,302,942 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on WFS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731649
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.