Map1s (microtubule-associated protein 1S) - Rat Genome Database
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Gene: Map1s (microtubule-associated protein 1S) Mus musculus
Analyze
Symbol: Map1s
Name: microtubule-associated protein 1S
RGD ID: 1616467
MGI Page MGI
Description: Exhibits actin filament binding activity; identical protein binding activity; and microtubule binding activity. Involved in brain development and microtubule cytoskeleton organization. Localizes to dendrite; microtubule cytoskeleton; and neuronal cell body. Is expressed in brain and spinal cord. Orthologous to human MAP1S (microtubule associated protein 1S); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430517J16Rik; Bpy2; BPY2 interacting protein 1; BPY2-interacting protein 1; Bpy2ip1; Ma; MAP-1S; Map8; microtubule-associated protein 8; Mta; Mtap1s; VCY2; VCY2IP1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18681  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,358,618 - 71,370,173 (+)NCBIGRCm39mm39
GRCm38870,905,974 - 70,917,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,905,932 - 70,917,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,429,873 - 73,441,428 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,834,976 - 73,846,514 (+)NCBImm8
Celera873,467,068 - 73,478,623 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15528209   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16297881   PMID:16565160   PMID:18799693   PMID:21262964   PMID:21267068   PMID:21486449   PMID:21873635   PMID:22037873   PMID:22301994   PMID:26565030   PMID:26750654  
PMID:27236336   PMID:28386016   PMID:32325033  


Genomics

Comparative Map Data
Map1s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,358,618 - 71,370,173 (+)NCBIGRCm39mm39
GRCm38870,905,974 - 70,917,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,905,932 - 70,917,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,429,873 - 73,441,428 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,834,976 - 73,846,514 (+)NCBImm8
Celera873,467,068 - 73,478,623 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
MAP1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,719,242 - 17,734,513 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,719,480 - 17,734,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,830,303 - 17,845,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,691,303 - 17,706,324 (+)NCBINCBI36hg18NCBI36
Build 341917,691,302 - 17,706,324NCBI
Celera1917,731,926 - 17,747,113 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,396,489 - 17,410,239 (+)NCBIHuRef
CHM1_11917,829,785 - 17,844,852 (+)NCBICHM1_1
Map1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,268,663 - 20,278,850 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,267,581 - 20,278,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,126,207 - 20,136,394 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,017,018 - 19,027,148 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,017,014 - 19,027,144 (-)NCBI
Celera1618,710,209 - 18,720,404 (-)NCBICelera
Cytogenetic Map16p14NCBI
MAP1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,165,267 - 18,192,959 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,178,445 - 18,192,873 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,201,883 - 17,217,116 (+)NCBIMhudiblu_PPA_v0panPan3
MAP1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,147,751 - 45,162,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,147,720 - 45,162,431 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Map1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,286,031 - 3,296,855 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,999,162 - 60,029,939 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,003,116 - 60,043,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,583,390 - 59,610,014 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1S
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,192,707 - 16,208,729 (+)NCBI
ChlSab1.1 Ensembl616,192,734 - 16,209,553 (+)Ensembl
Map1s
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908400,765 - 408,154 (-)NCBI

Position Markers
UniSTS:235920  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,906,328 - 70,906,407UniSTSGRCm38
MGSCv37873,430,227 - 73,430,306UniSTSGRCm37
Celera873,467,422 - 73,467,501UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:147
Interacting mature miRNAs:155
Transcripts:ENSMUST00000019405
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA048974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC019302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB857804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ387862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000019405   ⟹   ENSMUSP00000019405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,932 - 70,917,527 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211880
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,990 - 70,911,479 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211910   ⟹   ENSMUSP00000148822
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,990 - 70,911,850 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,911,818 - 70,917,526 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212227   ⟹   ENSMUSP00000148554
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,993 - 70,917,529 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212511   ⟹   ENSMUSP00000148752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,990 - 70,911,895 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212544
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,987 - 70,911,954 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212697
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,982 - 70,911,990 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212823
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,906,244 - 70,908,154 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213001   ⟹   ENSMUSP00000148773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,906,262 - 70,912,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,905,993 - 70,917,529 (+)Ensembl
RefSeq Acc Id: NM_173013   ⟹   NP_766601
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,358,618 - 71,370,173 (+)NCBI
GRCm38870,905,974 - 70,917,529 (+)NCBI
MGSCv37873,429,873 - 73,441,428 (+)RGD
Celera873,467,068 - 73,478,623 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242305   ⟹   XP_011240607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,358,634 - 71,370,173 (+)NCBI
GRCm38870,905,990 - 70,917,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154077   ⟹   XP_036009970
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,358,624 - 71,370,173 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_766601   ⟸   NM_173013
- UniProtKB: Q8C052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240607   ⟸   XM_011242305
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000148822   ⟸   ENSMUST00000211910
RefSeq Acc Id: ENSMUSP00000148773   ⟸   ENSMUST00000213001
RefSeq Acc Id: ENSMUSP00000148752   ⟸   ENSMUST00000212511
RefSeq Acc Id: ENSMUSP00000148554   ⟸   ENSMUST00000212227
RefSeq Acc Id: ENSMUSP00000019405   ⟸   ENSMUST00000019405
RefSeq Acc Id: XP_036009970   ⟸   XM_036154077
- Peptide Label: isoform X2

Promoters
RGD ID:8667373
Promoter ID:EPDNEW_M11717
Type:initiation region
Name:Map1s_1
Description:Mus musculus microtubule-associated protein 1S , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,905,982 - 70,906,042EPDNEW
RGD ID:6843501
Promoter ID:MM_KWN:54758
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_173013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,429,356 - 73,430,352 (+)MPROMDB
RGD ID:6848324
Promoter ID:MM_ACW:47870
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:MTAP1S.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,435,026 - 73,435,992 (+)MPROMDB
RGD ID:6848327
Promoter ID:MM_ACW:47871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   Spleen
Transcripts:MTAP1S.ESEP07,   MTAP1S.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,437,621 - 73,438,592 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443304 AgrOrtholog
Ensembl Genes ENSMUSG00000019261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000019405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148554 UniProtKB/TrEMBL
  ENSMUSP00000148752 UniProtKB/TrEMBL
  ENSMUSP00000148773 UniProtKB/TrEMBL
  ENSMUSP00000148822 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211910 UniProtKB/TrEMBL
  ENSMUST00000212227 UniProtKB/TrEMBL
  ENSMUST00000212511 UniProtKB/TrEMBL
  ENSMUST00000213001 UniProtKB/TrEMBL
InterPro MAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP1S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:270058 UniProtKB/Swiss-Prot
MGD MGI:2443304 ENTREZGENE
NCBI Gene 270058 ENTREZGENE
PANTHER PTHR13843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13843:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map1s PhenoGen
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.248559 ENTREZGENE
UniProt A0A1D5RLY6_MOUSE UniProtKB/TrEMBL
  A0A1D5RMF1_MOUSE UniProtKB/TrEMBL
  A0A1D5RMG7_MOUSE UniProtKB/TrEMBL
  A0A1D5RML0_MOUSE UniProtKB/TrEMBL
  B2RWW1_MOUSE UniProtKB/TrEMBL
  MAP1S_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QKR8 UniProtKB/Swiss-Prot
  Q3TSD6 UniProtKB/Swiss-Prot
  Q7TMW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-25 Map1s  microtubule-associated protein 1S  Mtap1s    Symbol and/or name change 5135510 APPROVED