Crhbp (corticotropin releasing hormone binding protein) - Rat Genome Database

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Gene: Crhbp (corticotropin releasing hormone binding protein) Mus musculus
Analyze
Symbol: Crhbp
Name: corticotropin releasing hormone binding protein
RGD ID: 730852
MGI Page MGI
Description: Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and maternal aggressive behavior. Acts upstream of or within hormone metabolic process. Located in extracellular space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: corticotropin-releasing factor-binding protein; corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; CRH-; CRH-BP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,567,884 - 95,581,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,567,879 - 95,581,432 (-)EnsemblGRCm39 Ensembl
GRCm381395,431,376 - 95,444,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,431,371 - 95,444,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,201,331 - 96,214,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,532,075 - 96,545,471 (-)NCBIMGSCv36mm8
Celera1399,051,989 - 99,065,285 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Claes S, etal., Biol Psychiatry 2003 Nov 1;54(9):867-72.
2. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Pan Y, etal., Psychoneuroendocrinology. 2010 Feb;35(2):272-83. Epub 2009 Jul 23.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
10. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Timofeeva E, etal., Am J Physiol. 1999 Dec;277(6 Pt 2):R1749-59.
Additional References at PubMed
PMID:7556876   PMID:8198617   PMID:8211130   PMID:8889548   PMID:9266612   PMID:10349636   PMID:10500222   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11223175   PMID:12446601  
PMID:12466851   PMID:12477932   PMID:12895416   PMID:15226823   PMID:15345745   PMID:15459106   PMID:15489334   PMID:15904718   PMID:15976007   PMID:16141072   PMID:16141073   PMID:16368564  
PMID:18929624   PMID:19449303   PMID:21050473   PMID:21677750   PMID:21873635   PMID:25356765   PMID:25731977   PMID:26247973   PMID:27277803   PMID:27374820   PMID:28837622   PMID:32813270  


Genomics

Comparative Map Data
Crhbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,567,884 - 95,581,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,567,879 - 95,581,432 (-)EnsemblGRCm39 Ensembl
GRCm381395,431,376 - 95,444,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,431,371 - 95,444,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,201,331 - 96,214,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,532,075 - 96,545,471 (-)NCBIMGSCv36mm8
Celera1399,051,989 - 99,065,285 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.5NCBI
CRHBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,953,045 - 76,981,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,953,045 - 76,981,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,248,870 - 76,265,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,284,436 - 76,301,055 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,284,435 - 76,301,054NCBI
Celera572,143,194 - 72,159,812 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,455,341 - 71,471,960 (+)NCBIHuRef
CHM1_1575,681,815 - 75,698,436 (+)NCBICHM1_1
T2T-CHM13v2.0577,434,877 - 77,462,968 (+)NCBIT2T-CHM13v2.0
Crhbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,692,403 - 26,704,710 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,692,403 - 26,704,710 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,730,555 - 33,742,870 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,830,779 - 31,843,094 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,646,279 - 26,658,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,141,471 - 25,153,334 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,141,471 - 25,153,334 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,299,507 - 44,311,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,801,371 - 25,813,457 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,721,739 - 25,733,799 (-)NCBI
Celera222,758,077 - 22,770,045 (-)NCBICelera
Cytogenetic Map2q12NCBI
Crhbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,953,912 - 23,966,352 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542523,953,957 - 23,966,207 (-)NCBIChiLan1.0ChiLan1.0
CRHBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1536,477,602 - 36,495,622 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,327,305 - 38,343,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,852,934 - 38,869,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,845,925 - 38,869,549 (-)Ensemblpanpan1.1panPan2
CRHBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,726,316 - 29,737,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,705,031 - 29,758,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,965,624 - 30,977,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,645,525 - 29,657,242 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,645,521 - 29,657,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,582,245 - 29,593,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,562,941 - 29,574,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,932,261 - 29,943,976 (-)NCBIUU_Cfam_GSD_1.0
Crhbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,780,826 - 190,794,463 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493654964,866 - 78,272 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493654964,866 - 78,272 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,816,816 - 85,831,179 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,814,399 - 85,830,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,431,375 - 87,447,099 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRHBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,203,335 - 71,223,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,205,932 - 71,223,172 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,043,907 - 20,061,809 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crhbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,412,499 - 1,423,932 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,412,541 - 1,423,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crhbp
665 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:162
Interacting mature miRNAs:187
Transcripts:ENSMUST00000045583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000045583   ⟹   ENSMUSP00000042578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1395,567,885 - 95,581,339 (-)Ensembl
GRCm38.p6 Ensembl1395,431,377 - 95,444,831 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221025   ⟹   ENSMUSP00000152083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1395,567,879 - 95,581,432 (-)Ensembl
GRCm38.p6 Ensembl1395,431,371 - 95,444,924 (-)Ensembl
RefSeq Acc Id: NM_198408   ⟹   NP_940800
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391395,567,884 - 95,581,339 (-)NCBI
GRCm381395,431,376 - 95,444,831 (-)ENTREZGENE
MGSCv371396,201,331 - 96,214,786 (-)RGD
Celera1399,051,989 - 99,065,285 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_940800 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61247 (Get FASTA)   NCBI Sequence Viewer  
  BAE22406 (Get FASTA)   NCBI Sequence Viewer  
  BAE37662 (Get FASTA)   NCBI Sequence Viewer  
  EDL00904 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000042578.9
  ENSMUSP00000152083
  ENSMUSP00000152083.2
GenBank Protein Q60571 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_940800   ⟸   NM_198408
- Peptide Label: precursor
- UniProtKB: Q60571 (UniProtKB/Swiss-Prot),   Q3UY07 (UniProtKB/TrEMBL),   A0A217FL62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000042578   ⟸   ENSMUST00000045583
RefSeq Acc Id: ENSMUSP00000152083   ⟸   ENSMUST00000221025

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60571-F1-model_v2 AlphaFold Q60571 1-322 view protein structure

Promoters
RGD ID:8681052
Promoter ID:EPDNEW_M18557
Type:multiple initiation site
Name:Crhbp_1
Description:Mus musculus corticotropin releasing hormone binding protein, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381395,444,772 - 95,444,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88497 AgrOrtholog
Ensembl Genes ENSMUSG00000021680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045583.9 UniProtKB/TrEMBL
  ENSMUST00000221025 ENTREZGENE
  ENSMUST00000221025.2 UniProtKB/Swiss-Prot
InterPro CRF-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12919 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88497 ENTREZGENE
NCBI Gene 12919 ENTREZGENE
PANTHER CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10278 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRF-BP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crhbp PhenoGen
PIRSF CRF_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A217FL62 ENTREZGENE, UniProtKB/TrEMBL
  CRHBP_MOUSE UniProtKB/Swiss-Prot
  Q3TPS3_MOUSE UniProtKB/TrEMBL
  Q3UY07 ENTREZGENE, UniProtKB/TrEMBL
  Q60571 ENTREZGENE