Ugt2a3 (UDP glucuronosyltransferase 2 family, polypeptide A3) - Rat Genome Database

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Gene: Ugt2a3 (UDP glucuronosyltransferase 2 family, polypeptide A3) Mus musculus
Analyze
Symbol: Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
RGD ID: 1551260
MGI Page MGI
Description: Predicted to enable glucuronosyltransferase activity. Predicted to be located in membrane. Is expressed in nervous system; nose; and olfactory epithelium. Orthologous to human UGT2A3 (UDP glucuronosyltransferase family 2 member A3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010321J07Rik; UDP-glucuronosyltransferase 2A3; UDPGT 2A3
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39587,472,694 - 87,485,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl587,472,831 - 87,485,054 (-)EnsemblGRCm39 Ensembl
GRCm38587,324,972 - 87,337,195 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,324,972 - 87,337,195 (-)EnsemblGRCm38mm10GRCm38
MGSCv37587,753,997 - 87,766,220 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36588,399,533 - 88,411,737 (-)NCBIMGSCv36mm8
Celera584,541,315 - 84,553,528 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mouseautism spectrum disorder  ISOUGT2A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546

1 to 20 of 83 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mouse(+)-schisandrin B multiple interactionsISOUgt2a3 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of UGT2A3 mRNA]CTDPMID:31150632
Ugt2a3Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of UGT2A3 mRNACTDPMID:36331819
Ugt2a3Mouse(2,4,5-trichlorophenoxy)acetic acid increases expressionEXP 64804642 more ...CTDPMID:18579281
Ugt2a3Mouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of UGT2A3 mRNACTDPMID:28189721 and PMID:28960355
Ugt2a3Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of UGT2A3 mRNACTDPMID:39298647
Ugt2a3Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of UGT2A3 mRNACTDPMID:19144771 more ...
Ugt2a3Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOUgt2a3 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of UGT2A3 mRNACTDPMID:32109520
Ugt2a3Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOUgt2a3 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of UGT2A3 mRNACTDPMID:21724226
Ugt2a3Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of UGT2A3 mRNA]CTDPMID:22496397
Ugt2a3Mouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
Ugt2a3Mouse3,3',4,4'-tetrachlorobiphenyl multiple interactionsEXP 64804643 more ...CTDPMID:19467301
Ugt2a3Mouse3,4-dihydroxybenzoic acid multiple interactionsISOUgt2a3 (Rattus norvegicus)6480464protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of UGT2A3 mRNA]CTDPMID:37105472
Ugt2a3Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of UGT2A3 mRNACTDPMID:39298647
Ugt2a3Mouseacetamide decreases expressionISOUgt2a3 (Rattus norvegicus)6480464acetamide results in decreased expression of UGT2A3 mRNACTDPMID:31881176
Ugt2a3Mouseaflatoxin B1 decreases methylationISOUGT2A3 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of UGT2A3 geneCTDPMID:27153756
Ugt2a3Mousearotinoid acid multiple interactionsISOUGT2A3 (Homo sapiens)6480464[4-(2-(5 more ...CTDPMID:34480604
Ugt2a3Mousearsane affects methylationISOUGT2A3 (Homo sapiens)6480464Arsenic affects the methylation of UGT2A3 geneCTDPMID:25304211
Ugt2a3Mousearsenic atom affects methylationISOUGT2A3 (Homo sapiens)6480464Arsenic affects the methylation of UGT2A3 geneCTDPMID:25304211
Ugt2a3Mouseatrazine affects methylationISOUgt2a3 (Rattus norvegicus)6480464Atrazine affects the methylation of UGT2A3 geneCTDPMID:28931070
Ugt2a3Mousebenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of UGT2A3 mRNACTDPMID:20127859

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mousexenobiotic metabolic process involved_inISOUGT2A3 (Homo sapiens)9068941 PMID:19858781BHF-UCLPMID:19858781

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mousemembrane located_inIEAUniProtKB-SubCell:SL-01622290270 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mouseglucuronosyltransferase activity enablesIBAPANTHER:PTN002629957 more ...2290270 GO_CentralGO_REF:0000033
Ugt2a3Mouseglucuronosyltransferase activity enablesIEARHEA:210322290270 RHEAGO_REF:0000116
Ugt2a3Mouseglucuronosyltransferase activity enablesISOUniProtKB:Q6UWM92290270 GO_CentralGO_REF:0000119
Ugt2a3Mouseglucuronosyltransferase activity enablesIEAEC:2.4.1.172290270 UniProtGO_REF:0000003

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt2a3Mouseascorbate and aldarate metabolic pathway  IEA 6907045 KEGGmmu:00053
Ugt2a3MouseO-linked glycan biosynthetic pathway  IEA 6907045 KEGGmmu:00514
Ugt2a3Mousepentose and glucuronate interconversion pathway  IEA 6907045 KEGGmmu:00040
Ugt2a3Mouseporphyrin and chlorophyll metabolic pathway  IEA 6907045 KEGGmmu:00860
Ugt2a3Mouseretinol metabolic pathway   IEA 6907045 KEGGmmu:00830
Ugt2a3Mousestarch and sucrose metabolic pathway  IEA 6907045 KEGGmmu:00500
Ugt2a3Mousesteroid hormone biosynthetic pathway   IEA 6907045 KEGGmmu:00140

#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635   PMID:28167773   PMID:32325033  



Ugt2a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39587,472,694 - 87,485,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl587,472,831 - 87,485,054 (-)EnsemblGRCm39 Ensembl
GRCm38587,324,972 - 87,337,195 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,324,972 - 87,337,195 (-)EnsemblGRCm38mm10GRCm38
MGSCv37587,753,997 - 87,766,220 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36588,399,533 - 88,411,737 (-)NCBIMGSCv36mm8
Celera584,541,315 - 84,553,528 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
UGT2A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38468,928,463 - 68,951,804 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl468,928,463 - 68,951,804 (-)EnsemblGRCh38hg38GRCh38
GRCh37469,794,181 - 69,817,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36469,828,756 - 69,852,093 (-)NCBINCBI36Build 36hg18NCBI36
Celera467,135,540 - 67,158,847 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,589,708 - 65,613,015 (-)NCBIHuRef
CHM1_1469,830,758 - 69,854,100 (-)NCBICHM1_1
T2T-CHM13v2.0472,369,135 - 72,392,453 (-)NCBIT2T-CHM13v2.0
Ugt2a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,851,970 - 20,869,974 (+)NCBIGRCr8
mRatBN7.21420,572,793 - 20,590,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,572,808 - 20,590,729 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,762,277 - 20,779,780 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,081,193 - 22,098,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,836,549 - 20,854,042 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,251,507 - 22,267,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,192,970 - 22,619,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,165,755 - 22,182,147 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,099,350 - 22,116,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,099,349 - 22,116,820 (+)NCBI
Celera1419,976,311 - 19,993,782 (+)NCBICelera
Cytogenetic Map14p21NCBI
LOC100978938
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2361,009,787 - 61,033,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1461,212,686 - 61,236,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0455,157,059 - 55,180,507 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1461,613,083 - 61,636,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl461,612,932 - 61,636,511 (+)Ensemblpanpan1.1panPan2
UGT2A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,036,107 - 59,057,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,885,246 - 58,886,599 (-)NCBIDog10K_Boxer_Tasha
LOC100624788
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1866,646,241 - 66,689,685 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,984,983 - 71,021,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Ugt2a3
606 total Variants

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:100
Interacting mature miRNAs:104
Transcripts:ENSMUST00000031195
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse

1 to 10 of 55 rows






Ensembl Acc Id: ENSMUST00000031195   ⟹   ENSMUSP00000031195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl587,472,831 - 87,485,054 (-)Ensembl
GRCm38.p6 Ensembl587,324,972 - 87,337,195 (-)Ensembl
RefSeq Acc Id: NM_028094   ⟹   NP_082370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39587,472,694 - 87,485,054 (-)NCBI
GRCm38587,324,972 - 87,337,195 (-)ENTREZGENE
MGSCv37587,753,997 - 87,766,220 (-)RGD
Celera584,541,315 - 84,553,528 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Protein RefSeqs NP_082370 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH25795 (Get FASTA)   NCBI Sequence Viewer  
  BAB25770 (Get FASTA)   NCBI Sequence Viewer  
  BAC34191 (Get FASTA)   NCBI Sequence Viewer  
  EDL37977 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031195
  ENSMUSP00000031195.3
GenBank Protein Q8BWQ1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082370   ⟸   NM_028094
- Peptide Label: precursor
- UniProtKB: Q8R129 (UniProtKB/Swiss-Prot),   Q9D811 (UniProtKB/Swiss-Prot),   Q8BWQ1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031195   ⟸   ENSMUST00000031195

Name Modeler Protein Id AA Range Protein Structure
AF-Q8BWQ1-F1-model_v2 AlphaFold Q8BWQ1 1-534 view protein structure

RGD ID:6887036
Promoter ID:EPDNEW_M6969
Type:multiple initiation site
Name:Ugt2a3_1
Description:Mus musculus UDP glucuronosyltransferase 2 family, polypeptideA3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38587,337,195 - 87,337,255EPDNEW
RGD ID:6838584
Promoter ID:MM_KWN:42755
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_028094
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36587,765,806 - 87,766,306 (-)MPROMDB


1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000035780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031195 ENTREZGENE
  ENSMUST00000031195.3 UniProtKB/Swiss-Prot
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report mmu:72094 UniProtKB/Swiss-Prot
MGD MGI:1919344 ENTREZGENE
NCBI Gene 72094 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP-GLUCURONOSYLTRANSFERASE 2A3 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt2a3 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt Q8BWQ1 ENTREZGENE
  Q8R129 ENTREZGENE
  Q9D811 ENTREZGENE
  UD2A3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8R129 UniProtKB/Swiss-Prot
  Q9D811 UniProtKB/Swiss-Prot
1 to 22 of 22 rows