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Gene: Aldh18a1 (aldehyde dehydrogenase 18 family, member A1) Mus musculus
Symbol: Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Description: Exhibits glutamate 5-kinase activity. Predicted to be involved in alpha-amino acid metabolic process and response to temperature stimulus. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Is expressed in several structures, including alimentary system; brain; cardiovascular system; respiratory system; and sensory organ. Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810433K04Rik; AI429789; aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; glutamate gamma-semialdehyde synthetase; MGC32233; P5CS; Pycs; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
Homo sapiens (human) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aldh18a1 (aldehyde dehydrogenase 18 family, member A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh18a1 (aldehyde dehydrogenase 18 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Canis lupus familiaris (dog) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101975532 (delta-1-pyrroline-5-carboxylate synthase)
Sus scrofa (pig) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1940,550,257 - 40,588,463 (-)Ensembl
GRCm381940,550,257 - 40,588,463 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371940,624,747 - 40,662,953 (-)NCBIGRCm37mm9NCBIm37
MGSCv361940,603,568 - 40,641,680 (-)NCBImm8
Celera1941,354,703 - 41,390,340 (-)NCBICelera
Cytogenetic Map19 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aldh18a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553733
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.