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Gene: Acta2 (actin, alpha 2, smooth muscle, aorta) Mus musculus
Symbol: Acta2
Name: actin, alpha 2, smooth muscle, aorta
RGD ID: 1616012
Description: Exhibits protein kinase binding activity. Involved in regulation of blood pressure and vascular smooth muscle contraction. Localizes to actin cytoskeleton and smooth muscle contractile fiber. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 0610041G09Rik; a-; a-SMA; Ac; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actvs; al; alpha-actin-2; alphaSMA; SM; SMAalpha; SMalphaA
Homo sapiens (human) : ACTA2 (actin alpha 2, smooth muscle)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Acta2 (actin alpha 2, smooth muscle)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acta2 (actin alpha 2, smooth muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTA2 (actin alpha 2, smooth muscle)
Canis lupus familiaris (dog) : ACTA2 (actin alpha 2, smooth muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acta2 (actin alpha 2, smooth muscle)
Sus scrofa (pig) : ACTA2 (actin alpha 2, smooth muscle)
Chlorocebus sabaeus (African green monkey) : ACTA2 (actin alpha 2, smooth muscle)
Heterocephalus glaber (naked mole-rat) : Acta2 (actin alpha 2, smooth muscle)
more info ...
Related Pseudogenes: Gm14739  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1934,241,090 - 34,255,590 (-)EnsemblGRCm38mm10GRCm38
GRCm381934,240,336 - 34,255,585 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371934,315,581 - 34,329,826 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,307,088 - 34,321,333 (-)NCBImm8
Celera1935,018,279 - 35,032,476 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Acta2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1616012
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.