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Gene: Cryab (crystallin, alpha B) Mus musculus
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Symbol: Cryab
Name: crystallin, alpha B
Description: Predicted to have several functions, including amyloid-beta binding activity; protein homodimerization activity; and unfolded protein binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; response to hydrogen peroxide; and tubulin complex assembly. Localizes to several cellular components, including the Z disc; cytosol; and mitochondrion. Used to study cataract 16 multiple types and myofibrillar myopathy 2. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Is expressed in several structures, including brain; embryo mesenchyme; eye; heart; and musculature. Orthologous to human CRYAB (crystallin alpha B).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; Crya-2; Crya2; crystallin, alpha 2; heat shock protein CryAB; heat shock protein HspB5; HspB5; P23
Orthologs:
Homo sapiens (human) : CRYAB (crystallin alpha B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cryab (crystallin, alpha B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cryab (crystallin alpha B)
Pan paniscus (bonobo/pygmy chimpanzee) : CRYAB (crystallin alpha B)
Canis lupus familiaris (dog) : CRYAB (crystallin alpha B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cryab (crystallin alpha B)
Sus scrofa (pig) : CRYAB (crystallin alpha B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38950,745,951 - 50,756,636 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,560,863 - 50,564,738 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,504,988 - 50,508,863 (+)NCBImm8
Celera948,038,491 - 48,043,798 (+)NCBICelera
Cytogenetic Map9 A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cryab
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10400
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.