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Gene: Cryab (crystallin, alpha B) Mus musculus
Symbol: Cryab
Name: crystallin, alpha B
Description: Predicted to have several functions, including amyloid-beta binding activity; protein homodimerization activity; and unfolded protein binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; response to hydrogen peroxide; and tubulin complex assembly. Localizes to several cellular components, including the Z disc; cytosol; and mitochondrion. Used to study cataract 16 multiple types and myofibrillar myopathy 2. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Is expressed in several structures, including brain; embryo mesenchyme; eye; heart; and musculature. Orthologous to human CRYAB (crystallin alpha B).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; Crya-2; Crya2; crystallin, alpha 2; heat shock protein CryAB; heat shock protein HspB5; HspB5; P23
Homo sapiens (human) : CRYAB (crystallin alpha B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cryab (crystallin, alpha B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cryab (crystallin alpha B)
Pan paniscus (bonobo/pygmy chimpanzee) : CRYAB (crystallin alpha B)
Canis lupus familiaris (dog) : CRYAB (crystallin alpha B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cryab (crystallin alpha B)
Sus scrofa (pig) : CRYAB (crystallin alpha B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38950,745,951 - 50,756,636 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,560,863 - 50,564,738 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,504,988 - 50,508,863 (+)NCBImm8
Celera948,038,491 - 48,043,798 (+)NCBICelera
Cytogenetic Map9 A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cryab
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10400
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.