Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4) - Rat Genome Database
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Gene: Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4) Mus musculus
Analyze
Symbol: Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
RGD ID: 11094
MGI Page MGI
Description: Predicted to have ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in bile acid secretion and response to fenofibrate. Localizes to intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4); PARTICIPATES IN multidrug resistance protein mediated transport pathway; bile acid transport pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (RS)-coclaurine; (RS)-norcoclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-binding cassette sub-family B member 4; Mdr; mdr-; mdr-2; Mdr2; multidrug resistance protein 2; multidrug resistance protein 3; P glycoprotein 2; P-glycoprotein 2; P-glycoprotein 3; Pgy; Pgy-; Pgy-2; Pgy2; phosphatidylcholine translocator ABCB4
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,943,614 - 9,009,226 (+)NCBIGRCm39mm39
GRCm3858,893,614 - 8,959,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,893,717 - 8,959,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,893,721 - 8,959,226 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,899,723 - 8,965,232 (+)NCBImm8
Celera58,813,446 - 8,878,635 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,9-dideoxyforskolin  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
adefovir  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atorvastatin calcium  (EXP)
azathioprine  (ISO)
beclomethasone  (ISO)
benzarone  (ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benziodarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
biperiden  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromosulfophthalein  (ISO)
brompheniramine  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
cholic acid  (EXP)
chromium(6+)  (EXP)
ciprofibrate  (EXP)
clemastine  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dihydroergotamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
doxylamine  (ISO)
ebrotidine  (ISO)
emodin  (ISO)
entinostat  (ISO)
esmolol  (ISO)
ethanol  (EXP)
fenofibrate  (EXP,ISO)
flutamide  (ISO)
fluvoxamine  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (EXP)
glyburide  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (EXP)
guanethidine  (ISO)
guggulsterone  (EXP)
GW 4064  (EXP,ISO)
herbicide  (EXP)
hydroxyzine  (ISO)
indocyanine green  (EXP)
isoprenaline  (ISO)
ketoconazole  (ISO)
labetalol  (ISO)
lapatinib  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
Loratadine  (ISO)
LY-2157299  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methyltestosterone  (ISO)
methysergide  (ISO)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nitrofurantoin  (ISO)
nomifensine  (ISO)
nortriptyline  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
oxybutynin  (ISO)
oxycodone  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP,ISO)
pazopanib  (ISO)
penbutolol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
phenazopyridine  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (EXP,ISO)
physcion  (ISO)
pirinixic acid  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (ISO)
procyclidine  (ISO)
procymidone  (ISO)
propiconazole  (EXP)
protriptyline  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
soybean oil  (ISO)
streptozocin  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tamsulosin  (ISO)
tasosartan  (ISO)
taurocholic acid  (ISO)
Technetium tc 99m sestamibi  (EXP)
tenofovir disoproxil fumarate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
thioacetamide  (ISO)
tipranavir  (ISO)
titanium dioxide  (EXP)
tolterodine tartrate  (ISO)
topotecan  (ISO)
triadimefon  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
yohimbine  (EXP)
zafirlukast  (ISO)
zimeldine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile canaliculus morphology  (IAGP)
abnormal bile composition  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal bile salt homeostasis  (IAGP)
abnormal bile secretion  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal circulating alanine transaminase level  (IAGP)
abnormal circulating alkaline phosphatase level  (IAGP)
abnormal circulating aspartate transaminase level  (IAGP)
abnormal circulating bilirubin level  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal feces composition  (IAGP)
abnormal gallbladder size  (IAGP)
abnormal hepatobiliary system morphology  (IAGP)
abnormal hepatobiliary system physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal portal triad morphology  (IAGP)
abnormal sodium ion homeostasis  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal trabecular bone volume  (IAGP)
bile duct inflammation  (IAGP)
bile duct proliferation  (IAGP)
biliary cirrhosis  (IAGP)
cholestasis  (IAGP)
decreased bile salt level  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased intestinal cholesterol absorption  (IAGP)
decreased mean corpuscular hemoglobin  (IEA)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased trabecular bone connectivity density  (IAGP)
decreased vitamin D level  (IAGP)
dilated bile duct  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
focal hepatic necrosis  (IAGP)
gallstones  (IAGP)
hepatic necrosis  (IAGP)
increased alkaline phosphatase activity  (IAGP)
increased bile salt level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating phosphate level  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased leukocyte cell number  (IEA)
increased liver weight  (IAGP)
increased monocyte cell number  (IEA)
increased red blood cell distribution width  (IEA)
increased spleen weight  (IEA)
increased transforming growth factor beta level  (IAGP)
intrahepatic cholestasis  (IAGP)
liver cirrhosis  (IAGP)
liver fibrosis  (IAGP)
liver hemorrhage  (IAGP)
liver inflammation  (IAGP)
portal hypertension  (IAGP)
reduced female fertility  (IAGP)
thrombocytosis  (IEA)
weight loss  (IAGP)
References

References - curated
1. Aronson SJ, etal., J Hepatol. 2019 Jul;71(1):153-162. doi: 10.1016/j.jhep.2019.03.021. Epub 2019 Mar 29.
2. de Vree JM, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):282-7.
3. Degiorgio D, etal., J Gastroenterol. 2016 Mar;51(3):271-80. doi: 10.1007/s00535-015-1110-z. Epub 2015 Sep 1.
4. Fickert P, etal., Gastroenterology. 2004 Jul;127(1):261-74.
5. Gotthardt D, etal., Hepatology. 2008 Oct;48(4):1157-66. doi: 10.1002/hep.22485.
6. Hyogo H, etal., Dig Dis Sci. 2001 Oct;46(10):2089-97.
7. Jirsa M, etal., World J Gastroenterol. 2014 May 21;20(19):5867-74. doi: 10.3748/wjg.v20.i19.5867.
8. MGD and Homologene mouse data transfer
9. MGD data from the GO Consortium
10. MGD IEA
11. Nakken KE, etal., Scand J Gastroenterol. 2007 Oct;42(10):1245-55. doi: 10.1080/00365520701320521.
12. Ohishi Y, etal., Hepatology. 2008 Sep;48(3):853-62. doi: 10.1002/hep.22382.
13. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline
15. Pipeline to import KEGG annotations from KEGG into RGD
16. RGD automated import pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. Smit JJ, etal., Cell 1993 Nov 5;75(3):451-62.
20. Tomaiuolo R, etal., Dig Liver Dis. 2009 Nov;41(11):817-22. Epub 2009 May 20.
21. van Waarde WM, etal., Gastroenterology. 2002 Jun;122(7):1842-52.
22. Ziol M, etal., Gastroenterology. 2008 Jul;135(1):131-41. doi: 10.1053/j.gastro.2008.03.044. Epub 2008 Mar 26.
Additional References at PubMed
PMID:1381362   PMID:1969609   PMID:1980424   PMID:1990275   PMID:2069718   PMID:2248681   PMID:2471060   PMID:2473069   PMID:2570420   PMID:3022150   PMID:3405218   PMID:3768958  
PMID:7498666   PMID:7558881   PMID:7814632   PMID:7832992   PMID:7857397   PMID:7912658   PMID:7915194   PMID:7977654   PMID:8102093   PMID:8547326   PMID:8615769   PMID:8679007  
PMID:8698195   PMID:8725158   PMID:8759018   PMID:8763339   PMID:9034162   PMID:9148004   PMID:9196326   PMID:9473291   PMID:9558293   PMID:9696021   PMID:9778357   PMID:9927146  
PMID:10349636   PMID:10453001   PMID:10488067   PMID:10526224   PMID:10551403   PMID:10552998   PMID:10611166   PMID:11042159   PMID:11076861   PMID:11113093   PMID:11208732   PMID:11217851  
PMID:11279518   PMID:11368757   PMID:11826402   PMID:12068294   PMID:12223350   PMID:12381268   PMID:12477932   PMID:12512040   PMID:14681479   PMID:14752830   PMID:15329734   PMID:15633131  
PMID:15910498   PMID:15930516   PMID:16141072   PMID:16141073   PMID:16144842   PMID:16376450   PMID:16384875   PMID:16458078   PMID:16472600   PMID:16498401   PMID:16618719   PMID:16679290  
PMID:17283071   PMID:17431106   PMID:17440929   PMID:17854600   PMID:18025261   PMID:18215618   PMID:18242748   PMID:18538673   PMID:19340302   PMID:20133864   PMID:20193684   PMID:20921947  
PMID:21209952   PMID:21267068   PMID:21292027   PMID:21677750   PMID:21820390   PMID:21873635   PMID:21912653   PMID:22022477   PMID:22434064   PMID:22982378   PMID:23049784   PMID:23066040  
PMID:23102701   PMID:23416526   PMID:23423643   PMID:23526353   PMID:23540693   PMID:23545228   PMID:23588707   PMID:23707514   PMID:24264436   PMID:24481602   PMID:24517519   PMID:24687604  
PMID:24819516   PMID:25068656   PMID:25331529   PMID:25340599   PMID:25422452   PMID:25478810   PMID:25915586   PMID:26542370   PMID:27391331   PMID:27995969   PMID:28027584   PMID:28184004  
PMID:28355206   PMID:28432216   PMID:28502477   PMID:28508871   PMID:28634212   PMID:28894223   PMID:29125588   PMID:29404503   PMID:29416088   PMID:29558367   PMID:29734330   PMID:29895698  
PMID:29941600   PMID:29977037   PMID:30389969   PMID:30416103   PMID:30447270   PMID:30464200   PMID:30862875   PMID:30890428   PMID:30897344   PMID:31176036   PMID:31243614   PMID:31521820  
PMID:31832573   PMID:31953035   PMID:32325033   PMID:32332110   PMID:32712019   PMID:32994489  


Genomics

Comparative Map Data
Abcb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,943,614 - 9,009,226 (+)NCBIGRCm39mm39
GRCm3858,893,614 - 8,959,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,893,717 - 8,959,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,893,721 - 8,959,226 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,899,723 - 8,965,232 (+)NCBImm8
Celera58,813,446 - 8,878,635 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
ABCB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl787,401,696 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl787,401,697 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38787,398,988 - 87,476,722 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,031,012 - 87,104,996 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37787,031,361 - 87,105,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,869,297 - 86,942,955 (-)NCBINCBI36hg18NCBI36
Build 34786,676,016 - 86,754,402NCBI
Celera781,736,239 - 81,809,903 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,642,357 - 81,716,022 (-)NCBIHuRef
CHM1_1786,961,467 - 87,035,121 (-)NCBICHM1_1
CRA_TCAGchr7v2786,362,871 - 86,436,531 (-)NCBI
Abcb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2425,150,998 - 25,209,489 (-)NCBI
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0422,133,984 - 22,192,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0422,070,806 - 22,128,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,946,274 - 22,004,328 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1421,946,273 - 22,004,328 (+)NCBI
Celera420,645,103 - 20,702,285 (-)NCBICelera
Cytogenetic Map4q12NCBI
ABCB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1793,046,085 - 93,119,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,046,085 - 93,119,439 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0779,395,924 - 79,469,755 (-)NCBIMhudiblu_PPA_v0panPan3
ABCB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1413,548,462 - 13,614,571 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11413,542,610 - 13,614,334 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Abcb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367631,339,849 - 1,415,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,651,665 - 102,741,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,459,344 - 61,529,017 (+)NCBI

Position Markers
AW113832  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3858,958,965 - 8,959,071UniSTSGRCm38
MGSCv3758,958,965 - 8,959,071UniSTSGRCm37
Celera58,878,374 - 8,878,480UniSTS
Cytogenetic Map5A1UniSTS
cM Map51.0UniSTS
cM Map51.0UniSTS
Whitehead/MRC_RH545.22UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121223552Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121879650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123556323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129371157Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
13442491Mecth1_mmechanosensation threshold 1 (mouse)5446800019630000Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5879767233318293Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:4
Interacting mature miRNAs:7
Transcripts:ENSMUST00000003717
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA239419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC151474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB951185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ071650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX204859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000003717   ⟹   ENSMUSP00000003717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,893,717 - 8,959,226 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196067   ⟹   ENSMUSP00000142425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,893,949 - 8,941,087 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197150
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,958,552 - 8,959,231 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197458
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,893,721 - 8,901,304 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199954
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,928,726 - 8,932,044 (+)Ensembl
RefSeq Acc Id: NM_008830   ⟹   NP_032856
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3958,943,721 - 9,009,226 (+)NCBI
GRCm3858,893,721 - 8,959,226 (+)NCBI
MGSCv3758,893,721 - 8,959,226 (+)RGD
Celera58,813,446 - 8,878,635 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503551   ⟹   XP_006503614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3958,943,654 - 9,009,226 (+)NCBI
GRCm3858,893,632 - 8,959,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503552   ⟹   XP_006503615
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3958,943,614 - 9,009,219 (+)NCBI
GRCm3858,893,614 - 8,959,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503554   ⟹   XP_006503617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3958,957,311 - 9,009,219 (+)NCBI
GRCm3858,907,311 - 8,959,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164874   ⟹   XP_036020767
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3958,943,661 - 9,009,219 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_032856   ⟸   NM_008830
- UniProtKB: P21440 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503615   ⟸   XM_006503552
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006503614   ⟸   XM_006503551
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006503617   ⟸   XM_006503554
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000003717   ⟸   ENSMUST00000003717
RefSeq Acc Id: ENSMUSP00000142425   ⟸   ENSMUST00000196067
RefSeq Acc Id: XP_036020767   ⟸   XM_036164874
- Peptide Label: isoform X3
Promoters
RGD ID:6836835
Promoter ID:MM_KWN:41341
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Liver,   Spleen
Transcripts:ENSMUST00000003717,   ENSMUST00000101612,   UC008WKS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3658,893,606 - 8,894,106 (+)MPROMDB
RGD ID:6885970
Promoter ID:EPDNEW_M6436
Type:initiation region
Name:Abcb4_1
Description:Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3858,893,713 - 8,893,773EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97569 AgrOrtholog
Ensembl Genes ENSMUSG00000042476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000003717 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142425 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003717 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000196067 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18670 UniProtKB/Swiss-Prot
MGD MGI:97569 ENTREZGENE
NCBI Gene 18670 ENTREZGENE
PANTHER PTHR24221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24221:SF241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCB4 RGD
PhenoGen Abcb4 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDM4_MOUSE UniProtKB/TrEMBL
  MDR3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TN75_MOUSE UniProtKB/TrEMBL
UniProt Secondary B9EK77 UniProtKB/Swiss-Prot
  Q6LCL9 UniProtKB/Swiss-Prot