Fga (fibrinogen alpha chain) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fga (fibrinogen alpha chain) Mus musculus
Analyze
Symbol: Fga
Name: fibrinogen alpha chain
RGD ID: 10576
MGI Page MGI
Description: Predicted to enable protein-macromolecule adaptor activity and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Acts upstream of or within blood coagulation. Located in cell cortex. Is active in synapse. Is expressed in several structures, including heart; liver; lung; nephron; and telencephalon. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI303526; ENSMUSG00000059807; expressed sequence AI303526; Fi; Fib; fibrinogen, A alpha polypeptide; fibrinogen, alpha polypeptide
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,933,460 - 82,940,934 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,933,383 - 82,940,934 (+)EnsemblGRCm39 Ensembl
GRCm38383,026,153 - 83,033,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,026,076 - 83,033,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,830,075 - 82,837,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,112,081 - 83,118,197 (+)NCBIMGSCv36mm8
Celera383,030,275 - 83,037,743 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
CGP 52608  (ISO)
chloroform  (ISO)
chlorpromazine  (ISO)
choline  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP,ISO)
dabigatran  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diisopropyl fluorophosphate  (ISO)
diquat  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
erythromycin estolate  (ISO)
Evodiamine  (EXP)
fenofibrate  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
genistein  (ISO)
gestodene  (ISO)
glafenine  (ISO)
glyphosate  (EXP)
GW 4064  (EXP)
heparin  (ISO)
hydrazine  (EXP)
icariin  (EXP)
inulin  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (ISO)
natamycin  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
nystatin  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinidine  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulfasalazine  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
Triptolide  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
adaptive immune response  (IEA)
blood coagulation  (IMP)
blood coagulation, common pathway  (IBA,ISO)
blood coagulation, fibrin clot formation  (ISO)
cell-matrix adhesion  (ISO)
cellular response to granulocyte colony-stimulating factor  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
fibrinolysis  (IBA,ISO)
induction of bacterial agglutination  (ISO)
innate immune response  (IEA)
liver regeneration  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
plasminogen activation  (ISO)
platelet activation  (IEA)
platelet aggregation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of exocytosis  (ISO)
positive regulation of heterotypic cell-cell adhesion  (IBA,ISO)
positive regulation of peptide hormone secretion  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of vasoconstriction  (ISO)
protein polymerization  (IEA,ISO)
protein-containing complex assembly  (ISO)
response to calcium ion  (ISO)
response to cycloheximide  (ISO)
response to estradiol  (ISO)
response to genistein  (ISO)
response to growth hormone  (ISO)
response to insulin  (ISO)
response to thyroid hormone  (ISO)
response to toxic substance  (ISO)
response to X-ray  (ISO)
venom-mediated perturbation of blood coagulation  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Therapy with interleukin-22 alleviates hepatic injury and hemostasis dysregulation in rat model of acute liver failure. Ashour TH Adv Hematol. 2014;2014:705290. doi: 10.1155/2014/705290. Epub 2014 Apr 1.
2. Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. Bai J, etal., Proteome Sci. 2014 Sep 16;12(1):49. doi: 10.1186/s12953-014-0049-y. eCollection 2014.
3. Preliminary identification of differentially expressed tear proteins in keratoconus. Balasubramanian SA, etal., Mol Vis. 2013 Oct 30;19:2124-34. eCollection 2013.
4. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
5. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Benson MD, etal., Nat Genet. 1993 Mar;3(3):252-5.
6. alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism. Carter AM, etal., Blood. 2000 Aug 1;96(3):1177-9.
7. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
8. Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice. Choi SA, etal., Mol Biol Rep. 2013 Feb;40(2):1753-65. doi: 10.1007/s11033-012-2229-0. Epub 2012 Oct 20.
9. Puerarin attenuates ovalbumin-induced lung inflammation and hemostatic unbalance in rat asthma model. Dong F, etal., Evid Based Complement Alternat Med. 2014;2014:726740. doi: 10.1155/2014/726740. Epub 2014 Jan 2.
10. The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats. Feng J, etal., PLoS One. 2010 Oct 6;5(10):e13201. doi: 10.1371/journal.pone.0013201.
11. Enoxaparin attenuates endothelial damage with less bleeding compared with unfractionated heparin in endotoxemic rats. Iba T and Takayama T, Shock. 2009 Nov;32(5):530-4. doi: 10.1097/SHK.0b013e3181a2e279.
12. [Protective effects and anticoagulation effect of polysaccharides from the sea cucumber on acute incomplete cerebral ischemia in rats]. Jiang X, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):170-2.
13. Identification of potential biomarkers by serum proteomics analysis in rats with sepsis. Jiao J, etal., Shock. 2014 Jul;42(1):75-81. doi: 10.1097/SHK.0000000000000173.
14. Down-regulated expression of AQP5 on lung in rat DIC model induced by LPS and its effect on the development of pulmonary edema. Jin Y, etal., Pulm Pharmacol Ther. 2013 Dec;26(6):661-5. doi: 10.1016/j.pupt.2013.03.013. Epub 2013 Mar 26.
15. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
16. Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Krishnamoorthy A, etal., Blood. 2011 Aug 18;118(7):1934-42. Epub 2011 Jun 17.
17. The fibrin-derived peptide bbeta15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury. Liu A, etal., Shock. 2013 Apr;39(4):397-403. doi: 10.1097/SHK.0b013e31828c2b75.
18. [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. Liu F, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Mar;30(3):190-3.
19. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
20. Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes. Lotta LA, etal., BMC Med Genomics. 2012 Feb 21;5(1):7.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
25. A label-free nano-liquid chromatography-mass spectrometry approach for quantitative serum peptidomics in Crohn's disease patients. Nanni P, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3127-36. Epub 2009 Aug 7.
26. The 11 kb FGA deletion responsible for congenital afibrinogenaemia is mediated by a short direct repeat in the fibrinogen gene cluster. Neerman-Arbez M, etal., Eur J Hum Genet. 1999 Dec;7(8):897-902.
27. Antiplatelet and antithrombotic effects of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y (SC-46749). Nicholson NS, etal., J Pharmacol Exp Ther. 1991 Mar;256(3):876-82.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Thukral SK, etal., Toxicol Pathol. 2005;33(3):343-55.
36. Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study. van Oijen M, etal., J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):799-803. Epub 2007 Oct 19.
37. Congenital afibrinogenaemia in a newborn infant due to a novel mutation in the fibrinogen aalpha gene. Vlietman JJ, etal., Br J Haematol. 2002 Oct;119(1):282-3.
38. Pre-treatment with bone marrow-derived mesenchymal stem cells inhibits systemic intravascular coagulation and attenuates organ dysfunction in lipopolysaccharide-induced disseminated intravascular coagulation rat model. Wang B, etal., Chin Med J (Engl). 2012 May;125(10):1753-9.
39. Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Wang C, etal., Thromb Res. 2013 Jan;131(1):e31-8. doi: 10.1016/j.thromres.2012.11.002. Epub 2012 Nov 28.
40. Identification of novel biomarkers in seasonal allergic rhinitis by combining proteomic, multivariate and pathway analysis. Wang H, etal., PLoS One. 2011;6(8):e23563. Epub 2011 Aug 24.
41. Uncovering the protective mechanism of Huoxue Anxin Recipe against coronary heart disease by network analysis and experimental validation. Wang J, etal., Biomed Pharmacother. 2020 Jan;121:109655. doi: 10.1016/j.biopha.2019.109655. Epub 2019 Nov 14.
42. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
43. A novel nonsense mutation in the FGA gene in a Chinese family with congenital afibrinogenaemia. Wu S, etal., Blood Coagul Fibrinolysis. 2005 Apr;16(3):221-6.
Additional References at PubMed
PMID:7649481   PMID:8288233   PMID:8497848   PMID:8929539   PMID:9275201   PMID:9473227   PMID:9486990   PMID:9788960   PMID:9819035   PMID:10349636   PMID:10749569   PMID:10829076  
PMID:10903997   PMID:10922068   PMID:10930441   PMID:11018075   PMID:11042159   PMID:11076861   PMID:11104787   PMID:11154109   PMID:11159184   PMID:11217851   PMID:11389004   PMID:11704568  
PMID:11733368   PMID:11891199   PMID:11906694   PMID:12218060   PMID:12460914   PMID:12466851   PMID:12477932   PMID:12579195   PMID:12750384   PMID:12819125   PMID:14504091   PMID:14615369  
PMID:14644995   PMID:14709993   PMID:15031212   PMID:15096619   PMID:15304043   PMID:15364412   PMID:15367435   PMID:15914557   PMID:15972474   PMID:16006527   PMID:16141072   PMID:16141073  
PMID:16434493   PMID:16452087   PMID:16707424   PMID:16824188   PMID:16877357   PMID:17307940   PMID:17371949   PMID:17664291   PMID:17722076   PMID:17932565   PMID:18593877   PMID:19036705  
PMID:19056689   PMID:19332769   PMID:20028811   PMID:20152176   PMID:20547128   PMID:20876456   PMID:21267068   PMID:21305474   PMID:21356363   PMID:21677750   PMID:21724997   PMID:21734641  
PMID:21873635   PMID:22006565   PMID:22159717   PMID:22272319   PMID:22381526   PMID:22507835   PMID:22539596   PMID:22819533   PMID:23029147   PMID:23187627   PMID:23487423   PMID:23804451  
PMID:24574269   PMID:24664548   PMID:24821909   PMID:24990151   PMID:25007874   PMID:25336631   PMID:26214526   PMID:26228483   PMID:26238780   PMID:26647393   PMID:27140400   PMID:28071719  
PMID:28275164   PMID:28378742   PMID:29199018   PMID:29723163   PMID:30335684   PMID:30737131   PMID:31101623   PMID:32315384   PMID:32325033   PMID:34572594   PMID:34633287   PMID:34905618  
PMID:34941394   PMID:34958662   PMID:35041705   PMID:35257941   PMID:35599984   PMID:37142655   PMID:37291385   PMID:39198643  


Genomics

Comparative Map Data
Fga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,933,460 - 82,940,934 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,933,383 - 82,940,934 (+)EnsemblGRCm39 Ensembl
GRCm38383,026,153 - 83,033,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,026,076 - 83,033,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,830,075 - 82,837,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,112,081 - 83,118,197 (+)NCBIMGSCv36mm8
Celera383,030,275 - 83,037,743 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.96NCBI
FGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,583,126 - 154,590,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,583,126 - 154,590,742 (-)EnsemblGRCh38hg38GRCh38
GRCh374155,504,278 - 155,511,894 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,723,730 - 155,731,347 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,864,033 - 155,869,470NCBI
Celera4152,835,246 - 152,842,862 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4151,244,861 - 151,252,473 (-)NCBIHuRef
CHM1_14155,482,201 - 155,489,817 (-)NCBICHM1_1
T2T-CHM13v2.04157,914,895 - 157,922,551 (-)NCBIT2T-CHM13v2.0
Fga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,672,169 - 170,679,572 (+)NCBIGRCr8
mRatBN7.22168,374,120 - 168,381,523 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,374,120 - 168,381,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,564,269 - 175,571,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,585,204 - 173,592,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,186,618 - 168,194,000 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,997,562 - 182,013,726 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,006,242 - 182,013,763 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,412,182 - 201,428,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,737,640 - 174,753,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,694,725 - 174,703,904 (+)NCBI
Celera2162,392,064 - 162,408,023 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,806,650 - 8,816,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,806,964 - 8,814,671 (+)NCBIChiLan1.0ChiLan1.0
FGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,495,579 - 152,503,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,851,017 - 152,858,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,949,680 - 146,957,291 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,767,782 - 158,775,414 (-)NCBIpanpan1.1PanPan1.1panPan2
FGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,238,305 - 52,247,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,236,198 - 52,246,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,584,628 - 52,591,483 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,924,743 - 52,933,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,925,657 - 52,933,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,179,682 - 52,188,900 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,283,995 - 52,293,478 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,601,176 - 52,608,068 (-)NCBIUU_Cfam_GSD_1.0
Fga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,217,093 - 38,224,715 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365761,322,406 - 1,329,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,574,882 - 74,584,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,574,870 - 74,584,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,935,842 - 78,938,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,127,554 - 101,134,881 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,125,791 - 101,134,405 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,782,883 - 80,789,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248585,848,817 - 5,856,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fga
560 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:539
Count of miRNA genes:348
Interacting mature miRNAs:405
Transcripts:ENSMUST00000029630, ENSMUST00000166581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
RH128215  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,033,318 - 83,033,504UniSTSGRCm38
MGSCv37382,837,240 - 82,837,426UniSTSGRCm37
Celera383,037,435 - 83,037,621UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
RH128930  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,032,053 - 83,032,228UniSTSGRCm38
MGSCv37382,835,975 - 82,836,150UniSTSGRCm37
Celera383,036,178 - 83,036,346UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
AI303526  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,033,318 - 83,033,431UniSTSGRCm38
MGSCv37382,837,240 - 82,837,353UniSTSGRCm37
Celera383,037,435 - 83,037,548UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
Whitehead/MRC_RH3803.78UniSTS
GDB:633003  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,031,065 - 83,031,486UniSTSGRCm38
MGSCv37382,834,987 - 82,835,408UniSTSGRCm37
Celera383,035,192 - 83,035,613UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
PMC303338P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,030,867 - 83,031,278UniSTSGRCm38
MGSCv37382,834,789 - 82,835,200UniSTSGRCm37
Celera383,034,994 - 83,035,405UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
Fga  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,030,211 - 83,030,900UniSTSGRCm38
MGSCv37382,835,367 - 82,835,617UniSTSGRCm37
Celera383,034,338 - 83,035,027UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
cM Map344.8UniSTS
Fga  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,031,445 - 83,031,695UniSTSGRCm38
MGSCv37382,835,367 - 82,835,617UniSTSGRCm37
Celera383,035,572 - 83,035,822UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000029630   ⟹   ENSMUSP00000029630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,933,383 - 82,939,570 (+)Ensembl
GRCm38.p6 Ensembl383,026,076 - 83,032,263 (+)Ensembl
Ensembl Acc Id: ENSMUST00000166581   ⟹   ENSMUSP00000133117
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,933,522 - 82,940,934 (+)Ensembl
GRCm38.p6 Ensembl383,026,215 - 83,033,627 (+)Ensembl
RefSeq Acc Id: NM_001111048   ⟹   NP_001104518
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,933,460 - 82,940,934 (+)NCBI
GRCm38383,026,153 - 83,033,627 (+)ENTREZGENE
MGSCv37382,830,075 - 82,837,549 (+)RGD
Celera383,030,275 - 83,037,743 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010196   ⟹   NP_034326
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,933,460 - 82,940,934 (+)NCBI
GRCm38383,026,153 - 83,033,627 (+)ENTREZGENE
MGSCv37382,830,075 - 82,837,549 (+)RGD
Celera383,030,275 - 83,037,743 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034326   ⟸   NM_010196
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PV24 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104518   ⟸   NM_001111048
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q99K47 (UniProtKB/Swiss-Prot),   E9PV24 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029630   ⟸   ENSMUST00000029630
Ensembl Acc Id: ENSMUSP00000133117   ⟸   ENSMUST00000166581
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PV24-F1-model_v2 AlphaFold E9PV24 1-789 view protein structure

Promoters
RGD ID:6833773
Promoter ID:MM_KWN:34683
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:NM_001111048,   NM_010196
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,829,814 - 82,830,314 (+)MPROMDB
RGD ID:6849131
Promoter ID:MM_XEF:4581
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_000508,   NM_001002039,   NM_001033626,   NM_001086860,   NM_021871
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,832,471 - 82,832,971 (+)MPROMDB
RGD ID:6880970
Promoter ID:EPDNEW_M3936
Type:multiple initiation site
Name:Fga_1
Description:Mus musculus fibrinogen alpha chain , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38383,026,157 - 83,026,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1316726 AgrOrtholog
Ensembl Genes ENSMUSG00000028001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029630 ENTREZGENE
  ENSMUST00000029630.15 UniProtKB/Swiss-Prot
  ENSMUST00000166581 ENTREZGENE
  ENSMUST00000166581.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.50 UniProtKB/Swiss-Prot
  3.90.215.10 UniProtKB/Swiss-Prot
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_coil_dom UniProtKB/Swiss-Prot
  Fibrinogen_aC UniProtKB/Swiss-Prot
  Fibrinogen_alpha UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
KEGG Report mmu:14161 UniProtKB/Swiss-Prot
MGD MGI:1316726 ENTREZGENE
NCBI Gene 14161 ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
  PTHR47221 UniProtKB/Swiss-Prot
Pfam Fib_alpha UniProtKB/Swiss-Prot
  Fibrinogen_aC UniProtKB/Swiss-Prot
  Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Fga PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
SMART FBG UniProtKB/Swiss-Prot
  Fib_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP Fibrinogen coiled-coil and central regions UniProtKB/Swiss-Prot
  SSF56496 UniProtKB/Swiss-Prot
UniProt E9PV24 ENTREZGENE, UniProtKB/Swiss-Prot
  Q99K47 ENTREZGENE
UniProt Secondary Q99K47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-28 Fga  fibrinogen alpha chain  AI303526  expressed sequence AI303526  Data merged from RGD:1610060 737654 PROVISIONAL