Ric8a (RIC8 guanine nucleotide exchange factor A)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Ric8a (RIC8 guanine nucleotide exchange factor A) Mus musculus

Analyze

Symbol:

Ric8a

Name:

RIC8 guanine nucleotide exchange factor A

RGD ID:

1558180

MGI Page

MGI

Description:

Predicted to have G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including basement membrane organization; gastrulation; and visual learning. Localizes to membrane. Is expressed in several structures, including embryo mesoderm; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A); INTERACTS WITH carbon nanotube; choline; clofibrate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AI114950; resistance to inhibitors of cholinesterase 8 homolog; Ri; RIC; RIC-8; Ric8; synem; synembryn; synembryn-A

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,437,310 - 140,443,644 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	140,436,870 - 140,444,285 (+)	Ensembl
GRCm38	7	140,857,397 - 140,863,731 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,856,957 - 140,864,372 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,043,296 - 148,049,630 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	140,708,717 - 140,715,051 (+)	NCBI			mm8
Celera	7	140,649,681 - 140,656,018 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

ammonium chloride (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

carbon nanotube (EXP)

chloropicrin (ISO)

choline (EXP)

clofibrate (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

disodium selenite (ISO)

ethanol (EXP)

folic acid (EXP)

furan (ISO)

hydrogen peroxide (EXP)

hypochlorous acid (EXP)

indometacin (ISO)

L-methionine (EXP)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP,ISO)

tetrachloromethane (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IDA)

basement membrane organization (IMP)

cell migration involved in gastrulation (IMP)

cell-cell adhesion involved in gastrulation (IMP)

G protein-coupled receptor signaling pathway (IBA)

gastrulation (IMP)

in utero embryonic development (IMP)

regulation of G protein-coupled receptor signaling pathway (ISO)

response to light stimulus (IMP)

vasculature development (IMP)

visual learning (IMP)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

membrane (IDA)

plasma membrane (IBA,ISO)

Molecular Function

G-protein alpha-subunit binding (IBA,ISO)

GTPase activator activity (IBA,ISO)

guanyl-nucleotide exchange factor activity (IBA,ISO)

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal basement membrane morphology (IAGP)

abnormal Bergmann glial cell morphology (IAGP)

abnormal cerebellar foliation (IAGP)

abnormal cerebellar granule cell migration (IAGP)

abnormal cerebellum development (IAGP)

abnormal cerebellum lobule morphology (IAGP)

abnormal cerebellum morphology (IAGP)

abnormal spatial learning (IAGP)

absent cerebellum fissure (IAGP)

ataxia (IAGP)

ectopic cerebellar granule cells (IAGP)

ectopic Purkinje cell (IAGP)

embryonic lethality between implantation and somite formation, complete penetrance (IAGP)

embryonic lethality prior to organogenesis (IEA)

enlarged cerebellum (IAGP)

impaired pupillary reflex (IEA)

increased anxiety-related response (IAGP)

increased circulating serum albumin level (IEA)

increased vertical activity (IEA)

neonatal lethality, complete penetrance (IAGP)

preweaning lethality, complete penetrance (IEA)

References

References - curated


1.	MGD data from the GO Consortium
2.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3.	RGD automated import pipeline
4.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:10922068	PMID:10985349	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:12971991	PMID:15489334	PMID:15782199	PMID:16141072
PMID:16141073	PMID:16221497	PMID:16629901	PMID:17431699	PMID:17593019	PMID:18799693	PMID:21069829	PMID:21158412	PMID:21267068	PMID:21565611	PMID:21677750	PMID:21771786
PMID:21873635	PMID:22114146	PMID:22384181	PMID:23100420	PMID:23212907	PMID:23384070	PMID:23977396	PMID:24092753	PMID:25641781	PMID:26062014	PMID:26232433	PMID:27348266
PMID:28378742	PMID:28526238	PMID:28535372	PMID:29380551	PMID:30683698	PMID:32325033

Genomics

Comparative Map Data

Ric8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,437,310 - 140,443,644 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	140,436,870 - 140,444,285 (+)	Ensembl
GRCm38	7	140,857,397 - 140,863,731 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,856,957 - 140,864,372 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,043,296 - 148,049,630 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	140,708,717 - 140,715,051 (+)	NCBI			mm8
Celera	7	140,649,681 - 140,656,018 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI

RIC8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	207,511 - 215,113 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	207,708 - 215,113 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	207,708 - 215,113 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	198,530 - 205,113 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	11	343,749 - 350,332 (-)	NCBI
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	28,547 - 35,130 (+)	NCBI		HuRef
CHM1_1	11	206,186 - 213,849 (+)	NCBI		CHM1_1

Ric8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	195,935,162 - 195,941,469 (+)	NCBI
Rnor_6.0 Ensembl	1	213,606,599 - 213,612,904 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	213,606,599 - 213,612,905 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	220,531,948 - 220,538,536 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,014,483 - 201,020,790 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	201,164,714 - 201,170,146 (+)	NCBI
Celera	1	193,579,108 - 193,585,413 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Ric8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,827,004 - 11,833,162 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	11,827,004 - 11,833,495 (-)	NCBI	ChiLan1.0	ChiLan1.0

RIC8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	248,881 - 255,274 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	248,880 - 255,269 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	203,317 - 210,135 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

RIC8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,363,031 - 25,368,645 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,362,875 - 25,368,378 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,012,985 - 25,018,594 (+)	NCBI
ROS_Cfam_1.0	18	25,889,581 - 25,895,184 (+)	NCBI
UMICH_Zoey_3.1	18	25,457,590 - 25,463,198 (+)	NCBI
UNSW_CanFamBas_1.0	18	25,102,367 - 25,107,976 (+)	NCBI
UU_Cfam_GSD_1.0	18	25,715,214 - 25,720,830 (+)	NCBI

Ric8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	57,369 - 62,720 (+)	NCBI
SpeTri2.0	NW_004936888	57,212 - 62,722 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RIC8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	32,215 - 39,360 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	32,135 - 37,682 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	162,187,001 - 162,192,480 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RIC8A
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	18,597 - 25,398 (+)	NCBI
ChlSab1.1 Ensembl	1	19,013 - 25,473 (+)	Ensembl

Ric8a
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624766	22,234,484 - 22,240,874 (-)	NCBI

Position Markers

AI848213

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	140,863,885 - 140,864,003	UniSTS	GRCm38
MGSCv37	7	148,049,784 - 148,049,902	UniSTS	GRCm37
Celera	7	140,656,172 - 140,656,290	UniSTS
Cytogenetic Map	7	F4	UniSTS
Cytogenetic Map	7	F5	UniSTS
Whitehead/MRC_RH	7	1429.19	UniSTS

AI114950

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	140,862,724 - 140,862,868	UniSTS	GRCm38
MGSCv37	7	148,048,623 - 148,048,767	UniSTS	GRCm37
Celera	7	140,655,011 - 140,655,155	UniSTS
Cytogenetic Map	7	F5	UniSTS
Whitehead/MRC_RH	7	1428.08	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19413473	142366067	Mouse
27226751	Femd5_m	femur midshaft diameter 5, 10 week (mouse)					7	53600000	143600000	Mouse
27095933	Ulnl3_m	ulna length 3, 5 week (mouse)					7	73500000	143600000	Mouse
14700684	Civq1_m	cerebral infarct volume QTL 1 (mouse)					7	110108163	144108163	Mouse
14700687	Civq5_m	cerebral infarct volume QTL 5 (mouse)					7	110108163	144108163	Mouse
14700688	Civq6_m	cerebral infarct volume QTL 6 (mouse)					7	110108163	144108163	Mouse
10402499	Lmr21_m	leishmaniasis resistance 21 (mouse)			Not determined		7	111365511	145365612	Mouse
11059562	Lmr21b_m	leishmaniasis resistance 21b (mouse)					7	111365511	145365612	Mouse
1301898	Alcp14_m	alcohol preference locus 14 (mouse)			Not determined		7	111564398	145441459	Mouse
1302032	Alcp12_m	alcohol preference locus 12 (mouse)			Not determined		7	111564398	145441459	Mouse
1300670	Sluc19_m	susceptibility to lung cancer 19 (mouse)			Not determined		7	111564398	145441459	Mouse
4142444	Femwf5_m	femur work to failure 5 (mouse)			Not determined			112950524	145441459	Mouse
1300747	Skts2_m	skin tumor susceptibility 2 (mouse)			Not determined		7	113321003	145441459	Mouse
1300677	Bmd9_m	bone mineral density 9 (mouse)			Not determined		7	117032360	145441459	Mouse
1357711	Adbg1_m	adult body growth 1 (mouse)			Not determined		7	119094158	144844577	Mouse
1301773	Stheal7_m	soft tissue heal 7 (mouse)			Not determined		7	119530844	145441459	Mouse
13207594	Nigsq1_m	neuroglucopenia-induced glucagon secretion QTL 1 (mouse)					7	127436844	145441459	Mouse
1301590	Pbwg3_m	postnatal body weight growth 3 (mouse)			Not determined		7	127757504	145441459	Mouse
1300566	Sluc8_m	susceptibility to lung cancer 8 (mouse)			Not determined		7	127844414	145441459	Mouse
14746988	Manh63_m	mandible shape 63 (mouse)					7	128181700	145441459	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1324
Count of miRNA genes:	628
Interacting mature miRNAs:	770
Transcripts:	ENSMUST00000026558, ENSMUST00000123925, ENSMUST00000131850, ENSMUST00000139956, ENSMUST00000147815, ENSMUST00000151384, ENSMUST00000152212, ENSMUST00000153498
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF288813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK031466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK080192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK155282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK169367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK171093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK177636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK178181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK183673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK187026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK188871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK198480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK207026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK210129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK211143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK212668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK217651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC022917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY256573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000026558 ⟹ ENSMUSP00000026558

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,856,957 - 140,863,730 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000123925

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,699 - 140,862,959 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000131850

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,860,642 - 140,863,143 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000139956

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,442 - 140,858,542 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000147815

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,858,162 - 140,859,734 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000151384

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,315 - 140,858,342 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000152212

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,861,173 - 140,862,619 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000153498

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,422 - 140,858,558 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000209766 ⟹ ENSMUSP00000147952

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,858,555 - 140,864,372 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000210601

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,485 - 140,860,858 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000210708 ⟹ ENSMUSP00000147773

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	7	140,857,451 - 140,863,489 (+)	Ensembl

RefSeq Acc Id:

NM_053194 ⟹ NP_444424

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,437,310 - 140,443,644 (+)	NCBI
GRCm38	7	140,857,397 - 140,863,731 (+)	ENTREZGENE
MGSCv37	7	148,043,296 - 148,049,630 (+)	RGD
Celera	7	140,649,681 - 140,656,018 (+)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

CCTGGGCGGAGCCCCGGGGTTTGGCCGATTGCGTCTTCCCAGCCCAAGCCTTCCAGCACCCGGT
GCCAGGGGCCATGGAGCCCCGGGCAGTTGCGGATGCCTTGGAGACCGGAGAGGAAGATGCGGTG
ACAGAAGCTCTGCGGTCGTTCAACCGGGAGCATTCTCAGAGCTTCACCTTCGATGATGCCCAGC
AGGAGGACAGGAAGAGACTCGCAAAGCTACTGGTCTCCGTCCTGGAGCAGGGCTTGTCACCAAA
GCACCGTGTCACCTGGCTGCAGACTATCCGAATCCTATCCCGAGACCGCAGCTGCCTGGACTCA
TTTGCCAGCCGCCAGAGCTTACATGCACTAGCCTGCTATGCTGACATTACCGTCTCAGAGGAAC
CCATCCCACAGTCCCCAGACATGGATGTCCTCCTCGAGTCTCTCAAATGCCTGTGTAATCTTGT
GCTCAGCAGTCCAACAGCACAGATGCTAGCAGCAGAGGCTCGCCTGGTGGTGAGGCTAGCGGAG
CGTGTGGGACTGTACCGCAAGAGGAGCTATCCCCACGAAGTCCAGTTCTTTGACTTGAGGCTCC
TTTTCCTGCTAACAGCCCTTCGCACGGATGTGCGCCAGCAACTGTTTCAGGAGCTGCACGGTGT
ACGCCTGCTGACTGATGCGCTGGAACTAACACTGGGCGTGGCCCCCAAAGAAAACCCTCCGGTG
ATGCTTCCAGCCCAAGAGACGGAGAGGGCCATGGAGATCCTCAAAGTGCTCTTTAATATCACCT
TTGACTCTGTCAAGAGGGAAGTTGATGAGGAAGATGCTGCCCTTTACCGGTACCTGGGGACTCT
TCTGCGGCACTGCGTGATGGTTGAAGCTGCTGGGGACCGCACAGAGGAGTTCCACGGCCACACG
GTGAATCTCCTGGGGAACTTGCCCCTCAAGTGTTTGGATGTGCTTCTGGCCCTGGAGCTCCACG
AAGGATCCTTAGAGTTCATGGGAGTTAACATGGATGTGATCAGTGCCCTCCTCGCCTTCCTAGA
GAAACGTCTGCACCAGACCCACAGGCTGAAGGAATGTGTGGCACCTGTGCTGAACGTGTTGACA
GAATGTGCCCGCATGCACCGTCCTGCCAGGAAGTTCCTGAAGGCCCAGGTCCTGCCCCCTCTGA
GGGATGTGAGGACTCGGCCTGAGGTGGGGGACCTGCTTCGAAACAAGCTTGTCCGCCTCATGAC
ACACCTGGATACAGATGTGAAGAGAGTAGCTGCCGAGTTCCTCTTTGTCTTATGTTCTGAAAGT
GTGCCCCGATTCATCAAGTACACAGGCTACGGGAATGCTGCCGGCCTCCTGGCTGCCAGGGGCC
TCATGGCTGGGGGCCGACCCGAGGGCCAGTACTCAGAGGACGAGGACACGGACACAGAGGAGTA
CAGGGAAGCCAAGGCCAGCATCAACCCTGTGACTGGAAGGGTGGAGGAGAAGCCGCCTAATCCT
ATGGAAGGCATGACAGAGGAGCAGAAGGAACATGAGGCCATGAAGCTAGTGAACATGTTTGACA
AGCTCTCCAGGCACAGAGTCATCCAACCCATGGGGATGAGTCCCAGGGGTCACCTCACTTCTCT
GCAAGATGCGATGTGTGAGACAATGGAGGGACAGCTCTCCTCAGACCCTGACTCAGATCCTGAC
TGAAGATGCCAGCGGCCTTGCTCCCCTTCAGAACTGGTGCTGCTTCCAGACATGTCCTGGGGTG
CTGCCTCAAGAAGCCACACCCCTCTCCAGCTGGGGAGCCCTTCTCTCTCCTCCTCACATTTCTG
TCATCTGCCTTTGGTCCAGTTTCCTGTGTTTAGGACTGTGGTAGTCTTACCCTCTGTGAAGACG
GGGAACCCACCTTTCATTTCCACAAGTGAAGTTGTTTCTTGGATGTGGCTGCAGCCACGAGCAG
AATTGCCCTGGCACATAAATGAACATGCGTGTATGAGGGTGGTAATGGAGCAGGGTACACATGG
TGTAAGCATGACTGGGCTGGATGCCAGCCCAGAGCCCGTATGTGGGGCATACGCTGTGTTTCAA
ACATTTTAGAATCTGTTGAAATTGTTTAAGTATGTCAGAAAACACACCAAGCGTCATGGTTCCT
GCTTCTGGCCCCACTGAGCACAGGGCTAGTGGCCTCTTCTTAACTTTTTGGTCCTGGCGCTGCC
ACCCACTGCAGTATCCGCATACCCAAGCCTCACTAGTTGTGACAACTAACTCAGTCACAACCAC
TGGCTTAGTAATTCTGTGAAGGCGAAAGTAAGACAAAGTCAAATCTGAGATTCTGAGGCACAGA
ATACAGGAGAGTTTGGGACAAGACTGTGTATGTGAAGTAGTCAGGTGAAAGGCTATTAAACAGA
AACTGATTTCATTCTGTTTAACATTCATGATTTCCTACATCACCACACATCTGCTGTCAACGAA
GAACAAGGATAGAAGACAAGACCCCAGTTCCTGGAATCTCGTTGGGTCGGCTACATACTGTCAG
CCGCAGTCAAATGGGTCGTAACAGCAATGGGGTGCTTCTGCCTGGCAAACAGCCTGAACTGTTT
CTGAGTAGGCGCCGAGGAGGAGGCAGCCTGTGCTTAGTAATGACTGCACACAGGACAGGAAAAC
AGGAGGCTCAATGGGGTTTCCCGGAGTAATGCCTGCCATTGGTTTTAGCATCGTTACTGGAAGA
AACCTGGGTAGTGTGGCGGGAAGTGGCTCAGGGAGGGCTGGGCAGATGGGGATTCTGAAGGACA
TGGGTATTCTCCAGGGACTGCAGAAGAGGAGCCTGAGTGAACACGAGAGTAAGTCAAGGGACAA
ATGGGCTCCGTCCTGTCATCCAGGAGGAGAACACCCACATAACCTGAAGTTTGTCAACACTCAC
TATCCCAAAGAGACAGGATGCCAAGTTTTTATACTAAGTTTATTTCATGCAAGAAATGATGTTG
TAGTTAAAGATGCCACTTTACCG

hide sequence

Protein Sequences


Protein RefSeqs	NP_444424	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG10200	(Get FASTA)	NCBI Sequence Viewer
	AAH22917	(Get FASTA)	NCBI Sequence Viewer
	BAC27418	(Get FASTA)	NCBI Sequence Viewer
	BAC37844	(Get FASTA)	NCBI Sequence Viewer
	BAE33163	(Get FASTA)	NCBI Sequence Viewer
	BAE39783	(Get FASTA)	NCBI Sequence Viewer
	BAE41115	(Get FASTA)	NCBI Sequence Viewer
	EDL17960	(Get FASTA)	NCBI Sequence Viewer
	Q3TIR3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_444424 ⟸ NM_053194

- UniProtKB:

Q3TIR3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRV
TWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSS
PTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLL
TDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRH
CVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRL
HQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLD
TDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREA
KASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDA
MCETMEGQLSSDPDSDPD

hide sequence

RefSeq Acc Id:

ENSMUSP00000026558 ⟸ ENSMUST00000026558

RefSeq Acc Id:

ENSMUSP00000147773 ⟸ ENSMUST00000210708

RefSeq Acc Id:

ENSMUSP00000147952 ⟸ ENSMUST00000209766

Promoters

RGD ID:

8666031

Promoter ID:

EPDNEW_M11047

Type:

initiation region

Name:

Ric8a_1

Description:

Mus musculus RIC8 guanine nucleotide exchange factor A , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	140,857,423 - 140,857,483	EPDNEW

RGD ID:

6841925

Promoter ID:

MM_KWN:53191

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000056992, OTTMUST00000056993, OTTMUST00000056995, OTTMUST00000056996, OTTMUST00000056997, OTTMUST00000056998

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	148,042,071 - 148,044,222 (+)	MPROMDB

RGD ID:

6841928

Promoter ID:

MM_KWN:53192

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, Brain, Kidney, MEF_B6

Transcripts:

OTTMUST00000056994, OTTMUST00000056999

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	148,047,399 - 148,047,899 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2141866	AgrOrtholog
Ensembl Genes	ENSMUSG00000025485	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000026558	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000147773	UniProtKB/TrEMBL
	ENSMUSP00000147952	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000026558	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000209766	UniProtKB/TrEMBL
	ENSMUST00000210708	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/Swiss-Prot
InterPro	ARM-like	UniProtKB/Swiss-Prot
	ARM-type_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gua_nucleotide_exch_fac_Ric8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Synembryn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:101489	UniProtKB/Swiss-Prot
MGD	MGI:2141866	ENTREZGENE
NCBI Gene	101489	ENTREZGENE
PANTHER	PTHR12425	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ric8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ric8a	PhenoGen
PRINTS	SYNEMBRYN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1B0GS30_MOUSE	UniProtKB/TrEMBL
	A0A1B0GSI8_MOUSE	UniProtKB/TrEMBL
	Q3TIR3	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q3TEY3	UniProtKB/Swiss-Prot
	Q99JW0	UniProtKB/Swiss-Prot
	Q9ERR6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-29	Ric8a	RIC8 guanine nucleotide exchange factor A	Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD