Ric8a (RIC8 guanine nucleotide exchange factor A) - Rat Genome Database
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Gene: Ric8a (RIC8 guanine nucleotide exchange factor A) Mus musculus
Analyze
Symbol: Ric8a
Name: RIC8 guanine nucleotide exchange factor A
RGD ID: 1558180
MGI Page MGI
Description: Predicted to have G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including basement membrane organization; gastrulation; and visual learning. Localizes to membrane. Is expressed in several structures, including embryo mesoderm; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A); INTERACTS WITH carbon nanotube; choline; clofibrate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI114950; resistance to inhibitors of cholinesterase 8 homolog; Ri; RIC; RIC-8; Ric8; synem; synembryn; synembryn-A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,437,310 - 140,443,644 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,436,870 - 140,444,285 (+)Ensembl
GRCm387140,857,397 - 140,863,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,856,957 - 140,864,372 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,043,296 - 148,049,630 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,708,717 - 140,715,051 (+)NCBImm8
Celera7140,649,681 - 140,656,018 (+)NCBICelera
Cytogenetic Map7F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:10985349   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12971991   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16221497   PMID:16629901   PMID:17431699   PMID:17593019   PMID:18799693   PMID:21069829   PMID:21158412   PMID:21267068   PMID:21565611   PMID:21677750   PMID:21771786  
PMID:21873635   PMID:22114146   PMID:22384181   PMID:23100420   PMID:23212907   PMID:23384070   PMID:23977396   PMID:24092753   PMID:25641781   PMID:26062014   PMID:26232433   PMID:27348266  
PMID:28378742   PMID:28526238   PMID:28535372   PMID:29380551   PMID:30683698   PMID:32325033  


Genomics

Comparative Map Data
Ric8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,437,310 - 140,443,644 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,436,870 - 140,444,285 (+)Ensembl
GRCm387140,857,397 - 140,863,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,856,957 - 140,864,372 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,043,296 - 148,049,630 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,708,717 - 140,715,051 (+)NCBImm8
Celera7140,649,681 - 140,656,018 (+)NCBICelera
Cytogenetic Map7F4NCBI
RIC8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11207,511 - 215,113 (+)EnsemblGRCh38hg38GRCh38
GRCh3811207,708 - 215,113 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711207,708 - 215,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611198,530 - 205,113 (+)NCBINCBI36hg18NCBI36
Celera11343,749 - 350,332 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef1128,547 - 35,130 (+)NCBIHuRef
CHM1_111206,186 - 213,849 (+)NCBICHM1_1
Ric8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21195,935,162 - 195,941,469 (+)NCBI
Rnor_6.0 Ensembl1213,606,599 - 213,612,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,606,599 - 213,612,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,531,948 - 220,538,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,014,483 - 201,020,790 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,164,714 - 201,170,146 (+)NCBI
Celera1193,579,108 - 193,585,413 (+)NCBICelera
Cytogenetic Map1q41NCBI
Ric8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,827,004 - 11,833,162 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,827,004 - 11,833,495 (-)NCBIChiLan1.0ChiLan1.0
RIC8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111248,881 - 255,274 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11248,880 - 255,269 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011203,317 - 210,135 (+)NCBIMhudiblu_PPA_v0panPan3
RIC8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,363,031 - 25,368,645 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,362,875 - 25,368,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,012,985 - 25,018,594 (+)NCBI
ROS_Cfam_1.01825,889,581 - 25,895,184 (+)NCBI
UMICH_Zoey_3.11825,457,590 - 25,463,198 (+)NCBI
UNSW_CanFamBas_1.01825,102,367 - 25,107,976 (+)NCBI
UU_Cfam_GSD_1.01825,715,214 - 25,720,830 (+)NCBI
Ric8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494757,369 - 62,720 (+)NCBI
SpeTri2.0NW_00493688857,212 - 62,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIC8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,215 - 39,360 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,135 - 37,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,187,001 - 162,192,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIC8A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,597 - 25,398 (+)NCBI
ChlSab1.1 Ensembl119,013 - 25,473 (+)Ensembl
Ric8a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476622,234,484 - 22,240,874 (-)NCBI

Position Markers
AI848213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,863,885 - 140,864,003UniSTSGRCm38
MGSCv377148,049,784 - 148,049,902UniSTSGRCm37
Celera7140,656,172 - 140,656,290UniSTS
Cytogenetic Map7F4UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71429.19UniSTS
AI114950  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,862,724 - 140,862,868UniSTSGRCm38
MGSCv377148,048,623 - 148,048,767UniSTSGRCm37
Celera7140,655,011 - 140,655,155UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71428.08UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1324
Count of miRNA genes:628
Interacting mature miRNAs:770
Transcripts:ENSMUST00000026558, ENSMUST00000123925, ENSMUST00000131850, ENSMUST00000139956, ENSMUST00000147815, ENSMUST00000151384, ENSMUST00000152212, ENSMUST00000153498
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY256573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026558   ⟹   ENSMUSP00000026558
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,856,957 - 140,863,730 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,699 - 140,862,959 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131850
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,860,642 - 140,863,143 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,442 - 140,858,542 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,858,162 - 140,859,734 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,315 - 140,858,342 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152212
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,861,173 - 140,862,619 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,422 - 140,858,558 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209766   ⟹   ENSMUSP00000147952
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,858,555 - 140,864,372 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210601
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,485 - 140,860,858 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210708   ⟹   ENSMUSP00000147773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,857,451 - 140,863,489 (+)Ensembl
RefSeq Acc Id: NM_053194   ⟹   NP_444424
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,437,310 - 140,443,644 (+)NCBI
GRCm387140,857,397 - 140,863,731 (+)ENTREZGENE
MGSCv377148,043,296 - 148,049,630 (+)RGD
Celera7140,649,681 - 140,656,018 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_444424   ⟸   NM_053194
- UniProtKB: Q3TIR3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026558   ⟸   ENSMUST00000026558
RefSeq Acc Id: ENSMUSP00000147773   ⟸   ENSMUST00000210708
RefSeq Acc Id: ENSMUSP00000147952   ⟸   ENSMUST00000209766

Promoters
RGD ID:8666031
Promoter ID:EPDNEW_M11047
Type:initiation region
Name:Ric8a_1
Description:Mus musculus RIC8 guanine nucleotide exchange factor A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,857,423 - 140,857,483EPDNEW
RGD ID:6841925
Promoter ID:MM_KWN:53191
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000056992,   OTTMUST00000056993,   OTTMUST00000056995,   OTTMUST00000056996,   OTTMUST00000056997,   OTTMUST00000056998
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,042,071 - 148,044,222 (+)MPROMDB
RGD ID:6841928
Promoter ID:MM_KWN:53192
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   MEF_B6
Transcripts:OTTMUST00000056994,   OTTMUST00000056999
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,047,399 - 148,047,899 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2141866 AgrOrtholog
Ensembl Genes ENSMUSG00000025485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026558 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147773 UniProtKB/TrEMBL
  ENSMUSP00000147952 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026558 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000209766 UniProtKB/TrEMBL
  ENSMUST00000210708 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gua_nucleotide_exch_fac_Ric8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synembryn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:101489 UniProtKB/Swiss-Prot
MGD MGI:2141866 ENTREZGENE
NCBI Gene 101489 ENTREZGENE
PANTHER PTHR12425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ric8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ric8a PhenoGen
PRINTS SYNEMBRYN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GS30_MOUSE UniProtKB/TrEMBL
  A0A1B0GSI8_MOUSE UniProtKB/TrEMBL
  Q3TIR3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TEY3 UniProtKB/Swiss-Prot
  Q99JW0 UniProtKB/Swiss-Prot
  Q9ERR6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Ric8a  RIC8 guanine nucleotide exchange factor A  Ric8  resistance to inhibitors of cholinesterase 8 homolog (C. elegans)  Symbol and/or name change 5135510 APPROVED