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Gene: Eif2b5 (eukaryotic translation initiation factor 2B, subunit 5 epsilon) Mus musculus
Symbol: Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Description: Predicted to have guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; glial cell development; and response to glucose. Localizes to cytoplasm and nucleus. Is expressed in central nervous system and retina. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon); PARTICIPATES IN translation initiation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C81315; eIF-2B GDP-GTP exchange factor subunit epsilon; translation initiation factor eIF-2B subunit epsilon
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1620,498,817 - 20,509,323 (+)EnsemblGRCm38mm10GRCm38
GRCm381620,498,795 - 20,509,325 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371620,498,890 - 20,509,398 (+)NCBIGRCm37mm9NCBIm37
MGSCv361620,412,371 - 20,422,866 (+)NCBImm8
Celera1621,062,563 - 21,073,067 (+)NCBICelera
Cytogenetic Map16A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eif2b5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731554
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.