Suclg1 (succinate-CoA ligase, GDP-forming, alpha subunit)

Gene: Suclg1 (succinate-CoA ligase, GDP-forming, alpha subunit) Mus musculus

Analyze

Symbol:

Suclg1

Name:

succinate-CoA ligase, GDP-forming, alpha subunit

RGD ID:

731610

MGI Page

MGI

Description:

Predicted to enable GDP binding activity; succinate-CoA ligase (ADP-forming) activity; and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1500000I01Rik; SCS-alpha; Suc; succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; succinyl-CoA synthetase subunit alpha; Sucla1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Suclg1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Suclg1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Suclg1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Suclg1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Suclg1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	suclg1 (succinate-CoA ligase, alpha subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LSC1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Scsalpha1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Scsalpha2	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	sucl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sucl-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	suclg1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	73,225,488 - 73,253,890 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	73,225,365 - 73,253,894 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	73,248,505 - 73,276,907 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	73,248,382 - 73,276,911 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	73,198,499 - 73,226,901 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	73,178,182 - 73,206,391 (+)	NCBI		MGSCv36	mm8
Celera	6	75,301,953 - 75,330,652 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	32.4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Disease Progression (ISO)

genetic disease (ISO)

mitochondrial DNA depletion syndrome (ISO)

mitochondrial DNA depletion syndrome 9 (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(1->4)-beta-D-glucan (EXP)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (EXP)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxynon-2-enal (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

aflatoxin B1 (ISO)

amiodarone (EXP,ISO)

ammonium chloride (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzatropine (ISO)

benzbromarone (ISO)

benzo[a]pyrene (EXP)

beta-naphthoflavone (ISO)

bezafibrate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP)

clofibrate (EXP,ISO)

clozapine (ISO)

copper(II) sulfate (ISO)

dexamethasone (EXP)

dibutyl phthalate (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

fenbendazole (ISO)

fenofibrate (ISO)

finasteride (ISO)

folic acid (EXP)

gentamycin (ISO)

indometacin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (ISO)

lead diacetate (EXP)

methidathion (EXP)

methoxychlor (ISO)

morphine (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (ISO)

omeprazole (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenylpropanolamine (EXP)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

rac-lactic acid (ISO)

resveratrol (EXP)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

Soman (ISO)

sulindac (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

tributylstannane (EXP)

tungsten (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

succinate metabolic process (ISO)

succinyl-CoA metabolic process (ISO)

tricarboxylic acid cycle (IBA,ISO)

Cellular Component

mitochondrial inner membrane (HDA)

mitochondrion (HDA,IBA)

protein-containing complex (ISO)

succinate-CoA ligase complex (ADP-forming) (IBA,ISO)

succinate-CoA ligase complex (GDP-forming) (ISO)

Molecular Function

catalytic activity (IEA)

GDP binding (ISO)

ligase activity (IEA)

nucleotide binding (IEA)

protein binding (IPI)

protein-containing complex binding (ISO)

succinate-CoA ligase (ADP-forming) activity (IBA,ISO)

succinate-CoA ligase (GDP-forming) activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

citric acid cycle pathway (IEA,ISO)

fumaric aciduria pathway (ISO)

mitochondrial complex II deficiency pathway (ISO)

propanoate metabolic pathway (IEA)

pyruvate dehydrogenase E2 deficiency pathway (ISO)

pyruvate dehydrogenase E3 deficiency pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

embryonic lethality prior to tooth bud stage (IEA)

preweaning lethality, complete penetrance (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Mitochondrial GTP regulates glucose-stimulated insulin secretion.	Kibbey RG, etal., Cell Metab. 2007 Apr;5(4):253-64.
3.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
6.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9765291	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12520002	PMID:12865426	PMID:14610273	PMID:14681479	PMID:15234968
PMID:15489334	PMID:15782199	PMID:16141072	PMID:16141073	PMID:17626619	PMID:18554416	PMID:18614015	PMID:18799693	PMID:19521500	PMID:21267068	PMID:21677750	PMID:21873635
PMID:22496890	PMID:22794259	PMID:27160897	PMID:27215380	PMID:27484306	PMID:28245920	PMID:28378742	PMID:28609438	PMID:29518331	PMID:29676259	PMID:30068389	PMID:30333137
PMID:30498063	PMID:30550785	PMID:30562941	PMID:32325033	PMID:34354145	PMID:36114006	PMID:36293380	PMID:36417873

Genomics

Comparative Map Data

Suclg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	73,225,488 - 73,253,890 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	73,225,365 - 73,253,894 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	73,248,505 - 73,276,907 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	73,248,382 - 73,276,911 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	73,198,499 - 73,226,901 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	73,178,182 - 73,206,391 (+)	NCBI		MGSCv36	mm8
Celera	6	75,301,953 - 75,330,652 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	32.4	NCBI

SUCLG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	84,423,528 - 84,459,280 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	84,423,528 - 84,460,045 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	84,650,652 - 84,686,404 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	84,504,163 - 84,540,097 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	84,562,333 - 84,598,043	NCBI
Celera	2	84,479,456 - 84,515,401 (-)	NCBI		Celera
Cytogenetic Map	2	p11.2	NCBI
HuRef	2	84,546,643 - 84,582,492 (-)	NCBI		HuRef
CHM1_1	2	84,580,608 - 84,616,546 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	84,425,228 - 84,460,977 (-)	NCBI		T2T-CHM13v2.0

Suclg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	106,866,329 - 106,895,686 (+)	NCBI		GRCr8
mRatBN7.2	4	105,308,236 - 105,337,595 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	105,308,039 - 105,337,600 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	110,679,963 - 110,709,281 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	106,455,073 - 106,484,379 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	105,075,992 - 105,105,347 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	101,181,315 - 101,210,692 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	101,180,404 - 101,210,746 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	165,937,922 - 165,967,277 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	106,572,140 - 106,601,495 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	36,133,697 - 36,137,263 (-)	NCBI
Celera	4	94,449,454 - 94,478,818 (+)	NCBI		Celera
Cytogenetic Map	4	q32	NCBI

Suclg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	2,810,557 - 2,842,036 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	2,810,557 - 2,838,827 (+)	NCBI	ChiLan1.0	ChiLan1.0

SUCLG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	41,918,257 - 41,954,439 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	41,921,021 - 41,957,203 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	84,476,814 - 84,512,920 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	86,035,506 - 86,071,537 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	86,035,723 - 86,066,622 (-)	Ensembl	panpan1.1		panPan2

SUCLG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	40,392,969 - 40,424,875 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	40,393,178 - 40,424,711 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	40,072,920 - 40,104,818 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	41,200,797 - 41,232,708 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	41,200,984 - 41,232,708 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	40,277,386 - 40,309,286 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	40,340,635 - 40,372,518 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	40,741,593 - 40,773,497 (+)	NCBI		UU_Cfam_GSD_1.0

Suclg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	869,277 - 904,045 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936650	3,275,019 - 3,313,599 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936650	3,278,769 - 3,313,537 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SUCLG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	60,142,435 - 60,177,378 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	60,142,340 - 60,177,497 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	63,138,718 - 63,174,813 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SUCLG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	22,712,622 - 22,748,648 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	22,712,661 - 22,748,845 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	89,647,622 - 89,683,679 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Suclg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	18,551,188 - 18,583,183 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	18,552,154 - 18,580,676 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Suclg1
1278 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	578
Count of miRNA genes:	414
Interacting mature miRNAs:	477
Transcripts:	ENSMUST00000064740, ENSMUST00000123159, ENSMUST00000127660, ENSMUST00000173366, ENSMUST00000173409
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	3050001	117476961	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139076998	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87403016	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96633110	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96633110	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96633110	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96633110	Mouse
26884441	Sklq3_m	skull length QTL 3, 5 week (mouse)					6	7600000	80576983	Mouse
1357442	Dbts1_m	diabetes 1 (mouse)			Not determined		6	18234147	73364675	Mouse
13208564	Bmiq7_m	body mass index QTL 7 (mouse)					6	24999999	79976983	Mouse
4141782	Mrdq5_m	modifier of retinal degeneration QTL 5 (mouse)			Not determined			32827585	78215957	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38646560	92584431	Mouse
12880424	V25Dq4_m	vitamin D inactive form serum level QTL 4 (mouse)					6	41576985	75576985	Mouse
11040600	Lmr4c_m	leishmaniasis resistance 4c (mouse)					6	42093358	76093500	Mouse
11040601	Lmr4a_m	leishmaniasis resistance 4a (mouse)					6	42093358	76093500	Mouse
11533915	Mts4_m	mammary tumor susceptibility 4 (mouse)					6	42093358	76093500	Mouse
1301266	Lmr4_m	leishmaniasis resistance 4 (mouse)			Not determined		6	42093358	76093500	Mouse
12910785	Pwgrq16_m	post-weaning growth rate QTL 16 (mouse)					6	43803747	77788506	Mouse
12910798	Pwgrq5_m	pre-weaning growth rate QTL 5 (mouse)					6	43803747	77788506	Mouse
12910802	Pwbwq12_m	post-weaning body weight QTL 12 (mouse)					6	43803747	77788506	Mouse
12910807	Pwbwq11_m	post-weaning body weight QTL 11 (mouse)					6	43803747	77788506	Mouse
12910809	Pwbwq10_m	post-weaning body weight QTL 10 (mouse)					6	43803747	77788506	Mouse
12910820	Ogrq3_m	overall growth rate QTL 3 (mouse)					6	43803747	77788506	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45290993	87403016	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45290993	128811995	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46912919	136400690	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48696934	125336963	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48696934	148351498	Mouse
4140983	Srilp_m	sleep response to influenza, light phase (mouse)			Not determined			48703490	75424693	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48703490	125333748	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51156134	85156284	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52138693	116132228	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54350411	88356155	Mouse
15039373	Adip28_m	adiposity 28 (mouse)					6	56285194	90285194	Mouse
15039375	Bw41_m	body weight QTL 41 (mouse)					6	56285194	90285194	Mouse
1558977	Skmw10_m	skeletal muscle weight 10 (mouse)			Not determined		6	58424566	92424693	Mouse
10043972	Obq28_m	obesity QTL 28 (mouse)			Not determined		6	58517416	92517416	Mouse
10412119	Stv_m	striatal volumne (mouse)			Not determined		6	60026991	100026967	Mouse
1301740	Bwq2_m	body weight QTL 2 (mouse)			Not determined		6	60034663	94034782	Mouse
1301369	Im4_m	immunoregulatory 4 (mouse)			Not determined		6	63461721	97461888	Mouse
1300650	Bw18_m	body weight QTL 18 (mouse)			Not determined		6	66690851	100691013	Mouse
1301813	Skl3_m	skeletal size (tail length) 3 (mouse)			Not determined		6	70402880	104403016	Mouse
1301034	Egrm2_m	early growth rate (mouse)			Not determined		6	70402880	104403016	Mouse
1301876	Bits2_m	bitterness sensitivity 2 (mouse)			Not determined		6	70402880	104403016	Mouse
4141990	Etax6_m	ethanol induced ataxia 6 (mouse)			Not determined			71299605	86252701	Mouse
1302020	Bbaa20_m	B.burgdorferi-associated arthritis 20 (mouse)			Not determined		6	71299605	93441074	Mouse
1300869	Stheal5_m	soft tissue heal 5 (mouse)			Not determined		6	71552042	105552160	Mouse
1301521	Pas1c_m	pulmonary adenoma susceptibility 1c (mouse)			Not determined		6	71958006	105958152	Mouse
1300954	Fcsa1_m	femoral cross-sectional area 1 (mouse)			Not determined		6	71958006	105958152	Mouse

Markers in Region

Suclg1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	C3	UniSTS
cM Map	6		UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC122201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF144101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI840979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK002754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK005080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK087390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK088888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK139288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK184184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK194483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK204482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK209595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK210494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC011087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY061062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000064740 ⟹ ENSMUSP00000065113

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,225,365 - 73,253,894 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,248,382 - 73,276,911 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000123159 ⟹ ENSMUSP00000134171

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,225,635 - 73,241,256 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,248,652 - 73,264,273 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000127660

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,225,651 - 73,240,034 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,248,668 - 73,263,051 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000173366

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,225,644 - 73,234,563 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,248,661 - 73,257,580 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000173409

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,237,343 - 73,241,252 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,260,360 - 73,264,269 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000203632 ⟹ ENSMUSP00000145246

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	73,225,643 - 73,253,887 (+)	Ensembl
GRCm38.p6 Ensembl	6	73,248,660 - 73,276,904 (+)	Ensembl

RefSeq Acc Id:

NM_019879 ⟹ NP_063932

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	73,225,488 - 73,253,890 (+)	NCBI
GRCm38	6	73,248,505 - 73,276,907 (+)	ENTREZGENE
MGSCv37	6	73,198,499 - 73,226,901 (+)	RGD
Celera	6	75,301,953 - 75,330,652 (+)	RGD
cM Map	6		ENTREZGENE

Sequence:

show sequence

GTCATCCTTCTTGTTCTTTTCCACTTGTAACGTTCACTGTTTGAGAAGAGACTCCGAGGAGCGT
AAGATATTCAGGCTACTCCTCTAGACACCTTTCTGCGCGAGCCTGAGCCCATGCCAAGGTCCCG
GGGTCCTGAGAGTGTCATTGGGGGATGACCGCAACAGTAGTTGCTGCGGCTGCCACTGCAACCA
TGGTCTCCAGCAGCAGCGGCCTCGCCGCCGCCCGCCTGTTGTCGCGCACCTTCCTCCTGCAACA
GAATGGGATACGACACGGGTCTTACACAGCCTCTCGGAAACATATCTATATTGATAAAAATACG
AAGATTATTTGCCAGGGTTTCACAGGCAAACAGGGTACCTTTCACAGTCAGCAGGCTTTGGAGT
ACGGCACCAAACTCGTGGGAGGAACCACTCCAGGGAAGGGTGGCCAGAAGCACCTGGGCTTGCC
CGTCTTTAATACTGTGAAGGAAGCCAAAGAGAAAACAGGAGCAACGGCTTCTGTCATCTATGTC
CCTCCTCCTTTTGCTGCTGCTGCCATTAATGAAGCAATCGACGCGGAGATTCCCTTGGTTGTGT
GCATTACGGAAGGTATTCCGCAGCAGGATATGGTGCGGGTCAAGCACAGACTGACACGCCAGGG
AACGACGAGGCTAATCGGGCCAAACTGCCCCGGCGTCATCAACCCTGGAGAATGCAAAATCGGC
ATCATGCCTGGCCACATTCACAAGAAGGGAAGAATAGGTATCGTGTCCAGGTCCGGTACTCTGA
CTTATGAAGCAGTTCACCAAACAACCCAAGTCGGATTGGGGCAGTCCTTGTGTATTGGCATTGG
AGGTGACCCTTTTAATGGGACTGATTTTATTGATTGCCTTGAAGTCTTCCTGAATGATCCAGCC
ACAGAAGGCATCATACTGATTGGTGAAATTGGTGGTCACGCTGAAGAAAATGCTGCCGCGTTTC
TGAAGGAGCATAACTCAGGTCCAAAGGCCAAGCCTGTAGTGTCCTTCATTGCTGGTATAACTGC
TCCTCCTGGCAGAAGGATGGGCCATGCAGGGGCAATTATTGCTGGAGGAAAAGGTGGCGCTAAA
GAGAAGATCTCTGCTCTTCAGAGTGCTGGGGTGGTTGTCAGCATGTCCCCCGCACAGCTGGGAA
CTACCATTTATAAGGAGTTTGAAAAGAGGAAGATGCTTTGAAGGACACAACAAGAAATTCTTTA
AAGCTGTGGAAGAAATCTAGACGTGAGGGCCAGTCCAGGCTGTCAGCCCATGCAGCTGACACTG
GTTGGTCTCTCAGTATGTGGGAAATCCAGGCAAGTTTTAGAATGTCCTAAATTGAGCTATTTTC
ACTTACTGTGTAACAGAGACAGATAATAAATCTATCATTTGATTTGAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_063932	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD33927	(Get FASTA)	NCBI Sequence Viewer
	AAH11087	(Get FASTA)	NCBI Sequence Viewer
	BAB22331	(Get FASTA)	NCBI Sequence Viewer
	BAB23804	(Get FASTA)	NCBI Sequence Viewer
	BAC40634	(Get FASTA)	NCBI Sequence Viewer
	EDK99000	(Get FASTA)	NCBI Sequence Viewer
	EDK99001	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000065113
	ENSMUSP00000065113.7
	ENSMUSP00000134171.2
	ENSMUSP00000145246.2
GenBank Protein	Q9WUM5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_063932 ⟸ NM_019879
- Peptide Label:	precursor
- UniProtKB:	Q9DBA3 (UniProtKB/Swiss-Prot), Q8C2C3 (UniProtKB/Swiss-Prot), Q9DCI8 (UniProtKB/Swiss-Prot), Q9WUM5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MTATVVAAAATATMVSSSSGLAAARLLSRTFLLQQNGIRHGSYTASRKHIYIDKNTKIICQGFT GKQGTFHSQQALEYGTKLVGGTTPGKGGQKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAA INEAIDAEIPLVVCITEGIPQQDMVRVKHRLTRQGTTRLIGPNCPGVINPGECKIGIMPGHIHK KGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTDFIDCLEVFLNDPATEGIILIG EIGGHAEENAAAFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQS AGVVVSMSPAQLGTTIYKEFEKRKML hide sequence

RefSeq Acc Id:

ENSMUSP00000145246 ⟸ ENSMUST00000203632

RefSeq Acc Id:

ENSMUSP00000134171 ⟸ ENSMUST00000123159

RefSeq Acc Id:

ENSMUSP00000065113 ⟸ ENSMUST00000064740

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WUM5-F1-model_v2	AlphaFold	Q9WUM5	1-346	view protein structure

Promoters

RGD ID:

6840036

Promoter ID:

MM_KWN:46494

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000057082, OTTMUST00000057083, OTTMUST00000057084

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	6	73,198,396 - 73,198,896 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1927234	AgrOrtholog
Ensembl Genes	ENSMUSG00000052738	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000064740	ENTREZGENE
	ENSMUST00000064740.9	UniProtKB/Swiss-Prot
	ENSMUST00000123159.8	UniProtKB/TrEMBL
	ENSMUST00000203632.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.261	UniProtKB/Swiss-Prot
	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cit_synth/succinyl-CoA_lig_AS	UniProtKB/Swiss-Prot
	Citrt_syn/SCS-alpha_CS	UniProtKB/Swiss-Prot
	CoA-bd	UniProtKB/Swiss-Prot
	CoA_lig_alpha	UniProtKB/Swiss-Prot
	CoA_ligase	UniProtKB/Swiss-Prot
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot
	Succinyl-CoA_synth-like	UniProtKB/Swiss-Prot
KEGG Report	mmu:56451	UniProtKB/Swiss-Prot
MGD	MGI:1927234	ENTREZGENE
NCBI Gene	56451	ENTREZGENE
PANTHER	SUCCINATE--COA LIGASE [ADP/GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	SUCCINYL-COA LIGASE SUBUNIT ALPHA	UniProtKB/Swiss-Prot
Pfam	CoA_binding	UniProtKB/Swiss-Prot
	Ligase_CoA	UniProtKB/Swiss-Prot
PhenoGen	Suclg1	PhenoGen
PIRSF	SucCS_alpha	UniProtKB/Swiss-Prot
PRINTS	SCOASYNTHASE	UniProtKB/Swiss-Prot
PROSITE	SUCCINYL_COA_LIG_1	UniProtKB/Swiss-Prot
	SUCCINYL_COA_LIG_2	UniProtKB/Swiss-Prot
SMART	CoA_binding	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot
	SSF52210	UniProtKB/Swiss-Prot
UniProt	A0A0N4SVU4_MOUSE	UniProtKB/TrEMBL
	G3UYP8_MOUSE	UniProtKB/TrEMBL
	Q8C2C3	ENTREZGENE
	Q9DBA3	ENTREZGENE
	Q9DCI8	ENTREZGENE
	Q9WUM5	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q8C2C3	UniProtKB/Swiss-Prot
	Q9DBA3	UniProtKB/Swiss-Prot
	Q9DCI8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype