Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1) - Rat Genome Database
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Gene: Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1) Mus musculus
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Symbol: Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
RGD ID: 1321628
MGI Page MGI
Description: Is expressed in several structures, including limb; lower jaw; metanephros; nervous system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness and enlarged vestibular aqueduct. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1); PARTICIPATES IN oxidative phosphorylation pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,1-dichloroethene; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atp6; Atp6b1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1; ATPase, H+ transporting, V1 subunit B; ATPase, H+ transporting, V1 subunit B, isoform 1; AW208839; D630003L15; D630030L16Rik; D630039P21Rik; lysosomal 56/58kDa; V; V-type proton ATPase subunit B, kidney isoform; Vp; Vpp-3; Vpp3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,719,999 - 83,735,837 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,719,972 - 83,735,837 (+)Ensembl
GRCm38683,743,017 - 83,758,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,742,990 - 83,758,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,693,011 - 83,708,804 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,708,675 - 83,724,468 (+)NCBImm8
Celera685,725,645 - 85,742,032 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7663508   PMID:7945239   PMID:8751373   PMID:9680377   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12782355   PMID:14585495   PMID:14611657  
PMID:14681479   PMID:16077082   PMID:16141072   PMID:16141073   PMID:16144965   PMID:16174750   PMID:16177003   PMID:16602821   PMID:16985514   PMID:17079272   PMID:17392376   PMID:17686781  
PMID:17898041   PMID:17959750   PMID:17971301   PMID:18667600   PMID:19214237   PMID:19470676   PMID:19855135   PMID:20181927   PMID:20428099   PMID:20711468   PMID:21267068   PMID:22872862  
PMID:23028982   PMID:23269648   PMID:23761626   PMID:23874234   PMID:24051376   PMID:24583262   PMID:25107366   PMID:26404731   PMID:26442671   PMID:26490995   PMID:26839965   PMID:27384406  
PMID:28215940   PMID:28577314   PMID:28705898   PMID:28934385   PMID:28994389   PMID:29054531   PMID:29843146   PMID:29993276   PMID:30377232   PMID:31386675  


Genomics

Comparative Map Data
Atp6v1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,719,999 - 83,735,837 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,719,972 - 83,735,837 (+)Ensembl
GRCm38683,743,017 - 83,758,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,742,990 - 83,758,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,693,011 - 83,708,804 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,708,675 - 83,724,468 (+)NCBImm8
Celera685,725,645 - 85,742,032 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
ATP6V1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,935,900 - 70,965,431 (+)EnsemblGRCh38hg38GRCh38
GRCh38270,935,900 - 70,965,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37271,163,030 - 71,192,561 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36271,016,506 - 71,046,069 (+)NCBINCBI36hg18NCBI36
Build 34271,074,674 - 71,104,207NCBI
Celera271,013,684 - 71,043,243 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,899,497 - 70,928,997 (+)NCBIHuRef
CHM1_1271,092,347 - 71,121,872 (+)NCBICHM1_1
Atp6v1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24116,223,799 - 116,242,475 (+)NCBI
Rnor_6.0 Ensembl4115,416,580 - 115,437,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04115,417,100 - 115,435,754 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04180,004,952 - 180,024,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,931,972 - 117,950,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14118,176,425 - 118,194,509 (+)NCBI
Celera4105,216,251 - 105,234,921 (+)NCBICelera
Cytogenetic Map4q34NCBI
Atp6v1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,256,096 - 14,282,410 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,256,096 - 14,281,572 (-)NCBIChiLan1.0ChiLan1.0
ATP6V1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A72,113,863 - 72,143,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A72,113,859 - 72,143,612 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A71,000,096 - 71,030,306 (+)NCBIMhudiblu_PPA_v0panPan3
ATP6V1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1069,252,926 - 69,287,542 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11069,261,311 - 69,287,540 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Atp6v1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649115,112,422 - 15,138,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6V1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,560,738 - 71,591,856 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,560,102 - 71,591,885 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,019,974 - 75,027,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6V1B1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,149,074 - 36,179,145 (-)NCBI
ChlSab1.1 Ensembl1436,149,006 - 36,177,671 (-)Ensembl
Atp6v1b1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247622,445,840 - 2,480,377 (-)NCBI

Position Markers
AW208839  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,751,084 - 83,751,196UniSTSGRCm38
MGSCv37683,701,078 - 83,701,190UniSTSGRCm37
Celera685,733,718 - 85,733,830UniSTS
Cytogenetic Map6C3UniSTS
cM Map632.9UniSTS
Whitehead/MRC_RH6855.51UniSTS
Atp6v1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
cM Map632.9UniSTS
Atp6b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,102,777 - 69,103,284UniSTSGRCm38
MGSCv37871,626,676 - 71,627,183UniSTSGRCm37
Celera871,652,521 - 71,653,028UniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map6 UniSTS
cM Map833.0UniSTS
Atp6b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,102,777 - 69,103,413UniSTSGRCm38
MGSCv37871,626,676 - 71,627,312UniSTSGRCm37
Celera871,652,521 - 71,653,158UniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.0UniSTS
Atp6v1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:132
Interacting mature miRNAs:141
Transcripts:ENSMUST00000006431
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_134157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC090647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB173989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000006431   ⟹   ENSMUSP00000006431
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,742,990 - 83,758,855 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205763   ⟹   ENSMUSP00000145710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,743,094 - 83,754,759 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205867
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,743,049 - 83,750,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206052
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,757,139 - 83,758,232 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206652
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,751,833 - 83,753,866 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206911   ⟹   ENSMUSP00000146154
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,743,064 - 83,751,305 (+)Ensembl
RefSeq Acc Id: NM_134157   ⟹   NP_598918
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,719,999 - 83,735,837 (+)NCBI
GRCm38683,743,017 - 83,758,855 (+)NCBI
MGSCv37683,693,011 - 83,708,804 (+)RGD
Celera685,725,645 - 85,742,032 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598918   ⟸   NM_134157
- UniProtKB: Q91YH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006431   ⟸   ENSMUST00000006431
RefSeq Acc Id: ENSMUSP00000146154   ⟸   ENSMUST00000206911
RefSeq Acc Id: ENSMUSP00000145710   ⟸   ENSMUST00000205763
Protein Domains
ATP-synt_ab   ATP-synt_ab_N

Promoters
RGD ID:6838968
Promoter ID:MM_KWN:46627
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_134157
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,692,781 - 83,693,281 (+)MPROMDB
RGD ID:6890184
Promoter ID:EPDNEW_M8543
Type:initiation region
Name:Atp6v1b1_1
Description:Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,743,017 - 83,743,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103285 AgrOrtholog
Ensembl Genes ENSMUSG00000006269 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000006431 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000145710 UniProtKB/TrEMBL
  ENSMUSP00000146154 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006431 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000205763 UniProtKB/TrEMBL
  ENSMUST00000206911 UniProtKB/TrEMBL
InterPro ATPase_a/bsu_AS UniProtKB/TrEMBL
  ATPase_a/bsu_N UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/TrEMBL
  ATPase_V1-cplx_bsu UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  V-ATPase_su_B/beta UniProtKB/TrEMBL
KEGG Report mmu:110935 UniProtKB/TrEMBL
MGD MGI:103285 ENTREZGENE
NCBI Gene 110935 ENTREZGENE
PANTHER PTHR43389 UniProtKB/TrEMBL
Pfam ATP-synt_ab UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/TrEMBL
PhenoGen Atp6v1b1 PhenoGen
PIRSF V-ATPsynth_beta/V-ATPase_B UniProtKB/TrEMBL
PROSITE ATPASE_ALPHA_BETA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs V-ATPase_V1_B UniProtKB/TrEMBL
UniProt A0A0U1RNU9_MOUSE UniProtKB/TrEMBL
  A0A0U1RPW7_MOUSE UniProtKB/TrEMBL
  Q66JS0_MOUSE UniProtKB/TrEMBL
  Q6P6I3_MOUSE UniProtKB/TrEMBL
  Q8C3L6_MOUSE UniProtKB/TrEMBL
  Q91YH6 ENTREZGENE, UniProtKB/TrEMBL
  Q99KA3_MOUSE UniProtKB/TrEMBL