Hint3 (histidine triad nucleotide binding protein 3) - Rat Genome Database

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Gene: Hint3 (histidine triad nucleotide binding protein 3) Mus musculus
Analyze
Symbol: Hint3
Name: histidine triad nucleotide binding protein 3
RGD ID: 1550488
MGI Page MGI
Description: Predicted to enable adenosine 5'-monophosphoramidase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in embryo; liver; lung; metanephros; and spleen. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0610010I17Rik; adenosine 5'-monophosphoramidase HINT3; AV009015; expressed sequence AV009015; HIN; HINT-3; HINT-4; HINT4; histidine triad nucleotide-binding protein 3; histidine triad protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,479,191 - 30,499,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,484,137 - 30,505,628 (-)EnsemblGRCm39 Ensembl
GRCm381030,603,195 - 30,623,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,608,141 - 30,629,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,328,013 - 30,338,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,297,623 - 30,307,782 (-)NCBIMGSCv36mm8
Celera1031,534,282 - 31,544,441 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12748294   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:28609438   PMID:31088288  


Genomics

Comparative Map Data
Hint3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,479,191 - 30,499,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,484,137 - 30,505,628 (-)EnsemblGRCm39 Ensembl
GRCm381030,603,195 - 30,623,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,608,141 - 30,629,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,328,013 - 30,338,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,297,623 - 30,307,782 (-)NCBIMGSCv36mm8
Celera1031,534,282 - 31,544,441 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.1NCBI
HINT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,956,770 - 125,980,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6125,956,770 - 125,980,244 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,277,916 - 126,301,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,319,629 - 126,341,265 (+)NCBINCBI36Build 36hg18NCBI36
Build 346126,319,628 - 126,341,265NCBI
Celera6127,020,206 - 127,043,674 (+)NCBICelera
Cytogenetic Map6q22.32NCBI
HuRef6123,854,165 - 123,877,740 (+)NCBIHuRef
CHM1_16126,541,832 - 126,565,299 (+)NCBICHM1_1
T2T-CHM13v2.06127,145,464 - 127,168,867 (+)NCBIT2T-CHM13v2.0
Hint3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,854,860 - 28,864,723 (+)NCBIGRCr8
mRatBN7.2127,035,936 - 27,045,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,035,905 - 27,047,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,787,103 - 26,796,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,786,909 - 32,796,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,987,684 - 26,997,532 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,413,425 - 29,423,288 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,413,365 - 29,423,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,852,923 - 30,864,803 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,719,396 - 27,729,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,722,396 - 27,732,198 (+)NCBI
Celera125,712,849 - 25,722,713 (+)NCBICelera
Cytogenetic Map1p11NCBI
Hint3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,254,675 - 7,266,111 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,254,572 - 7,265,936 (+)NCBIChiLan1.0ChiLan1.0
HINT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25145,946,826 - 145,970,499 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16143,852,094 - 143,875,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06123,741,237 - 123,764,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16127,859,194 - 127,882,535 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,859,194 - 127,882,535 (+)Ensemblpanpan1.1panPan2
HINT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,831,833 - 64,850,594 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,636,112 - 65,660,357 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,036,946 - 65,061,118 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,036,893 - 65,127,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1164,964,622 - 64,988,869 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,752,433 - 64,777,544 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,403,324 - 65,427,591 (+)NCBIUU_Cfam_GSD_1.0
Hint3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,902,766 - 114,914,010 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366393,505,101 - 3,516,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366393,505,107 - 3,516,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HINT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,008,504 - 37,023,935 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,008,063 - 37,024,203 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,782,700 - 40,795,796 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,741,551 - 47,764,977 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,740,440 - 47,764,916 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604020,052,713 - 20,081,126 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hint3
384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:82
Interacting mature miRNAs:88
Transcripts:ENSMUST00000019925, ENSMUST00000160646, ENSMUST00000161074
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102689026446720483Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019925   ⟹   ENSMUSP00000019925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,484,379 - 30,494,333 (-)Ensembl
GRCm38.p6 Ensembl1030,608,383 - 30,618,337 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160646   ⟹   ENSMUSP00000125125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,484,345 - 30,494,329 (-)Ensembl
GRCm38.p6 Ensembl1030,608,349 - 30,618,333 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161074   ⟹   ENSMUSP00000125552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,484,137 - 30,494,475 (-)Ensembl
GRCm38.p6 Ensembl1030,608,141 - 30,618,479 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,492,197 - 30,494,361 (-)Ensembl
GRCm38.p6 Ensembl1030,616,201 - 30,618,365 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,484,227 - 30,505,628 (-)Ensembl
GRCm38.p6 Ensembl1030,608,231 - 30,629,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217266
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,488,104 - 30,490,548 (-)Ensembl
GRCm38.p6 Ensembl1030,612,108 - 30,614,552 (-)Ensembl
RefSeq Acc Id: NM_025798   ⟹   NP_080074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391030,484,203 - 30,494,362 (-)NCBI
GRCm381030,608,207 - 30,618,366 (-)NCBI
MGSCv371030,328,013 - 30,338,172 (-)RGD
Celera1031,534,282 - 31,544,441 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512823   ⟹   XP_006512886
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391030,479,191 - 30,499,526 (-)NCBI
GRCm381030,603,195 - 30,623,530 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080074   ⟸   NM_025798
- UniProtKB: Q9CPS6 (UniProtKB/Swiss-Prot),   F8WH96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512886   ⟸   XM_006512823
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000125125   ⟸   ENSMUST00000160646
RefSeq Acc Id: ENSMUSP00000019925   ⟸   ENSMUST00000019925
RefSeq Acc Id: ENSMUSP00000125552   ⟸   ENSMUST00000161074
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CPS6-F1-model_v2 AlphaFold Q9CPS6 1-165 view protein structure

Promoters
RGD ID:6819434
Promoter ID:MM_KWN:3841
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000069486,   OTTMUST00000069487,   OTTMUST00000069488
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361030,337,841 - 30,338,452 (-)MPROMDB
RGD ID:8671810
Promoter ID:EPDNEW_M13899
Type:multiple initiation site
Name:Hint3_1
Description:Mus musculus histidine triad nucleotide binding protein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381030,618,359 - 30,618,419EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914097 AgrOrtholog
Ensembl Genes ENSMUSG00000019791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019925.7 UniProtKB/TrEMBL
  ENSMUST00000160646.3 UniProtKB/TrEMBL
  ENSMUST00000161074 ENTREZGENE
  ENSMUST00000161074.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.428.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HIT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66847 UniProtKB/Swiss-Prot
MGD MGI:1914097 ENTREZGENE
NCBI Gene 66847 ENTREZGENE
PANTHER APRATAXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DcpS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hint3 PhenoGen
PROSITE HIT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q7F8_MOUSE UniProtKB/TrEMBL
  F8WH96 ENTREZGENE, UniProtKB/TrEMBL
  HINT3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Hint3  histidine triad nucleotide binding protein 3  AV009015  expressed sequence AV009015  Data merged from RGD:1610540 737654 PROVISIONAL