Arhgef15 (Rho guanine nucleotide exchange factor 15) - Rat Genome Database

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Gene: Arhgef15 (Rho guanine nucleotide exchange factor 15) Mus musculus
Analyze
Symbol: Arhgef15
Name: Rho guanine nucleotide exchange factor 15 (Ensembl:Rho guanine nucleotide exchange factor (GEF) 15)
RGD ID: 1617148
MGI Page MGI
Description: Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation and regulation of postsynapse assembly. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D130071N09; D530030K12Rik; E5; ephexin-5; MGC102247; MGC144141; MGC144142; Rho guanine nucleotide exchange factor (GEF) 15; RP23-396M19.6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,819,726 - 68,847,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,833,981 - 68,848,306 (-)EnsemblGRCm39 Ensembl
GRCm381168,928,900 - 68,956,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,943,155 - 68,957,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,756,656 - 68,770,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,759,349 - 68,773,053 (-)NCBIMGSCv36mm8
Celera1175,885,590 - 75,899,659 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15368895   PMID:16141072   PMID:16141073   PMID:18799693   PMID:19501082   PMID:21029865  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22535667   PMID:23029280   PMID:24003143   PMID:24194600   PMID:26073538   PMID:27626380   PMID:28185854   PMID:28346227   PMID:30485813  
PMID:32325033   PMID:36001358   PMID:36603298   PMID:36929019  


Genomics

Comparative Map Data
Arhgef15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,819,726 - 68,847,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,833,981 - 68,848,306 (-)EnsemblGRCm39 Ensembl
GRCm381168,928,900 - 68,956,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,943,155 - 68,957,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,756,656 - 68,770,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,759,349 - 68,773,053 (-)NCBIMGSCv36mm8
Celera1175,885,590 - 75,899,659 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.21NCBI
ARHGEF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,310,241 - 8,322,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,310,241 - 8,322,514 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,213,559 - 8,225,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,154,315 - 8,166,554 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,154,314 - 8,166,553NCBI
Celera178,244,326 - 8,256,604 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,108,796 - 8,121,074 (+)NCBIHuRef
CHM1_1178,222,461 - 8,234,738 (+)NCBICHM1_1
T2T-CHM13v2.0178,216,478 - 8,228,747 (+)NCBIT2T-CHM13v2.0
Arhgef15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,149,372 - 54,162,128 (-)NCBIGRCr8
mRatBN7.21053,650,521 - 53,663,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,650,553 - 53,663,913 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,311,746 - 58,324,031 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,800,344 - 57,812,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,309,305 - 53,321,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,532,097 - 55,545,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,532,077 - 55,544,429 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,274,558 - 55,288,124 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,703,919 - 55,716,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,719,072 - 55,729,109 (-)NCBI
Celera1052,816,914 - 52,829,189 (-)NCBICelera
Cytogenetic Map10q24NCBI
Arhgef15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,587,873 - 8,602,747 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,590,217 - 8,603,778 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,430,225 - 65,448,985 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,239,706 - 70,258,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,336,764 - 43,349,787 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,070,223 - 48,082,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,070,223 - 48,082,499 (-)Ensemblpanpan1.1panPan2
ARHGEF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,096,108 - 33,110,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,098,159 - 33,121,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,232,023 - 33,246,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,199,015 - 33,213,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,199,053 - 33,213,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,165,967 - 33,180,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,121,691 - 33,136,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,301,486 - 33,316,166 (+)NCBIUU_Cfam_GSD_1.0
Arhgef15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,057,476 - 48,071,035 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,534,717 - 1,543,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,531,694 - 1,545,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,495,453 - 53,506,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,495,409 - 53,506,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,970,955 - 55,981,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,674,190 - 7,687,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,674,577 - 7,687,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,892,422 - 10,901,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,872,793 - 10,902,948 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef15
823 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1845
Count of miRNA genes:622
Interacting mature miRNAs:809
Transcripts:ENSMUST00000065040, ENSMUST00000108670, ENSMUST00000108671, ENSMUST00000131686, ENSMUST00000141747, ENSMUST00000151520
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001364772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001780023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_388487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_388488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_879714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK051749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY132845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000065040   ⟹   ENSMUSP00000067684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,833,981 - 68,845,900 (-)Ensembl
GRCm38.p6 Ensembl1168,943,155 - 68,955,074 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108670
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,839,058 - 68,843,000 (-)Ensembl
GRCm38.p6 Ensembl1168,948,232 - 68,952,174 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108671   ⟹   ENSMUSP00000104311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,833,983 - 68,848,306 (-)Ensembl
GRCm38.p6 Ensembl1168,943,157 - 68,957,480 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,835,353 - 68,838,206 (-)Ensembl
GRCm38.p6 Ensembl1168,944,527 - 68,947,380 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,837,273 - 68,838,491 (-)Ensembl
GRCm38.p6 Ensembl1168,946,447 - 68,947,665 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1168,837,127 - 68,838,651 (-)Ensembl
GRCm38.p6 Ensembl1168,946,301 - 68,947,825 (-)Ensembl
RefSeq Acc Id: NM_001364772   ⟹   NP_001351701
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,713 (-)NCBI
GRCm381168,943,154 - 68,956,887 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177566   ⟹   NP_808234
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,713 (-)NCBI
GRCm381168,943,154 - 68,956,887 (-)NCBI
MGSCv371168,756,656 - 68,770,360 (-)RGD
Celera1175,885,590 - 75,899,659 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006533664   ⟹   XP_006533727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006533669   ⟹   XP_006533732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,837,434 - 68,847,760 (-)NCBI
GRCm381168,946,608 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249112   ⟹   XP_011247414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,726 - 68,847,760 (-)NCBI
GRCm381168,928,900 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249114   ⟹   XP_011247416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,991 - 68,847,760 (-)NCBI
GRCm381168,929,165 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249115   ⟹   XP_011247417
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249116   ⟹   XP_011247418
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249117   ⟹   XP_011247419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,991 - 68,847,760 (-)NCBI
GRCm381168,929,165 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249118   ⟹   XP_011247420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,726 - 68,847,760 (-)NCBI
GRCm381168,929,017 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249119   ⟹   XP_011247421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,991 - 68,847,760 (-)NCBI
GRCm381168,929,165 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249120   ⟹   XP_011247422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249121   ⟹   XP_011247423
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,825,160 - 68,847,760 (-)NCBI
GRCm381168,934,334 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249122   ⟹   XP_011247424
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,726 - 68,847,760 (-)NCBI
GRCm381168,934,326 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017314643   ⟹   XP_017170132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246113   ⟹   XP_030101973
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,991 - 68,847,760 (-)NCBI
GRCm381168,929,165 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246114   ⟹   XP_030101974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246115   ⟹   XP_030101975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001780023
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949471
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XR_388487
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XR_388488
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,833,980 - 68,847,760 (-)NCBI
GRCm381168,943,154 - 68,956,934 (-)NCBI
Sequence:
RefSeq Acc Id: XR_879714
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,819,726 - 68,847,760 (-)NCBI
GRCm381168,933,065 - 68,956,934 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001351701 (Get FASTA)   NCBI Sequence Viewer  
  NP_808234 (Get FASTA)   NCBI Sequence Viewer  
  XP_006533727 (Get FASTA)   NCBI Sequence Viewer  
  XP_006533732 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247414 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247416 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247417 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247418 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247419 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247420 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247421 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247422 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247423 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247424 (Get FASTA)   NCBI Sequence Viewer  
  XP_017170132 (Get FASTA)   NCBI Sequence Viewer  
  XP_030101973 (Get FASTA)   NCBI Sequence Viewer  
  XP_030101974 (Get FASTA)   NCBI Sequence Viewer  
  XP_030101975 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89365 (Get FASTA)   NCBI Sequence Viewer  
  AAI16344 (Get FASTA)   NCBI Sequence Viewer  
  AAI16345 (Get FASTA)   NCBI Sequence Viewer  
  BAC34752 (Get FASTA)   NCBI Sequence Viewer  
  BAD32339 (Get FASTA)   NCBI Sequence Viewer  
  EDL10460 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000067684
  ENSMUSP00000067684.7
  ENSMUSP00000104311.2
GenBank Protein Q5FWH6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_808234   ⟸   NM_177566
- Peptide Label: isoform 1
- UniProtKB: Q14B44 (UniProtKB/Swiss-Prot),   Q69ZV7 (UniProtKB/Swiss-Prot),   Q5FWH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006533727   ⟸   XM_006533664
- Peptide Label: isoform X5
- UniProtKB: Q14B44 (UniProtKB/Swiss-Prot),   Q69ZV7 (UniProtKB/Swiss-Prot),   Q5FWH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006533732   ⟸   XM_006533669
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_011247414   ⟸   XM_011249112
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011247420   ⟸   XM_011249118
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_011247419   ⟸   XM_011249117
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011247421   ⟸   XM_011249119
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_011247416   ⟸   XM_011249114
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011247424   ⟸   XM_011249122
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_011247423   ⟸   XM_011249121
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_011247422   ⟸   XM_011249120
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_011247418   ⟸   XM_011249116
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011247417   ⟸   XM_011249115
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017170132   ⟸   XM_017314643
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_030101973   ⟸   XM_030246113
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030101975   ⟸   XM_030246115
- Peptide Label: isoform X13
RefSeq Acc Id: XP_030101974   ⟸   XM_030246114
- Peptide Label: isoform X11
RefSeq Acc Id: NP_001351701   ⟸   NM_001364772
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000067684   ⟸   ENSMUST00000065040
RefSeq Acc Id: ENSMUSP00000104311   ⟸   ENSMUST00000108671
Protein Domains
DH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FWH6-F1-model_v2 AlphaFold Q5FWH6 1-849 view protein structure

Promoters
RGD ID:6820413
Promoter ID:MM_KWN:8006
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC007JOM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361168,769,261 - 68,769,761 (-)MPROMDB
RGD ID:6820412
Promoter ID:MM_KWN:8007
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_177566
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361168,770,111 - 68,770,611 (-)MPROMDB
RGD ID:8675126
Promoter ID:EPDNEW_M15594
Type:multiple initiation site
Name:Arhgef15_1
Description:Mus musculus Rho guanine nucleotide exchange factor 15 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381168,956,887 - 68,956,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045246 AgrOrtholog
Ensembl Genes ENSMUSG00000052921 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065040 ENTREZGENE
  ENSMUST00000065040.13 UniProtKB/Swiss-Prot
  ENSMUST00000108671.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephexin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_ephexin UniProtKB/Swiss-Prot
KEGG Report mmu:442801 UniProtKB/Swiss-Prot
MGD MGI:3045246 ENTREZGENE
NCBI Gene 442801 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef15 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARHGF_MOUSE UniProtKB/Swiss-Prot
  Q14B44 ENTREZGENE
  Q5FWH6 ENTREZGENE
  Q69ZV7 ENTREZGENE
  Q8BII0_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q14B44 UniProtKB/Swiss-Prot
  Q69ZV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Arhgef15  Rho guanine nucleotide exchange factor 15  Arhgef15  Rho guanine nucleotide exchange factor (GEF) 15  Symbol and/or name change 5135510 APPROVED