Mrpl53 (mitochondrial ribosomal protein L53) - Rat Genome Database

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Gene: Mrpl53 (mitochondrial ribosomal protein L53) Mus musculus
Analyze
Symbol: Mrpl53
Name: mitochondrial ribosomal protein L53
RGD ID: 1315481
MGI Page MGI
Description: Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; pancreas epithelium; retina; and submandibular gland primordium. Orthologous to human MRPL53 (mitochondrial ribosomal protein L53).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1110007K17Rik; 39S ribosomal protein L53, mitochondrial; L53mt; large ribosomal subunit protein mL53; MRP-L53
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,086,089 - 83,086,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,086,021 - 83,086,920 (+)EnsemblGRCm39 Ensembl
GRCm38683,109,108 - 83,109,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,109,040 - 83,109,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,059,102 - 83,059,926 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,072,709 - 83,075,597 (+)NCBIMGSCv36mm8
Celera685,091,808 - 85,092,632 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18554416   PMID:18614015  
PMID:21267068   PMID:21873635   PMID:23341629   PMID:25278503   PMID:27023846   PMID:29222160   PMID:32325033   PMID:32987154  


Genomics

Comparative Map Data
Mrpl53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,086,089 - 83,086,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,086,021 - 83,086,920 (+)EnsemblGRCm39 Ensembl
GRCm38683,109,108 - 83,109,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,109,040 - 83,109,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,059,102 - 83,059,926 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,072,709 - 83,075,597 (+)NCBIMGSCv36mm8
Celera685,091,808 - 85,092,632 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
MRPL53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,471,982 - 74,472,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,471,982 - 74,472,687 (-)EnsemblGRCh38hg38GRCh38
GRCh37274,699,109 - 74,699,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,552,617 - 74,553,435 (-)NCBINCBI36Build 36hg18NCBI36
Build 34274,610,765 - 74,611,582NCBI
Celera274,530,297 - 74,531,115 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,435,357 - 74,436,214 (-)NCBIHuRef
CHM1_1274,628,501 - 74,629,358 (-)NCBICHM1_1
T2T-CHM13v2.0274,480,549 - 74,481,247 (-)NCBIT2T-CHM13v2.0
Mrpl53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,173,043 - 117,173,933 (+)NCBIGRCr8
mRatBN7.24115,615,329 - 115,616,219 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4121,091,950 - 121,092,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,867,143 - 116,868,033 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,481,711 - 115,482,601 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,942,037 - 113,942,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,942,041 - 113,942,674 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,807,765 - 114,808,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,627,009 - 178,627,899 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,321,318 - 117,322,208 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,565,528 - 117,566,686 (+)NCBI
Celera4104,609,848 - 104,610,738 (+)NCBICelera
Cytogenetic Map4q34NCBI
Mrpl53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,312,778 - 11,314,564 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,312,778 - 11,314,564 (+)NCBIChiLan1.0ChiLan1.0
MRPL53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,663,271 - 48,666,078 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,663,598 - 48,664,554 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,305,344 - 48,307,970 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,522,699 - 49,525,326 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11748,539,822 - 48,542,449 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,606,586 - 48,609,212 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,164,289 - 49,166,915 (+)NCBIUU_Cfam_GSD_1.0
Mrpl53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,045,414 - 10,046,385 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556691,511 - 692,563 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556691,511 - 693,366 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1368,570,198 - 68,573,584 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,848,728 - 71,850,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mrpl53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,035,241 - 29,036,502 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,035,274 - 29,035,895 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:356
Count of miRNA genes:278
Interacting mature miRNAs:291
Transcripts:ENSMUST00000113938, ENSMUST00000129656
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000113938   ⟹   ENSMUSP00000109571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,086,021 - 83,086,920 (+)Ensembl
GRCm38.p6 Ensembl683,109,040 - 83,109,939 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,086,101 - 83,086,920 (+)Ensembl
GRCm38.p6 Ensembl683,109,120 - 83,109,939 (+)Ensembl
RefSeq Acc Id: NM_026744   ⟹   NP_081020
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,086,089 - 83,086,913 (+)NCBI
GRCm38683,109,108 - 83,109,932 (+)ENTREZGENE
MGSCv37683,059,102 - 83,059,926 (+)RGD
Celera685,091,808 - 85,092,632 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_081020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH22162 (Get FASTA)   NCBI Sequence Viewer  
  AAH65995 (Get FASTA)   NCBI Sequence Viewer  
  BAB22849 (Get FASTA)   NCBI Sequence Viewer  
  EDK99060 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000109571
  ENSMUSP00000109571.4
GenBank Protein Q9D1H8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_081020   ⟸   NM_026744
- UniProtKB: Q9D1H8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000109571   ⟸   ENSMUST00000113938

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D1H8-F1-model_v2 AlphaFold Q9D1H8 1-118 view protein structure

Promoters
RGD ID:6839658
Promoter ID:MM_KWN:46573
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000059406,   UC009CMM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,057,801 - 83,059,192 (+)MPROMDB
RGD ID:6890164
Promoter ID:EPDNEW_M8516
Type:multiple initiation site
Name:Mrpl53_1
Description:Mus musculus mitochondrial ribosomal protein L53 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,109,082 - 83,109,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915749 AgrOrtholog
Ensembl Genes ENSMUSG00000030037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113938 ENTREZGENE
  ENSMUST00000113938.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro mtLSU_mL53 UniProtKB/Swiss-Prot
  Ribosomal_L53_mit UniProtKB/Swiss-Prot
KEGG Report mmu:68499 UniProtKB/Swiss-Prot
MGD MGI:1915749 ENTREZGENE
NCBI Gene 68499 ENTREZGENE
PANTHER 39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL UniProtKB/Swiss-Prot
  39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam MRP_L53 UniProtKB/Swiss-Prot
PhenoGen Mrpl53 PhenoGen
UniProt Q9D1H8 ENTREZGENE, UniProtKB/Swiss-Prot