Prkcb (protein kinase C, beta) - Rat Genome Database

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Gene: Prkcb (protein kinase C, beta) Mus musculus
Analyze
Symbol: Prkcb
Name: protein kinase C, beta
RGD ID: 1550017
MGI Page MGI
Description: Enables calcium channel regulator activity and protein kinase C activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; and response to hypoxia. Located in cytoplasm; membrane; and nucleus. Part of spectrin. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; retina; and salivary gland. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1-dichloroethene; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A130082F03Rik; Pkc; PKC-B; PKC-Be; PKC-Beta; Pkcb; Prkc; Prkcb1; Prkcb2; protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,888,327 - 122,233,625 (+)NCBIGRCm39mm39
GRCm39 Ensembl7121,887,974 - 122,233,625 (+)Ensembl
GRCm387122,289,104 - 122,634,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,288,751 - 122,634,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,432,639 - 129,777,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv367122,080,445 - 122,419,795 (+)NCBImm8
Celera7122,177,656 - 122,520,472 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bryostatin 1  (ISO)
bupivacaine  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
cannabigerol  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clopidogrel  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
D-mannitol  (ISO)
daidzein  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dicofol  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluvoxamine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
losartan  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
Mezerein  (ISO)
ML-7  (ISO)
morphine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pterostilbene  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sotrastaurin  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
tetrodotoxin  (ISO)
thapsigargin  (ISO)
thiabendazole  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
1. Amemiya T, etal., Brain Res. 2005 Apr 8;1040(1-2):129-36.
2. Bowling N, etal., Circulation. 1999 Jan 26;99(3):384-91.
3. Corsini E, etal., Chem Res Toxicol. 2003 Dec;16(12):1520-7.
4. Devaraj S, etal., Diabetes. 2005 Jan;54(1):85-91.
5. Gareskog M and Wentzel P, Pediatr Res. 2004 Dec;56(6):849-57. Epub 2004 Oct 20.
6. Ghanim H, etal., Diabetologia. 2007 Feb;50(2):278-85. Epub 2006 Dec 16.
7. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
8. Igwe OJ Neuroscience. 2006;138(1):313-28. Epub 2005 Dec 19.
9. Inagaki K, etal., J Mol Cell Cardiol. 2002 Oct;34(10):1377-85.
10. Kawai Y, etal., IUBMB Life. 2002 Dec;54(6):365-70.
11. Kelly DJ, etal., Diabetes 2003 Feb;52(2):512-8.
12. Koide Y, etal., Hypertens Res. 2003 May;26(5):421-6.
13. Liu S, etal., Oncotarget. 2017 May 30;8(22):36354-36367. doi: 10.18632/oncotarget.16754.
14. MGD data from the GO Consortium
15. MGD IEA
16. Miluzio A, etal., EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17.
17. Nabika T, etal., Mamm Genome 1997 Mar;8(3):215-7.
18. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
19. Omiyi D, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):542-51. Epub 2005 May 5.
20. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. RGD automated import pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Sentex E, etal., Can J Physiol Pharmacol. 2006 Feb;84(2):227-38.
27. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
28. Su TT, etal., Nat Immunol 2002 Aug;3(8):780-6.
29. Tang FR, etal., Hippocampus. 2004;14(1):87-98.
30. Xia Z, etal., Cardiovasc Res. 2007 Mar 1;73(4):770-82. Epub 2006 Nov 30.
31. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:1535334   PMID:2402470   PMID:2590242   PMID:7513693   PMID:7537734   PMID:7606770   PMID:7734624   PMID:7760054   PMID:7873880   PMID:7985811   PMID:8499656   PMID:8670417  
PMID:8694767   PMID:8889548   PMID:8922669   PMID:8948582   PMID:9256480   PMID:9368018   PMID:9410895   PMID:9486851   PMID:9653087   PMID:10330400   PMID:10349636   PMID:10391924  
PMID:10499500   PMID:10534118   PMID:10557356   PMID:10688834   PMID:10766820   PMID:10862698   PMID:10879655   PMID:10882525   PMID:10934237   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11299230   PMID:11668067   PMID:11805327   PMID:11880265   PMID:12070292   PMID:12114511   PMID:12117979   PMID:12149258   PMID:12466851   PMID:12477932   PMID:12509514   PMID:12618484  
PMID:12648500   PMID:12667549   PMID:12761849   PMID:12782152   PMID:12826667   PMID:14613966   PMID:14985314   PMID:15140758   PMID:15163535   PMID:15170225   PMID:15173888   PMID:15188402  
PMID:15229137   PMID:15364915   PMID:15367584   PMID:15383592   PMID:15545601   PMID:15662033   PMID:15684423   PMID:15728476   PMID:15814670   PMID:16141072   PMID:16141073   PMID:16183638  
PMID:16183862   PMID:16301747   PMID:16430878   PMID:16452087   PMID:16476769   PMID:16505232   PMID:16564096   PMID:16582576   PMID:16585392   PMID:16585572   PMID:16602821   PMID:16735462  
PMID:16870209   PMID:16950644   PMID:17010989   PMID:17065350   PMID:17114649   PMID:17145500   PMID:17259378   PMID:17272725   PMID:17404251   PMID:17474092   PMID:17661397   PMID:17893151  
PMID:17936705   PMID:17962198   PMID:18245560   PMID:18287559   PMID:18313852   PMID:18323529   PMID:18641643   PMID:18774262   PMID:18840708   PMID:18996181   PMID:19036858   PMID:19066285  
PMID:19116344   PMID:19122165   PMID:19132529   PMID:19138174   PMID:19147581   PMID:19168795   PMID:19221092   PMID:19296465   PMID:19494314   PMID:19556521   PMID:19686698   PMID:19900507  
PMID:20179320   PMID:20237998   PMID:20392936   PMID:20569275   PMID:20594553   PMID:20685851   PMID:20713153   PMID:20815813   PMID:20923971   PMID:20936827   PMID:20971075   PMID:21048081  
PMID:21190563   PMID:21467074   PMID:21540297   PMID:21550971   PMID:21596041   PMID:21658591   PMID:21665150   PMID:21677750   PMID:21873635   PMID:22171059   PMID:22210924   PMID:22265677  
PMID:22313801   PMID:22318721   PMID:22609332   PMID:22633971   PMID:22761313   PMID:22819675   PMID:22826029   PMID:22993418   PMID:22994860   PMID:23028752   PMID:23035091   PMID:23280626  
PMID:23328482   PMID:23335970   PMID:23434935   PMID:23458603   PMID:23474486   PMID:23552399   PMID:23599343   PMID:23759514   PMID:23766264   PMID:23775122   PMID:23778835   PMID:23824069  
PMID:23959874   PMID:23960082   PMID:24125957   PMID:24151077   PMID:24349059   PMID:24478091   PMID:24493668   PMID:24550541   PMID:24722289   PMID:24794094   PMID:24863469   PMID:24920628  
PMID:24952961   PMID:25256217   PMID:25450684   PMID:25616575   PMID:25808972   PMID:25962121   PMID:26081415   PMID:26739493   PMID:26745713   PMID:26936881   PMID:26965927   PMID:27160897  
PMID:27214373   PMID:27307229   PMID:27444685   PMID:27507650   PMID:27624939   PMID:27657532   PMID:28228266   PMID:28369050   PMID:28378742   PMID:28626026   PMID:28671696   PMID:28706196  
PMID:28755662   PMID:28760865   PMID:28966330   PMID:29111976   PMID:29307535   PMID:29436516   PMID:29744369   PMID:30013171   PMID:30247663   PMID:30485813   PMID:30562941   PMID:30730241  
PMID:30889825   PMID:31585911   PMID:31941829   PMID:32325033   PMID:32753714   PMID:32818536   PMID:33271332   PMID:33460682   PMID:33723318  


Genomics

Comparative Map Data
Prkcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,888,327 - 122,233,625 (+)NCBIGRCm39mm39
GRCm39 Ensembl7121,887,974 - 122,233,625 (+)Ensembl
GRCm387122,289,104 - 122,634,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,288,751 - 122,634,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,432,639 - 129,777,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv367122,080,445 - 122,419,795 (+)NCBImm8
Celera7122,177,656 - 122,520,472 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.75NCBI
PRKCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1623,835,983 - 24,220,611 (+)EnsemblGRCh38hg38GRCh38
GRCh381623,835,983 - 24,220,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,847,304 - 24,231,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,754,823 - 24,139,063 (+)NCBINCBI36hg18NCBI36
Build 341623,754,822 - 24,139,063NCBI
Celera1622,625,642 - 23,009,889 (+)NCBI
Cytogenetic Map16p12.2-p12.1NCBI
HuRef1621,938,281 - 22,322,666 (+)NCBIHuRef
CHM1_11624,859,040 - 25,244,985 (+)NCBICHM1_1
Prkcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
Prkcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,395,109 - 2,710,934 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,395,494 - 2,710,522 (+)NCBIChiLan1.0ChiLan1.0
PRKCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11624,091,284 - 24,466,701 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1624,091,289 - 24,466,203 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01613,888,936 - 14,268,759 (-)NCBIMhudiblu_PPA_v0panPan3
PRKCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,742,970 - 22,064,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,742,973 - 22,065,185 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,304,828 - 23,630,068 (-)NCBI
ROS_Cfam_1.0621,880,650 - 22,206,417 (-)NCBI
UMICH_Zoey_3.1621,685,773 - 22,010,753 (-)NCBI
UNSW_CanFamBas_1.0621,587,647 - 21,912,745 (-)NCBI
UU_Cfam_GSD_1.0621,982,425 - 22,308,075 (-)NCBI
Prkcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,339,861 - 120,631,378 (+)NCBI
SpeTri2.0NW_0049365018,410,273 - 8,729,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl321,995,231 - 22,383,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1321,995,227 - 22,383,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,949,682 - 23,174,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,558,608 - 21,940,536 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBIVero_WHO_p1.0
Prkcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247828,974,995 - 9,287,609 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105651440139651588Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105750785139750785Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7116100000128900000Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117600000134500000Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7118151499128365612Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
1558745Tsiq1_mT-cell secretion of IL-4 QTL 1 (mouse)Not determined7119885996125542177Mouse
38501070Tip5_mtuberculosis immunophenotype 5, IFN-g level (mouse)7121000000130700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1052
Count of miRNA genes:561
Interacting mature miRNAs:674
Transcripts:ENSMUST00000064921, ENSMUST00000064989, ENSMUST00000127910, ENSMUST00000131167, ENSMUST00000143692, ENSMUST00000149583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001316672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC016522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC151986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU701138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY729820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ050078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000064921   ⟹   ENSMUSP00000064812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,888,532 - 122,233,625 (+)Ensembl
GRCm38.p6 Ensembl7122,289,309 - 122,634,402 (+)Ensembl
RefSeq Acc Id: ENSMUST00000064989   ⟹   ENSMUSP00000070019
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,888,520 - 122,227,878 (+)Ensembl
GRCm38.p6 Ensembl7122,289,297 - 122,628,655 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127910
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7122,199,205 - 122,227,301 (+)Ensembl
GRCm38.p6 Ensembl7122,599,982 - 122,628,078 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131167
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,889,251 - 122,024,264 (+)Ensembl
GRCm38.p6 Ensembl7122,290,028 - 122,425,041 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143692   ⟹   ENSMUSP00000138788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,887,974 - 122,233,622 (+)Ensembl
GRCm38.p6 Ensembl7122,288,751 - 122,634,399 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149583
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7122,015,291 - 122,056,549 (+)Ensembl
GRCm38.p6 Ensembl7122,416,068 - 122,457,326 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205550
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7122,193,144 - 122,195,937 (+)Ensembl
GRCm38.p6 Ensembl7122,593,921 - 122,596,714 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7122,232,671 - 122,233,625 (+)Ensembl
GRCm38.p6 Ensembl7122,633,448 - 122,634,402 (+)Ensembl
RefSeq Acc Id: NM_001316672   ⟹   NP_001303601
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,888,348 - 122,233,625 (+)NCBI
GRCm387122,289,125 - 122,634,402 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008855   ⟹   NP_032881
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,888,348 - 122,233,625 (+)NCBI
GRCm387122,289,125 - 122,634,402 (+)NCBI
MGSCv377129,432,639 - 129,777,916 (+)RGD
Celera7122,173,462 - 122,520,472 (+)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030242217   ⟹   XP_030098077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,888,327 - 122,233,625 (+)NCBI
GRCm387122,289,104 - 122,634,402 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032881   ⟸   NM_008855
- Peptide Label: isoform 1
- UniProtKB: P68404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303601   ⟸   NM_001316672
- Peptide Label: isoform 2
- UniProtKB: P68404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030098077   ⟸   XM_030242217
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000138788   ⟸   ENSMUST00000143692
RefSeq Acc Id: ENSMUSP00000070019   ⟸   ENSMUST00000064989
RefSeq Acc Id: ENSMUSP00000064812   ⟸   ENSMUST00000064921
Protein Domains
AGC-kinase C-terminal   C2   Protein kinase

Promoters
RGD ID:8665475
Promoter ID:EPDNEW_M10769
Type:initiation region
Name:Prkcb_1
Description:Mus musculus protein kinase C, beta , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10770  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387122,289,135 - 122,289,195EPDNEW
RGD ID:8665477
Promoter ID:EPDNEW_M10770
Type:multiple initiation site
Name:Prkcb_2
Description:Mus musculus protein kinase C, beta , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10769  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387122,289,327 - 122,289,387EPDNEW
RGD ID:6841845
Promoter ID:MM_KWN:52582
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Spleen
Transcripts:ENSMUST00000064989,   OTTMUST00000039929,   UC009JOT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367129,432,381 - 129,432,881 (+)MPROMDB
RGD ID:6841828
Promoter ID:MM_KWN:52583
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000039931
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367129,433,086 - 129,434,037 (+)MPROMDB
RGD ID:6841827
Promoter ID:MM_KWN:52584
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000039932
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367129,559,676 - 129,560,176 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97596 AgrOrtholog
Ensembl Genes ENSMUSG00000052889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000064812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000070019 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000138788 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064921 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000064989 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000143692 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  cPKC_beta UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Protein_kinase_C_a/b/g UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:18751 UniProtKB/Swiss-Prot
MGD MGI:97596 ENTREZGENE
NCBI Gene 18751 ENTREZGENE
Pfam C1_1 UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkcb PhenoGen
PIRSF PKC_alpha UniProtKB/Swiss-Prot
PRINTS C2DOMAIN UniProtKB/Swiss-Prot
  DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt KPCB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q80ZQ8_MOUSE UniProtKB/TrEMBL
UniProt Secondary A0JNZ5 UniProtKB/Swiss-Prot
  F2Z441 UniProtKB/Swiss-Prot
  P04410 UniProtKB/Swiss-Prot
  P04411 UniProtKB/Swiss-Prot