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Gene: Glul (glutamate-ammonia ligase (glutamine synthetase)) Mus musculus
Symbol: Glul
Name: glutamate-ammonia ligase (glutamine synthetase)
Description: Predicted to have several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in several processes, including regulation of endothelial cell migration; regulation of sprouting angiogenesis; and response to glucose. Localizes to the cell body; cytoplasm; and glial cell projection. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human GLUL (glutamate-ammonia ligase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Glns; glutamate decarboxylase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamine synthetase; GS; palmitoyltransferase GLUL
Homo sapiens (human) : GLUL (glutamate-ammonia ligase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glul (glutamate-ammonia ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glul (glutamate-ammonia ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : GLUL (glutamate-ammonia ligase)
Canis lupus familiaris (dog) : GLUL (glutamate-ammonia ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glul (glutamate-ammonia ligase)
Sus scrofa (pig) : GLUL (glutamate-ammonia ligase)
Chlorocebus sabaeus (green monkey) : GLUL (glutamate-ammonia ligase)
Heterocephalus glaber (naked mole-rat) : Glul (glutamate-ammonia ligase)
more info ...
Related Pseudogenes: Glns-ps1   Gm18975   Gm4949   Gm8642  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1153,899,944 - 153,909,723 (+)Ensembl
GRCm381153,899,929 - 153,909,723 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371155,747,075 - 155,756,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv361155,662,163 - 155,671,932 (+)NCBImm8
Celera1156,333,049 - 156,342,895 (+)NCBICelera
Cytogenetic Map1 G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Glul
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736181
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.