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Gene: Glul (glutamate-ammonia ligase (glutamine synthetase)) Mus musculus
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Symbol: Glul
Name: glutamate-ammonia ligase (glutamine synthetase)
Description: Predicted to have several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in several processes, including regulation of endothelial cell migration; regulation of sprouting angiogenesis; and response to glucose. Localizes to the cell body; cytoplasm; and glial cell projection. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human GLUL (glutamate-ammonia ligase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Glns; glutamate decarboxylase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamine synthetase; GS; palmitoyltransferase GLUL
Orthologs:
Homo sapiens (human) : GLUL (glutamate-ammonia ligase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glul (glutamate-ammonia ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glul (glutamate-ammonia ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : GLUL (glutamate-ammonia ligase)
Canis lupus familiaris (dog) : GLUL (glutamate-ammonia ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glul (glutamate-ammonia ligase)
Sus scrofa (pig) : GLUL (glutamate-ammonia ligase)
Chlorocebus sabaeus (green monkey) : GLUL (glutamate-ammonia ligase)
Heterocephalus glaber (naked mole-rat) : Glul (glutamate-ammonia ligase)
more info ...
Related Pseudogenes: Glns-ps1   Gm18975   Gm4949   Gm8642  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1153,899,944 - 153,909,723 (+)Ensembl
GRCm381153,899,929 - 153,909,723 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371155,747,075 - 155,756,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv361155,662,163 - 155,671,932 (+)NCBImm8
Celera1156,333,049 - 156,342,895 (+)NCBICelera
Cytogenetic Map1 G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Glul
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736181
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.