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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diphenhydramine
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Accession:CHEBI:4636 term browser browse the term
Definition:An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Synonyms:exact_synonym: 2-(diphenylmethoxy)-N,N-dimethylethanamine
 related_synonym: 2-(benzhydryloxy)-N,N-dimethylethylamine;   2-diphenylmethoxy-N,N-demthylethanamine;   Formula=C17H21NO;   InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3;   InChIKey=ZZVUWRFHKOJYTH-UHFFFAOYSA-N;   N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine;   O-benzhydryldimethylaminoethanol;   SMILES=CN(C)CCOC(c1ccccc1)c1ccccc1;   alpha-(2-dimethylaminoethoxy)diphenylmethane;   beta-dimethylaminoethanol diphenylmethyl ether;   beta-dimethylaminoethyl benzhydryl ether;   difenhidramina;   diphenhydraminum
 xref: Beilstein:1914136;   CAS:58-73-1;   DrugBank:DB01075;   HMDB:HMDB0001927;   KEGG:C14015;   KEGG:D00300;   KEGG:D02419;   LINCS:LSM-5581
 xref_mesh: MESH:D004155
 xref: PDBeChem:2PM;   Patent:US2421714;   Patent:US2427878;   VSDB:2973;   Wikipedia:Diphenhydramine

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diphenhydramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 affects response to substance ISO ATG5 protein affects the susceptibility to Diphenhydramine CTD PMID:22310178 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein] CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Gnai1 G protein subunit alpha i1 increases response to substance ISO GNAI1 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases response to substance ISO GNAI2 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP		 Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin		 CTD PMID:1912125, PMID:2419744, PMID:2461127, PMID:7522859, PMID:9609743, PMID:12856827 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Diphenhydramine results in increased expression of IL1B mRNA CTD PMID:28138970 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein] CTD PMID:11336536 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Diphenhydramine results in increased activity of MAPK8 CTD PMID:17390763 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091, PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
dimenhydrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Dimenhydrinate results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            anti-allergic agent 3796
              diphenhydramine 15
                dimenhydrinate 2
                diphenhydramine hydrochloride 0
                diphenhydramine salicylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          diphenhydramine 15
                                            dimenhydrinate 2
                                            diphenhydramine hydrochloride 0
                                            diphenhydramine salicylate 0
paths to the root

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