CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: diphenhydramine
Accession: CHEBI:4636
browse the term
Definition: An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Synonyms: exact_synonym: 2-(diphenylmethoxy)-N,N-dimethylethanamine
related_synonym: 2-(benzhydryloxy)-N,N-dimethylethylamine; 2-diphenylmethoxy-N,N-demthylethanamine; Formula=C17H21NO; InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3; InChIKey=ZZVUWRFHKOJYTH-UHFFFAOYSA-N; N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine; O-benzhydryldimethylaminoethanol; SMILES=CN(C)CCOC(c1ccccc1)c1ccccc1; alpha-(2-dimethylaminoethoxy)diphenylmethane; beta-dimethylaminoethanol diphenylmethyl ether; beta-dimethylaminoethyl benzhydryl ether; difenhidramina; diphenhydraminum
xref: Beilstein:1914136; CAS:58-73-1; DrugBank:DB01075; HMDB:HMDB0001927; KEGG:C14015; KEGG:D00300; KEGG:D02419; LINCS:LSM-5581
xref_mesh: MESH:D004155
xref: PDBeChem:2PM; Patent:US2421714; Patent:US2427878; VSDB:2973; Wikipedia:Diphenhydramine
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Atg5
autophagy related 5
affects response to substance
ISO
ATG5 protein affects the susceptibility to Diphenhydramine
CTD
PMID:22310178
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
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Bche
butyrylcholinesterase
multiple interactions decreases activity
ISO
Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]
CTD
PMID:236606
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
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Bmp6
bone morphogenetic protein 6
decreases expression
ISO
Diphenhydramine results in decreased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,523,704...26,675,261
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Ereg
epiregulin
decreases expression
ISO
Diphenhydramine results in decreased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260
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F3
coagulation factor III, tissue factor
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]
CTD
PMID:16009787
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
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Gnai1
G protein subunit alpha i1
increases response to substance
ISO
GNAI1 results in increased susceptibility to Diphenhydramine
CTD
PMID:14614911
NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198
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Gnai2
G protein subunit alpha i2
increases response to substance
ISO
GNAI2 results in increased susceptibility to Diphenhydramine
CTD
PMID:14614911
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:117,167,045...117,187,622
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Hrh1
histamine receptor H 1
multiple interactions
ISO EXP
Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein] [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin
CTD
PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 PMID:12856827 More...
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:149,120,039...149,208,248
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Il1b
interleukin 1 beta
increases expression decreases expression
ISO
Diphenhydramine results in increased expression of IL1B mRNA Diphenhydramine results in decreased expression of IL1B mRNA
CTD
PMID:28138970 PMID:32816093
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il24
interleukin 24
decreases expression
ISO
Diphenhydramine results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:44,905,363...44,910,760
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Il6
interleukin 6
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]
CTD
PMID:11336536
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Mapk8
mitogen-activated protein kinase 8
increases activity
ISO
Diphenhydramine results in increased activity of MAPK8
CTD
PMID:17390763
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:20869355
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:86,165,349...86,170,370
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Pla2g4a
phospholipase A2 group 4A
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]
CTD
PMID:9609743
NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Diphenhydramine results in decreased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:16263091 PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353
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Slc22a5
solute carrier family 22 member 5
multiple interactions
ISO
Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]
CTD
PMID:19821448
NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
Diphenhydramine results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Diphenhydramine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:173,501,573...173,503,822
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Bche
butyrylcholinesterase
decreases activity
ISO
Dimenhydrinate results in decreased activity of BCHE protein
CTD
PMID:236606
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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