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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diphenhydramine
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Accession:CHEBI:4636 term browser browse the term
Definition:An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Synonyms:exact_synonym: 2-(diphenylmethoxy)-N,N-dimethylethanamine
 related_synonym: 2-(benzhydryloxy)-N,N-dimethylethylamine;   2-diphenylmethoxy-N,N-demthylethanamine;   Formula=C17H21NO;   InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3;   InChIKey=ZZVUWRFHKOJYTH-UHFFFAOYSA-N;   N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine;   O-benzhydryldimethylaminoethanol;   SMILES=CN(C)CCOC(c1ccccc1)c1ccccc1;   alpha-(2-dimethylaminoethoxy)diphenylmethane;   beta-dimethylaminoethanol diphenylmethyl ether;   beta-dimethylaminoethyl benzhydryl ether;   difenhidramina;   diphenhydraminum
 xref: Beilstein:1914136;   CAS:58-73-1;   DrugBank:DB01075;   HMDB:HMDB0001927;   KEGG:C14015;   KEGG:D00300;   KEGG:D02419;   LINCS:LSM-5581
 xref_mesh: MESH:D004155
 xref: PDBeChem:2PM;   Patent:US2421714;   Patent:US2427878;   VSDB:2973;   Wikipedia:Diphenhydramine

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diphenhydramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 affects response to substance ISO ATG5 protein affects the susceptibility to Diphenhydramine CTD PMID:22310178 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein] CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Diphenhydramine results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Ereg epiregulin decreases expression ISO Diphenhydramine results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Gnai1 G protein subunit alpha i1 increases response to substance ISO GNAI1 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 4:16,813,941...16,898,111
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases response to substance ISO GNAI2 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP		 Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin		 CTD PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More... NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression		 ISO Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA		 CTD PMID:28138970 PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Diphenhydramine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein] CTD PMID:11336536 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Diphenhydramine results in increased activity of MAPK8 CTD PMID:17390763 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Diphenhydramine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Diphenhydramine results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Diphenhydramine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
dimenhydrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Dimenhydrinate results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            anti-allergic agent 3826
              diphenhydramine 21
                dimenhydrinate 2
                diphenhydramine hydrochloride 0
                diphenhydramine salicylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8679
                                          diphenhydramine 21
                                            dimenhydrinate 2
                                            diphenhydramine hydrochloride 0
                                            diphenhydramine salicylate 0
paths to the root