Lipa (lysosomal acid lipase A) - Rat Genome Database

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Gene: Lipa (lysosomal acid lipase A) Mus musculus
Analyze
Symbol: Lipa
Name: lysosomal acid lipase A
RGD ID: 736563
MGI Page MGI
Description: Predicted to have sterol esterase activity. Involved in several processes, including homeostasis of number of cells within a tissue; lung development; and tissue remodeling. Predicted to localize to cytosol; lysosome; and nuclear lumen. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Used to study Wolman disease and lysosomal and lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960673; acid cholesteryl ester hydrolase; cholesteryl esterase; L; Lal; Li; Lip-1; Lip1; lipase A; lysosomal acid lipase 1; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,469,716 - 34,504,874 (-)NCBIGRCm39mm39
GRCm39 Ensembl1934,469,718 - 34,504,874 (-)Ensembl
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBImm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxynon-2-enal  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
antimony(0)  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbamate ester  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenamidone  (EXP)
folic acid  (EXP)
folpet  (EXP)
glafenine  (ISO)
lead diacetate  (EXP)
linalool  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
pentachlorophenol  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
Propiverine  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium dichromate  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thiadiazoles  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland morphology  (IAGP)
abnormal alveolar macrophage morphology  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal carbohydrate metabolism  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal inguinal fat pad morphology  (IAGP)
abnormal interscapular fat pad morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal jejunum morphology  (IAGP)
abnormal Kupffer cell morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal lipid oxidation  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal retroperitoneal fat pad morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal tricarboxylic acid cycle  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal white fat cell size  (IAGP)
absent subcutaneous adipose tissue  (IAGP)
chronic inflammation  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased triglyceride lipase activity  (IAGP)
decreased unsaturated fatty acids level  (IAGP)
decreased white adipose tissue amount  (IAGP)
emphysema  (IAGP)
enlarged liver  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged spleen  (IAGP)
hepatic steatosis  (IAGP)
hepatosplenomegaly  (IAGP)
impaired gluconeogenesis  (IAGP)
improved glucose tolerance  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased club cell number  (IAGP)
increased food intake  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver cholesterol level  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased respiratory quotient  (IAGP)
increased spleen weight  (IAGP)
increased type II pneumocyte number  (IAGP)
increased unsaturated fatty acids level  (IAGP)
insulin resistance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
pale kidney  (IAGP)
pale liver  (IAGP)
premature death  (IAGP)
References

Additional References at PubMed
PMID:7292252   PMID:8725147   PMID:9524282   PMID:9700186   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11290820   PMID:11487567   PMID:12477932   PMID:14644759  
PMID:14681479   PMID:15782199   PMID:16127159   PMID:16141072   PMID:16141073   PMID:16380916   PMID:16602821   PMID:16936266   PMID:18039279   PMID:19179613   PMID:20348241   PMID:21289032  
PMID:21308776   PMID:21697390   PMID:21873635   PMID:21900179   PMID:22045912   PMID:22383970   PMID:22395110   PMID:23990661   PMID:24136225   PMID:24287405   PMID:24370824   PMID:24837159  
PMID:24882582   PMID:25000979   PMID:25086775   PMID:25124681   PMID:25147230   PMID:25450374   PMID:25807535   PMID:26212911   PMID:27354281   PMID:27461363   PMID:27480124   PMID:27997605  
PMID:28402950   PMID:28924047   PMID:29166610   PMID:29374543   PMID:29599133   PMID:30639734   PMID:31023823   PMID:32325033   PMID:32361002   PMID:33357458  


Genomics

Comparative Map Data
Lipa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,469,716 - 34,504,874 (-)NCBIGRCm39mm39
GRCm39 Ensembl1934,469,718 - 34,504,874 (-)Ensembl
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBImm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
LIPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1089,213,569 - 89,414,557 (-)EnsemblGRCh38hg38GRCh38
GRCh381089,213,571 - 89,251,926 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,973,329 - 91,011,532 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,963,309 - 91,001,640 (-)NCBINCBI36hg18NCBI36
Build 341090,963,308 - 91,001,640NCBI
Celera1084,720,143 - 84,758,472 (-)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,607,788 - 84,646,145 (-)NCBIHuRef
CHM1_11091,255,383 - 91,293,855 (-)NCBICHM1_1
Lipa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21232,024,351 - 232,167,329 (-)NCBI
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Celera1229,136,934 - 229,170,119 (-)NCBICelera
Cytogenetic Map1q53NCBI
Lipa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,718,206 - 3,756,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,718,291 - 3,755,942 (+)NCBIChiLan1.0ChiLan1.0
LIPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,478,502 - 89,516,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,477,082 - 89,516,874 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,938,240 - 85,976,610 (-)NCBIMhudiblu_PPA_v0panPan3
LIPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,892,771 - 38,918,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,893,337 - 38,918,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,643,855 - 38,671,678 (-)NCBI
ROS_Cfam_1.02640,476,944 - 40,504,767 (-)NCBI
UMICH_Zoey_3.12638,347,241 - 38,375,054 (-)NCBI
UNSW_CanFamBas_1.02637,910,947 - 37,938,676 (-)NCBI
UU_Cfam_GSD_1.02639,180,692 - 39,208,434 (-)NCBI
LIPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,123,381 - 101,254,725 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,131,372 - 101,254,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,116,088 - 110,152,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,639,220 - 82,677,479 (-)NCBI
ChlSab1.1 Ensembl982,638,621 - 82,677,488 (-)Ensembl
Lipa
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473749,471 - 82,981 (-)NCBI

Position Markers
AA960673  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381934,492,389 - 34,492,678UniSTSGRCm38
MGSCv371934,566,879 - 34,567,168UniSTSGRCm37
Celera1935,267,962 - 35,268,251UniSTS
Cytogenetic Map19C1UniSTS
Whitehead/MRC_RH19330.53UniSTS
Lipa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C1UniSTS
cM Map1929.7UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192779458535317981Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse
4141562Pas3b_mpulmonary adenoma susceptibility 3b (mouse)Not determined2977296261431566Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193015278561431566Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193015279261431566Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193015279261431566Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193090944161431566Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193300371961431566Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193396351461431566Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:928
Count of miRNA genes:368
Interacting mature miRNAs:390
Transcripts:ENSMUST00000049572, ENSMUST00000178114
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA881350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE198807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE449010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z31689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000049572   ⟹   ENSMUSP00000053270
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178114   ⟹   ENSMUSP00000136967
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,494,046 - 34,501,853 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,495,060 - 34,510,980 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,522,360 - 34,527,452 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1934,522,334 - 34,527,411 (-)Ensembl
RefSeq Acc Id: NM_001111100   ⟹   NP_001104570
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391934,469,716 - 34,504,874 (-)NCBI
GRCm381934,492,316 - 34,527,474 (-)ENTREZGENE
MGSCv371934,566,806 - 34,601,964 (-)RGD
Celera1935,267,889 - 35,303,040 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_021460   ⟹   NP_067435
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391934,469,716 - 34,504,874 (-)NCBI
GRCm381934,492,316 - 34,527,474 (-)ENTREZGENE
MGSCv371934,566,806 - 34,601,964 (-)RGD
Celera1935,267,889 - 35,303,040 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067435   ⟸   NM_021460
- Peptide Label: precursor
- UniProtKB: Q9Z0M5 (UniProtKB/Swiss-Prot),   Q3TEL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104570   ⟸   NM_001111100
- Peptide Label: precursor
- UniProtKB: Q9Z0M5 (UniProtKB/Swiss-Prot),   Q3TEL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136967   ⟸   ENSMUST00000178114
RefSeq Acc Id: ENSMUSP00000053270   ⟸   ENSMUST00000049572
Protein Domains
AB hydrolase-1

Promoters
RGD ID:13679314
Promoter ID:EPDNEW_M23806
Type:initiation region
Name:Lipa_1
Description:Mus musculus lysosomal acid lipase A , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381934,527,415 - 34,527,475EPDNEW
RGD ID:6830165
Promoter ID:MM_KWN:26901
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001111100,   NM_021460,   UC008HGL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361934,601,611 - 34,602,111 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96789 AgrOrtholog
Ensembl Genes ENSMUSG00000024781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000053270 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000136967 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000178114 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96789 ENTREZGENE
NCBI Gene 16889 ENTREZGENE
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lipa PhenoGen
PIRSF Steryl_ester_lip UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LICH_MOUSE UniProtKB/Swiss-Prot
  Q3TEL5 ENTREZGENE, UniProtKB/TrEMBL
  Q6PDR1_MOUSE UniProtKB/TrEMBL
  Q9Z0M5 ENTREZGENE
UniProt Secondary Q8C2G7 UniProtKB/Swiss-Prot