Shh (sonic hedgehog) - Rat Genome Database

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Gene: Shh (sonic hedgehog) Mus musculus
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Symbol: Shh
Name: sonic hedgehog
RGD ID: 736830
MGI Page MGI
Description: Enables several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hemopoiesis; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including nervous system development; respiratory system development; and tube morphogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study brachydactyly type A1; holoprosencephaly 3; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly (multiple). Orthologous to human SHH (sonic hedgehog signaling molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9530036O11Rik; Dsh; hemimelic extra toes; HHG-1; Hhg1; Hx; Hxl3; M100081; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; short digits; sonic hedgehog protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,661,838 - 28,672,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl528,661,813 - 28,672,254 (-)EnsemblGRCm39 Ensembl
GRCm38528,456,840 - 28,467,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,456,815 - 28,467,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv37528,783,380 - 28,793,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36528,787,627 - 28,797,875 (-)NCBIMGSCv36mm8
Celera525,997,895 - 26,008,156 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map514.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acrocallosal syndrome  (ISO)
Anorectal Malformations  (ISO)
atrioventricular septal defect  (IMP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
basal cell carcinoma  (ISO)
biliary atresia  (ISO)
brachydactyly type A1  (IEP)
chronic kidney disease  (IEP,ISO)
cleft palate  (IGI)
colorectal cancer  (ISO)
Congenital Limb Deformities  (IMP)
demyelinating disease  (IEP)
esophageal atresia/tracheoesophageal fistula  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Eye Abnormalities  (ISO)
Facial Dysmorphism with Multiple Malformations  (ISO)
Failure to Thrive  (ISO)
Fluoride Poisoning  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung's disease  (ISO)
holoprosencephaly  (IEP,ISO)
holoprosencephaly 3  (IAGP,ISO)
Hyperoxic Lung Injury  (ISO)
hypoplastic or aplastic tibia with polydactyly  (ISO)
hypothyroidism  (ISO)
IgA glomerulonephritis  (ISO)
Isolated Microphthalmia with Coloboma 5  (ISO)
Kidney Reperfusion Injury  (IEP)
membranous glomerulonephritis  (ISO)
microphthalmia  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
neurodevelopmental disorder with dysmorphic facies and distal limb anomalies  (ISO)
nevoid basal cell carcinoma syndrome  (IAGP,IMP)
ocular hypertension  (ISO)
pancreatic cancer  (ISO)
Parkinsonism  (ISO)
Partial Agenesis of Corpus Callosum  (ISO)
Patterson Stevenson Syndrome  (ISO)
Peripheral Nerve Injuries  (ISO)
Persistent Cloaca  (IMP,ISO)
polydactyly  (IEP,ISO)
pre-malignant neoplasm  (ISO)
preaxial polydactyly II  (ISO)
primary progressive multiple sclerosis  (ISO)
Schizencephaly  (ISO)
secondary Parkinson disease  (ISO)
septooptic dysplasia  (ISO)
solitary median maxillary central incisor  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
syndactyly type 4  (ISO)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (ISO)
ureteral obstruction  (IEP)
VACTERL association  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
apomorphine  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
curcumin  (ISO)
Cyclopamine  (EXP,ISO)
D-glucose  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
ethanol  (EXP)
Ethylenethiourea  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
goralatide  (ISO)
hydrogen peroxide  (ISO)
ipriflavone  (EXP,ISO)
isotretinoin  (ISO)
lansoprazole  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
melittin  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
nitrofen  (ISO)
Nonylphenol  (EXP,ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
purmorphamine  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saccharin  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetramethylpyrazine  (EXP)
thyroxine  (ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
tolnaftate  (EXP,ISO)
trans-piceid  (EXP)
triadimefon  (ISO)
triptonide  (ISO)
udenafil  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vismodegib  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IMP)
alpha-tubulin acetylation  (IDA)
anatomical structure formation involved in morphogenesis  (IMP)
androgen metabolic process  (IMP)
angiogenesis  (IDA,IGI,IMP)
animal organ formation  (IMP)
anterior/posterior pattern specification  (IMP)
apoptotic signaling pathway  (IDA)
artery development  (IGI,IMP)
astrocyte differentiation  (IMP)
axon guidance  (IDA,IMP)
Bergmann glial cell differentiation  (IDA)
blood coagulation  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
branching involved in prostate gland morphogenesis  (IDA)
branching involved in salivary gland morphogenesis  (IGI,IMP)
branching involved in ureteric bud morphogenesis  (IMP)
branching morphogenesis of an epithelial tube  (IMP)
bud outgrowth involved in lung branching  (IMP)
camera-type eye development  (IDA,IGI,IMP)
canonical Wnt signaling pathway  (IMP)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (IMP,ISO)
cell development  (IMP)
cell fate commitment  (IGI)
cell fate specification  (IBA,IDA,IGI,IMP)
cell migration  (IDA)
cell population proliferation  (IGI,IMP)
cell proliferation in external granule layer  (IDA)
cell-cell signaling  (IMP)
cellular response to L-glutamate  (ISO)
cellular response to lithium ion  (IDA)
central nervous system development  (IMP)
cerebellar granule cell precursor proliferation  (IDA,IGI)
commissural neuron axon guidance  (ISO)
determination of left/right asymmetry in lateral mesoderm  (IMP)
determination of left/right symmetry  (IMP)
developmental growth  (IMP)
digestive tract mesoderm development  (ISO)
digestive tract morphogenesis  (IMP)
dopaminergic neuron differentiation  (TAS)
dorsal/ventral neural tube patterning  (IDA,IGI,IMP)
dorsal/ventral pattern formation  (IGI)
ectoderm development  (IMP)
embryonic digestive tract morphogenesis  (IMP,TAS)
embryonic digit morphogenesis  (IGI,IMP)
embryonic foregut morphogenesis  (IMP)
embryonic forelimb morphogenesis  (IMP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IGI,IMP)
embryonic morphogenesis  (IMP)
embryonic organ development  (IMP)
embryonic skeletal system development  (IGI)
endocytosis  (IDA)
epithelial cell proliferation  (IGI,IMP)
epithelial cell proliferation involved in prostate gland development  (IMP)
epithelial cell proliferation involved in salivary gland morphogenesis  (IMP)
epithelial tube branching involved in lung morphogenesis  (IMP,ISO)
epithelial-mesenchymal cell signaling  (IMP)
epithelial-mesenchymal signaling involved in prostate gland development  (IGI)
establishment of epithelial cell polarity  (IDA)
forebrain development  (IGI)
forebrain regionalization  (IMP)
formation of anatomical boundary  (IMP)
fungiform papilla development  (ISO)
fungiform papilla formation  (ISO)
fungiform papilla morphogenesis  (ISO)
gene expression  (IDA,IMP)
hair follicle development  (IMP)
hair follicle morphogenesis  (IMP)
heart development  (IMP)
heart looping  (IMP)
hindbrain development  (IGI,IMP)
hindgut morphogenesis  (IMP)
inner ear development  (IGI,IMP)
intein-mediated protein splicing  (IEA)
intermediate filament organization  (IMP)
kidney development  (IMP)
left lung development  (IMP)
limb bud formation  (IMP)
limb development  (IGI,IMP)
liver regeneration  (ISO)
lung development  (IGI,IMP)
lung epithelium development  (IMP)
lung lobe morphogenesis  (IMP)
lung morphogenesis  (IMP)
lung-associated mesenchyme development  (IMP)
lymphoid progenitor cell differentiation  (IMP,ISO)
male genitalia development  (IMP)
male genitalia morphogenesis  (ISO)
mesenchymal cell apoptotic process  (IMP)
mesenchymal cell proliferation  (IMP)
mesenchymal cell proliferation involved in lung development  (IDA)
mesenchymal smoothened signaling pathway involved in prostate gland development  (IMP)
mesenchymal-epithelial cell signaling involved in prostate gland development  (ISO)
metanephric collecting duct development  (IEA)
metanephric mesenchymal cell proliferation involved in metanephros development  (IMP)
metanephros development  (IMP)
midbrain development  (IGI)
myoblast differentiation  (IDA)
myotube differentiation  (IMP)
negative regulation of alpha-beta T cell differentiation  (IMP)
negative regulation of apoptotic process  (IDA,IGI,IMP,ISO)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of cell migration  (IDA)
negative regulation of cellular process  (ISO)
negative regulation of cholesterol efflux  (IMP)
negative regulation of dopaminergic neuron differentiation  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of kidney smooth muscle cell differentiation  (IDA)
negative regulation of mesenchymal cell apoptotic process  (IMP)
negative regulation of neuron differentiation  (IDA,IMP)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
negative regulation of protein catabolic process  (IMP)
negative regulation of T cell differentiation in thymus  (IMP)
negative regulation of T cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
negative regulation of transcription elongation by RNA polymerase II  (IDA)
negative regulation of ureter smooth muscle cell differentiation  (IDA)
negative regulation of Wnt signaling pathway  (IDA)
negative thymic T cell selection  (IMP)
neural crest cell migration  (IMP)
neural tube formation  (ISO)
neuroblast proliferation  (IDA,IMP)
neuron differentiation  (IDA,IMP)
neuron fate commitment  (IMP)
odontogenesis  (IDA)
odontogenesis of dentin-containing tooth  (IMP)
oligodendrocyte development  (IDA)
oligodendrocyte differentiation  (IBA,IGI)
osteoblast development  (IDA)
pancreas development  (IGI,IMP)
pattern specification process  (IGI,IMP)
polarity specification of anterior/posterior axis  (IMP)
positive regulation of alpha-beta T cell differentiation  (IMP)
positive regulation of astrocyte differentiation  (IMP)
positive regulation of cell division  (IEA,ISO)
positive regulation of cell population proliferation  (IDA,IGI,IMP,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IDA)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of epithelial cell proliferation  (IGI,IMP)
positive regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of immature T cell proliferation in thymus  (IMP)
positive regulation of kidney smooth muscle cell differentiation  (IDA)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of mesenchymal cell proliferation involved in ureter development  (IMP)
positive regulation of neuroblast proliferation  (IDA,IMP,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neurotrophin production  (ISO)
positive regulation of oligodendrocyte differentiation  (IDA)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of photoreceptor cell differentiation  (ISO)
positive regulation of protein import into nucleus  (IGI)
positive regulation of sclerotome development  (IEA,ISO)
positive regulation of skeletal muscle cell proliferation  (IMP)
positive regulation of skeletal muscle tissue development  (IMP)
positive regulation of smoothened signaling pathway  (ISO,ISS)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of striated muscle cell differentiation  (IMP)
positive regulation of T cell differentiation in thymus  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
positive regulation of ureter smooth muscle cell differentiation  (IMP)
positive regulation of Wnt signaling pathway  (IMP)
positive thymic T cell selection  (IMP)
primary prostatic bud elongation  (IDA)
prostate epithelial cord elongation  (IDA)
prostate gland development  (IGI,IMP,ISO)
prostatic bud formation  (IGI)
protein autoprocessing  (IEA)
protein import into nucleus  (IGI)
protein localization to nucleus  (IDA)
regulation of cell population proliferation  (ISO)
regulation of cerebellar granule cell precursor proliferation  (IDA,IMP)
regulation of DNA-templated transcription  (IMP)
regulation of epithelial cell differentiation  (ISO)
regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
regulation of gene expression  (IBA,IDA,IGI,IMP,ISO)
regulation of glial cell proliferation  (IDA)
regulation of mesenchymal cell proliferation involved in prostate gland development  (IMP)
regulation of odontogenesis  (IMP)
regulation of prostatic bud formation  (IDA,IMP)
regulation of protein localization to nucleus  (ISO)
regulation of proteolysis  (IDA)
regulation of stem cell proliferation  (IMP)
respiratory tube development  (IMP)
response to axon injury  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to retinoic acid  (ISO)
right lung development  (IMP)
roof of mouth development  (IMP)
salivary gland cavitation  (IDA)
self proteolysis  (IDA)
signal transduction  (TAS)
skeletal muscle cell proliferation  (IMP)
skeletal muscle fiber differentiation  (IMP)
skeletal muscle tissue development  (IMP)
skin development  (IMP)
smooth muscle tissue development  (IEA)
smoothened signaling pathway  (IBA,IDA,IGI,IMP,ISO)
somite development  (IMP)
spinal cord dorsal/ventral patterning  (IMP,ISO)
spinal cord motor neuron differentiation  (IGI)
stem cell development  (IMP)
stem cell proliferation  (IDA)
striated muscle cell differentiation  (IDA)
striated muscle tissue development  (IMP)
T cell differentiation in thymus  (IMP)
T cell proliferation  (IMP)
telencephalon regionalization  (IMP,ISO)
thalamus development  (IGI,IMP)
thymus development  (IMP)
thyroid gland development  (IMP)
tongue development  (ISO)
tongue morphogenesis  (ISO)
trachea development  (IMP)
trachea morphogenesis  (IMP)
tracheoesophageal septum formation  (IMP)
trunk neural crest cell migration  (IDA)
vasculature development  (IMP)
vasculogenesis  (IDA)
vasculogenesis involved in coronary vascular morphogenesis  (TAS)
ventral spinal cord interneuron specification  (ISO)
zona limitans intrathalamica formation  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis development  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland physiology  (IAGP)
abnormal adrenocortical cell morphology  (IAGP)
abnormal airway basal cell morphology  (IAGP)
abnormal aldosterone level  (IAGP)
abnormal ameloblast morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal arytenoid cartilage morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal atrium myocardium morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchiole epithelium morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar lobule formation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal dentin morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermis papillary layer morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive organ placement  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ear morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo size  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic autopod plate morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal esophagus morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal floor plate morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal forestomach morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal frontonasal prominence morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gallbladder smooth muscle morphology  (IAGP)
abnormal gastric surface mucous cell morphology  (IAGP)
abnormal genital tubercle morphology  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart left atrium morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal intervertebral disk morphology  (IAGP)
abnormal ischium morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal kidney inner medulla morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney outer medulla inner stripe morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lower incisor morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung lobe morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal lung-associated mesenchyme development  (IAGP)
abnormal magnocellular neurosecretory cell morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal maxillary shelf morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal medial nasal prominence morphology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal cavity morphology  (IAGP)
abnormal nasal pit morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural crest cell apoptosis  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal neurohypophysis development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron specification  (IAGP)
abnormal nose morphology  (IAGP)
abnormal odontoblast morphology  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal optic stalk morphology  (IAGP)
abnormal optic vesicle formation  (IAGP)
abnormal orbit morphology  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal palatal rugae morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal parvocellular neurosecretory cell morphology  (IAGP)
abnormal pectoral girdle bone morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal pharynx morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal posterior semicircular canal morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal prenatal growth/weight/body size  (IAGP)
abnormal primitive urogenital sinus morphology  (IAGP)
abnormal pterygoid bone morphology  (IAGP)
abnormal pubis morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal pulmonary vein morphology  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal reproductive system development  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal respiratory conducting tube morphology  (IAGP)
abnormal respiratory epithelium morphology  (IAGP)
abnormal respiratory epithelium physiology  (IAGP)
abnormal respiratory motile cilium morphology  (IAGP)
abnormal respiratory system development  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal body axis extension  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal smooth muscle morphology  (IAGP)
abnormal somite shape  (IAGP)
abnormal spinal cord interneuron morphology  (IAGP)
abnormal spinal cord lateral motor column morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal stomach glandular epithelium morphology  (IAGP)
abnormal stomach pH  (IAGP)
abnormal submandibular gland morphology  (IAGP)
abnormal superior semicircular canal morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal tail development  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal trachea morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal tracheal ciliated epithelium morphology  (IAGP)
abnormal tracheal smooth muscle morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter smooth muscle morphology  (IAGP)
abnormal urethra urothelium morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal ventral interneuron 2 morphology  (IAGP)
abnormal ventral interneuron 3 morphology  (IAGP)
abnormal ventral tubercle of atlas morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal xiphoid process morphology  (IAGP)
absent alveolar process  (IAGP)
absent cartilage  (IAGP)
absent cerebellar lobules  (IAGP)
absent club cells  (IAGP)
absent corpus callosum  (IAGP)
absent deltoid tuberosity  (IAGP)
absent diencephalon  (IAGP)
absent enamel cord  (IAGP)
absent endolymphatic duct  (IAGP)
absent external female genitalia  (IAGP)
absent external male genitalia  (IAGP)
absent fibula  (IAGP)
absent floor plate  (IAGP)
absent forelimb  (IAGP)
absent gonial bone  (IAGP)
absent hair follicle inner root sheath  (IAGP)
absent hair follicles  (IAGP)
absent hindlimb  (IAGP)
absent incus  (IAGP)
absent lateral semicircular canal  (IAGP)
absent lung buds  (IAGP)
absent lungs  (IAGP)
absent malleus  (IAGP)
absent mandible  (IAGP)
absent mandibular symphysis  (IAGP)
absent mouth  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent notochord  (IAGP)
absent olfactory bulb  (IAGP)
absent olfactory epithelium  (IAGP)
absent parietal bone  (IAGP)
absent philtrum  (IAGP)
absent premaxilla  (IAGP)
absent pulmonary vein  (IAGP)
absent scala media  (IAGP)
absent tibia  (IAGP)
absent tongue  (IAGP)
absent tracheal cartilage rings  (IAGP)
absent tympanic ring  (IAGP)
absent utricle  (IAGP)
absent vertebrae  (IAGP)
absent vestibular saccule  (IAGP)
absent vestibulocochlear ganglion  (IAGP)
absent vibrissae  (IAGP)
absent vitelline blood vessels  (IAGP)
acephaly  (IAGP)
adactyly  (IAGP)
aerophagia  (IAGP)
alisphenoid bone hypoplasia  (IAGP)
alopecia  (IAGP)
anal atresia  (IAGP)
annular pancreas  (IAGP)
anophthalmia  (IAGP)
aphakia  (IAGP)
arrest of tooth development  (IAGP)
ataxia  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
brachydactyly  (IAGP)
brachyphalangia  (IAGP)
cardiac edema  (IAGP)
cerebellum hypoplasia  (IAGP)
cervical vertebral fusion  (IEA)
cleft secondary palate  (IAGP)
cyclopia  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased cell migration  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased club cell number  (IAGP)
decreased dopamine level  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased lean body mass  (IEA)
decreased locomotor activity  (IAGP)
decreased midbrain size  (IAGP)
decreased motor neuron number  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased respiratory mucosa goblet cell number  (IAGP)
decreased rib number  (IAGP)
decreased somite size  (IAGP)
decreased spinal cord size  (IAGP)
decreased tracheal cartilage ring number  (IAGP)
delayed wound healing  (IAGP)
disorganized thalamus  (IAGP)
ectopic neurohypophysis  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged adrenocortical cells  (IAGP)
enlarged brain ventricles  (IAGP)
enlarged lung  (IAGP)
enlarged pericardium  (IAGP)
epidermal hyperplasia  (IAGP)
epiglottis hypoplasia  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
failure of heart looping  (IAGP)
failure of initiation of embryo turning  (IAGP)
fetal growth retardation  (IAGP)
forelimb oligodactyly  (IAGP)
frontonasal prominence hypoplasia  (IAGP)
fused joints  (IAGP)
fusion of atlas and odontoid process  (IAGP)
gastric metaplasia  (IAGP)
growth retardation of incisors  (IAGP)
growth retardation of molars  (IAGP)
hindlimb oligodactyly  (IAGP)
hindlimb paralysis  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IAGP)
hydroureter  (IAGP)
hyperactivity  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired glucose tolerance  (IEA)
impaired lung lobe morphogenesis  (IAGP)
impaired myofibroblast differentiation  (IAGP)
increased apoptosis  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating HDL cholesterol level  (IEA)
increased dopamine level  (IAGP)
increased forebrain size  (IAGP)
increased lung apoptosis  (IAGP)
increased mesenchymal cell proliferation involved in lung development  (IAGP)
increased midbrain size  (IAGP)
increased neuron number  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased solitary pulmonary neuroendocrine cell number  (IAGP)
increased total body fat amount  (IEA)
kidney cortex hypoplasia  (IAGP)
kidney medulla hypoplasia  (IAGP)
left pulmonary isomerism  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
loss of dopaminergic neurons  (IAGP)
lung cyst  (IAGP)
lung inflammation  (IAGP)
mandible hypoplasia  (IAGP)
megacephaly  (IAGP)
microcephaly  (IAGP)
microphthalmia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
notochord degeneration  (IAGP)
occipital bone foramen  (IAGP)
ocular hypertelorism  (IAGP)
ocular hypotelorism  (IAGP)
olfactory bulb hypoplasia  (IAGP)
oligodactyly  (IAGP)
open neural tube  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus  (IAGP)
polydactyly  (IAGP)
polyphalangy  (IAGP)
postaxial polydactyly  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preaxial polydactyly  (IAGP)
premature coronal suture closure  (IAGP)
premature death  (IAGP)
premature neuronal precursor differentiation  (IAGP)
premaxilla hypoplasia  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
proboscis  (IAGP)
pulmonary hypoplasia  (IAGP)
renal hypoplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
round head  (IAGP)
seizures  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short Meckel's cartilage  (IAGP)
short metacarpal bones  (IAGP)
short snout  (IAGP)
short tibia  (IAGP)
short ureter  (IAGP)
single external naris  (IAGP)
slow postnatal weight gain  (IAGP)
small adrenal glands  (IAGP)
small cerebellum  (IAGP)
small cranium  (IAGP)
small gallbladder  (IAGP)
small incisors  (IAGP)
small kidney  (IAGP)
small lung  (IAGP)
small lung lobe  (IAGP)
small molars  (IAGP)
small olfactory bulb  (IAGP)
small snout  (IAGP)
small stomach  (IAGP)
spina bifida  (IAGP)
stomach epithelial hyperplasia  (IAGP)
syndactyly  (IAGP)
synostosis  (IAGP)
thick epidermis  (IAGP)
thin adrenal cortex  (IAGP)
thin epidermis  (IAGP)
thin external granule cell layer  (IAGP)
thin interparietal bone  (IAGP)
trachea stenosis  (IAGP)
tracheoesophageal fistula  (IAGP)
vomer bone hypoplasia  (IAGP)
References

References - curated
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33. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
34. MGDs mouse GO annotations MGD data from the GO Consortium
35. MGD IEA MGD IEA
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42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Mouse MP Annotation Import Pipeline RGD automated import pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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48. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Runck LA, etal., Dis Model Mech. 2014 Apr;7(4):483-93. doi: 10.1242/dmm.014530. Epub 2014 Feb 13.
49. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Sagai T, etal., Development. 2005 Feb;132(4):797-803.
50. Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos. Sasaki Y, etal., Arch Oral Biol. 2007 Mar;52(3):260-7. Epub 2006 Nov 13.
51. Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer. Saze Z, etal., Dig Surg. 2012;29(2):115-23. doi: 10.1159/000336949. Epub 2012 Mar 27.
52. Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis. Seifert T, etal., J Neuropathol Exp Neurol. 2005 May;64(5):404-11.
53. Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch. Sharpe J, etal., Curr Biol. 1999 Jan 28;9(2):97-100.
54. Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer. Sun M, etal., J Med Genet. 2008 Sep;45(9):589-95. doi: 10.1136/jmg.2008.057646. Epub 2008 Apr 16.
55. Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. Wang H, etal., Asian Pac J Cancer Prev. 2012;13(5):2319-24. doi: 10.7314/apjcp.2012.13.5.2319.
56. Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Wang Y, etal., Ann Neurol. 2008 Oct;64(4):417-27. doi: 10.1002/ana.21457.
57. A specific mutation in the distant sonic hedgehog (SHH) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb. Wieczorek D, etal., Hum Mutat. 2010 Jan;31(1):81-9. doi: 10.1002/humu.21142.
58. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
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PMID:25977363   PMID:25978641   PMID:25995356   PMID:25997579   PMID:26001200   PMID:26015562   PMID:26023097   PMID:26027930   PMID:26035863   PMID:26042621   PMID:26051001   PMID:26056142  
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PMID:26166575   PMID:26186931   PMID:26189100   PMID:26192445   PMID:26201092   PMID:26220830   PMID:26235626   PMID:26238256   PMID:26238476   PMID:26271722   PMID:26272614   PMID:26284287  
PMID:26293299   PMID:26305214   PMID:26305926   PMID:26311466   PMID:26319366   PMID:26321050   PMID:26329601   PMID:26334330   PMID:26354024   PMID:26370082   PMID:26387942   PMID:26393505  
PMID:26395479   PMID:26395480   PMID:26407529   PMID:26416758   PMID:26427874   PMID:26436454   PMID:26439398   PMID:26441343   PMID:26446920   PMID:26450968   PMID:26452989   PMID:26457609  
PMID:26459360   PMID:26471504   PMID:26485363   PMID:26487719   PMID:26494787   PMID:26496195   PMID:26509735   PMID:26517967   PMID:26525674   PMID:26534985   PMID:26542012   PMID:26549569  
PMID:26555052   PMID:26560359   PMID:26577380   PMID:26586225   PMID:26598695   PMID:26620267   PMID:26632490   PMID:26648290   PMID:26653852   PMID:26661618   PMID:26674308   PMID:26678520  
PMID:26685326   PMID:26687222   PMID:26702830   PMID:26721501   PMID:26725322   PMID:26745863   PMID:26746790   PMID:26755636   PMID:26764381   PMID:26773732   PMID:26795843   PMID:26797124  
PMID:26830657   PMID:26832331   PMID:26837596   PMID:26869039   PMID:26884322   PMID:26902390   PMID:26906632   PMID:26912819   PMID:26912893   PMID:26921296   PMID:26921474   PMID:26931153  
PMID:26932670   PMID:26952187   PMID:26959361   PMID:26965371   PMID:26967474   PMID:26985044   PMID:26992132   PMID:26999738   PMID:27006501   PMID:27026076   PMID:27046536   PMID:27064252  
PMID:27066502   PMID:27086929   PMID:27106761   PMID:27113760   PMID:27120109   PMID:27171818   PMID:27173853   PMID:27184910   PMID:27212025   PMID:27214567   PMID:27272319   PMID:27289556  
PMID:27299863   PMID:27302476   PMID:27313319   PMID:27320915   PMID:27325696   PMID:27335464   PMID:27341756   PMID:27349434   PMID:27352137   PMID:27364009   PMID:27395006   PMID:27402708  
PMID:27405641   PMID:27414798   PMID:27414999   PMID:27454381   PMID:27498049   PMID:27510750   PMID:27552050   PMID:27558455   PMID:27585885   PMID:27600805   PMID:27611193   PMID:27621227  
PMID:27626380   PMID:27632999   PMID:27633995   PMID:27660324   PMID:27666792   PMID:27705744   PMID:27713059   PMID:27720610   PMID:27720745   PMID:27727273   PMID:27736991   PMID:27760115  
PMID:27768887   PMID:27770010   PMID:27787957   PMID:27789623   PMID:27793670   PMID:27794000   PMID:27802136   PMID:27806288   PMID:27807033   PMID:27811357   PMID:27821748   PMID:27827819  
PMID:27845689   PMID:27849569   PMID:27852806   PMID:27864382   PMID:27867070   PMID:27887593   PMID:27899315   PMID:27918915   PMID:27924807   PMID:27935818   PMID:27935821   PMID:27989796  
PMID:27998989   PMID:28028137   PMID:28031228   PMID:28049658   PMID:28052057   PMID:28052872   PMID:28067220   PMID:28069589   PMID:28069742   PMID:28073938   PMID:28077488   PMID:28122228  
PMID:28131983   PMID:28154153   PMID:28155855   PMID:28174238   PMID:28174244   PMID:28182636   PMID:28202523   PMID:28215635   PMID:28219675   PMID:28233033   PMID:28235772   PMID:28244870  
PMID:28250409   PMID:28262664   PMID:28263766   PMID:28264835   PMID:28323616   PMID:28344083   PMID:28352167   PMID:28379358   PMID:28379564   PMID:28379718   PMID:28380258   PMID:28407057  
PMID:28424350   PMID:28432216   PMID:28434801   PMID:28438836   PMID:28441416   PMID:28445456   PMID:28445731   PMID:28467430   PMID:28483978   PMID:28490013   PMID:28492365   PMID:28501478  
PMID:28506989   PMID:28506991   PMID:28527696   PMID:28530676   PMID:28533268   PMID:28547659   PMID:28560839   PMID:28566470   PMID:28576769   PMID:28578539   PMID:28579317   PMID:28581526  
PMID:28589954   PMID:28591579   PMID:28595615   PMID:28619823   PMID:28619992   PMID:28633908   PMID:28650075   PMID:28675157   PMID:28679037   PMID:28688895   PMID:28694256   PMID:28694260  
PMID:28696225   PMID:28715412   PMID:28726779   PMID:28733464   PMID:28737769   PMID:28743797   PMID:28771384   PMID:28778798   PMID:28778988   PMID:28793263   PMID:28797033   PMID:28807898  
PMID:28808032   PMID:28813629   PMID:28817564   PMID:28820907   PMID:28827394   PMID:28839193   PMID:28859094   PMID:28874804   PMID:28885142   PMID:28891097   PMID:28892064   PMID:28893950  
PMID:28931923   PMID:28938441   PMID:28941984   PMID:28943241   PMID:28950910   PMID:28954202   PMID:28990069   PMID:29016745   PMID:29021530   PMID:29031500   PMID:29038301   PMID:29044125  
PMID:29045809   PMID:29068314   PMID:29083321   PMID:29088375   PMID:29107074   PMID:29118110   PMID:29133390   PMID:29138054   PMID:29139542   PMID:29155305   PMID:29158396   PMID:29166577  
PMID:29179813   PMID:29180573   PMID:29180744   PMID:29196093   PMID:29203676   PMID:29205155   PMID:29211850   PMID:29222391   PMID:29255029   PMID:29272992   PMID:29279401   PMID:29284139  
PMID:29292497   PMID:29321139   PMID:29343636   PMID:29343638   PMID:29346753   PMID:29359685   PMID:29361554   PMID:29365079   PMID:29378965   PMID:29386246   PMID:29394901   PMID:29396625  
PMID:29408236   PMID:29420258   PMID:29428562   PMID:29437780   PMID:29438014   PMID:29440304   PMID:29475039   PMID:29487191   PMID:29532549   PMID:29535725   PMID:29562183   PMID:29571613  
PMID:29615464   PMID:29684311   PMID:29700203   PMID:29705333   PMID:29725084   PMID:29729398   PMID:29739868   PMID:29768039   PMID:29784673   PMID:29787797   PMID:29792854   PMID:29796621  
PMID:29853539   PMID:29866044   PMID:29869132   PMID:29874522   PMID:29878134   PMID:29879378   PMID:29885287   PMID:29897331   PMID:29903911   PMID:29933500   PMID:29945863   PMID:29950483  
PMID:29981310   PMID:29992973   PMID:30016620   PMID:30021842   PMID:30026494   PMID:30046041   PMID:30058223   PMID:30061411   PMID:30063881   PMID:30085028   PMID:30116001   PMID:30134070  
PMID:30144507   PMID:30177510   PMID:30193838   PMID:30194919   PMID:30228103   PMID:30228991   PMID:30232009   PMID:30235284   PMID:30236923   PMID:30244870   PMID:30250269   PMID:30254141  
PMID:30254199   PMID:30286078   PMID:30291164   PMID:30292786   PMID:30305289   PMID:30317648   PMID:30352686   PMID:30352852   PMID:30366903   PMID:30380057   PMID:30389913   PMID:30420661  
PMID:30445565   PMID:30464171   PMID:30485816   PMID:30487124   PMID:30504126   PMID:30541888   PMID:30559277   PMID:30570432   PMID:30630826   PMID:30638444   PMID:30651296   PMID:30659230  
PMID:30659795   PMID:30661738   PMID:30661739   PMID:30689541   PMID:30692221   PMID:30696710   PMID:30714224   PMID:30745430   PMID:30745437   PMID:30765517   PMID:30787437   PMID:30791390  
PMID:30814516   PMID:30814736   PMID:30841515   PMID:30843579   PMID:30853186   PMID:30853403   PMID:30872278   PMID:30875130   PMID:30886905   PMID:30914320   PMID:30923168   PMID:30931988  
PMID:30944105   PMID:30959515   PMID:30963569   PMID:30973324   PMID:30977233   PMID:31006513   PMID:31028279   PMID:31038803   PMID:31071314   PMID:31072004   PMID:31076486   PMID:31080015  
PMID:31107948   PMID:31118412   PMID:31120883   PMID:31133375   PMID:31145830   PMID:31147463   PMID:31163988   PMID:31171577   PMID:31194676   PMID:31226309   PMID:31242446   PMID:31242448  
PMID:31264977   PMID:31269445   PMID:31291246   PMID:31291587   PMID:31301300   PMID:31305241   PMID:31345929   PMID:31371375   PMID:31373354   PMID:31379834   PMID:31427537   PMID:31461626  
PMID:31486675   PMID:31488567   PMID:31494034   PMID:31506300   PMID:31511252   PMID:31548395   PMID:31558711   PMID:31570121   PMID:31589904   PMID:31591086   PMID:31597917   PMID:31631021  
PMID:31631837   PMID:31634536   PMID:31638600   PMID:31669249   PMID:31670387   PMID:31685615   PMID:31690747   PMID:31700187   PMID:31719045   PMID:31767619   PMID:31813796   PMID:31813798  
PMID:31825820   PMID:31838787   PMID:31844668   PMID:31845891   PMID:31875564   PMID:31875961   PMID:31887266   PMID:31896583   PMID:31913118   PMID:31924792   PMID:31950080   PMID:31964774  
PMID:31968603   PMID:31989924   PMID:32001436   PMID:32048989   PMID:32059772   PMID:32108165   PMID:32127497   PMID:32129762   PMID:32149370   PMID:32156750   PMID:32156757   PMID:32169553  
PMID:32179481   PMID:32219310   PMID:32243674   PMID:32253237   PMID:32268095   PMID:32276104   PMID:32286221   PMID:32317081   PMID:32317643   PMID:32320667   PMID:32332736   PMID:32345752  
PMID:32392211   PMID:32394892   PMID:32414917   PMID:32435793   PMID:32439755   PMID:32439762   PMID:32450229   PMID:32450295   PMID:32453714   PMID:32456161   PMID:32457352   PMID:32495183  
PMID:32515350   PMID:32537777   PMID:32552877   PMID:32553121   PMID:32554499   PMID:32561646   PMID:32562661   PMID:32568216   PMID:32574593   PMID:32581832   PMID:32597756   PMID:32616504  
PMID:32628936   PMID:32645357   PMID:32662771   PMID:32664967   PMID:32665241   PMID:32674056   PMID:32679029   PMID:32680935   PMID:32683324   PMID:32685006   PMID:32702291   PMID:32708917  
PMID:32737167   PMID:32746867   PMID:32758357   PMID:32772391   PMID:32848868   PMID:32855415   PMID:32855417   PMID:32866472   PMID:32882513   PMID:32938678   PMID:32994164   PMID:33006313  
PMID:33023974   PMID:33051257   PMID:33060832   PMID:33063110   PMID:33090184   PMID:33103996   PMID:33153107   PMID:33158935   PMID:33177537   PMID:33184218   PMID:33230114   PMID:33234718  
PMID:33305180   PMID:33314622   PMID:33318148   PMID:33328171   PMID:33329029   PMID:33355093   PMID:33382037   PMID:33385344   PMID:33469032   PMID:33472083   PMID:33475496   PMID:33510480  
PMID:33515576   PMID:33530552   PMID:33561442   PMID:33570491   PMID:33659251   PMID:33707239   PMID:33804256   PMID:33811429   PMID:33863273   PMID:33863876   PMID:33869166   PMID:33882290  
PMID:33898467   PMID:33914869   PMID:33932339   PMID:33946098   PMID:33947861   PMID:33951080   PMID:34004180   PMID:34009125   PMID:34010630   PMID:34062094   PMID:34108685   PMID:34121118  
PMID:34129836   PMID:34132778   PMID:34150743   PMID:34210780   PMID:34289374   PMID:34321664   PMID:34321999   PMID:34330843   PMID:34339499   PMID:34346313   PMID:34353359   PMID:34419491  
PMID:34427305   PMID:34433966   PMID:34449628   PMID:34463328   PMID:34482626   PMID:34518367   PMID:34547244   PMID:34552196   PMID:34557485   PMID:34557486   PMID:34638864   PMID:34643182  
PMID:34671097   PMID:34672258   PMID:34698766   PMID:34707294   PMID:34767969   PMID:34796774   PMID:34822715   PMID:34851738   PMID:34928956   PMID:34932949   PMID:34998785   PMID:35020897  
PMID:35027088   PMID:35044299   PMID:35051272   PMID:35103284   PMID:35112129   PMID:35114852   PMID:35132078   PMID:35145123   PMID:35170357   PMID:35196485   PMID:35210288   PMID:35283102  
PMID:35294885   PMID:35302583   PMID:35303432   PMID:35322202   PMID:35353806   PMID:35377797   PMID:35399523   PMID:35421372   PMID:35438410   PMID:35504891   PMID:35512705   PMID:35547246  
PMID:35577801   PMID:35593225   PMID:35652338   PMID:35676931   PMID:35682694   PMID:35686648   PMID:35700056   PMID:35770682   PMID:35831953   PMID:35854647   PMID:35864091   PMID:35867784  
PMID:35905011   PMID:35931079   PMID:35942101   PMID:35950911   PMID:35951005   PMID:35974013   PMID:35976093   PMID:35977544   PMID:36026468   PMID:36064547   PMID:36067211   PMID:36094016  
PMID:36108627   PMID:36115458   PMID:36123354   PMID:36173678   PMID:36196625   PMID:36218069   PMID:36220081   PMID:36260151   PMID:36265686   PMID:36281454   PMID:36302841   PMID:36342840  
PMID:36398878   PMID:36403857   PMID:36433959   PMID:36465133   PMID:36476860   PMID:36517931   PMID:36543133   PMID:36619975   PMID:36680528   PMID:36699680   PMID:36737666   PMID:36745682  
PMID:36762637   PMID:36764291   PMID:36853961   PMID:36864068   PMID:36916392   PMID:36971701   PMID:37190906   PMID:37228654   PMID:37250135   PMID:37279266   PMID:37296573   PMID:37298583  
PMID:37307487   PMID:37315133   PMID:37318953   PMID:37364687   PMID:37390294   PMID:37414772   PMID:37414952   PMID:37442233   PMID:37460185   PMID:37481204   PMID:37497597   PMID:37516749  
PMID:37524711   PMID:37573008   PMID:37591247   PMID:37595582   PMID:37608075   PMID:37680190   PMID:37704733   PMID:37726288   PMID:37756583   PMID:37776236   PMID:37794731   PMID:37805104  
PMID:37843535   PMID:37850829   PMID:37861292   PMID:37863656   PMID:37873566   PMID:37966260   PMID:38041813   PMID:38051593   PMID:38062245   PMID:38079471   PMID:38085183   PMID:38108472  
PMID:38131461   PMID:38159590   PMID:38171360   PMID:38233525   PMID:38234039   PMID:38267260   PMID:38329543   PMID:38355793   PMID:38358805   PMID:38411462   PMID:38466355   PMID:38492220  
PMID:38509075   PMID:38509385   PMID:38511331   PMID:38558491   PMID:38569553   PMID:38582368   PMID:38669326   PMID:38696583   PMID:38721990   PMID:38750698   PMID:38760361   PMID:38770834  
PMID:38781326   PMID:38781967   PMID:38828908   PMID:38848388   PMID:38865239   PMID:38871845   PMID:38941190   PMID:39000154   PMID:39001875   PMID:39029571   PMID:39107332   PMID:39157903  
PMID:39160068   PMID:39178848   PMID:39181129   PMID:39225402   PMID:39284798   PMID:39413781   PMID:39579767   PMID:39629522   PMID:39641142   PMID:39704783   PMID:39817691   PMID:39831750  
PMID:39890843   PMID:39900499  


Genomics

Comparative Map Data
Shh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,661,838 - 28,672,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl528,661,813 - 28,672,254 (-)EnsemblGRCm39 Ensembl
GRCm38528,456,840 - 28,467,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,456,815 - 28,467,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv37528,783,380 - 28,793,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36528,787,627 - 28,797,875 (-)NCBIMGSCv36mm8
Celera525,997,895 - 26,008,156 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map514.39NCBI
SHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7155,799,980 - 155,812,463 (-)EnsemblGRCh38hg38GRCh38
GRCh377155,592,674 - 155,605,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36Build 36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,604,000 - 155,613,409 (-)NCBICHM1_1
T2T-CHM13v2.07156,983,127 - 156,995,607 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
Shh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr847,687,872 - 7,697,025 (+)NCBIGRCr8
mRatBN7.246,954,017 - 6,963,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl46,954,017 - 6,963,170 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx411,962,609 - 11,971,762 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.047,776,827 - 7,785,980 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,123,054 - 6,132,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04718,538 - 727,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4718,538 - 727,691 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04711,420 - 720,573 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,200,504 - 2,209,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.142,200,503 - 2,209,657 (+)NCBI
Celera43,316,537 - 3,325,690 (-)NCBICelera
Cytogenetic Map4q11NCBI
Shh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554918,647,133 - 8,657,381 (-)NCBIChiLan1.0ChiLan1.0
SHH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26192,227,225 - 192,240,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1744,237,491 - 44,251,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07147,400,112 - 147,414,036 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17159,116,966 - 159,126,660 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7159,114,666 - 159,126,651 (-)Ensemblpanpan1.1panPan2
SHH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11618,650,553 - 18,663,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1618,484,809 - 18,662,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1619,286,449 - 19,295,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01620,382,879 - 20,392,367 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1620,382,707 - 20,392,037 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11618,753,210 - 18,762,671 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01619,333,131 - 19,342,583 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01619,386,812 - 19,396,258 (-)NCBIUU_Cfam_GSD_1.0
Shh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051182,860,455 - 2,871,247 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652710,033,299 - 10,042,599 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652710,033,095 - 10,042,713 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,545,994 - 2,555,484 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,546,202 - 2,555,484 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,664,794 - 2,673,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121123,929,937 - 123,942,451 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21123,932,900 - 123,942,395 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607220,134,625 - 20,147,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248002,203,393 - 2,212,068 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248002,202,986 - 2,215,309 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shh
378 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:193
Interacting mature miRNAs:197
Transcripts:ENSMUST00000002708
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse

Markers in Region
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37528,785,132 - 28,785,310UniSTSGRCm37
MGSCv37528,784,397 - 28,784,656UniSTSGRCm37
Celera525,998,912 - 25,999,171UniSTS
Celera525,999,647 - 25,999,825UniSTS
Cytogenetic Map5B1UniSTS
cM Map516.0UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38528,457,857 - 28,458,116UniSTSGRCm38
MGSCv37528,784,397 - 28,784,656UniSTSGRCm37
Celera525,998,912 - 25,999,171UniSTS
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
cM Map516.0UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38528,458,592 - 28,458,770UniSTSGRCm38
MGSCv37528,785,132 - 28,785,310UniSTSGRCm37
Celera525,999,647 - 25,999,825UniSTS
Cytogenetic Map5B1UniSTS
cM Map516.0UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
Shh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000002708   ⟹   ENSMUSP00000002708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl528,661,813 - 28,672,254 (-)Ensembl
GRCm38.p6 Ensembl528,456,815 - 28,467,256 (-)Ensembl
RefSeq Acc Id: NM_009170   ⟹   NP_033196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39528,661,838 - 28,672,099 (-)NCBI
GRCm38528,456,840 - 28,467,101 (-)ENTREZGENE
MGSCv37528,783,380 - 28,793,641 (-)RGD
Celera525,997,895 - 26,008,156 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006535648   ⟹   XP_006535711
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39528,661,838 - 28,670,146 (-)NCBI
GRCm38528,456,840 - 28,465,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006535649   ⟹   XP_006535712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39528,661,838 - 28,670,522 (-)NCBI
GRCm38528,456,840 - 28,465,523 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033196   ⟸   NM_009170
- Peptide Label: precursor
- UniProtKB: Q62226 (UniProtKB/Swiss-Prot),   Q8C765 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006535712   ⟸   XM_006535649
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006535711   ⟸   XM_006535648
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000002708   ⟸   ENSMUST00000002708
Protein Domains
Hedgehog N-terminal signalling   Hedgehog protein Hint   Hint

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62226-F1-model_v2 AlphaFold Q62226 1-437 view protein structure

Promoters
RGD ID:6886250
Promoter ID:EPDNEW_M6576
Type:single initiation site
Name:Shh_1
Description:Mus musculus sonic hedgehog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38528,467,101 - 28,467,161EPDNEW
RGD ID:6838347
Promoter ID:MM_KWN:41706
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000002708
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36528,793,211 - 28,793,711 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98297 AgrOrtholog
Ensembl Genes ENSMUSG00000002633 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000002708 ENTREZGENE
  ENSMUST00000002708.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1380.10 UniProtKB/Swiss-Prot
  Hedgehog/Intein (Hint) domain UniProtKB/Swiss-Prot
InterPro Hedgehog UniProtKB/Swiss-Prot
  Hedgehog_Hint UniProtKB/Swiss-Prot
  Hedgehog_sig/DD-Pept_Zn-bd_sf UniProtKB/Swiss-Prot
  Hedgehog_Signaling UniProtKB/Swiss-Prot
  Hedgehog_signalling_dom UniProtKB/Swiss-Prot
  Hint_dom_C UniProtKB/Swiss-Prot
  Hint_dom_N UniProtKB/Swiss-Prot
  Hint_dom_sf UniProtKB/Swiss-Prot
  Intein_N UniProtKB/Swiss-Prot
KEGG Report mmu:20423 UniProtKB/Swiss-Prot
MGD MGI:98297 ENTREZGENE
NCBI Gene 20423 ENTREZGENE
PANTHER HEDGEHOG UniProtKB/Swiss-Prot
  SONIC HEDGEHOG PROTEIN UniProtKB/Swiss-Prot
Pfam HH_signal UniProtKB/Swiss-Prot
  Hint UniProtKB/Swiss-Prot
PharmGKB SHH RGD
PhenoGen Shh PhenoGen
PIRSF Peptidase_C46 UniProtKB/Swiss-Prot
PRINTS SONICHHOG UniProtKB/Swiss-Prot
PROSITE INTEIN_N_TER UniProtKB/Swiss-Prot
SMART HintC UniProtKB/Swiss-Prot
  HintN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51294 UniProtKB/Swiss-Prot
  SSF55166 UniProtKB/Swiss-Prot
UniProt B3GAP8_MOUSE UniProtKB/TrEMBL
  Q62226 ENTREZGENE
  Q8C765 ENTREZGENE, UniProtKB/TrEMBL
  SHH_MOUSE UniProtKB/Swiss-Prot