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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ropinirole
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Accession:CHEBI:8888 term browser browse the term
Definition:An indolone that has formula C16H24N2O.
Synonyms:exact_synonym: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C16H24N2O;   InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);   InChIKey=UHSKFQJFRQCDBE-UHFFFAOYSA-N;   SMILES=CCCN(CCC)CCc1cccc2NC(=O)Cc12;   ropinirol;   ropinirolum
 xref: Beilstein:6062222;   CAS:91374-21-9;   DrugBank:DB00268;   Drug_Central:2402;   KEGG:C07564;   KEGG:D08489;   LINCS:LSM-2351
 xref_mesh: MESH:C046649
 xref: Patent:US4452808;   Wikipedia:Ropinirole



show annotations for term's descendants           Sort by:
ropinirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression ISO ropinirole results in increased expression of BCL2 protein CTD PMID:18242171 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein] CTD PMID:18242171 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:18242171 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]] CTD PMID:25053526 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO ropinirole binds to and results in increased activity of DRD2 protein CTD PMID:18393062 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO ropinirole binds to and results in increased activity of DRD3 protein CTD PMID:18242171 PMID:18393062 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO ropinirole binds to and results in increased activity of DRD4 protein CTD PMID:18393062 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Egr1 early growth response 1 decreases expression EXP ropinirole results in decreased expression of EGR1 mRNA CTD PMID:20452347 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein] CTD PMID:18242171 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ropinirole results in increased phosphorylation of MAPK1 protein CTD PMID:18242171 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ropinirole results in increased phosphorylation of MAPK3 protein CTD PMID:18242171 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            central nervous system drug 16785
              ropinirole 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic heterocyclic compound 18857
                                  organic heteropolycyclic compound 18303
                                    organic heterobicyclic compound 17221
                                      benzopyrrole 9728
                                        indoles 9414
                                          indolones 5931
                                            ropinirole 13
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