Med31 (mediator complex subunit 31) - Rat Genome Database

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Gene: Med31 (mediator complex subunit 31) Mus musculus
Analyze
Symbol: Med31
Name: mediator complex subunit 31
RGD ID: 1553215
MGI Page MGI
Description: Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleus. Predicted to be part of core mediator complex; mediator complex; and ubiquitin ligase complex. Is expressed in testis. Orthologous to human MED31 (mediator complex subunit 31).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3110004H13Rik; CGI-125; l11Jus; l11Jus15; mediator complex subunit SOH1; mediator of RNA polymerase II transcription subunit 31; mediator of RNA polymerase II transcription, subunit 31 homolog; RP23-207N15.5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,102,550 - 72,106,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,102,550 - 72,106,418 (-)EnsemblGRCm39 Ensembl
GRCm381172,211,724 - 72,215,592 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,211,724 - 72,215,592 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,025,226 - 72,029,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,027,919 - 72,031,787 (-)NCBIMGSCv36mm8
Celera1179,738,234 - 79,742,078 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11559591   PMID:11591653   PMID:12477932   PMID:12584197   PMID:12955145   PMID:14681479   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:17696610   PMID:18799693   PMID:20011118   PMID:20059953   PMID:20211142   PMID:20347762   PMID:20508642   PMID:21873635   PMID:23273896   PMID:34506481  


Genomics

Comparative Map Data
Med31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,102,550 - 72,106,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,102,550 - 72,106,418 (-)EnsemblGRCm39 Ensembl
GRCm381172,211,724 - 72,215,592 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,211,724 - 72,215,592 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,025,226 - 72,029,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,027,919 - 72,031,787 (-)NCBIMGSCv36mm8
Celera1179,738,234 - 79,742,078 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.93NCBI
MED31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,643,311 - 6,651,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,643,311 - 6,651,634 (-)EnsemblGRCh38hg38GRCh38
GRCh37176,546,631 - 6,554,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,487,357 - 6,495,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34176,487,788 - 6,495,650NCBI
Celera176,567,689 - 6,576,019 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,441,917 - 6,450,238 (-)NCBIHuRef
CHM1_1176,556,928 - 6,565,240 (-)NCBICHM1_1
T2T-CHM13v2.0176,543,942 - 6,552,234 (-)NCBIT2T-CHM13v2.0
Med31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,335,507 - 57,338,889 (-)NCBIGRCr8
mRatBN7.21056,836,944 - 56,840,326 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1056,836,944 - 56,840,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1061,499,924 - 61,503,307 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01060,988,409 - 60,991,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,487,487 - 56,490,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01058,780,987 - 58,784,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1058,780,597 - 58,784,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01058,521,398 - 58,524,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,104,233 - 59,107,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,117,860 - 59,121,235 (-)NCBI
Celera1055,966,875 - 55,970,257 (-)NCBICelera
Cytogenetic Map10q24NCBI
Med31
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,147,277 - 12,155,066 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,147,277 - 12,155,066 (-)NCBIChiLan1.0ChiLan1.0
MED31
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,244,412 - 14,256,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,210,583 - 16,217,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0176,681,675 - 6,689,115 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,669,582 - 6,676,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,669,582 - 6,676,882 (-)Ensemblpanpan1.1panPan2
MED31
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1530,693,844 - 30,700,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl530,700,188 - 30,700,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha530,826,228 - 30,833,199 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0530,795,346 - 30,802,318 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl530,795,424 - 30,802,316 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,761,347 - 30,768,295 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0530,720,189 - 30,727,161 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,893,358 - 30,900,363 (+)NCBIUU_Cfam_GSD_1.0
Med31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560254,548,817 - 54,555,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366771,345,456 - 1,351,176 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366771,345,448 - 1,352,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,728,871 - 50,736,074 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,728,681 - 50,734,469 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,727,955 - 52,732,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED31
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,019,668 - 6,027,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605915,413,649 - 15,421,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med31
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,388,698 - 7,395,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247867,388,621 - 7,395,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med31
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:220
Interacting mature miRNAs:235
Transcripts:ENSMUST00000021157, ENSMUST00000129264
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse

Markers in Region
Med31  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B4UniSTS
cM Map11 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000021157   ⟹   ENSMUSP00000021157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,102,550 - 72,106,418 (-)Ensembl
GRCm38.p6 Ensembl1172,211,724 - 72,215,592 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,104,034 - 72,105,879 (-)Ensembl
GRCm38.p6 Ensembl1172,213,208 - 72,215,053 (-)Ensembl
RefSeq Acc Id: NM_026068   ⟹   NP_080344
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391172,102,550 - 72,106,418 (-)NCBI
GRCm381172,211,724 - 72,215,592 (-)ENTREZGENE
MGSCv371172,025,226 - 72,029,094 (-)RGD
Celera1179,738,234 - 79,742,078 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_080344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH51929 (Get FASTA)   NCBI Sequence Viewer  
  BAB24169 (Get FASTA)   NCBI Sequence Viewer  
  BAB29102 (Get FASTA)   NCBI Sequence Viewer  
  EDL12666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000021157
  ENSMUSP00000021157.9
GenBank Protein Q9CXU1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_080344   ⟸   NM_026068
- UniProtKB: Q9DAP5 (UniProtKB/Swiss-Prot),   Q9CXU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021157   ⟸   ENSMUST00000021157

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CXU1-F1-model_v2 AlphaFold Q9CXU1 1-131 view protein structure

Promoters
RGD ID:6821250
Promoter ID:MM_KWN:8307
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   MEF_B6
Transcripts:NM_026068,   OTTMUST00000013790
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361172,028,471 - 72,028,971 (-)MPROMDB
RGD ID:8675418
Promoter ID:EPDNEW_M15740
Type:initiation region
Name:Med31_1
Description:Mus musculus mediator complex subunit 31 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15743  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381172,215,042 - 72,215,102EPDNEW
RGD ID:8675424
Promoter ID:EPDNEW_M15743
Type:initiation region
Name:Med31_2
Description:Mus musculus mediator complex subunit 31 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15740  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381172,215,591 - 72,215,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914529 AgrOrtholog
Ensembl Genes ENSMUSG00000020801 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021157 ENTREZGENE
  ENSMUST00000021157.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1340 UniProtKB/Swiss-Prot
InterPro Med31_sf UniProtKB/Swiss-Prot
  Mediator_Med31 UniProtKB/Swiss-Prot
KEGG Report mmu:67279 UniProtKB/Swiss-Prot
MGD MGI:1914529 ENTREZGENE
NCBI Gene 67279 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 UniProtKB/Swiss-Prot
  PTHR13186 UniProtKB/Swiss-Prot
Pfam Med31 UniProtKB/Swiss-Prot
PhenoGen Med31 PhenoGen
UniProt MED31_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9DAP5 ENTREZGENE
UniProt Secondary Q9DAP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Med31  mediator complex subunit 31    mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)  Symbol and/or name change 5135510 APPROVED