Kank2 (KN motif and ankyrin repeat domains 2) - Rat Genome Database

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Gene: Kank2 (KN motif and ankyrin repeat domains 2) Mus musculus
Analyze
Symbol: Kank2
Name: KN motif and ankyrin repeat domains 2
RGD ID: 1557688
MGI Page MGI
Description: Involved in podocyte cell migration and regulation of Rho protein signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in 2nd branchial arch; blastocyst; cerebral cortex; limb; and meninges. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16 and palmoplantar keratoderma and woolly hair. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI504612; Ankr; Ankrd25; ankyrin repeat domain 25; ankyrin repeat domain-containing protein 25; KN motif and ankyrin repeat domain-containing protein 2; MGC12143; MGC7734; MGC:12143; MGC:7734
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,678,069 - 21,709,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,678,080 - 21,710,040 (-)EnsemblGRCm39 Ensembl
GRCm38921,766,773 - 21,798,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,766,784 - 21,798,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,571,217 - 21,602,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,518,479 - 21,548,919 (-)NCBIMGSCv36mm8
Celera919,036,363 - 19,068,137 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
fipronil  (ISO)
folic acid  (EXP)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
methimazole  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
mitochondrion  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16325481   PMID:16602821   PMID:17967808   PMID:17996375   PMID:18799693   PMID:20059953   PMID:20720434   PMID:21267068   PMID:21873635   PMID:24960163  
PMID:25961457   PMID:26792178   PMID:27548916   PMID:28378742   PMID:28671696   PMID:32325033   PMID:33253712   PMID:33903225   PMID:34274317   PMID:34321999   PMID:37142655  


Genomics

Comparative Map Data
Kank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,678,069 - 21,709,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,678,080 - 21,710,040 (-)EnsemblGRCm39 Ensembl
GRCm38921,766,773 - 21,798,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,766,784 - 21,798,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,571,217 - 21,602,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,518,479 - 21,548,919 (-)NCBIMGSCv36mm8
Celera919,036,363 - 19,068,137 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.88NCBI
KANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,164,270 - 11,197,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,164,270 - 11,197,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,274,946 - 11,308,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,135,946 - 11,167,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,135,946 - 11,167,496NCBI
Celera1911,169,761 - 11,203,056 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,851,580 - 10,884,321 (-)NCBIHuRef
CHM1_11911,276,193 - 11,309,454 (-)NCBICHM1_1
T2T-CHM13v2.01911,291,296 - 11,324,866 (-)NCBIT2T-CHM13v2.0
Kank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,587,770 - 28,617,212 (-)NCBIGRCr8
mRatBN7.2820,311,676 - 20,341,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,311,676 - 20,340,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,347,039 - 24,376,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,642,587 - 22,671,915 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,541,282 - 20,570,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,792,000 - 22,821,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,791,995 - 22,821,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,846,154 - 22,875,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,865,615 - 20,892,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,702,311 - 21,731,556 (-)NCBICelera
Cytogenetic Map8q13NCBI
Kank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554952,168,992 - 2,173,581 (-)NCBIChiLan1.0ChiLan1.0
KANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,080,285 - 16,113,351 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,078,983 - 15,111,807 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,713,582 - 10,746,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,426,149 - 11,457,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,426,149 - 11,457,359 (-)Ensemblpanpan1.1panPan2
KANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,067,749 - 50,093,377 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,067,760 - 50,091,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,941,266 - 49,966,898 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,588,664 - 50,614,343 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,588,642 - 50,614,335 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,798,849 - 49,824,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,225,723 - 50,251,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,468,431 - 50,494,081 (+)NCBIUU_Cfam_GSD_1.0
Kank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,015,097 - 209,034,537 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,321,980 - 1,337,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,320,169 - 1,340,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,896,120 - 69,924,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,896,116 - 69,925,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,095,319 - 10,131,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,095,246 - 10,131,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,755,298 - 9,792,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,041,991 - 3,062,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,039,871 - 3,060,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kank2
944 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:732
Count of miRNA genes:489
Interacting mature miRNAs:555
Transcripts:ENSMUST00000034717
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse

Markers in Region
AI504612  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,766,928 - 21,767,044UniSTSGRCm38
MGSCv37921,571,372 - 21,571,488UniSTSGRCm37
Celera919,036,518 - 19,036,634UniSTS
Cytogenetic Map9A3UniSTS
Whitehead/MRC_RH9256.33UniSTS
UniSTS:236071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,766,917 - 21,767,117UniSTSGRCm38
MGSCv37921,571,361 - 21,571,561UniSTSGRCm37
Celera919,036,507 - 19,036,707UniSTS
Cytogenetic Map9A3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034717   ⟹   ENSMUSP00000034717
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,678,080 - 21,710,040 (-)Ensembl
GRCm38.p6 Ensembl921,766,784 - 21,798,744 (-)Ensembl
Ensembl Acc Id: ENSMUST00000213691   ⟹   ENSMUSP00000150735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,706,936 - 21,709,822 (-)Ensembl
GRCm38.p6 Ensembl921,795,640 - 21,798,526 (-)Ensembl
Ensembl Acc Id: ENSMUST00000216008   ⟹   ENSMUSP00000151181
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,679,358 - 21,709,799 (-)Ensembl
GRCm38.p6 Ensembl921,768,062 - 21,798,503 (-)Ensembl
RefSeq Acc Id: NM_145611   ⟹   NP_663586
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,678,069 - 21,709,842 (-)NCBI
GRCm38921,766,773 - 21,798,546 (-)ENTREZGENE
MGSCv37921,571,217 - 21,602,990 (-)RGD
Celera919,036,363 - 19,068,137 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_663586   ⟸   NM_145611
- UniProtKB: Q91Z35 (UniProtKB/Swiss-Prot),   Q8BX02 (UniProtKB/Swiss-Prot),   Q8BLD5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034717   ⟸   ENSMUST00000034717
Ensembl Acc Id: ENSMUSP00000150735   ⟸   ENSMUST00000213691
Ensembl Acc Id: ENSMUSP00000151181   ⟸   ENSMUST00000216008

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BX02-F1-model_v2 AlphaFold Q8BX02 1-843 view protein structure

Promoters
RGD ID:6849271
Promoter ID:MM_XEF:7367
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:NM_001076531
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,601,971 - 21,602,471 (-)MPROMDB
RGD ID:6844707
Promoter ID:MM_KWN:56589
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000086340,   NM_145611
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,602,596 - 21,603,102 (-)MPROMDB
RGD ID:8668974
Promoter ID:EPDNEW_M12518
Type:initiation region
Name:Kank2_1
Description:Mus musculus KN motif and ankyrin repeat domains 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38921,798,517 - 21,798,577EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384568 AgrOrtholog
Ensembl Genes ENSMUSG00000032194 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034717 ENTREZGENE
  ENSMUST00000034717.7 UniProtKB/Swiss-Prot
  ENSMUST00000213691.2 UniProtKB/TrEMBL
  ENSMUST00000216008.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  KANK1-4 UniProtKB/Swiss-Prot
  KN_motif UniProtKB/Swiss-Prot
KEGG Report mmu:235041 UniProtKB/Swiss-Prot
MGD MGI:2384568 ENTREZGENE
NCBI Gene Kank2 ENTREZGENE
PANTHER KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  KN_motif UniProtKB/Swiss-Prot
PhenoGen Kank2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A1L1SUF5_MOUSE UniProtKB/TrEMBL
  KANK2_MOUSE UniProtKB/Swiss-Prot
  Q8BLD5 ENTREZGENE
  Q8BX02 ENTREZGENE
  Q91Z35 ENTREZGENE
UniProt Secondary Q8BLD5 UniProtKB/Swiss-Prot
  Q91Z35 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Kank2  KN motif and ankyrin repeat domains 2  BC010245  cDNA sequence BC010245  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 BC010245  cDNA sequence BC010245  Kank2  KN motif and ankyrin repeat domains 2  Symbol and/or name change 5135510 APPROVED