Kank2 (KN motif and ankyrin repeat domains 2) - Rat Genome Database

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Gene: Kank2 (KN motif and ankyrin repeat domains 2) Rattus norvegicus
Analyze
Symbol: Kank2
Name: KN motif and ankyrin repeat domains 2
RGD ID: 2320289
Description: Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; podocyte cell migration; and regulation of signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KN motif and ankyrin repeat domain-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2-like; LOC100361376; rCG31687-like; RGD1563532
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,311,676 - 20,341,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,311,676 - 20,340,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,347,039 - 24,376,370 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,642,587 - 22,671,915 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,541,282 - 20,570,501 (-)NCBIRnor_WKY
Rnor_6.0822,792,000 - 22,821,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,791,995 - 22,821,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,846,154 - 22,875,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,865,615 - 20,892,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,702,311 - 21,731,556 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
mitochondrion  (IEA,ISO)

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Gee HY, etal., J Clin Invest. 2015 Jun;125(6):2375-84. doi: 10.1172/JCI79504. Epub 2015 May 11.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17476305   PMID:22371500   PMID:24671081   PMID:32544715   PMID:32570033   PMID:33450132  


Genomics

Comparative Map Data
Kank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,311,676 - 20,341,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,311,676 - 20,340,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,347,039 - 24,376,370 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,642,587 - 22,671,915 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,541,282 - 20,570,501 (-)NCBIRnor_WKY
Rnor_6.0822,792,000 - 22,821,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,791,995 - 22,821,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,846,154 - 22,875,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,865,615 - 20,892,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,702,311 - 21,731,556 (-)NCBICelera
Cytogenetic Map8q13NCBI
KANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,164,270 - 11,197,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1911,164,270 - 11,197,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,274,946 - 11,308,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,135,946 - 11,167,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,135,946 - 11,167,496NCBI
Celera1911,169,761 - 11,203,056 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,851,580 - 10,884,321 (-)NCBIHuRef
CHM1_11911,276,193 - 11,309,454 (-)NCBICHM1_1
T2T-CHM13v2.01911,291,296 - 11,324,866 (-)NCBIT2T-CHM13v2.0
Kank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,678,069 - 21,709,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,678,080 - 21,710,040 (-)EnsemblGRCm39 Ensembl
GRCm38921,766,773 - 21,798,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,766,784 - 21,798,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,571,217 - 21,602,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,518,479 - 21,548,919 (-)NCBIMGSCv36mm8
Celera919,036,363 - 19,068,137 (-)NCBICelera
Cytogenetic Map9A3NCBI
Kank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554952,168,992 - 2,173,581 (-)NCBIChiLan1.0ChiLan1.0
KANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11911,426,149 - 11,457,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,426,149 - 11,457,359 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01910,713,582 - 10,746,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,067,749 - 50,093,377 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,067,760 - 50,091,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,941,266 - 49,966,898 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,588,664 - 50,614,343 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,588,642 - 50,614,335 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,798,849 - 49,824,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,225,723 - 50,251,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,468,431 - 50,494,081 (+)NCBIUU_Cfam_GSD_1.0
Kank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,015,097 - 209,034,537 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,321,980 - 1,337,746 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366591,320,169 - 1,340,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,896,120 - 69,924,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,896,116 - 69,925,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,095,319 - 10,131,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,095,246 - 10,131,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,755,298 - 9,792,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,041,991 - 3,062,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,039,871 - 3,060,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kank2
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:117
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000014135, ENSRNOT00000045488
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
RH130874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,315,153 - 20,315,354 (+)MAPPERmRatBN7.2
Rnor_6.0822,795,478 - 22,795,678NCBIRnor6.0
Rnor_5.0822,849,632 - 22,849,832UniSTSRnor5.0
RGSC_v3.4820,869,104 - 20,869,304UniSTSRGSC3.4
Celera821,705,789 - 21,705,989UniSTS
RH133408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,311,770 - 20,311,971 (+)MAPPERmRatBN7.2
Rnor_6.0822,792,095 - 22,792,295NCBIRnor6.0
Rnor_5.0822,846,249 - 22,846,449UniSTSRnor5.0
RGSC_v3.4820,865,710 - 20,865,910UniSTSRGSC3.4
Celera821,702,406 - 21,702,606UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 50 40 13 40 7 10 44 32 34 11 7
Low 7 1 6 1 1 1 30 3 7 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014135   ⟹   ENSRNOP00000014135
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,311,676 - 20,340,900 (-)Ensembl
Rnor_6.0 Ensembl822,792,000 - 22,821,223 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000045488   ⟹   ENSRNOP00000048736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,312,245 - 20,339,532 (-)Ensembl
Rnor_6.0 Ensembl822,791,995 - 22,821,397 (-)Ensembl
RefSeq Acc Id: NM_001270413   ⟹   NP_001257342
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,311,676 - 20,340,900 (-)NCBI
Rnor_6.0822,792,000 - 22,821,223 (-)NCBI
Rnor_5.0822,846,154 - 22,875,574 (-)NCBI
Celera821,702,311 - 21,731,556 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242589   ⟹   XP_006242651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,311,676 - 20,341,107 (-)NCBI
Rnor_6.0822,792,001 - 22,821,459 (-)NCBI
Rnor_5.0822,846,154 - 22,875,574 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242590   ⟹   XP_006242652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,311,676 - 20,341,107 (-)NCBI
Rnor_6.0822,792,001 - 22,821,459 (-)NCBI
Rnor_5.0822,846,154 - 22,875,574 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257342 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242651 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242652 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZD05 (Get FASTA)   NCBI Sequence Viewer  
  EDL78271 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001257342   ⟸   NM_001270413
- UniProtKB: D4ACC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242652   ⟸   XM_006242590
- Peptide Label: isoform X1
- UniProtKB: D3ZD05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242651   ⟸   XM_006242589
- Peptide Label: isoform X1
- UniProtKB: D3ZD05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048736   ⟸   ENSRNOT00000045488
RefSeq Acc Id: ENSRNOP00000014135   ⟸   ENSRNOT00000014135

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD05-F1-model_v2 AlphaFold D3ZD05 1-847 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695789
Promoter ID:EPDNEW_R6313
Type:multiple initiation site
Name:Kank2_1
Description:KN motif and ankyrin repeat domains 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,821,177 - 22,821,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320289 AgrOrtholog
BioCyc Gene G2FUF-31409 BioCyc
Ensembl Genes ENSRNOG00000010643 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014135 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000048736 ENTREZGENE
  ENSRNOP00000048736.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014135 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000045488 ENTREZGENE
  ENSRNOT00000045488.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KN_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100361376 UniProtKB/TrEMBL
NCBI Gene 100361376 ENTREZGENE
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KN_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kank2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QNK4_RAT UniProtKB/TrEMBL
  D3ZD05 ENTREZGENE
  D4ACC2 ENTREZGENE, UniProtKB/TrEMBL
  KANK2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-10 Kank2  KN motif and ankyrin repeat domains 2  LOC100361376  rCG31687-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-02 LOC100361376  rCG31687-like  RGD1563532  similar to ankyrin repeat domain 25  Data Merged 1643240 APPROVED
2010-05-05 LOC100361376  rCG31687-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1563532  similar to ankyrin repeat domain 25   RGD1563532_predicted  similar to ankyrin repeat domain 25 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563532_predicted  similar to ankyrin repeat domain 25 (predicted)  LOC300439  similar to ankyrin repeat domain 25  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300439  similar to ankyrin repeat domain 25      Symbol and Name status set to provisional 70820 PROVISIONAL