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Gene: Pde5a (phosphodiesterase 5A, cGMP-specific) Mus musculus
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Symbol: Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Description: Exhibits 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in several processes, including cGMP catabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CGB-PDE; Cgbpde; cGMP-binding cGMP-specific phosphodiesterase; cGMP-binding/cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; Cn5n; Pde5; Pde5a1; PDE5a2; phosphodiesterase 5A
Orthologs:
Homo sapiens (human) : PDE5A (phosphodiesterase 5A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde5a (phosphodiesterase 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde5a (phosphodiesterase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE5A (phosphodiesterase 5A)
Canis lupus familiaris (dog) : PDE5A (phosphodiesterase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde5a (phosphodiesterase 5A)
Sus scrofa (pig) : PDE5A (phosphodiesterase 5A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm383122,729,158 - 122,859,374 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373122,432,076 - 122,562,292 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,721,209 - 122,848,174 (+)NCBImm8
Celera3129,135,905 - 129,269,158 (+)NCBICelera
Cytogenetic Map3 G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pde5a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737352
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.