Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pde5a (phosphodiesterase 5A, cGMP-specific) Mus musculus
Symbol: Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Description: Exhibits 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in several processes, including cGMP catabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CGB-PDE; Cgbpde; cGMP-binding cGMP-specific phosphodiesterase; cGMP-binding/cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; Cn5n; Pde5; Pde5a1; PDE5a2; phosphodiesterase 5A
Homo sapiens (human) : PDE5A (phosphodiesterase 5A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde5a (phosphodiesterase 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde5a (phosphodiesterase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE5A (phosphodiesterase 5A)
Canis lupus familiaris (dog) : PDE5A (phosphodiesterase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde5a (phosphodiesterase 5A)
Sus scrofa (pig) : PDE5A (phosphodiesterase 5A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm383122,729,158 - 122,859,374 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373122,432,076 - 122,562,292 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,721,209 - 122,848,174 (+)NCBImm8
Celera3129,135,905 - 129,269,158 (+)NCBICelera
Cytogenetic Map3 G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pde5a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737352
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.