Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density membrane; and synaptic vesicle. Part of AMPA glutamate receptor complex. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4).
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein] and Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein]
[BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated with Ascorbic Acid] results in increased expression of DLG4 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of DLG4 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of DLG4 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of DLG4 protein] and MIR93 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of DLG4 protein]
HDAC2 protein affects the reaction [bisphenol A results in decreased expression of DLG4 mRNA] and HDAC2 protein affects the reaction [bisphenol A results in decreased expression of DLG4 protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA more ...
[Dronabinol co-treated with Cannabidiol] results in decreased susceptibility to [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of DLG4 protein]
Ascorbic Acid inhibits the reaction [Corticosterone results in decreased expression of DLG4 protein] and Ketamine inhibits the reaction [Corticosterone results in decreased expression of DLG4 protein]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of DLG4 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA more ...
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in decreased expression of DLG4 protein and m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in decreased expression of DLG4 protein]
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA] and Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein]
honokiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of DLG4 protein] and SIRT3 protein affects the reaction [honokiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of DLG4 protein]]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of DLG4 mRNA
IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein] and PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]
Ketamine inhibits the reaction [Corticosterone results in decreased expression of DLG4 protein] and Sirolimus inhibits the reaction [Ketamine results in increased expression of DLG4 protein]
[BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated with Ascorbic Acid] results in increased expression of DLG4 mRNA
[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG4 mRNA and [lead acetate results in increased abundance of Lead] which results in decreased expression of DLG4 protein
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein] and Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein]
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein] and resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA] and Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein]
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA
[DDO protein affects the susceptibility to Phencyclidine] which affects the expression of DLG4 mRNA and DDO protein affects the reaction [Phencyclidine results in increased expression of DLG4 mRNA]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA
Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] and Memantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA and [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.