Dlg4 (discs large MAGUK scaffold protein 4) - Rat Genome Database

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Gene: Dlg4 (discs large MAGUK scaffold protein 4) Mus musculus
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Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
RGD ID: 68631
MGI Page MGI
Description: Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density membrane; and synaptic vesicle. Part of AMPA glutamate receptor complex. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: discs large homolog 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlgh; Dlgh4; postsynaptic density protein 95; PSD; PSD-; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD95; SA; SAP-90; SAP90; SAP90A; synapse-associated protein 90
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,908,029 - 69,938,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,907,768 - 69,938,348 (+)EnsemblGRCm39 Ensembl
GRCm381170,017,203 - 70,045,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,016,942 - 70,047,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,832,107 - 69,859,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,835,059 - 69,860,963 (+)NCBIMGSCv36mm8
Celera1177,566,529 - 77,594,216 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
agomelatine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Solamarine  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
androgen antagonist  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (ISO)
azithromycin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP,ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlordecone  (EXP)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
citric acid  (ISO)
cocaine  (EXP,ISO)
corticosterone  (EXP)
curcumin  (ISO)
cyhalothrin  (EXP,ISO)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diquat  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fisetin  (EXP)
fluoranthene  (EXP)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
glutathione  (ISO)
hexachlorophene  (EXP)
Honokiol  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP)
melittin  (EXP)
memantine  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitrofen  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
phencyclidine  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP)
poly(vinylpyrrolidone)  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tunicamycin  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA glutamate receptor clustering  (IBA,ISO)
cell-cell adhesion  (IBA)
cellular response to potassium ion  (IDA)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IBA)
dendritic spine morphogenesis  (IDA,ISO)
dendritic spine organization  (ISO)
establishment of protein localization  (ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA)
locomotory behavior  (NAS)
locomotory exploration behavior  (IMP)
negative regulation of receptor internalization  (ISO)
neuromuscular process controlling balance  (IMP)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IEP,IMP)
positive regulation of AMPA glutamate receptor clustering  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of neuron projection arborization  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission  (ISO)
postsynaptic neurotransmitter receptor diffusion trapping  (IBA,ISO)
protein localization to synapse  (IDA,ISO)
protein-containing complex assembly  (ISO)
receptor localization to synapse  (ISO)
regulation of grooming behavior  (IMP)
regulation of long-term neuronal synaptic plasticity  (IGI)
regulation of neuronal synaptic plasticity  (ISO,NAS)
response to cocaine  (NAS)
social behavior  (IMP)
synaptic vesicle maturation  (IDA,IGI)
vocalization behavior  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal AMPA-mediated synaptic currents  (IAGP)
abnormal anxiety-related response  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal discrimination learning  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal glutamate-mediated receptor currents  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal NMDA-mediated synaptic currents  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal pain threshold  (IAGP)
abnormal sebaceous gland morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal synaptic transmission  (IAGP)
allodynia  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased grip strength  (IAGP)
decreased locomotor activity  (IAGP)
decreased neurotransmitter release  (IAGP)
decreased startle reflex  (IAGP)
decreased stereotypic behavior  (IAGP)
decreased total body fat amount  (IEA)
decreased vertical activity  (IAGP)
decreased vocalization  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced long-term potentiation  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
impaired balance  (IAGP)
impaired behavioral response to cocaine  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased bone mineral content  (IEA)
increased circulating corticosterone level  (IAGP)
increased circulating sodium level  (IEA)
increased grip strength  (IAGP)
increased grooming behavior  (IAGP)
increased lean body mass  (IEA)
increased response to stress-induced hyperthermia  (IAGP)
maternal effect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
reduced AMPA-mediated synaptic currents  (IAGP)
tremors  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
2. Identification of PSD-95 palmitoylating enzymes. Fukata M, etal., Neuron 2004 Dec 16;44(6):987-96.
3. Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5-choice serial reaction time task. Guo H, etal., J Neurosci Res. 2019 Sep;97(9):1051-1065. doi: 10.1002/jnr.24427. Epub 2019 May 12.
4. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
5. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch O, etal., Genes Dev 2004 Mar 1;18(5):559-71.
6. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
7. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Marco EM, etal., Pharmacol Biochem Behav. 2017 Jan;152:68-80. doi: 10.1016/j.pbb.2016.11.005. Epub 2016 Nov 25.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Altered sensory experience exacerbates stable dendritic spine and synapse loss in a mouse model of Huntington's disease. Murmu RP, etal., J Neurosci. 2015 Jan 7;35(1):287-98. doi: 10.1523/JNEUROSCI.0244-14.2015.
12. Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia. Nash JE, etal., FASEB J. 2005 Apr;19(6):583-5. Epub 2005 Feb 9.
13. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Pichon X, etal., Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Smith GA, etal., Hum Mol Genet. 2014 Sep 1;23(17):4510-27. doi: 10.1093/hmg/ddu166. Epub 2014 Apr 12.
19. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
Additional References at PubMed
PMID:9278515   PMID:9286702   PMID:9458051   PMID:9647694   PMID:9853749   PMID:9870943   PMID:9882498   PMID:9892651   PMID:10211776   PMID:10349636   PMID:10493740   PMID:10531433  
PMID:10827173   PMID:10862698   PMID:11042159   PMID:11076861   PMID:11134026   PMID:11161476   PMID:11172053   PMID:11217851   PMID:11483650   PMID:11739749   PMID:11925566   PMID:12067714  
PMID:12097473   PMID:12115694   PMID:12427827   PMID:12438413   PMID:12466851   PMID:12467588   PMID:12477932   PMID:12531901   PMID:12591944   PMID:12593798   PMID:12972605   PMID:14559234  
PMID:14559911   PMID:14610273   PMID:14614133   PMID:14622142   PMID:14622577   PMID:14645471   PMID:14980210   PMID:14988405   PMID:15014045   PMID:15024750   PMID:15071120   PMID:15082021  
PMID:15082773   PMID:15145078   PMID:15207857   PMID:15226823   PMID:15255944   PMID:15317856   PMID:15345243   PMID:15358863   PMID:15603740   PMID:15657400   PMID:15661374   PMID:15663482  
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PMID:16672052   PMID:16677619   PMID:16710293   PMID:16777849   PMID:16814779   PMID:16818724   PMID:16828986   PMID:16882004   PMID:16914526   PMID:16980967   PMID:16987237   PMID:16990796  
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PMID:18353676   PMID:18374309   PMID:18410515   PMID:18431124   PMID:18448421   PMID:18480165   PMID:18652896   PMID:18936077   PMID:18945678   PMID:19022416   PMID:19029045   PMID:19073225  
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PMID:19494135   PMID:19571134   PMID:19640847   PMID:19679819   PMID:19723784   PMID:19726645   PMID:19756182   PMID:20040602   PMID:20089912   PMID:20124353   PMID:20141836   PMID:20178993  
PMID:20185686   PMID:20220006   PMID:20460989   PMID:20467438   PMID:20519520   PMID:20547133   PMID:20551902   PMID:20554866   PMID:20573181   PMID:20573893   PMID:20577261   PMID:20824214  
PMID:20831617   PMID:20861378   PMID:20861386   PMID:20952458   PMID:21031555   PMID:21092061   PMID:21102461   PMID:21119615   PMID:21144999   PMID:21190219   PMID:21267068   PMID:21309945  
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PMID:36604605   PMID:36801452   PMID:37071993   PMID:37261953   PMID:37307456   PMID:37416774   PMID:37442439   PMID:37536482   PMID:37686246   PMID:37704377   PMID:37758766   PMID:38427737  


Genomics

Comparative Map Data
Dlg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,908,029 - 69,938,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,907,768 - 69,938,348 (+)EnsemblGRCm39 Ensembl
GRCm381170,017,203 - 70,045,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,016,942 - 70,047,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,832,107 - 69,859,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,835,059 - 69,860,963 (+)NCBIMGSCv36mm8
Celera1177,566,529 - 77,594,216 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
DLG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,187,187 - 7,220,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,187,187 - 7,219,841 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,090,506 - 7,123,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,033,933 - 7,063,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,033,935 - 7,063,745NCBI
Celera177,117,875 - 7,148,003 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,984,911 - 7,015,359 (-)NCBIHuRef
CHM1_1177,102,006 - 7,132,134 (-)NCBICHM1_1
T2T-CHM13v2.0177,088,092 - 7,120,961 (-)NCBIT2T-CHM13v2.0
Dlg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,239,397 - 55,267,780 (+)NCBIGRCr8
mRatBN7.21054,740,700 - 54,769,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,739,470 - 54,767,153 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,403,247 - 59,429,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,891,827 - 58,917,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,399,117 - 54,425,128 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,625,845 - 56,655,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,627,411 - 56,653,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,369,703 - 56,400,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,864,459 - 56,890,626 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,878,081 - 56,904,246 (+)NCBI
Celera1053,894,685 - 53,920,691 (+)NCBICelera
Cytogenetic Map10q24NCBI
Dlg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,690,469 - 9,715,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,691,733 - 9,715,872 (+)NCBIChiLan1.0ChiLan1.0
DLG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,782,686 - 14,812,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,748,876 - 16,776,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,219,911 - 7,247,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,207,483 - 7,236,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,207,483 - 7,235,985 (-)Ensemblpanpan1.1panPan2
DLG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,165,399 - 32,175,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,163,594 - 32,188,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,303,501 - 32,327,281 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,271,402 - 32,294,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,272,047 - 32,293,737 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,236,680 - 32,259,896 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,195,151 - 32,218,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,372,643 - 32,395,864 (-)NCBIUU_Cfam_GSD_1.0
Dlg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,013,899 - 47,039,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595485,554 - 513,815 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595487,918 - 513,843 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,550,141 - 52,575,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,550,138 - 52,574,021 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,824,633 - 139,849,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,562,953 - 6,592,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,562,691 - 6,590,867 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,818,727 - 14,848,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,811,780 - 9,837,100 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,811,201 - 9,835,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlg4
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3137
Count of miRNA genes:721
Interacting mature miRNAs:904
Transcripts:ENSMUST00000018700, ENSMUST00000108586, ENSMUST00000108588, ENSMUST00000108589, ENSMUST00000123687, ENSMUST00000124568, ENSMUST00000131497, ENSMUST00000132597, ENSMUST00000133140, ENSMUST00000134376, ENSMUST00000135916, ENSMUST00000138004, ENSMUST00000143920
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
D11Mit243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,041,223 - 70,041,290UniSTSGRCm38
GRCm381170,041,158 - 70,041,290UniSTSGRCm38
MGSCv371169,854,660 - 69,854,792UniSTSGRCm37
MGSCv371169,854,725 - 69,854,792UniSTSGRCm37
Celera1177,589,626 - 77,589,758UniSTS
Celera1177,589,691 - 77,589,758UniSTS
Cytogenetic Map11B4UniSTS
cM Map1143.0UniSTS
cM Map11 UniSTS
Whitehead Genetic1137.2UniSTS
Whitehead_YAC11 UniSTS
UniSTS:224404  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,027,629 - 70,027,780UniSTSGRCm38
MGSCv371169,841,131 - 69,841,282UniSTSGRCm37
Celera1177,576,089 - 77,576,240UniSTS
Cytogenetic Map11B4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001779872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH013176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI738861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ959940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA320223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000018700   ⟹   ENSMUSP00000018700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,351 - 69,935,966 (+)Ensembl
GRCm38.p6 Ensembl1170,029,525 - 70,045,140 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108586
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,908,101 - 69,921,480 (+)Ensembl
GRCm38.p6 Ensembl1170,017,275 - 70,030,654 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108588   ⟹   ENSMUSP00000104229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,909,270 - 69,936,358 (+)Ensembl
GRCm38.p6 Ensembl1170,018,444 - 70,045,532 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108589   ⟹   ENSMUSP00000104230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,907,768 - 69,936,358 (+)Ensembl
GRCm38.p6 Ensembl1170,016,942 - 70,045,532 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123687   ⟹   ENSMUSP00000134545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,907,768 - 69,935,942 (+)Ensembl
GRCm38.p6 Ensembl1170,016,942 - 70,045,116 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124568   ⟹   ENSMUSP00000121053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,914,746 - 69,921,957 (+)Ensembl
GRCm38.p6 Ensembl1170,023,920 - 70,031,131 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,935,023 - 69,935,544 (+)Ensembl
GRCm38.p6 Ensembl1170,044,197 - 70,044,718 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132597   ⟹   ENSMUSP00000114165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,643 - 69,929,873 (+)Ensembl
GRCm38.p6 Ensembl1170,029,817 - 70,039,047 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,908,067 - 69,922,081 (+)Ensembl
GRCm38.p6 Ensembl1170,017,241 - 70,031,255 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134376   ⟹   ENSMUSP00000115206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,909,687 - 69,922,299 (+)Ensembl
GRCm38.p6 Ensembl1170,018,861 - 70,031,473 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135916   ⟹   ENSMUSP00000135994
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,917,650 - 69,921,817 (+)Ensembl
GRCm38.p6 Ensembl1170,026,824 - 70,030,991 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,921,463 - 69,922,560 (+)Ensembl
GRCm38.p6 Ensembl1170,030,637 - 70,031,734 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143920   ⟹   ENSMUSP00000136419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,849 - 69,922,202 (+)Ensembl
GRCm38.p6 Ensembl1170,030,023 - 70,031,376 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231221   ⟹   ENSMUSP00000155975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,909,705 - 69,928,122 (+)Ensembl
GRCm38.p6 Ensembl1170,018,879 - 70,037,296 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231415   ⟹   ENSMUSP00000156345
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,909,267 - 69,938,348 (+)Ensembl
GRCm38.p6 Ensembl1170,018,441 - 70,047,522 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231452   ⟹   ENSMUSP00000155942
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,918,614 - 69,935,664 (+)Ensembl
GRCm38.p6 Ensembl1170,027,788 - 70,044,838 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231506   ⟹   ENSMUSP00000155973
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,907,768 - 69,935,780 (+)Ensembl
GRCm38.p6 Ensembl1170,016,942 - 70,044,954 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231628   ⟹   ENSMUSP00000156059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,313 - 69,935,645 (+)Ensembl
GRCm38.p6 Ensembl1170,029,487 - 70,044,819 (+)Ensembl
RefSeq Acc Id: ENSMUST00000232002   ⟹   ENSMUSP00000156019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,909,660 - 69,922,739 (+)Ensembl
GRCm38.p6 Ensembl1170,018,834 - 70,031,913 (+)Ensembl
RefSeq Acc Id: ENSMUST00000232115   ⟹   ENSMUSP00000156246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,981 - 69,922,602 (+)Ensembl
GRCm38.p6 Ensembl1170,030,155 - 70,031,776 (+)Ensembl
RefSeq Acc Id: ENSMUST00000232266   ⟹   ENSMUSP00000156189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,920,542 - 69,922,537 (+)Ensembl
GRCm38.p6 Ensembl1170,029,716 - 70,031,711 (+)Ensembl
RefSeq Acc Id: ENSMUST00000232659   ⟹   ENSMUSP00000156267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,917,825 - 69,921,975 (+)Ensembl
GRCm38.p6 Ensembl1170,026,999 - 70,031,149 (+)Ensembl
RefSeq Acc Id: NM_001109752   ⟹   NP_001103222
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,431 - 69,936,358 (+)NCBI
GRCm381170,018,605 - 70,045,532 (+)NCBI
MGSCv371169,832,107 - 69,859,034 (+)RGD
Celera1177,566,529 - 77,594,216 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001370671   ⟹   NP_001357600
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,914,808 - 69,936,358 (+)NCBI
GRCm381170,023,982 - 70,045,532 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001370672   ⟹   NP_001357601
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,914,808 - 69,936,358 (+)NCBI
GRCm381170,023,982 - 70,045,532 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001370674   ⟹   NP_001357603
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,920,661 - 69,936,358 (+)NCBI
GRCm381170,029,835 - 70,045,532 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001370675   ⟹   NP_001357604
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,908,029 - 69,936,358 (+)NCBI
GRCm381170,017,203 - 70,045,532 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007864   ⟹   NP_031890
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,431 - 69,936,358 (+)NCBI
GRCm381170,018,605 - 70,045,532 (+)NCBI
MGSCv371169,832,107 - 69,859,034 (+)RGD
Celera1177,566,529 - 77,594,216 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532144   ⟹   XP_006532207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,263 - 69,936,361 (+)NCBI
GRCm381170,018,455 - 70,045,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532147   ⟹   XP_006532210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,918,009 - 69,936,361 (+)NCBI
GRCm381170,029,828 - 70,045,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532148   ⟹   XP_006532211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,263 - 69,936,361 (+)NCBI
GRCm381170,018,455 - 70,045,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532150   ⟹   XP_006532213
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,263 - 69,936,361 (+)NCBI
GRCm381170,018,455 - 70,045,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156285   ⟹   XP_036012178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,909,263 - 69,936,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156286   ⟹   XP_036012179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,917,951 - 69,936,361 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001779872
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,917,852 - 69,938,107 (+)NCBI
GRCm381170,027,072 - 70,045,535 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001103222 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357600 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357601 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357603 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357604 (Get FASTA)   NCBI Sequence Viewer  
  NP_031890 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532207 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532210 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532211 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532213 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012178 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH14807 (Get FASTA)   NCBI Sequence Viewer  
  AAQ56705 (Get FASTA)   NCBI Sequence Viewer  
  AAQ56706 (Get FASTA)   NCBI Sequence Viewer  
  AAQ56707 (Get FASTA)   NCBI Sequence Viewer  
  BAA09297 (Get FASTA)   NCBI Sequence Viewer  
  EDL12524 (Get FASTA)   NCBI Sequence Viewer  
  EDL12525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000018700
  ENSMUSP00000018700.8
  ENSMUSP00000104229
  ENSMUSP00000104229.3
  ENSMUSP00000104230.3
  ENSMUSP00000114165.4
  ENSMUSP00000115206.4
  ENSMUSP00000121053.4
  ENSMUSP00000134545.3
  ENSMUSP00000135994.2
  ENSMUSP00000136419.3
  ENSMUSP00000155942.2
  ENSMUSP00000155973
  ENSMUSP00000155973.2
  ENSMUSP00000155975.2
  ENSMUSP00000156019.2
  ENSMUSP00000156059.2
  ENSMUSP00000156189.2
  ENSMUSP00000156246.2
  ENSMUSP00000156267.2
  ENSMUSP00000156345
  ENSMUSP00000156345.2
GenBank Protein Q62108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031890   ⟸   NM_007864
- Peptide Label: isoform 1
- UniProtKB: Q5NCV7 (UniProtKB/Swiss-Prot),   Q5NCV6 (UniProtKB/Swiss-Prot),   Q5NCV5 (UniProtKB/Swiss-Prot),   Q91WJ1 (UniProtKB/Swiss-Prot),   Q62108 (UniProtKB/Swiss-Prot),   G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103222   ⟸   NM_001109752
- Peptide Label: isoform 2
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532207   ⟸   XM_006532144
- Peptide Label: isoform X2
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532211   ⟸   XM_006532148
- Peptide Label: isoform X4
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532213   ⟸   XM_006532150
- Peptide Label: isoform X5
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532210   ⟸   XM_006532147
- Peptide Label: isoform X3
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357604   ⟸   NM_001370675
- Peptide Label: isoform 6 precursor
- UniProtKB: A0A338P6I6 (UniProtKB/TrEMBL),   G3UZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357600   ⟸   NM_001370671
- Peptide Label: isoform 3
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357601   ⟸   NM_001370672
- Peptide Label: isoform 4
- UniProtKB: A0A338P6E5 (UniProtKB/TrEMBL),   G3UZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357603   ⟸   NM_001370674
- Peptide Label: isoform 5
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000121053   ⟸   ENSMUST00000124568
RefSeq Acc Id: ENSMUSP00000136419   ⟸   ENSMUST00000143920
RefSeq Acc Id: ENSMUSP00000156059   ⟸   ENSMUST00000231628
RefSeq Acc Id: ENSMUSP00000104229   ⟸   ENSMUST00000108588
RefSeq Acc Id: ENSMUSP00000104230   ⟸   ENSMUST00000108589
RefSeq Acc Id: ENSMUSP00000155975   ⟸   ENSMUST00000231221
RefSeq Acc Id: ENSMUSP00000155973   ⟸   ENSMUST00000231506
RefSeq Acc Id: ENSMUSP00000156345   ⟸   ENSMUST00000231415
RefSeq Acc Id: ENSMUSP00000155942   ⟸   ENSMUST00000231452
RefSeq Acc Id: ENSMUSP00000114165   ⟸   ENSMUST00000132597
RefSeq Acc Id: ENSMUSP00000135994   ⟸   ENSMUST00000135916
RefSeq Acc Id: ENSMUSP00000156189   ⟸   ENSMUST00000232266
RefSeq Acc Id: ENSMUSP00000156246   ⟸   ENSMUST00000232115
RefSeq Acc Id: ENSMUSP00000156019   ⟸   ENSMUST00000232002
RefSeq Acc Id: ENSMUSP00000156267   ⟸   ENSMUST00000232659
RefSeq Acc Id: ENSMUSP00000115206   ⟸   ENSMUST00000134376
RefSeq Acc Id: ENSMUSP00000134545   ⟸   ENSMUST00000123687
RefSeq Acc Id: ENSMUSP00000018700   ⟸   ENSMUST00000018700
RefSeq Acc Id: XP_036012178   ⟸   XM_036156285
- Peptide Label: isoform X1
- UniProtKB: G3UZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012179   ⟸   XM_036156286
- Peptide Label: isoform X6
- UniProtKB: A0A338P6E5 (UniProtKB/TrEMBL),   G3UZL5 (UniProtKB/TrEMBL)
Protein Domains
Guanylate kinase-like   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62108-F1-model_v2 AlphaFold Q62108 1-724 view protein structure

Promoters
RGD ID:6820727
Promoter ID:MM_KWN:8174
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour
Transcripts:OTTMUST00000013521,   OTTMUST00000013523
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,830,059 - 69,830,559 (+)MPROMDB
RGD ID:6820721
Promoter ID:MM_KWN:8175
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:ENSMUST00000108588,   OTTMUST00000013522
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,831,191 - 69,831,857 (+)MPROMDB
RGD ID:6820725
Promoter ID:MM_KWN:8177
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain,   MEF_B6
Transcripts:OTTMUST00000013524,   OTTMUST00000038805
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,840,181 - 69,840,707 (+)MPROMDB
RGD ID:6820724
Promoter ID:MM_KWN:8178
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   MEF_B6
Transcripts:ENSMUST00000100956,   OTTMUST00000013525,   OTTMUST00000038806,   OTTMUST00000038807
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,842,406 - 69,843,007 (+)MPROMDB
RGD ID:6820729
Promoter ID:MM_KWN:8179
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000038854
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,852,506 - 69,853,157 (+)MPROMDB
RGD ID:6820726
Promoter ID:MM_KWN:8180
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000013526
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,857,056 - 69,857,857 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277959 AgrOrtholog
Ensembl Genes ENSMUSG00000020886 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018700 ENTREZGENE
  ENSMUST00000018700.14 UniProtKB/TrEMBL
  ENSMUST00000108588 ENTREZGENE
  ENSMUST00000108588.9 UniProtKB/Swiss-Prot
  ENSMUST00000108589.10 UniProtKB/Swiss-Prot
  ENSMUST00000123687.3 UniProtKB/TrEMBL
  ENSMUST00000124568.10 UniProtKB/TrEMBL
  ENSMUST00000132597.5 UniProtKB/TrEMBL
  ENSMUST00000134376.10 UniProtKB/TrEMBL
  ENSMUST00000135916.9 UniProtKB/TrEMBL
  ENSMUST00000143920.4 UniProtKB/TrEMBL
  ENSMUST00000231221.2 UniProtKB/TrEMBL
  ENSMUST00000231415 ENTREZGENE
  ENSMUST00000231415.2 UniProtKB/Swiss-Prot
  ENSMUST00000231452.2 UniProtKB/TrEMBL
  ENSMUST00000231506 ENTREZGENE
  ENSMUST00000231506.2 UniProtKB/TrEMBL
  ENSMUST00000231628.2 UniProtKB/TrEMBL
  ENSMUST00000232002.2 UniProtKB/TrEMBL
  ENSMUST00000232115.2 UniProtKB/TrEMBL
  ENSMUST00000232266.2 UniProtKB/TrEMBL
  ENSMUST00000232659.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DLG1_PEST_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13385 UniProtKB/Swiss-Prot
MGD MGI:1277959 ENTREZGENE
NCBI Gene 13385 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISKS LARGE HOMOLOG 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlg4 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P6E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A338P6H5_MOUSE UniProtKB/TrEMBL
  A0A338P6I6 ENTREZGENE, UniProtKB/TrEMBL
  A0A338P6L4_MOUSE UniProtKB/TrEMBL
  A0A338P713_MOUSE UniProtKB/TrEMBL
  A0A338P746_MOUSE UniProtKB/TrEMBL
  A0A338P7H1_MOUSE UniProtKB/TrEMBL
  B1AR31_MOUSE UniProtKB/TrEMBL
  DLG4_MOUSE UniProtKB/Swiss-Prot
  E9Q3Z8_MOUSE UniProtKB/TrEMBL
  F6TPQ6_MOUSE UniProtKB/TrEMBL
  G3UZL5 ENTREZGENE, UniProtKB/TrEMBL
  J3KMS4_MOUSE UniProtKB/TrEMBL
  J3QMR8_MOUSE UniProtKB/TrEMBL
  Q5NCV5 ENTREZGENE
  Q5NCV6 ENTREZGENE
  Q5NCV7 ENTREZGENE
  Q62108 ENTREZGENE
  Q91WJ1 ENTREZGENE
UniProt Secondary Q5NCV5 UniProtKB/Swiss-Prot
  Q5NCV6 UniProtKB/Swiss-Prot
  Q5NCV7 UniProtKB/Swiss-Prot
  Q91WJ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Dlg4  discs large MAGUK scaffold protein 4    discs, large homolog 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED