Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nlrc4 (NLR family, CARD domain containing 4) Mus musculus
Analyze
Symbol: Nlrc4
Name: NLR family, CARD domain containing 4
Description: Exhibits identical protein binding activity. Involved in several processes, including interleukin-1 beta secretion; pyroptosis; and response to bacterium. Localizes to the IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 4-hydroxynon-2-enal; lipopolysaccharide; sodium arsenite.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9530011P19Rik; Card12; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; ice protease-activating factor; IPAF; NLR family CARD domain-containing protein 4
Orthologs:
Homo sapiens (human) : NLRC4 (NLR family CARD domain containing 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nlrc4 (NLR family, CARD domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrc4 (NLR family CARD domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRC4 (NLR family CARD domain containing 4)
Canis lupus familiaris (dog) : NLRC4 (NLR family CARD domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrc4 (NLR family CARD domain containing 4)
Sus scrofa (pig) : NLRC4 (NLR family CARD domain containing 4)
Chlorocebus sabaeus (green monkey) : NLRC4 (NLR family CARD domain containing 4)
Heterocephalus glaber (naked mole-rat) : Nlrc4 (NLR family CARD domain containing 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1774,425,438 - 74,459,142 (-)Ensembl
GRCm381774,426,255 - 74,459,144 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371774,825,635 - 74,858,448 (-)NCBIGRCm37mm9NCBIm37
MGSCv361774,331,277 - 74,364,090 (-)NCBImm8
Celera1778,730,040 - 78,763,171 (-)NCBICelera
Cytogenetic Map17 E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nlrc4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1614838
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.