Sod2 (superoxide dismutase 2, mitochondrial) - Rat Genome Database

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Gene: Sod2 (superoxide dismutase 2, mitochondrial) Mus musculus
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Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
RGD ID: 11330
MGI Page MGI
Description: Enables superoxide dismutase activity. Acts upstream of or within several processes, including acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; apoptotic signaling pathway; and erythrophore differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: manganese SOD; manganese superoxide dismutase; MGC6144; Mn; MnSOD; Sod; Sod-2; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  (ISO)
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (IEP)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (IAGP)
anaplastic thyroid carcinoma  (ISO)
anemia  (IDA,ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
Arsenic Poisoning  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (IEP)
bilirubin metabolic disorder  (ISO)
bladder neck obstruction  (ISO)
brain edema  (ISO)
Brain Injuries  (IDA,ISO)
brain ischemia  (IAGP,ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Canavan disease  (IAGP)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (IDA,ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
Central Nervous System Infections  (ISO)
Chemical and Drug Induced Liver Injury  (IMP,ISO)
chronic progressive external ophthalmoplegia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (IAGP,ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (IAGP,IDA,ISO)
disease of cellular proliferation  (IMP,ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Esophageal Stenosis  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis  (ISO)
Farber lipogranulomatosis  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemolytic anemia  (IMP)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (IMP)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypopharyngeal Neoplasms  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
intestinal disease  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leber hereditary optic neuropathy  (IMP,ISO)
Leigh disease  (IAGP)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (IMP)
major depressive disorder  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
MELAS syndrome  (ISO)
Mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IEP)
methylmalonic acidemia  (ISO)
middle cerebral artery infarction  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple chemical sensitivity  (ISO)
multiple myeloma  (ISO)
mycosis fungoides  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA,ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
optic neuritis  (IMP,ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
Parkinson's disease  (IMP,ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary biliary cholangitis  (ISO)
primary ciliary dyskinesia 32  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (IEP)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (ISO)
Reticulocytosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinitis pigmentosa  (IDA)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sengers syndrome  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
Skin Neoplasms  (IEP,IMP,ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
systemic lupus erythematosus  (ISO)
Tardive Dyskinesia  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular disease  (ISO)
Ventricular Dysfunction, Left  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (EXP)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-sesamin  (ISO)
(+)-taxifolin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R)-tramadol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,1-dichloroethene  (EXP)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (EXP)
1,4-dithiothreitol  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,4-dihydroxybenzoate  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-chlorobiphenyl  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
5-methoxytryptamine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7H-xanthine  (EXP,ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP,ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acetamiprid  (ISO)
acetic acid  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
Actein  (EXP)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (EXP)
AICA ribonucleotide  (ISO)
alatrofloxacin  (EXP)
albendazole  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
Allylamine  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ametryn  (ISO)
aminoacetone  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
ANTIMYCIN  (EXP)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP)
atrasentan  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
barium chloride  (ISO)
Bavachalcone  (ISO)
Bay-K-8644  (EXP)
benzbromarone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP,ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bucladesine  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (EXP)
calcium(0)  (ISO)
Calphostin C  (ISO)
camphene  (ISO)
camptothecin  (ISO)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
carotenoid  (EXP)
carteolol  (ISO)
carvedilol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
cerium trichloride  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chicoric acid  (ISO)
Chikusetsusaponin-V  (ISO)
chloramine T  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
creatinine  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP,ISO)
curcumin  (EXP,ISO)
Cyanoginosin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cysteamine  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
dapsone  (EXP,ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (EXP)
dehydroepiandrosterone  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
dihydrogen  (EXP,ISO)
dimethylarsinous acid  (ISO)
Diosbulbin B  (EXP)
dioxygen  (EXP,ISO)
diprotium  (EXP,ISO)
diprotium oxide  (EXP)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithianon  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
docebenone  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
ebselen  (ISO)
eckol  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (EXP)
enniatin  (EXP)
enzyme inhibitor  (ISO)
epalrestat  (EXP)
eplerenone  (ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
febuxostat  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fraxetin  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (ISO)
galactose  (EXP,ISO)
gallium nitrate  (ISO)
gallocatechin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (EXP)
ginsenoside Re  (EXP)
Ginsenoside Rh4  (EXP)
glafenine  (ISO)
gliclazide  (ISO)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (ISO)
haloperidol  (ISO)
helenalin  (ISO)
hemin  (ISO)
hesperetin  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
idebenone  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoflurane  (EXP,ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kainic acid  (EXP,ISO)
ketorolac tromethamine  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-dehydroascorbic acid  (ISO)
L-methionine  (EXP,ISO)
lanthanum trichloride  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lenvatinib  (ISO)
Leonurine  (EXP,ISO)
leptomycin B  (ISO)
linalool  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
loliolide  (ISO)
losartan  (ISO)
lutein  (EXP)
luteolin  (ISO)
luzindole  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
malathion  (EXP,ISO)
maneb  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP,ISO)
metam  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotophos  (ISO)
morphine  (EXP,ISO)
myxothiazol  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylglycine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naringin  (EXP)
nebivolol  (EXP,ISO)
nefazodone  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (ISO)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (EXP)
NS-398  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
paroxetine  (EXP)
pentanal  (ISO)
peptidoglycan  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP,ISO)
phenanthrene  (ISO)
phencyclidine  (EXP)
phenobarbital  (ISO)
phenols  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
PhIP  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
physostigmine  (EXP)
pifithrin-?  (EXP)
pioglitazone  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
porphyrins  (ISO)
potassium atom  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (ISO)
prednisolone  (ISO)
probucol  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxamine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP,ISO)
salicyl alcohol  (ISO)
Salidroside  (EXP,ISO)
salsalate  (ISO)
salvianolic acid B  (ISO)
saquinavir  (EXP)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
silicic acid  (EXP)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium nitrate  (EXP,ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP)
staurosporine  (EXP)
sterigmatocystin  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfamethoxazole  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (EXP)
Sunset Yellow FCF  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thallium  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
Tiron  (ISO)
titanium atom  (EXP)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
topotecan  (ISO)
tramadol  (ISO)
trandolapril  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (EXP,ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichlorfon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trilobatin  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urea  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
verapamil  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
vosaroxin  (ISO)
water  (EXP)
withaferin A  (EXP,ISO)
wortmannin  (ISO)
WR-1065  (EXP,ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (EXP)
zidovudine  (EXP,ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IMP)
apoptotic mitochondrial changes  (IMP)
cellular response to ethanol  (ISO)
cellular response to oxidative stress  (ISO)
detection of oxygen  (IMP)
erythrophore differentiation  (IMP)
glutathione metabolic process  (IMP)
heart development  (IMP)
hemopoiesis  (IMP)
hydrogen peroxide biosynthetic process  (ISO)
hydrogen peroxide metabolic process  (ISO)
intracellular oxygen homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IMP)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IMP)
liver development  (IMP)
locomotory behavior  (IMP)
mitochondrion organization  (IMP)
multicellular organismal-level iron ion homeostasis  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fat cell differentiation  (IMP)
negative regulation of fibroblast proliferation  (IDA)
negative regulation of membrane hyperpolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron development  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
post-embryonic development  (IMP)
protein homotetramerization  (ISO)
regulation of blood pressure  (IMP)
regulation of mitochondrial membrane potential  (IMP)
regulation of transcription by RNA polymerase II  (IDA,ISO)
release of cytochrome c from mitochondria  (IMP)
removal of superoxide radicals  (IMP,ISO)
respiratory electron transport chain  (IMP)
response to activity  (IMP,ISO)
response to axon injury  (IMP)
response to cadmium ion  (ISO)
response to electrical stimulus  (ISO)
response to gamma radiation  (IGI)
response to hydrogen peroxide  (IMP,ISO)
response to hyperoxia  (IMP)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to isolation stress  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to magnetism  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (IGI,IMP,ISO)
response to reactive oxygen species  (IMP)
response to selenium ion  (ISO)
response to silicon dioxide  (ISO)
response to superoxide  (IMP,ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
sensory perception of sound  (IMP)
superoxide anion generation  (IMP)
superoxide metabolic process  (IMP,ISO)
vasodilation  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aerobic respiration  (IAGP)
abnormal blood gas level  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal blood pH regulation  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cardiac muscle tissue morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal gait  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver physiology  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal ocular fundus morphology  (IAGP)
abnormal optic choroid morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal oxidative phosphorylation  (IAGP)
abnormal redox activity  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal retina rod cell outer segment morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal skeletal muscle fiber mitochondrial morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal tricarboxylic acid cycle  (IAGP)
abnormal trigeminal motor nucleus morphology  (IAGP)
abnormal trigeminal V mesencephalic nucleus morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
acidosis  (IAGP)
anemia  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
brain vacuoles  (IAGP)
calcinosis  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiac muscle necrosis  (IAGP)
circling  (IAGP)
congestive heart failure  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased aerobic running capacity  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body surface temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating lactate level  (IAGP)
decreased epidermal stem cell number  (IAGP)
decreased fetal size  (IAGP)
decreased food intake  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased hematocrit  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased locomotor activity  (IAGP)
decreased mitochondrial size  (IAGP)
decreased neuron number  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased spinal cord size  (IAGP)
decreased spinal cord ventral horn cell number  (IAGP)
decreased substantia nigra size  (IAGP)
decreased total body fat amount  (IAGP)
delayed wound healing  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated distal convoluted tubule  (IAGP)
dilated heart  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
dilated heart ventricle  (IAGP)
early cellular replicative senescence  (IAGP)
enhanced wound healing  (IAGP)
enlarged heart  (IAGP)
fatigue  (IAGP)
hepatic steatosis  (IAGP)
hyperoxia  (IAGP)
hypocapnia  (IAGP)
hypotonia  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired myelopoiesis  (IAGP)
impaired righting response  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased cardiac muscle glycogen level  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased cell death  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating ketone body level  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased liver weight  (IAGP)
increased lymphoma incidence  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased muscle fatigability  (IAGP)
increased myocardial fiber size  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased tumor incidence  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
metabolic acidosis  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardial fiber disarray  (IAGP)
myocardium necrosis  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
organic aciduria  (IAGP)
oxidative stress  (IAGP)
pallor  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal cast  (IAGP)
retina degeneration  (IAGP)
retina hemorrhage  (IAGP)
retina photoreceptor degeneration  (IAGP)
retina pigment epithelium atrophy  (IAGP)
seizures  (IAGP)
short photoreceptor inner segment  (IAGP)
short photoreceptor outer segment  (IAGP)
skin lesions  (IAGP)
spongiform encephalopathy  (IAGP)
thick epidermis  (IAGP)
thin epidermis  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thin ventricular wall  (IAGP)
tremors  (IAGP)
weakness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Agharazii M, etal., Am J Hypertens. 2015 Jun;28(6):746-55. doi: 10.1093/ajh/hpu225. Epub 2014 Nov 27.
2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
4. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
5. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Archer SL, etal., Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.
6. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
7. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Assem M, etal., Am J Pathol. 1997 Aug;151(2):549-55.
8. Nutrition- and virus-induced stress represses the expression of manganese superoxide dismutase in vitro. Berger MM, etal., Exp Biol Med (Maywood). 2004 Sep;229(8):843-9.
9. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
10. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
11. Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. Botre C, etal., Cell Mol Biol Lett. 2015 Dec;20(4):685-97. doi: 10.1515/cmble-2015-0041.
12. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
13. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
14. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
15. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Comhair SA, etal., Am J Pathol. 2005 Mar;166(3):663-74.
16. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Connor KM, etal., Cancer Res. 2007 Nov 1;67(21):10260-7.
17. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
18. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Cullen JJ, etal., Pancreas. 2003 Jan;26(1):23-7.
19. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
20. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Dhar SK, etal., Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.
21. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. Ding F, etal., Int J Biol Markers. 2019 Sep;34(3):221-231. doi: 10.1177/1724600819841619. Epub 2019 May 1.
22. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
23. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. Flekac M, etal., BMC Med Genet. 2008 Apr 21;9:30.
24. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Fortunato G, etal., Clin Chem. 2004 Nov;50(11):2012-8. Epub 2004 Sep 2.
25. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. Friedman JS, etal., J Exp Med. 2001 Apr 16;193(8):925-34.
26. Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Fujimoto K, etal., Toxicol Pathol. 2009 Feb;37(2):193-200. doi: 10.1177/0192623308329282.
27. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Fujimura M, etal., J Neurosci. 1999 May 1;19(9):3414-22.
28. Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population. Gotoh N, etal., Am J Ophthalmol. 2008 Jul;146(1):146; author reply 146-7. doi: 10.1016/j.ajo.2008.03.017.
29. Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway. Guo S, etal., Eur J Pharmacol. 2019 Apr 15;849:50-58. doi: 10.1016/j.ejphar.2019.01.057. Epub 2019 Feb 1.
30. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Hakenewerth AM, etal., Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2438-49. doi: 10.1158/1055-9965.EPI-11-0649. Epub 2011 Sep 22.
31. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Hamilton KL, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1360-8.
32. RORalpha decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Han YH, etal., Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10.
33. Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues. Heine C, etal., Biochem J. 2003 Dec 1;376(Pt 2):369-76.
34. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Hiroi S, etal., Biochem Biophys Res Commun. 1999 Aug 2;261(2):332-9.
35. Molecular structure of a functional rat gene for manganese-containing superoxide dismutase. Ho YS, etal., Am J Respir Cell Mol Biol 1991 Mar;4(3):278-86.
36. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Hodge DR, etal., Cancer Biol Ther. 2005 May;4(5):585-92. Epub 2005 May 5.
37. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Holla LI, etal., Clin Biochem. 2006 Mar;39(3):299-302. Epub 2006 Jan 19.
38. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. Hu Y, etal., J Biol Chem. 2005 Nov 25;280(47):39485-92. Epub 2005 Sep 22.
39. MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. Huang C, etal., BMC Med Genomics. 2014 Jul 28;7:46. doi: 10.1186/1755-8794-7-46.
40. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Huang TT, etal., Free Radic Biol Med. 2001 Nov 1;31(9):1101-10.
41. Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis. Huang YS, etal., Alcohol Alcohol. 2016 Feb 11. pii: agw004.
42. Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis. Huang YS, etal., Liver Int. 2014 Jul;34(6):931-6. doi: 10.1111/liv.12533. Epub 2014 Apr 4.
43. Time response of carboplatin-induced hearing loss in rat. Husain K, etal., Hear Res. 2004 May;191(1-2):110-8.
44. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Hwang JH, etal., Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
45. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Jin ZQ, etal., Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2986-94. Epub 2005 Jan 28.
46. SOD2 knockdown mouse model of early AMD. Justilien V, etal., Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20.
47. The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis. Kakko S, etal., Atherosclerosis. 2003 May;168(1):147-52.
48. Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. Khaper N, etal., Mol Cell Biochem. 2003 Sep;251(1-2):9-15.
49. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Kim J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F461-70. Epub 2009 May 20.
50. An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia. Koistinen P, etal., Haematologica. 2006 Jun;91(6):829-32.
51. MnSOD expression within tumor cells is closely related to mode of invasion in human gastric cancer. Korenaga D, etal., Oncol Rep. 2003 Jan-Feb;10(1):27-30.
52. Involvement of superoxide dismutase isoenzymes and their genetic variants in progression of and higher susceptibility to vitiligo. Laddha NC, etal., Free Radic Biol Med. 2013 Dec;65:1110-25. doi: 10.1016/j.freeradbiomed.2013.08.189. Epub 2013 Sep 12.
53. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Lebovitz RM, etal., Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7.
54. Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice. Lee D, etal., Arch Pharm Res. 2020 Apr;43(4):449-461. doi: 10.1007/s12272-020-01231-4. Epub 2020 Mar 31.
55. Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway. Li P, etal., Expert Opin Ther Targets. 2015 Jul;19(7):997-1010. doi: 10.1517/14728222.2015.1054806.
56. Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. Li WJ, etal., J Korean Med Sci. 2010 Nov;25(11):1652-6. Epub 2010 Oct 26.
57. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. Lin HI, etal., Chin J Physiol. 2004 Sep 30;47(3):121-7.
58. Proteomic expression analysis of mycosis fungoides (MF) skin tissues: overexpressions of SOD2, S100A8 and FABP5 in MF. Liu J, etal., J Dermatol Sci. 2010 Oct;60(1):42-4. doi: 10.1016/j.jdermsci.2010.07.014. Epub 2010 Aug 10.
59. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Liu KM, etal., Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F318-31. doi: 10.1152/ajprenal.00607.2014. Epub 2015 Jun 24.
60. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. Liu X, etal., BMC Cancer. 2010 Jul 9;10:365. doi: 10.1186/1471-2407-10-365.
61. Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion. Liu Y, etal., Free Radic Biol Med. 2012 Mar 1;52(5):909-15. doi: 10.1016/j.freeradbiomed.2011.12.013. Epub 2011 Dec 24.
62. SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Liu YM, etal., Dis Markers. 2010;28(3):137-47. doi: 10.3233/DMA-2010-0693.
63. Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. Lontz W, etal., Free Radic Biol Med. 1995 Feb;18(2):349-55.
64. Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. Lucena MI, etal., Hepatology. 2010 Jul;52(1):303-12. doi: 10.1002/hep.23668.
65. Differential neuronal expression of manganese superoxide dismutase in Alzheimer's disease. Marcus DL, etal., Med Sci Monit. 2006 Jan;12(1):BR8-14. Epub 2005 Dec 19.
66. Chemoprevention of carcinogenic progression to esophageal adenocarcinoma by the manganese superoxide dismutase supplementation. Martin RC, etal., Clin Cancer Res. 2007 Sep 1;13(17):5176-82.
67. No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1). Martin RC, etal., J Surg Res. 2005 Mar;124(1):92-7.
68. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
69. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
70. MGDs mouse GO annotations MGD data from the GO Consortium
71. MGD IEA MGD IEA
72. A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. Mollsten A, etal., Diabetes. 2007 Jan;56(1):265-9.
73. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
74. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. Namikawa C, etal., J Hepatol. 2004 May;40(5):781-6.
75. Elevated serum manganese superoxide dismutase in acute leukemias. Nishiura T, etal., Cancer Lett. 1992 Mar 15;62(3):211-5.
76. In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Oberley TD, etal., Antioxid Redox Signal. 2004 Jun;6(3):537-48.
77. Wheat germ supplementation alleviates insulin resistance and cardiac mitochondrial dysfunction in an animal model of diet-induced obesity. Ojo B, etal., Br J Nutr. 2017 Aug;118(4):241-249. doi: 10.1017/S0007114517002082.
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. Ono M, etal., J Lab Clin Med. 1991 Nov;118(5):476-83.
80. Reduction in superoxide dismutase expression in the epithelial mucosa of eosinophilic chronic rhinosinusitis with nasal polyps. Ono N, etal., Int Arch Allergy Immunol. 2013;162(2):173-80. doi: 10.1159/000353122. Epub 2013 Jul 31.
81. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
82. Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells. Porntadavity S, etal., DNA Cell Biol. 2005 May;24(5):299-310.
83. SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Qi X, etal., Ann Neurol. 2004 Aug;56(2):182-91.
84. Optic neuropathy induced by reductions in mitochondrial superoxide dismutase. Qi X, etal., Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1088-96.
85. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Qi X, etal., Invest Ophthalmol Vis Sci. 2007 Feb;48(2):681-91.
86. Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. Raho G, etal., Clin Exp Dermatol. 2003 May;28(3):318-20.
87. Mouse MP Annotation Import Pipeline RGD automated import pipeline
88. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
89. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
90. Diabetic rat testes: morphological and functional alterations. Ricci G, etal., Andrologia. 2009 Dec;41(6):361-8.
91. Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection. Ritter K, etal., J Exp Med. 1994 Nov 1;180(5):1995-8.
92. Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. Russo D, etal., J Endocrinol Invest. 2005 Feb;28(2):137-44.
93. Serum manganese superoxide dismutase is a new tumour marker for malignant melanoma. Schadendorf D, etal., Melanoma Res. 1995 Oct;5(5):351-3.
94. Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants. Sinha I, etal., J Surg Res. 2007 Apr;138(2):156-62. Epub 2006 Dec 29.
95. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis. Stewart SF, etal., Hepatology. 2002 Dec;36(6):1355-60.
96. The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma. Stoehlmacher J, etal., Oncol Rep. 2002 Mar-Apr;9(2):235-8.
97. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Strassburger M, etal., Free Radic Biol Med. 2005 Jun 1;38(11):1458-70.
98. Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome. Strzalka-Mrozik B, etal., Mol Vis. 2013 Jun 12;19:1341-9. Print 2013.
99. Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma. Tsanou E, etal., Histol Histopathol. 2004 Jul;19(3):807-13.
100. Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles. Tsuruta Y, etal., Acta Neuropathol (Berl). 2002 Jan;103(1):59-65.
101. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S, etal., Mol Ther. 2009 May;17(5):778-86. doi: 10.1038/mt.2009.47. Epub 2009 Mar 17.
102. The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. Valenti L, etal., J Med Genet. 2004 Dec;41(12):946-50.
103. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Van Remmen H, etal., Physiol Genomics. 2003 Dec 16;16(1):29-37.
104. Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia. Venkataraman S, etal., Free Radic Res. 2004 Oct;38(10):1119-32.
105. Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease. Ventriglia M, etal., Aging Clin Exp Res. 2005 Dec;17(6):445-8.
106. Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk. Wang LI, etal., J Occup Environ Med. 2004 Jun;46(6):556-64.
107. Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. Wang R, etal., Aging (Albany NY). 2016 Jun;8(6):1184-200. doi: 10.18632/aging.100967.
108. Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein. Wang S, etal., Eur Rev Med Pharmacol Sci. 2014;18(3):359-64.
109. Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus. Wang SJ, etal., Mol Med Rep. 2015 Jan;11(1):521-6. doi: 10.3892/mmr.2014.2724. Epub 2014 Oct 21.
110. Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Weydert C, etal., Mol Cancer Ther. 2003 Apr;2(4):361-9.
111. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
112. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Wheeler MD, etal., J Biol Chem. 2001 Sep 28;276(39):36664-72. Epub 2001 Jul 26.
113. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. Xiong Y, etal., J Neurochem. 2005 Nov;95(3):732-44.
114. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
115. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Yao S, etal., Breast Cancer Res Treat. 2010 Nov;124(2):433-9. doi: 10.1007/s10549-010-0840-0. Epub 2010 Mar 23.
116. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Yen JH, etal., Immunol Lett. 2003 Aug 5;88(2):113-6.
117. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. Yen JH, etal., Immunol Lett. 2003 Dec 15;90(2-3):151-4.
118. Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. Yen JH, etal., Immunol Lett. 2003 Nov 15;90(1):19-24.
119. Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat. Yoshikawa Y, etal., Toxicology. 2009 Oct 1;264(1-2):89-95. doi: 10.1016/j.tox.2009.07.017. Epub 2009 Jul 30.
120. Down-regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome. Yoshioka T, etal., J Pediatr. 1997 May;130(5):800-7.
121. Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Zarbock R, etal., Clin Chem. 2007 Oct;53(10):1734-40. Epub 2007 Aug 10.
122. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
123. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Zeng Z, etal., Oxid Med Cell Longev. 2015;2015:965961. doi: 10.1155/2015/965961. Epub 2015 Aug 2.
124. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5558-66.
125. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
126. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Zhao Y, etal., Oncogene. 2002 May 30;21(24):3836-46.
127. [Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1] Zotova EV, etal., Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Additional References at PubMed
PMID:1612602   PMID:1799792   PMID:1845916   PMID:1936961   PMID:2076813   PMID:2901401   PMID:3003932   PMID:3082971   PMID:3797253   PMID:4358964   PMID:6816725   PMID:6860298  
PMID:7063884   PMID:7333654   PMID:7350646   PMID:7493016   PMID:7578676   PMID:7613035   PMID:7875582   PMID:8268651   PMID:8406027   PMID:8720919   PMID:8792216   PMID:8835526  
PMID:8889548   PMID:9096116   PMID:9264557   PMID:9268631   PMID:9372929   PMID:9398854   PMID:9412501   PMID:9462746   PMID:9533942   PMID:9582437   PMID:9651187   PMID:9724058  
PMID:9774481   PMID:9788901   PMID:9819222   PMID:9927656   PMID:10030845   PMID:10049502   PMID:10349636   PMID:10421798   PMID:10598322   PMID:10672232   PMID:10699751   PMID:10762155  
PMID:10927183   PMID:11042159   PMID:11076861   PMID:11156968   PMID:11217851   PMID:11226230   PMID:11259653   PMID:11507057   PMID:11514315   PMID:11527927   PMID:11583975   PMID:11595386  
PMID:11606622   PMID:11641723   PMID:11796207   PMID:11861570   PMID:12045468   PMID:12126755   PMID:12176043   PMID:12383507   PMID:12385642   PMID:12459471   PMID:12466851   PMID:12477932  
PMID:12527430   PMID:12646716   PMID:12865426   PMID:12919935   PMID:12931191   PMID:12934715   PMID:14610273   PMID:14651853   PMID:14681479   PMID:14684357   PMID:14720215   PMID:14980699  
PMID:15075214   PMID:15083518   PMID:15147524   PMID:15166009   PMID:15182862   PMID:15184255   PMID:15205258   PMID:15317674   PMID:15489334   PMID:15500641   PMID:15624308   PMID:15637112  
PMID:15637642   PMID:15642323   PMID:15650415   PMID:15683720   PMID:15721992   PMID:15735027   PMID:15746439   PMID:15755737   PMID:15781740   PMID:15782199   PMID:15855331   PMID:15964507  
PMID:15993853   PMID:16024798   PMID:16103131   PMID:16129095   PMID:16139868   PMID:16141072   PMID:16141073   PMID:16157693   PMID:16219542   PMID:16277008   PMID:16277013   PMID:16288465  
PMID:16326710   PMID:16405961   PMID:16443156   PMID:16445905   PMID:16450009   PMID:16497723   PMID:16514005   PMID:16611629   PMID:16677818   PMID:16682413   PMID:16687508   PMID:16777943  
PMID:16843623   PMID:16863992   PMID:16873728   PMID:16897347   PMID:16916647   PMID:16921198   PMID:16959785   PMID:17023572   PMID:17129739   PMID:17145560   PMID:17150972   PMID:17291655  
PMID:17322295   PMID:17367743   PMID:17394464   PMID:17556650   PMID:17579710   PMID:17597094   PMID:17616699   PMID:17617569   PMID:17634366   PMID:17640558   PMID:17640623   PMID:17652337  
PMID:17652755   PMID:17664889   PMID:17670746   PMID:17719231   PMID:17923681   PMID:17927981   PMID:18006575   PMID:18083119   PMID:18160224   PMID:18218638   PMID:18232058   PMID:18331617  
PMID:18495193   PMID:18596060   PMID:18599449   PMID:18614015   PMID:18720509   PMID:18762273   PMID:18776938   PMID:18799693   PMID:19048484   PMID:19063909   PMID:19141680   PMID:19293248  
PMID:19346295   PMID:19376215   PMID:19395552   PMID:19398959   PMID:19409972   PMID:19423573   PMID:19429140   PMID:19442681   PMID:19458032   PMID:19458341   PMID:19466610   PMID:19470681  
PMID:19478076   PMID:19482077   PMID:19506076   PMID:19549914   PMID:19627269   PMID:19633237   PMID:19633665   PMID:19666610   PMID:19703553   PMID:19738419   PMID:19776389   PMID:19805130  
PMID:19819231   PMID:19822147   PMID:19905985   PMID:20060889   PMID:20156551   PMID:20194298   PMID:20195488   PMID:20304815   PMID:20542495   PMID:20638473   PMID:20649542   PMID:21056117  
PMID:21060152   PMID:21069343   PMID:21108731   PMID:21109198   PMID:21123558   PMID:21130157   PMID:21172655   PMID:21195081   PMID:21215798   PMID:21241727   PMID:21267068   PMID:21326867  
PMID:21347610   PMID:21382473   PMID:21385310   PMID:21427411   PMID:21525761   PMID:21571061   PMID:21613372   PMID:21710439   PMID:21719741   PMID:21836049   PMID:21873635   PMID:21909133  
PMID:21942371   PMID:21954064   PMID:21984432   PMID:22200564   PMID:22229939   PMID:22278880   PMID:22328603   PMID:22370091   PMID:22440255   PMID:22474353   PMID:22516022   PMID:22613204  
PMID:22710435   PMID:22783967   PMID:22796328   PMID:22949407   PMID:23142655   PMID:23145165   PMID:23195678   PMID:23213199   PMID:23219873   PMID:23237540   PMID:23360182   PMID:23580200  
PMID:23624625   PMID:23744526   PMID:23792772   PMID:23806974   PMID:23819990   PMID:23862693   PMID:23872067   PMID:23933891   PMID:23997094   PMID:24024150   PMID:24068327   PMID:24135141  
PMID:24151936   PMID:24168989   PMID:24191052   PMID:24218554   PMID:24225087   PMID:24308935   PMID:24324727   PMID:24378874   PMID:24386432   PMID:24494196   PMID:24500690   PMID:24565075  
PMID:24740755   PMID:24874427   PMID:24922073   PMID:24947366   PMID:24975834   PMID:24985474   PMID:25036096   PMID:25152242   PMID:25215947   PMID:25348719   PMID:25362851   PMID:25368096  
PMID:25413331   PMID:25578653   PMID:25600213   PMID:25733727   PMID:25740847   PMID:25757953   PMID:25779629   PMID:25829510   PMID:25948732   PMID:25992608   PMID:26101341   PMID:26108578  
PMID:26240345   PMID:26251011   PMID:26315784   PMID:26374996   PMID:26422659   PMID:26424149   PMID:26427390   PMID:26588782   PMID:26642061   PMID:26689472   PMID:26816051   PMID:26876175  
PMID:26886890   PMID:26898144   PMID:26899340   PMID:26989455   PMID:27106802   PMID:27130031   PMID:27284109   PMID:27383386   PMID:27540894   PMID:27889641   PMID:27998725   PMID:28027652  
PMID:28163078   PMID:28189851   PMID:28241311   PMID:28286268   PMID:28398002   PMID:28401939   PMID:28433661   PMID:28552526   PMID:28584055   PMID:28629836   PMID:28756653   PMID:28771227  
PMID:28771279   PMID:28849346   PMID:28914882   PMID:29079564   PMID:29362278   PMID:29398562   PMID:29574582   PMID:29718367   PMID:29739985   PMID:30044789   PMID:30068389   PMID:30118401  
PMID:30165401   PMID:30265681   PMID:30390091   PMID:30414534   PMID:30550785   PMID:30565018   PMID:30733279   PMID:30737259   PMID:30818059   PMID:30858178   PMID:30938680   PMID:31015456  
PMID:31039480   PMID:31086870   PMID:31241994   PMID:31329595   PMID:31597917   PMID:31863909   PMID:32066884   PMID:32290105   PMID:32325033   PMID:32717420   PMID:33049519   PMID:33359244  
PMID:33421588   PMID:33663221   PMID:33680286   PMID:33805584   PMID:34371143   PMID:34469740   PMID:34598016   PMID:34880332   PMID:35036884   PMID:35394023   PMID:35581738   PMID:35700329  
PMID:35760531   PMID:35933512   PMID:35947192   PMID:36293380   PMID:36325902   PMID:36417873   PMID:36449070   PMID:36470129   PMID:36691076   PMID:37016576   PMID:37099996   PMID:37481014  
PMID:37948457   PMID:38142585   PMID:38154571   PMID:38191655   PMID:38243371   PMID:38266827   PMID:38310354   PMID:38412803   PMID:38892170  


Genomics

Comparative Map Data
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sod2
362 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:925
Count of miRNA genes:590
Interacting mature miRNAs:694
Transcripts:ENSMUST00000007012
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
RH94608  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381713,009,080 - 13,009,247UniSTSGRCm38
MGSCv371713,201,946 - 13,202,113UniSTSGRCm37
Celera1713,042,063 - 13,042,230UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS
X04972  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381713,015,218 - 13,015,292UniSTSGRCm38
MGSCv371713,208,084 - 13,208,158UniSTSGRCm37
Celera1713,048,200 - 13,048,274UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS
Whitehead_YAC17 UniSTS
Sod2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS
cM Map177.6UniSTS
L35528  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381713,015,168 - 13,015,258UniSTSGRCm38
MGSCv371713,208,034 - 13,208,124UniSTSGRCm37
Celera1713,048,150 - 13,048,240UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS
Whitehead/MRC_RH17216.1UniSTS
Sod2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS
Sod2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A1UniSTS
cM Map177.6UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF003694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL589878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY137511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z18857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000007012   ⟹   ENSMUSP00000007012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,226,704 - 13,239,021 (+)Ensembl
GRCm38.p6 Ensembl1713,007,817 - 13,020,134 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232726   ⟹   ENSMUSP00000156844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,226,883 - 13,258,950 (+)Ensembl
GRCm38.p6 Ensembl1713,007,996 - 13,040,063 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,229,227 - 13,232,356 (+)Ensembl
GRCm38.p6 Ensembl1713,010,340 - 13,013,469 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,226,747 - 13,229,638 (+)Ensembl
GRCm38.p6 Ensembl1713,007,860 - 13,010,751 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233451   ⟹   ENSMUSP00000156792
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,225,733 - 13,227,197 (+)Ensembl
GRCm38.p6 Ensembl1713,006,846 - 13,008,310 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,226,746 - 13,227,444 (+)Ensembl
GRCm38.p6 Ensembl1713,007,859 - 13,008,557 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,227,071 - 13,234,503 (+)Ensembl
GRCm38.p6 Ensembl1713,008,184 - 13,015,616 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,253,863 - 13,256,285 (+)Ensembl
GRCm38.p6 Ensembl1713,034,976 - 13,037,398 (+)Ensembl
RefSeq Acc Id: NM_013671   ⟹   NP_038699
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391713,226,726 - 13,237,006 (+)NCBI
GRCm381713,007,839 - 13,018,119 (+)ENTREZGENE
MGSCv371713,200,705 - 13,210,985 (+)RGD
Celera1713,040,822 - 13,051,101 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038699   ⟸   NM_013671
- Peptide Label: precursor
- UniProtKB: Q64670 (UniProtKB/Swiss-Prot),   Q8VEM5 (UniProtKB/Swiss-Prot),   P09671 (UniProtKB/Swiss-Prot),   Q4FJX9 (UniProtKB/TrEMBL),   Q3TJA2 (UniProtKB/TrEMBL),   Q3U8W4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000007012   ⟸   ENSMUST00000007012
Ensembl Acc Id: ENSMUSP00000156792   ⟸   ENSMUST00000233451
Ensembl Acc Id: ENSMUSP00000156844   ⟸   ENSMUST00000232726
Protein Domains
Manganese/iron superoxide dismutase C-terminal   Manganese/iron superoxide dismutase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09671-F1-model_v2 AlphaFold P09671 1-222 view protein structure

Promoters
RGD ID:13674774
Promoter ID:EPDNEW_M21536
Type:initiation region
Name:Sod2_1
Description:Mus musculus superoxide dismutase 2, mitochondrial , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381713,007,982 - 13,008,042EPDNEW
RGD ID:6828707
Promoter ID:MM_KWN:22140
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_013671,   UC008ALW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361713,200,464 - 13,200,964 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98352 AgrOrtholog
Ensembl Genes ENSMUSG00000006818 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000007012 ENTREZGENE
  ENSMUST00000007012.6 UniProtKB/Swiss-Prot
  ENSMUST00000232726.2 UniProtKB/TrEMBL
  ENSMUST00000233451.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.55.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20656 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98352 ENTREZGENE
NCBI Gene 20656 ENTREZGENE
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SOD2 RGD
PhenoGen Sod2 PhenoGen
PIRSF SODismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2W479_MOUSE UniProtKB/TrEMBL
  A0A3B2WBF0_MOUSE UniProtKB/TrEMBL
  P09671 ENTREZGENE
  Q3TJA2 ENTREZGENE, UniProtKB/TrEMBL
  Q3U8W4 ENTREZGENE, UniProtKB/TrEMBL
  Q4FJX9 ENTREZGENE, UniProtKB/TrEMBL
  Q64670 ENTREZGENE
  Q8VEM5 ENTREZGENE
  SODM_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q64670 UniProtKB/Swiss-Prot
  Q8VEM5 UniProtKB/Swiss-Prot