RGD Reference Report - Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. - Rat Genome Database

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Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss.

Authors: Fortunato, G  Marciano, E  Zarrilli, F  Mazzaccara, C  Intrieri, M  Calcagno, G  Vitale, DF  La Manna, P  Saulino, C  Marcelli, V  Sacchetti, L 
Citation: Fortunato G, etal., Clin Chem. 2004 Nov;50(11):2012-8. Epub 2004 Sep 2.
RGD ID: 8158044
Pubmed: PMID:15345661   (View Abstract at PubMed)
DOI: DOI:10.1373/clinchem.2004.037788   (Journal Full-text)

BACKGROUND: Noise-induced cochlear epithelium damage can cause hearing loss in industrial workers. In experimental systems, noise induces the release of free radicals and may damage the cochlear sensorial epithelium. Therefore, genes involved in regulating the reactive oxygen species manganese-superoxide dismutase (SOD2) and the antioxidant paraoxonase (PON) could influence cochlea vulnerability to noise. We evaluated whether susceptibility to noise-induced hearing loss (NIHL) is associated with SOD2, PON1, and PON2 polymorphisms in workers exposed to prolonged loud noise. METHODS: We enrolled 94 male workers from an aircraft factory in the study. The SOD2 gene was screened by denaturing reversed-phase HPLC, and the PON1 (Q192R and M55L) and PON2 (S311C) polymorphisms were analyzed by PCR amplification followed by digestion with restriction endonucleases. RESULTS: Three known (A16V, IVS3-23T/G, and IVS3-60T/G) and two new SOD2 polymorphisms (IVS1+ 8A/G and IVS3+107T/A) were identified. Regression analysis showed that PON2 (SC+CC) [odds ratio (OR) = 5.01; 95% confidence interval (CI), 1.11-22.54], SOD2 IVS3-23T/G and IVS3-60T/G (OR = 5.09; 95% CI, 1.27-20.47), age (OR = 1.22; 95% CI, 1.09-1.36), and smoking (OR = 49.49; 95% CI, 5.09-480.66) were associated with NIHL. No association was detected for PON1 (QQ+RR) and PON1 (LL) genotypes. CONCLUSIONS: Our data suggest that SOD2 and PON2 polymorphisms, by exerting variable local tissue antioxidant roles, could predispose to NIHL. However, caution should be exercised in interpreting these data given the small sample size and the difficulty in matching cases to controls regarding the overwhelming risk factor, i.e., smoking at least 10 cigarettes/day.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hearing Loss, Noise-Induced susceptibilityIAGP 8158044DNA:polymorphisms:intron:IVS3-23T>G and IVS3-60T>G (human)RGD 
Hearing Loss, Noise-Induced susceptibilityISOSOD2 (Homo sapiens)8158044; 8158044DNA:polymorphisms:intron:IVS3-23T>G and IVS3-60T>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sod2  (superoxide dismutase 2)

Genes (Mus musculus)
Sod2  (superoxide dismutase 2, mitochondrial)

Genes (Homo sapiens)
SOD2  (superoxide dismutase 2)


Additional Information