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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:25942
Term: peroxynitrous acid
Definition: A nitrogen oxoacid that has formula HNO3.
Chemical ID: MESH:D030421
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTDSOD2 protein affects the susceptibility to [alatrofloxacin results in increased abundance of Peroxynitrous Acid]PMID:20655887
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDPeroxynitrous Acid results in increased expression of SOD2 mRNAPMID:9741582
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; Cysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid]PMID:15855331 PMID:9741582
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