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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:41072
Term: 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Definition: An indole that has formula C25H24N4O2.
Chemical ID: MESH:C070515
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDbisindolylmaleimide I results in decreased expression of SOD2 proteinPMID:15330761
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDbisindolylmaleimide I inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein]; bisindolylmaleimide I inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; bisindolylmaleimide I promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]PMID:15308628 PMID:15330761 PMID:9852137
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