SOD2 (superoxide dismutase 2) - Rat Genome Database
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Gene: SOD2 (superoxide dismutase 2) Sus scrofa
Analyze
Symbol: SOD2
Name: superoxide dismutase 2
RGD ID: 14161060
Description: ENCODES a protein that exhibits DNA binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); age-dependent response to oxidative stress (ortholog); age-dependent response to reactive oxygen species (ortholog); PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); acute kidney tubular necrosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial nucleoid (ortholog); mitochondrion (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; cadmium dichloride; calcium atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: superoxide dismutase (Mn type); superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
Arsenic Poisoning  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bilirubin metabolic disorder  (ISO)
bladder neck obstruction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
Central Nervous System Infections  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Esophageal Stenosis  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis  (ISO)
Farber lipogranulomatosis  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypoglycemia  (ISO)
Hypopharyngeal Neoplasms  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
intestinal disease  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leber hereditary optic neuropathy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
major depressive disorder  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
MELAS syndrome  (ISO)
Mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (ISO)
middle cerebral artery infarction  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple chemical sensitivity  (ISO)
multiple myeloma  (ISO)
mycosis fungoides  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
optic neuritis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Radiation Injuries, Experimental  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (ISO)
Reticulocytosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sengers syndrome  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
systemic lupus erythematosus  (ISO)
Tardive Dyskinesia  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular disease  (ISO)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
age-dependent response to oxidative stress  (ISO)
age-dependent response to reactive oxygen species  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
cellular response to ethanol  (ISO)
detection of oxygen  (ISO)
erythrophore differentiation  (ISO)
glutathione metabolic process  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
hydrogen peroxide metabolic process  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
iron ion homeostasis  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of membrane hyperpolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron development  (ISO)
oxygen homeostasis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
post-embryonic development  (ISO)
protein homotetramerization  (ISO)
regulation of blood pressure  (ISO)
regulation of catalytic activity  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (IEA,ISO)
respiratory electron transport chain  (ISO)
response to activity  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to cold  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to isolation stress  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to magnetism  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (ISO)
response to silicon dioxide  (ISO)
response to superoxide  (ISO)
response to zinc ion  (ISO)
sensory perception of sound  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1556751   PMID:14681463   PMID:17145712   PMID:19293328   PMID:28624353  


Genomics

Comparative Map Data
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6159,669,069 - 159,745,186 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,679,119 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh376160,100,148 - 160,114,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,362,979 - 160,445,890 (-)NCBICHM1_1
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39mm39
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBImm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2147,638,318 - 47,645,163 (-)NCBI
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0panPan3
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBI
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)Ensembl
Sod2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000039602   ⟹   ENSSSCP00000040011
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054351   ⟹   ENSSSCP00000045952
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056447   ⟹   ENSSSCP00000039008
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,679,564 - 7,689,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085693   ⟹   ENSSSCP00000072625
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,679,351 - 7,688,880 (+)Ensembl
RefSeq Acc Id: NM_214127   ⟹   NP_999292
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.117,679,352 - 7,689,564 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999292 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK84036 (Get FASTA)   NCBI Sequence Viewer  
  CAA45413 (Get FASTA)   NCBI Sequence Viewer  
  P28768 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999292   ⟸   NM_214127
- Sequence:
RefSeq Acc Id: ENSSSCP00000045952   ⟸   ENSSSCT00000054351
RefSeq Acc Id: ENSSSCP00000040011   ⟸   ENSSSCT00000039602
RefSeq Acc Id: ENSSSCP00000072625   ⟸   ENSSSCT00000085693
RefSeq Acc Id: ENSSSCP00000039008   ⟸   ENSSSCT00000056447
Protein Domains
Sod_Fe_C   Sod_Fe_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040317 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000039008 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000040011 UniProtKB/TrEMBL
  ENSSSCP00000045952 UniProtKB/TrEMBL
  ENSSSCP00000072625 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039602 UniProtKB/TrEMBL
  ENSSSCT00000054351 UniProtKB/TrEMBL
  ENSSSCT00000056447 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000085693 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.500.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene SOD2 ENTREZGENE
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF SODismutase UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/TrEMBL
Superfamily-SCOP SSF46609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287A4Z2_PIG UniProtKB/TrEMBL
  A0A287A8A8_PIG UniProtKB/TrEMBL
  A0A287APZ8_PIG UniProtKB/TrEMBL
  A0A5G2RDT4_PIG UniProtKB/TrEMBL
  P28768 ENTREZGENE
  Q95JF1_PIG UniProtKB/TrEMBL
  SODM_PIG UniProtKB/Swiss-Prot