SOD2 (superoxide dismutase 2) - Rat Genome Database
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Gene: SOD2 (superoxide dismutase 2) Pan paniscus
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Symbol: SOD2
Name: superoxide dismutase 2
RGD ID: 11781982
Description: ENCODES a protein that exhibits DNA binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); age-dependent response to oxidative stress (ortholog); age-dependent response to reactive oxygen species (ortholog); PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); acute kidney tubular necrosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial matrix (ortholog); mitochondrial nucleoid (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
Arsenic Poisoning  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bilirubin metabolic disorder  (ISO)
bladder neck obstruction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
Central Nervous System Infections  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Esophageal Stenosis  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis  (ISO)
Farber lipogranulomatosis  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypoglycemia  (ISO)
Hypopharyngeal Neoplasms  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
intestinal disease  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leber hereditary optic neuropathy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
major depressive disorder  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
MELAS syndrome  (ISO)
Mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (ISO)
middle cerebral artery infarction  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple chemical sensitivity  (ISO)
multiple myeloma  (ISO)
mycosis fungoides  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
optic neuritis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Radiation Injuries, Experimental  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (ISO)
Reticulocytosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sengers syndrome  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
systemic lupus erythematosus  (ISO)
Tardive Dyskinesia  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular disease  (ISO)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
age-dependent response to oxidative stress  (ISO)
age-dependent response to reactive oxygen species  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
cellular response to ethanol  (ISO)
detection of oxygen  (ISO)
erythrophore differentiation  (ISO)
glutathione metabolic process  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
hydrogen peroxide metabolic process  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
iron ion homeostasis  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of membrane hyperpolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron development  (ISO)
oxygen homeostasis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
post-embryonic development  (ISO)
protein homotetramerization  (ISO)
regulation of blood pressure  (ISO)
regulation of catalytic activity  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
respiratory electron transport chain  (ISO)
response to activity  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to cold  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to isolation stress  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to magnetism  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (ISO)
response to silicon dioxide  (ISO)
response to superoxide  (ISO)
response to zinc ion  (ISO)
sensory perception of sound  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0panPan3
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6159,679,119 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,669,069 - 159,745,186 (-)EnsemblGRCh38hg38GRCh38
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,100,148 - 160,114,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,362,979 - 160,445,890 (-)NCBICHM1_1
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39mm39
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBImm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBI
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)Ensembl
Sod2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000053684   ⟹   ENSPPAP00000030820
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000053714   ⟹   ENSPPAP00000030850
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6162,579,461 - 162,589,868 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000053718   ⟹   ENSPPAP00000030854
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6162,579,461 - 162,589,868 (-)Ensembl
RefSeq Acc Id: XM_008959502   ⟹   XP_008957750
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.16162,576,082 - 162,589,960 (-)NCBI
Mhudiblu_PPA_v06157,562,814 - 157,577,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034963181   ⟹   XP_034819072
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06157,562,814 - 157,609,735 (-)NCBI
RefSeq Acc Id: XM_034963182   ⟹   XP_034819073
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBI
RefSeq Acc Id: XM_034963183   ⟹   XP_034819074
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06157,562,814 - 157,577,038 (-)NCBI
RefSeq Acc Id: XM_034963184   ⟹   XP_034819075
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06157,562,814 - 157,577,040 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008957750   ⟸   XM_008959502
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034819073   ⟸   XM_034963182
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034819072   ⟸   XM_034963181
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034819075   ⟸   XM_034963184
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034819074   ⟸   XM_034963183
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000030820   ⟸   ENSPPAT00000053684
RefSeq Acc Id: ENSPPAP00000030850   ⟸   ENSPPAT00000053714
RefSeq Acc Id: ENSPPAP00000030854   ⟸   ENSPPAT00000053718
Protein Domains
Sod_Fe_C   Sod_Fe_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038347 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000030820 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000030850 UniProtKB/TrEMBL
  ENSPPAP00000030854 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053684 UniProtKB/TrEMBL
  ENSPPAT00000053714 UniProtKB/TrEMBL
  ENSPPAT00000053718 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.990 UniProtKB/TrEMBL
  2.40.500.20 UniProtKB/TrEMBL
InterPro Mn/Fe_SOD UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/TrEMBL
KEGG Report pps:100990423 UniProtKB/TrEMBL
NCBI Gene SOD2 ENTREZGENE
Pfam Sod_Fe_C UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/TrEMBL
PIRSF SODismutase UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/TrEMBL
Superfamily-SCOP SSF46609 UniProtKB/TrEMBL
  SSF54719 UniProtKB/TrEMBL
UniProt A0A2R9BMB0_PANPA UniProtKB/TrEMBL
  A0A2R9BME1_PANPA UniProtKB/TrEMBL
  A0A2R9BN94_PANPA UniProtKB/TrEMBL